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Sandwich-Cultured Hepatocytes for Mechanistic Understanding of Hepatic Disposition of Parent Drugs and Metabolites by Transporter-Enzyme Interplay

Drug metabolism and disposition, 2018-05, Vol.46 (5), p.680-691

2018

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A Human Immortalized Cell-Based Blood–Brain Barrier Triculture Model: Development and Characterization as a Promising Tool for Drug−Brain Permeability Studies

Molecular pharmaceutics, 2019-11, Vol.16 (11), p.4461-4471

2019

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Hydrolase Activity of the Genetic Variants of Human Alpha-1-Acid Glycoprotein

Molecular pharmaceutics, 2022-03, Vol.19 (3), p.798-804

2022

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Analysis of Nonlinear Pharmacokinetics of a Highly Albumin-Bound Compound: Contribution of Albumin-Mediated Hepatic Uptake Mechanism

Journal of pharmaceutical sciences, 2017-09, Vol.106 (9), p.2704-2714

2017

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Semi-physiologically based pharmacokinetic model allows prediction of CNS disposition of ONO-2333MS in humans

Drug metabolism and pharmacokinetics, 2019-01, Vol.34 (1), p.S69-S70

2019

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Comprehensive PBPK Model of Rifampicin for Quantitative Prediction of Complex Drug‐Drug Interactions: CYP3A/2C9 Induction and OATP Inhibition Effects

CPT: pharmacometrics and systems pharmacology, 2018-03, Vol.7 (3), p.186-196

2018

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Unique Hydrolysis of an Ester-Type Prodrug of Levodopa in Human Plasma: Relay-Type Role Sharing between Alpha‑1 Acid Glycoprotein and Human Serum Albumin

Molecular pharmaceutics, 2019-10, Vol.16 (10), p.4131-4138

2019

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Species Difference in Hydrolysis of an Ester-type Prodrug of Levodopa in Human and Animal Plasma: Different Contributions of Alpha‑1 Acid Glycoprotein

Molecular pharmaceutics, 2021-05, Vol.18 (5), p.1985-1991

2021

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Expanded Physiologically‐Based Pharmacokinetic Model of Rifampicin for Predicting Interactions With Drugs and an Endogenous Biomarker via Complex Mechanisms Including Organic Anion Transporting Polypeptide 1B Induction

CPT: pharmacometrics and systems pharmacology, 2019-11, Vol.8 (11), p.845-857

2019

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P159 - A novel hydrolytic activation pathway for an ester-type prodrug in human plasma: Contribution of α1-acid glycoprotein variant

Drug metabolism and pharmacokinetics, 2020, Vol.35 (1), p.S71-S71

2020

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Modeling approach for multiple transporters-mediated drug–drug interactions in sandwich-cultured human hepatocytes: Effect of cyclosporin A on hepatic disposition of mycophenolic acid phenyl-glucuronide

Drug metabolism and pharmacokinetics, 2015-04, Vol.30 (2), p.142-148

2015

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Inclusion of Human Intravenous Study Data in New Drug Applications—Impact of the Japanese Guidance

Journal of pharmaceutical sciences, 2012-07, Vol.101 (7), p.2557-2563

2012

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Prediction of Human Bioavailability from Human Oral Administration Data and Animal Pharmacokinetic Data Without Data from Intravenous Administration of Drugs in Humans

Pharmaceutical research, 2009-08, Vol.26 (8), p.1881-1889

2009

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Predicting successful/unsuccessful extrapolation for in vivo total clearance of model compounds with a variety of hepatic intrinsic metabolism and protein bindings in humans from pharmacokinetic data using chimeric mice with humanised liver

Xenobiotica, 2020-05, Vol.50 (5), p.526-535

2020

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Species Difference in Hydrolysis of an Ester-Type Prodrug of Levodopa in Human and Animal Plasma: Different Contributions of Alpha‑1 Acid Glycoprotein

Molecular pharmaceutics, 2022-09, Vol.19 (9), p.3450-3450

2022

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The effect of continuous arterial infusion of Gabexate Mesilate (FOY-007) on experimental acute pancreatitis

The Journal of Medical Investigation, 2004, Vol.51(3,4), pp.186-193

2004

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Analysis of the Metabolic Pathway of Bosentan and of the Cytotoxicity of Bosentan Metabolites Based on a Quantitative Modeling of Metabolism and Transport in Sandwich-Cultured Human Hepatocytes

Drug metabolism and disposition, 2016-01, Vol.44 (1), p.16-27

2016

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Kinetic study of the hepatobiliary transport of a new prostaglandin receptor agonist

The Journal of pharmacology and experimental therapeutics, 1998-03, Vol.284 (3), p.949

1998

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Design and synthesis of new orally active inhibitors of human neutrophil elastase

Bioorganic & medicinal chemistry, 2001-05, Vol.9 (5), p.1307-1323

2001

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Studies on the Metabolic Fate of Neutrophil Elastase Inhibitor ONO-5046Na (2): Plasma concentration-profile, Distribusion and Excretion after Repeated Intravenous Bolus Administration to Rats and Effects on Metabolizing Enzyme Activities

Drug Metabolism and Pharmacokinetics, 1997, Vol.12 (6), p.566-575

1997

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Studies on the Metabolic Fate of Neutrophil Elastase Inhibitor ONO-5046Na(3): Metabolism and Binding to Serum Protein in Various Animal Species

Drug Metabolism and Pharmacokinetics, 1997, Vol.12 (6), p.576-588

1997

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Studies on the Metabolic Fate of Ultra Short Acting .BETA.1 Blocker ONO-1101. (3). Metabolism and Protein Binding

Drug Metabolism and Pharmacokinetics, 1997, Vol.12 (1), p.31-41

1997

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Studies on the Metabolic Fate of Neutrophil Elastase Inhibitor ONO-5046Na (1): Plasma Concentration-profile, Distribution and Excretion after Single Intravenous Administration to Rats

Drug Metabolism and Pharmacokinetics, 1997, Vol.12 (6), p.551-565

1997

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Studies on the Metabolic Fate on Ultra Short Acting .BETA.1 Blocker ONO-1101. (2). Plasma Concentration-Time Profile, Distribution, Excretion and Effects on Drug Metabolizing Enzyme Activities after Repeated Intravenous Administration to Rats

Drug Metabolism and Pharmacokinetics, 1997, Vol.12 (1), p.22-30

1997

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Studies on the Metabolic Fate of Ultra Short Acting .BETA.1 Blocker ONO-1101. (1). Plasma Concentration-time Profile, Distribution and Excretion after Single Intravenous Administration to Rats

Drug Metabolism and Pharmacokinetics, 1997, Vol.12 (1), p.5-21

1997

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Sandwich-Cultured Hepatocytes for Mechanistic Understanding of Hepatic Disposition of Parent Drugs and Metabolites by Transporter-Enzyme Interplay

A Human Immortalized Cell-Based Blood–Brain Barrier Triculture Model: Development and Characterization as a Promising Tool for Drug−Brain Permeability Studies

Hydrolase Activity of the Genetic Variants of Human Alpha-1-Acid Glycoprotein

Analysis of Nonlinear Pharmacokinetics of a Highly Albumin-Bound Compound: Contribution of Albumin-Mediated Hepatic Uptake Mechanism

Semi-physiologically based pharmacokinetic model allows prediction of CNS disposition of ONO-2333MS in humans

Comprehensive PBPK Model of Rifampicin for Quantitative Prediction of Complex Drug‐Drug Interactions: CYP3A/2C9 Induction and OATP Inhibition Effects

Unique Hydrolysis of an Ester-Type Prodrug of Levodopa in Human Plasma: Relay-Type Role Sharing between Alpha‑1 Acid Glycoprotein and Human Serum Albumin

Species Difference in Hydrolysis of an Ester-type Prodrug of Levodopa in Human and Animal Plasma: Different Contributions of Alpha‑1 Acid Glycoprotein

Expanded Physiologically‐Based Pharmacokinetic Model of Rifampicin for Predicting Interactions With Drugs and an Endogenous Biomarker via Complex Mechanisms Including Organic Anion Transporting Polypeptide 1B Induction

P159 - A novel hydrolytic activation pathway for an ester-type prodrug in human plasma: Contribution of α1-acid glycoprotein variant

Modeling approach for multiple transporters-mediated drug–drug interactions in sandwich-cultured human hepatocytes: Effect of cyclosporin A on hepatic disposition of mycophenolic acid phenyl-glucuronide

Inclusion of Human Intravenous Study Data in New Drug Applications—Impact of the Japanese Guidance

Prediction of Human Bioavailability from Human Oral Administration Data and Animal Pharmacokinetic Data Without Data from Intravenous Administration of Drugs in Humans

Predicting successful/unsuccessful extrapolation for in vivo total clearance of model compounds with a variety of hepatic intrinsic metabolism and protein bindings in humans from pharmacokinetic data using chimeric mice with humanised liver

Species Difference in Hydrolysis of an Ester-Type Prodrug of Levodopa in Human and Animal Plasma: Different Contributions of Alpha‑1 Acid Glycoprotein

The effect of continuous arterial infusion of Gabexate Mesilate (FOY-007) on experimental acute pancreatitis

Analysis of the Metabolic Pathway of Bosentan and of the Cytotoxicity of Bosentan Metabolites Based on a Quantitative Modeling of Metabolism and Transport in Sandwich-Cultured Human Hepatocytes

Kinetic study of the hepatobiliary transport of a new prostaglandin receptor agonist

Design and synthesis of new orally active inhibitors of human neutrophil elastase

Studies on the Metabolic Fate of Neutrophil Elastase Inhibitor ONO-5046Na (2): Plasma concentration-profile, Distribusion and Excretion after Repeated Intravenous Bolus Administration to Rats and Effects on Metabolizing Enzyme Activities

Studies on the Metabolic Fate of Neutrophil Elastase Inhibitor ONO-5046Na(3): Metabolism and Binding to Serum Protein in Various Animal Species

Studies on the Metabolic Fate of Ultra Short Acting .BETA.1 Blocker ONO-1101. (3). Metabolism and Protein Binding

Studies on the Metabolic Fate of Neutrophil Elastase Inhibitor ONO-5046Na (1): Plasma Concentration-profile, Distribution and Excretion after Single Intravenous Administration to Rats

Studies on the Metabolic Fate on Ultra Short Acting .BETA.1 Blocker ONO-1101. (2). Plasma Concentration-Time Profile, Distribution, Excretion and Effects on Drug Metabolizing Enzyme Activities after Repeated Intravenous Administration to Rats

Studies on the Metabolic Fate of Ultra Short Acting .BETA.1 Blocker ONO-1101. (1). Plasma Concentration-time Profile, Distribution and Excretion after Single Intravenous Administration to Rats

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