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Cutting Edge of the Pathogenesis of Atopic Dermatitis: Sphingomyelin Deacylase, the Enzyme Involved in Its Ceramide Deficiency, Plays a Pivotal Role

International journal of molecular sciences, 2021-02, Vol.22 (4), p.1613

Imokawa, Genji

2021

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Melanocyte Activation Mechanisms and Rational Therapeutic Treatments of Solar Lentigos

International journal of molecular sciences, 2019-07, Vol.20 (15), p.3666

Imokawa, Genji

2019

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Intracellular Signaling Mechanisms Involved in the Biological Effects of the Xanthophyll Carotenoid Astaxanthin to Prevent the Photo‐aging of the Skin in a Reactive Oxygen Species Depletion‐independent Manner: The Key Role of Mitogen and Stress‐activated Protein Kinase 1

Photochemistry and photobiology, 2019-03, Vol.95 (2), p.480-489

Imokawa, Genji

2019

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Biological mechanisms underlying the ultraviolet radiation-induced formation of skin wrinkling and sagging I: reduced skin elasticity, highly associated with enhanced dermal elastase activity, triggers wrinkling and sagging

International Journal of Molecular Sciences, 2015-04, Vol.16 (4), p.7753-7775

2015

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Mechanism of UVB-Induced Wrinkling of the Skin: Paracrine Cytokine Linkage between Keratinocytes and Fibroblasts Leading to the Stimulation of Elastase

The Journal of investigative dermatology symposium proceedings, 2009-08, Vol.14 (1), p.36-43

Imokawa, Genji

2009

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Signaling Cascades Activated by UVB in Human Melanocytes Lead to the Increased Expression of Melanocyte Receptors, Endothelin B Receptor and c‐KIT

Photochemistry and photobiology, 2018-05, Vol.94 (3), p.421-431

2018

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A possible mechanism underlying the ceramide deficiency in atopic dermatitis: Expression of a deacylase enzyme that cleaves the N -acyl linkage of sphingomyelin and glucosylceramide

Journal of dermatological science, 2009-07, Vol.55 (1), p.1-9

Imokawa, Genji

2009

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β-Sitosterol 3-O-D-glucoside increases ceramide levels in the stratum corneum via the up-regulated expression of ceramide synthase-3 and glucosylceramide synthase in a reconstructed human epidermal keratinization model

PloS one, 2021-03, Vol.16 (3), p.e0248150-e0248150

2021

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Inhibitors of intracellular signaling pathways that lead to stimulated epidermal pigmentation: perspective of anti-pigmenting agents

International journal of molecular sciences, 2014-05, Vol.15 (5), p.8293-8315

2014

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Strawberry seed extract and its major component, tiliroside, promote ceramide synthesis in the stratum corneum of human epidermal equivalents

PloS one, 2018-10, Vol.13 (10), p.e0205061-e0205061

2018

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Astaxanthin attenuates the UVA-induced up-regulation of matrix-metalloproteinase-1 and skin fibroblast elastase in human dermal fibroblasts

Journal of dermatological science, 2010-05, Vol.58 (2), p.136-142

2010

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Th1 cytokines accentuate but Th2 cytokines attenuate ceramide production in the stratum corneum of human epidermal equivalents: An implication for the disrupted barrier mechanism in atopic dermatitis

Journal of dermatological science, 2012-10, Vol.68 (1), p.25-35

2012

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A Nano-Emulsion Containing Ceramide-like Lipo-Amino Acid Cholesteryl Derivatives Improves Skin Symptoms in Patients with Atopic Dermatitis by Ameliorating the Water-Holding Function

International journal of molecular sciences, 2022-11, Vol.23 (21), p.13362

2022

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Biological mechanisms underlying the ultraviolet radiation-induced formation of skin wrinkling and sagging II: over-expression of neprilysin plays an essential role

International Journal of Molecular Sciences, 2015-04, Vol.16 (4), p.7776-7795

2015

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The Attenuated Secretion of Hyaluronan by UVA-Exposed Human Fibroblasts Is Associated with Up- and Downregulation of HYBID and HAS2 Expression via Activated and Inactivated Signaling of the p38/ATF2 and JAK2/STAT3 Cascades

International journal of molecular sciences, 2021-02, Vol.22 (4), p.2057

2021

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Overexpression of the β-Subunit of Acid Ceramidase in the Epidermis of Mice Provokes Atopic Dermatitis-like Skin Symptoms

International journal of molecular sciences, 2024-08, Vol.25 (16), p.8737

2024

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Recent advances in characterizing biological mechanisms underlying UV-induced wrinkles: a pivotal role of fibrobrast-derived elastase

Archives of Dermatological Research, 2008-04, Vol.300 (Suppl 1), p.7-20

Imokawa, Genji

2008

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The UVB-Stimulated Expression of Transglutaminase 1 Is Mediated Predominantly via the NFκB Signaling Pathway: New Evidence of Its Significant Attenuation through the Specific Interruption of the p38/MSK1/NFκBp65 Ser276 Axis

PloS one, 2015-08, Vol.10 (8), p.e0136311-e0136311

2015

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Amelioration of lactic acid sensations in sensitive skin by stimulating the barrier function and improving the ceramide profile

Archives of Dermatological Research, 2018-08, Vol.310 (6), p.495-504

2018

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The Inhibitory Effects of Anti-Oxidants on Ultraviolet-Induced Up-Regulation of the Wrinkling-Inducing Enzyme Neutral Endopeptidase in Human Fibroblasts

PloS one, 2016-09, Vol.11 (9), p.e0161580-e0161580

2016

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UVB Stimulates the Expression of Endothelin B Receptor in Human Melanocytes via a Sequential Activation of the p38/MSK1/CREB/MITF Pathway Which Can Be Interrupted by a French Maritime Pine Bark Extract through a Direct Inactivation of MSK1

PloS one, 2015-06, Vol.10 (6), p.e0128678-e0128678

2015

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The Xanthophyll Carotenoid Astaxanthin has Distinct Biological Effects to Prevent the Photoaging of the Skin Even by its Postirradiation Treatment

Photochemistry and photobiology, 2019-03, Vol.95 (2), p.490-500

Imokawa, Genji

2019

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Horse-Derived Ceramide Accentuates Glucosylceramide Synthase and Ceramide Synthase 3 by Activating PPARβ/δ and/or PPARγ to Stimulate Ceramide Synthesis

Biomedicines, 2023-02, Vol.11 (2), p.548

2023

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Astaxanthin and withaferin A block paracrine cytokine interactions between UVB-exposed human keratinocytes and human melanocytes via the attenuation of endothelin-1 secretion and its downstream intracellular signaling

Cytokine (Philadelphia, Pa.), 2015-06, Vol.73 (2), p.184-197

2015

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Sphingomyelin Deacylase, the Enzyme Involved in the Pathogenesis of Atopic Dermatitis, Is Identical to the β-Subunit of Acid Ceramidase

International journal of molecular sciences, 2020-11, Vol.21 (22), p.8789

2020

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Cutting Edge of the Pathogenesis of Atopic Dermatitis: Sphingomyelin Deacylase, the Enzyme Involved in Its Ceramide Deficiency, Plays a Pivotal Role

Melanocyte Activation Mechanisms and Rational Therapeutic Treatments of Solar Lentigos

Intracellular Signaling Mechanisms Involved in the Biological Effects of the Xanthophyll Carotenoid Astaxanthin to Prevent the Photo‐aging of the Skin in a Reactive Oxygen Species Depletion‐independent Manner: The Key Role of Mitogen and Stress‐activated Protein Kinase 1

Biological mechanisms underlying the ultraviolet radiation-induced formation of skin wrinkling and sagging I: reduced skin elasticity, highly associated with enhanced dermal elastase activity, triggers wrinkling and sagging

Mechanism of UVB-Induced Wrinkling of the Skin: Paracrine Cytokine Linkage between Keratinocytes and Fibroblasts Leading to the Stimulation of Elastase

Signaling Cascades Activated by UVB in Human Melanocytes Lead to the Increased Expression of Melanocyte Receptors, Endothelin B Receptor and c‐KIT

A possible mechanism underlying the ceramide deficiency in atopic dermatitis: Expression of a deacylase enzyme that cleaves the N -acyl linkage of sphingomyelin and glucosylceramide

β-Sitosterol 3-O-D-glucoside increases ceramide levels in the stratum corneum via the up-regulated expression of ceramide synthase-3 and glucosylceramide synthase in a reconstructed human epidermal keratinization model

Inhibitors of intracellular signaling pathways that lead to stimulated epidermal pigmentation: perspective of anti-pigmenting agents

Strawberry seed extract and its major component, tiliroside, promote ceramide synthesis in the stratum corneum of human epidermal equivalents

Astaxanthin attenuates the UVA-induced up-regulation of matrix-metalloproteinase-1 and skin fibroblast elastase in human dermal fibroblasts

Th1 cytokines accentuate but Th2 cytokines attenuate ceramide production in the stratum corneum of human epidermal equivalents: An implication for the disrupted barrier mechanism in atopic dermatitis

A Nano-Emulsion Containing Ceramide-like Lipo-Amino Acid Cholesteryl Derivatives Improves Skin Symptoms in Patients with Atopic Dermatitis by Ameliorating the Water-Holding Function

Biological mechanisms underlying the ultraviolet radiation-induced formation of skin wrinkling and sagging II: over-expression of neprilysin plays an essential role

The Attenuated Secretion of Hyaluronan by UVA-Exposed Human Fibroblasts Is Associated with Up- and Downregulation of HYBID and HAS2 Expression via Activated and Inactivated Signaling of the p38/ATF2 and JAK2/STAT3 Cascades

Overexpression of the β-Subunit of Acid Ceramidase in the Epidermis of Mice Provokes Atopic Dermatitis-like Skin Symptoms

Recent advances in characterizing biological mechanisms underlying UV-induced wrinkles: a pivotal role of fibrobrast-derived elastase

The UVB-Stimulated Expression of Transglutaminase 1 Is Mediated Predominantly via the NFκB Signaling Pathway: New Evidence of Its Significant Attenuation through the Specific Interruption of the p38/MSK1/NFκBp65 Ser276 Axis

Amelioration of lactic acid sensations in sensitive skin by stimulating the barrier function and improving the ceramide profile

The Inhibitory Effects of Anti-Oxidants on Ultraviolet-Induced Up-Regulation of the Wrinkling-Inducing Enzyme Neutral Endopeptidase in Human Fibroblasts

UVB Stimulates the Expression of Endothelin B Receptor in Human Melanocytes via a Sequential Activation of the p38/MSK1/CREB/MITF Pathway Which Can Be Interrupted by a French Maritime Pine Bark Extract through a Direct Inactivation of MSK1

The Xanthophyll Carotenoid Astaxanthin has Distinct Biological Effects to Prevent the Photoaging of the Skin Even by its Postirradiation Treatment

Horse-Derived Ceramide Accentuates Glucosylceramide Synthase and Ceramide Synthase 3 by Activating PPARβ/δ and/or PPARγ to Stimulate Ceramide Synthesis

Astaxanthin and withaferin A block paracrine cytokine interactions between UVB-exposed human keratinocytes and human melanocytes via the attenuation of endothelin-1 secretion and its downstream intracellular signaling

Sphingomyelin Deacylase, the Enzyme Involved in the Pathogenesis of Atopic Dermatitis, Is Identical to the β-Subunit of Acid Ceramidase

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