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Solution-Phase Synthesis of Phosphorothioate Oligonucleotides Using a Solid-Supported Acyl Chloride with H-Phosphonate Chemistry

European Journal of Organic Chemistry, 2006-01, Vol.2006 (2), p.436-448

2006

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Use of Allylic Protecting Groups for the Synthesis of Base-Sensitive Prooligonucleotides

European journal of organic chemistry, 2002-01, Vol.2002 (1), p.49-56

2002

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Fluoride-Labile Protecting Groups for the Synthesis of Base-Sensitive Methyl-SATE Oligonucleotide Prodrugs

European journal of organic chemistry, 2003-06, Vol.2003 (12), p.2327-2335

2003

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Photocleavable Protecting Groups as Nucleobase Protections Allowed the Solid-Phase Synthesis of Base-Sensitive SATE-Prooligonucleotides

Journal of organic chemistry, 1999-08, Vol.64 (17), p.6319-6328

1999

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Antiviral l-Nucleosides Specific for Hepatitis B Virus Infection

Antimicrobial Agents and Chemotherapy, 2001-01, Vol.45 (1), p.229-235

2001

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Lipophilic pro-oligonucleotides are rapidly and efficiently internalized in HeLa cells

Nucleic acids research, 1999-10, Vol.27 (20), p.4071-4076

1999

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High-Field NMR and Restrained Molecular Modeling Studies on a DNA Heteroduplex Containing a Modified Apurinic Abasic Site in the Form of Covalently Linked 9-Aminoellipticine

Biochemistry (Easton), 1994-08, Vol.33 (34), p.10271-10285

1994

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The Prooligonucleotide Approach: Synthesis of Mixed Phosphodiester and SATE Phosphotriester Prooligonucleotides Using H-Phosphonate and Phosphoramidite Chemistries

European journal of organic chemistry, 1999-09, Vol.1999 (9), p.2353-2358

1999

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Rational design for cytosolic delivery of nucleoside monphosphates : “SATE” and “DTE” as enzyme-labile transient phosphate protecting groups

Bioorganic & medicinal chemistry letters, 1993-12, Vol.3 (12), p.2521-2526

1993

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Kinetics study of the biotransformation of an oligonucleotide prodrug in cells extract by matrix-assisted laser desorption–ionization time-of-flight mass spectrometry

Journal of chromatography. B, Biomedical sciences and applications, 2001-03, Vol.753 (1), p.123-130

2001

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Analysis of solid-supported oligonucleotides by matrix-assisted laser desorption/ionization time-of-flight mass spectrometry

Rapid communications in mass spectrometry, 2000-02, Vol.14 (4), p.234-242

2000

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Mononucleoside Phosphotriester Derivatives with S-Acyl-2-thioethyl Bioreversible Phosphate-Protecting Groups: Intracellular Delivery of 3'-Azido-2',3'-dideoxythymidine 5'-Monophosphate

Journal of medicinal chemistry, 1995-09, Vol.38 (20), p.3941-3950

1995

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S-Acyl-2-thioethyl Phosphoramidate Diester Derivatives as Mononucleotide Prodrugs

Journal of medicinal chemistry, 2003-10, Vol.46 (21), p.4564-4571

2003

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First synthesis of alternating SATE-phosphotriester/ phosphodiester prooligonucleotides on solid support

Bioorganic & medicinal chemistry letters, 1998-10, Vol.8 (20), p.2913-2918

1998

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High-Yield Solution-Phase Synthesis of Di- and Trinucleotide Blocks Assisted by Polymer-Supported Reagents

Organic letters, 2005-08, Vol.7 (16), p.3485-3488

2005

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Intracellular Metabolism of β-l-2′,3′-Dideoxyadenosine: Relevance to Its Limited Antiviral Activity

Antimicrobial Agents and Chemotherapy, 2000-04, Vol.44 (4), p.853-858

2000

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Synthesis and Biological Evaluation in Human Monocyte-Derived Macrophages of N-(N-Acetyl-l-cysteinyl)-S-acetylcysteamine Analogues with Potent Antioxidant and Anti-HIV Activities

Journal of medicinal chemistry, 2004-03, Vol.47 (7), p.1789-1795

2004

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S-Acyl-2-Thioethyl Aryl Phosphotriester Derivatives of AZT: Synthesis, Antiviral Activity, and Stability Study

Journal of medicinal chemistry, 2003-02, Vol.46 (5), p.782-793

2003

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The pro-oligonucleotide approach: solid phase synthesis and preliminary evaluation of model pro-dodecathymidylates

Nucleic acids research, 1998-05, Vol.26 (9), p.2069-2074

1998

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Pharmacokinetics of Bis(t-butyl-SATE)-AZTMP, a Bispivaloylthioethyl Prodrug for Intracellular Delivery of Zidovudine Monophosphate, in Mice

Antiviral chemistry & chemotherapy, 2000-05, Vol.11 (3), p.203-211

2000

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Synthesis, Conformational Analysis, and Biological Activity of C-Thioribonucleosides Related to Tiazofurin

Journal of medicinal chemistry, 2000-04, Vol.43 (7), p.1264-1270

2000

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Decomposition Pathways and in Vitro HIV Inhibitory Effects of IsoddA Pronucleotides: Toward a Rational Approach for Intracellular Delivery of Nucleoside 5‘-Monophosphates

Journal of medicinal chemistry, 1996-05, Vol.39 (10), p.1981-1990

1996

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Pharmacokinetics of β-l-2′,3′-Dideoxy-5-Fluorocytidine in Rhesus Monkeys

Antimicrobial Agents and Chemotherapy, 1999-04, Vol.43 (4), p.920-924

1999

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Synthesis, in Vitro Antiviral Evaluation, and Stability Studies of Bis(S-acyl-2-thioethyl) Ester Derivatives of 9-[2-(Phosphonomethoxy)ethyl]adenine (PMEA) as Potential PMEA Prodrugs with Improved Oral Bioavailability

Journal of medicinal chemistry, 1996-12, Vol.39 (25), p.4958-4965

1996

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Antisense oligonucleotides in solution or encapsulated in immunoliposomes inhibit replication of HIV-1 by several different mechanisms

Nucleic acids research, 1994-10, Vol.22 (20), p.4307-4314

1994

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Solution-Phase Synthesis of Phosphorothioate Oligonucleotides Using a Solid-Supported Acyl Chloride with H-Phosphonate Chemistry

Use of Allylic Protecting Groups for the Synthesis of Base-Sensitive Prooligonucleotides

Fluoride-Labile Protecting Groups for the Synthesis of Base-Sensitive Methyl-SATE Oligonucleotide Prodrugs

Photocleavable Protecting Groups as Nucleobase Protections Allowed the Solid-Phase Synthesis of Base-Sensitive SATE-Prooligonucleotides

Antiviral l-Nucleosides Specific for Hepatitis B Virus Infection

Lipophilic pro-oligonucleotides are rapidly and efficiently internalized in HeLa cells

High-Field NMR and Restrained Molecular Modeling Studies on a DNA Heteroduplex Containing a Modified Apurinic Abasic Site in the Form of Covalently Linked 9-Aminoellipticine

The Prooligonucleotide Approach: Synthesis of Mixed Phosphodiester and SATE Phosphotriester Prooligonucleotides Using H-Phosphonate and Phosphoramidite Chemistries

Rational design for cytosolic delivery of nucleoside monphosphates : “SATE” and “DTE” as enzyme-labile transient phosphate protecting groups

Kinetics study of the biotransformation of an oligonucleotide prodrug in cells extract by matrix-assisted laser desorption–ionization time-of-flight mass spectrometry

Analysis of solid-supported oligonucleotides by matrix-assisted laser desorption/ionization time-of-flight mass spectrometry

Mononucleoside Phosphotriester Derivatives with S-Acyl-2-thioethyl Bioreversible Phosphate-Protecting Groups: Intracellular Delivery of 3'-Azido-2',3'-dideoxythymidine 5'-Monophosphate

S-Acyl-2-thioethyl Phosphoramidate Diester Derivatives as Mononucleotide Prodrugs

First synthesis of alternating SATE-phosphotriester/ phosphodiester prooligonucleotides on solid support

High-Yield Solution-Phase Synthesis of Di- and Trinucleotide Blocks Assisted by Polymer-Supported Reagents

Intracellular Metabolism of β-l-2′,3′-Dideoxyadenosine: Relevance to Its Limited Antiviral Activity

Synthesis and Biological Evaluation in Human Monocyte-Derived Macrophages of N-(N-Acetyl-l-cysteinyl)-S-acetylcysteamine Analogues with Potent Antioxidant and Anti-HIV Activities

S-Acyl-2-Thioethyl Aryl Phosphotriester Derivatives of AZT: Synthesis, Antiviral Activity, and Stability Study

The pro-oligonucleotide approach: solid phase synthesis and preliminary evaluation of model pro-dodecathymidylates

Pharmacokinetics of Bis(t-butyl-SATE)-AZTMP, a Bispivaloylthioethyl Prodrug for Intracellular Delivery of Zidovudine Monophosphate, in Mice

Synthesis, Conformational Analysis, and Biological Activity of C-Thioribonucleosides Related to Tiazofurin

Decomposition Pathways and in Vitro HIV Inhibitory Effects of IsoddA Pronucleotides: Toward a Rational Approach for Intracellular Delivery of Nucleoside 5‘-Monophosphates

Pharmacokinetics of β-l-2′,3′-Dideoxy-5-Fluorocytidine in Rhesus Monkeys

Synthesis, in Vitro Antiviral Evaluation, and Stability Studies of Bis(S-acyl-2-thioethyl) Ester Derivatives of 9-[2-(Phosphonomethoxy)ethyl]adenine (PMEA) as Potential PMEA Prodrugs with Improved Oral Bioavailability

Antisense oligonucleotides in solution or encapsulated in immunoliposomes inhibit replication of HIV-1 by several different mechanisms

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