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Natural products discovery from micro-organisms in the post-genome era

Bioscience, biotechnology, and biochemistry, 2017-01, Vol.81 (1), p.13-22

Ikeda, Haruo

2017

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Terpene synthases are widely distributed in bacteria

Proceedings of the National Academy of Sciences - PNAS, 2015-01, Vol.112 (3), p.857-862

2015

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Exploration and Mining of the Bacterial Terpenome

Accounts of chemical research, 2012-03, Vol.45 (3), p.463-472

2012

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Gastric myotomy length affects severity but not rate of post-procedure reflux: 3-year follow-up of a prospective randomized controlled trial of double-scope per-oral endoscopic myotomy (POEM) for esophageal achalasia

Surgical endoscopy, 2020-07, Vol.34 (7), p.2963-2968

2020

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Modifications to central carbon metabolism in an engineered Streptomyces host to enhance secondary metabolite production

Journal of bioscience and bioengineering, 2020-12, Vol.130 (6), p.563-570

2020

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Genome mining of the Streptomyces avermitilis genome and development of genome-minimized hosts for heterologous expression of biosynthetic gene clusters

Journal of industrial microbiology & biotechnology, 2014-02, Vol.41 (2), p.233-250

2014

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Dissection of goadsporin biosynthesis by in vitro reconstitution leading to designer analogues expressed in vivo

Nature communications, 2017-02, Vol.8 (1), p.14207-14207, Article 14207

2017

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In vitro Cas9-assisted editing of modular polyketide synthase genes to produce desired natural product derivatives

Nature communications, 2020-08, Vol.11 (1), p.4022-4022, Article 4022

2020

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Discovery of gene cluster for mycosporine-like amino acid biosynthesis from Actinomycetales microorganisms and production of a novel mycosporine-like amino acid by heterologous expression

Applied and environmental microbiology, 2014-08, Vol.80 (16), p.5028-5036

2014

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Genome-minimized Streptomyces host for the heterologous expression of secondary metabolism

Proceedings of the National Academy of Sciences - PNAS, 2010-02, Vol.107 (6), p.2646-2651

2010

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Per-Oral Endoscopic Myotomy: A Series of 500 Patients

Journal of the American College of Surgeons, 2015-08, Vol.221 (2), p.256-264

2015

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Novel macrolactam compound produced by the heterologous expression of a large cryptic biosynthetic gene cluster of Streptomyces rochei IFO12908

Journal of antibiotics, 2020-03, Vol.73 (3), p.171-174

2020

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Peroral Endoscopic Myotomy Is a Viable Option for Failed Surgical Esophagocardiomyotomy Instead of Redo Surgical Heller Myotomy: A Single Center Prospective Study

Journal of the American College of Surgeons, 2013-10, Vol.217 (4), p.598-605

2013

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Genome Sequence of the Streptomycin-Producing Microorganism Streptomyces griseus IFO 13350

Journal of Bacteriology, 2008-06, Vol.190 (11), p.4050-4060

2008

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Identification, cloning and heterologous expression of biosynthetic gene cluster for desertomycin

Journal of antibiotics, 2020-09, Vol.73 (9), p.650-654

2020

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Utility of a new automated diagnostic program in high-resolution esophageal manometry

Journal of gastroenterology, 2021-07, Vol.56 (7), p.633-639

2021

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SurE is a trans-acting thioesterase cyclizing two distinct non-ribosomal peptides

Organic & biomolecular chemistry, 2019-01, Vol.17 (5), p.1058-1061

2019

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Hydroxylation of Steroids by a Microbial Substrate-Promiscuous P450 Cytochrome (CYP105D7): Key Arginine Residues for Rational Design

Applied and environmental microbiology, 2019-12, Vol.85 (23), p.1

2019

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Endoscopic treatment of proton pump inhibitor‐refractory gastroesophageal reflux disease with anti‐reflux mucosectomy: Experience of 109 cases

Digestive endoscopy, 2021-03, Vol.33 (3), p.347-354

2021

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Biosynthesis of Quinolidomicin, the Largest Known Macrolide of Terrestrial Origin: Identification and Heterologous Expression of a Biosynthetic Gene Cluster over 200 kb

Organic letters, 2018-12, Vol.20 (24), p.7996-7999

2018

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Chemical diversity of labdane-type bicyclic diterpene biosynthesis in Actinomycetales microorganisms

Journal of antibiotics, 2016-07, Vol.69 (7), p.515-523

2016

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Discovery of prescopranone, a key intermediate in scopranone biosynthesis

Journal of antibiotics, 2022-06, Vol.75 (6), p.305-311

2022

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Reprogramming of the antimycin NRPS-PKS assembly lines inspired by gene evolution

Nature communications, 2018-08, Vol.9 (1), p.3534-10, Article 3534

2018

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Characterization of bafilomycin biosynthesis in Kitasatospora setae KM-6054 and comparative analysis of gene clusters in Actinomycetales microorganisms

Journal of antibiotics, 2017-05, Vol.70 (5), p.616-624

2017

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Identification and functional analysis of genes controlling biosynthesis of 2-methylisoborneol

Proceedings of the National Academy of Sciences - PNAS, 2008-05, Vol.105 (21), p.7422-7427

2008

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Natural products discovery from micro-organisms in the post-genome era

Terpene synthases are widely distributed in bacteria

Exploration and Mining of the Bacterial Terpenome

Gastric myotomy length affects severity but not rate of post-procedure reflux: 3-year follow-up of a prospective randomized controlled trial of double-scope per-oral endoscopic myotomy (POEM) for esophageal achalasia

Modifications to central carbon metabolism in an engineered Streptomyces host to enhance secondary metabolite production

Genome mining of the Streptomyces avermitilis genome and development of genome-minimized hosts for heterologous expression of biosynthetic gene clusters

Dissection of goadsporin biosynthesis by in vitro reconstitution leading to designer analogues expressed in vivo

In vitro Cas9-assisted editing of modular polyketide synthase genes to produce desired natural product derivatives

Discovery of gene cluster for mycosporine-like amino acid biosynthesis from Actinomycetales microorganisms and production of a novel mycosporine-like amino acid by heterologous expression

Genome-minimized Streptomyces host for the heterologous expression of secondary metabolism

Per-Oral Endoscopic Myotomy: A Series of 500 Patients

Novel macrolactam compound produced by the heterologous expression of a large cryptic biosynthetic gene cluster of Streptomyces rochei IFO12908

Peroral Endoscopic Myotomy Is a Viable Option for Failed Surgical Esophagocardiomyotomy Instead of Redo Surgical Heller Myotomy: A Single Center Prospective Study

Genome Sequence of the Streptomycin-Producing Microorganism Streptomyces griseus IFO 13350

Identification, cloning and heterologous expression of biosynthetic gene cluster for desertomycin

Utility of a new automated diagnostic program in high-resolution esophageal manometry

SurE is a trans-acting thioesterase cyclizing two distinct non-ribosomal peptides

Hydroxylation of Steroids by a Microbial Substrate-Promiscuous P450 Cytochrome (CYP105D7): Key Arginine Residues for Rational Design

Endoscopic treatment of proton pump inhibitor‐refractory gastroesophageal reflux disease with anti‐reflux mucosectomy: Experience of 109 cases

Biosynthesis of Quinolidomicin, the Largest Known Macrolide of Terrestrial Origin: Identification and Heterologous Expression of a Biosynthetic Gene Cluster over 200 kb

Chemical diversity of labdane-type bicyclic diterpene biosynthesis in Actinomycetales microorganisms

Discovery of prescopranone, a key intermediate in scopranone biosynthesis

Reprogramming of the antimycin NRPS-PKS assembly lines inspired by gene evolution

Characterization of bafilomycin biosynthesis in Kitasatospora setae KM-6054 and comparative analysis of gene clusters in Actinomycetales microorganisms

Identification and functional analysis of genes controlling biosynthesis of 2-methylisoborneol

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