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Immunomodulation by radiotherapy in tumour control and normal tissue toxicity

Nature reviews. Immunology, 2022-02, Vol.22 (2), p.124-138

2022

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Toll-Like Receptor Agonists and Radiation Therapy Combinations: An Untapped Opportunity to Induce Anticancer Immunity and Improve Tumor control

International journal of radiation oncology, biology, physics, 2020-09, Vol.108 (1), p.27-37

2020

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Fractionated Radiation Therapy Stimulates Antitumor Immunity Mediated by Both Resident and Infiltrating Polyclonal T-cell Populations when Combined with PD-1 Blockade

Clinical cancer research, 2017-09, Vol.23 (18), p.5514-5526

2017

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Radiotherapy-Immunotherapy Combination: How Will We Bridge the Gap Between Pre-Clinical Promise and Effective Clinical Delivery?

Cancers, 2021-01, Vol.13 (3), p.457

2021

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Understanding the Effects of Radiotherapy on the Tumour Immune Microenvironment to Identify Potential Prognostic and Predictive Biomarkers of Radiotherapy Response

Cancers, 2020-09, Vol.12 (10), p.2835

2020

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Inhibition of DNA-PK with AZD7648 Sensitizes Tumor Cells to Radiotherapy and Induces Type I IFN-Dependent Durable Tumor Control

Clinical cancer research, 2021-08, Vol.27 (15), p.4353-4366

2021

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The anti-PD-1 era - an opportunity to enhance radiotherapy for patients with bladder cancer

Nature reviews. Urology, 2018-04, Vol.15 (4), p.251-259

2018

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4 Gy versus 24 Gy radiotherapy for patients with indolent lymphoma (FORT): a randomised phase 3 non-inferiority trial

The lancet oncology, 2014-04, Vol.15 (4), p.457-463

2014

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Systemic delivery of a TLR7 agonist in combination with radiation primes durable antitumor immune responses in mouse models of lymphoma

Blood, 2013-01, Vol.121 (2), p.251-259

2013

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A Retrospective Chart Review of Treatment Patterns and Overall Survival among a Cohort of Patients with Relapsed/Refractory Mycosis Fungoides in France, Germany, Italy, Spain and the United Kingdom

Cancers, 2023-11, Vol.15 (23), p.5669

2023

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Immuno-regulatory antibodies for the treatment of cancer

Expert opinion on biological therapy, 2015-06, Vol.15 (6), p.787-801

2015

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Scientific rationale underpinning the development of biosimilar rituximab in hematological cancers and inflammatory diseases

Future oncology (London, England), 2019-12, Vol.15 (36), p.4223-4234

2019

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Contemporary Treatment Patterns and Response in Relapsed/Refractory Cutaneous T-Cell Lymphoma (CTCL) across Five European Countries

Cancers, 2021-12, Vol.14 (1), p.145

2021

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Hypoxia Is Associated with Increased Immune Infiltrates and Both Anti-Tumour and Immune Suppressive Signalling in Muscle-Invasive Bladder Cancer

International journal of molecular sciences, 2023-05, Vol.24 (10), p.8956

2023

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Revisiting the role of radiotherapy in Hodgkin lymphoma to augment systemic immunity

Leukemia & lymphoma, 2018-11, Vol.59 (11), p.2519-2520

2018

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The influence of radiation in the context of developing combination immunotherapies in cancer

Therapeutic Advances in Vaccines and Immunotherapy, 2017-12, Vol.5 (6), p.115-122

2017

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Clinical efficacy of zanolimumab (HuMax-CD4): two phase 2 studies in refractory cutaneous T-cell lymphoma

Blood, 2007-06, Vol.109 (11), p.4655-4662

2007

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Antitumor Efficacy of Radiation plus Immunotherapy Depends upon Dendritic Cell Activation of Effector CD8+ T Cells

Cancer immunology research, 2016-07, Vol.4 (7), p.621-630

2016

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A novel systemically administered toll‐like receptor 7 agonist potentiates the effect of ionizing radiation in murine solid tumor models

International journal of cancer, 2014-08, Vol.135 (4), p.820-829

2014

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Stromal cell inhibition of anti-CD20 antibody mediated killing of B-cell malignancies

Frontiers in cell and developmental biology, 2023, Vol.11, p.1270398-1270398

2023

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Low CD8 T Cell Counts Predict Benefit from Hypoxia-Modifying Therapy in Muscle-Invasive Bladder Cancer

Cancers, 2022-12, Vol.15 (1), p.41

2022

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Improving therapeutic activity of anti-CD20 antibody therapy through immunomodulation in lymphoid malignancies

Leukemia & lymphoma, 2016-06, Vol.57 (6), p.1269-1280

2016

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Intravenous administration of the selective toll-like receptor 7 agonist DSR-29133 leads to anti-tumor efficacy in murine solid tumor models which can be potentiated by combination with fractionated radiotherapy

Oncotarget, 2016-03, Vol.7 (13), p.17035-17046

2016

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Evaluation of apoptosis imaging biomarkers in a genetic model of cell death

EJNMMI research, 2019-02, Vol.9 (1), p.18-13, Article 18

2019

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Upregulation of meiosis-specific genes in lymphoma cell lines following genotoxic insult and induction of mitotic catastrophe

BMC cancer, 2006-01, Vol.6 (1), p.6-6, Article 6

2006

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Immunomodulation by radiotherapy in tumour control and normal tissue toxicity

Toll-Like Receptor Agonists and Radiation Therapy Combinations: An Untapped Opportunity to Induce Anticancer Immunity and Improve Tumor control

Fractionated Radiation Therapy Stimulates Antitumor Immunity Mediated by Both Resident and Infiltrating Polyclonal T-cell Populations when Combined with PD-1 Blockade

Radiotherapy-Immunotherapy Combination: How Will We Bridge the Gap Between Pre-Clinical Promise and Effective Clinical Delivery?

Understanding the Effects of Radiotherapy on the Tumour Immune Microenvironment to Identify Potential Prognostic and Predictive Biomarkers of Radiotherapy Response

Inhibition of DNA-PK with AZD7648 Sensitizes Tumor Cells to Radiotherapy and Induces Type I IFN-Dependent Durable Tumor Control

The anti-PD-1 era - an opportunity to enhance radiotherapy for patients with bladder cancer

4 Gy versus 24 Gy radiotherapy for patients with indolent lymphoma (FORT): a randomised phase 3 non-inferiority trial

Systemic delivery of a TLR7 agonist in combination with radiation primes durable antitumor immune responses in mouse models of lymphoma

A Retrospective Chart Review of Treatment Patterns and Overall Survival among a Cohort of Patients with Relapsed/Refractory Mycosis Fungoides in France, Germany, Italy, Spain and the United Kingdom

Immuno-regulatory antibodies for the treatment of cancer

Scientific rationale underpinning the development of biosimilar rituximab in hematological cancers and inflammatory diseases

Contemporary Treatment Patterns and Response in Relapsed/Refractory Cutaneous T-Cell Lymphoma (CTCL) across Five European Countries

Hypoxia Is Associated with Increased Immune Infiltrates and Both Anti-Tumour and Immune Suppressive Signalling in Muscle-Invasive Bladder Cancer

Revisiting the role of radiotherapy in Hodgkin lymphoma to augment systemic immunity

The influence of radiation in the context of developing combination immunotherapies in cancer

Clinical efficacy of zanolimumab (HuMax-CD4): two phase 2 studies in refractory cutaneous T-cell lymphoma

Antitumor Efficacy of Radiation plus Immunotherapy Depends upon Dendritic Cell Activation of Effector CD8+ T Cells

A novel systemically administered toll‐like receptor 7 agonist potentiates the effect of ionizing radiation in murine solid tumor models

Stromal cell inhibition of anti-CD20 antibody mediated killing of B-cell malignancies

Low CD8 T Cell Counts Predict Benefit from Hypoxia-Modifying Therapy in Muscle-Invasive Bladder Cancer

Improving therapeutic activity of anti-CD20 antibody therapy through immunomodulation in lymphoid malignancies

Intravenous administration of the selective toll-like receptor 7 agonist DSR-29133 leads to anti-tumor efficacy in murine solid tumor models which can be potentiated by combination with fractionated radiotherapy

Evaluation of apoptosis imaging biomarkers in a genetic model of cell death

Upregulation of meiosis-specific genes in lymphoma cell lines following genotoxic insult and induction of mitotic catastrophe

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