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Drug-drug interactions for UDP-glucuronosyltransferase substrates: a pharmacokinetic explanation for typically observed low exposure (AUCi/AUC) ratios

Drug metabolism and disposition, 2004-11, Vol.32 (11), p.1201

2004

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Optimized assays for human UDP-glucuronosyltransferase (UGT) activities: altered alamethicin concentration and utility to screen for UGT inhibitors

Drug metabolism and disposition, 2012-05, Vol.40 (5), p.1051

2012

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Comparison of different algorithms for predicting clinical drug-drug interactions, based on the use of CYP3A4 in vitro data: predictions of compounds as precipitants of interaction

Drug metabolism and disposition, 2009-08, Vol.37 (8), p.1658

2009

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Maraviroc: in vitro assessment of drug–drug interaction potential

British journal of clinical pharmacology, 2008-10, Vol.66 (4), p.498-507

2008

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Selective mechanism-based inactivation of CYP3A4 by CYP3cide (PF-04981517) and its utility as an in vitro tool for delineating the relative roles of CYP3A4 versus CYP3A5 in the metabolism of drugs

Drug metabolism and disposition, 2012-09, Vol.40 (9), p.1686

2012

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In vitro and in vivo glucuronidation of midazolam in humans

British journal of clinical pharmacology, 2009-04, Vol.67 (4), p.445-454

2009

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Application of CYP3A4 in vitro data to predict clinical drug–drug interactions; predictions of compounds as objects of interaction

British journal of clinical pharmacology, 2008-05, Vol.65 (5), p.680-692

2008

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Progress curve mechanistic modeling approach for assessing time-dependent inhibition of CYP3A4

Drug metabolism and disposition, 2012-09, Vol.40 (9), p.1658

2012

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Minimizing polymorphic metabolism in drug discovery: evaluation of the utility of in vitro methods for predicting pharmacokinetic consequences associated with CYP2D6 metabolism

Drug metabolism and disposition, 2006-09, Vol.34 (9), p.1516

2006

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Development of an in vitro drug–drug interaction assay to simultaneously monitor five cytochrome P450 isoforms and performance assessment using drug library compounds

Journal of pharmacological and toxicological methods, 2008-11, Vol.58 (3), p.206-214

2008

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Induction of cytochrome P450: assessment in an immortalized human hepatocyte cell line (Fa2N4) using a novel higher throughput cocktail assay

Drug metabolism and disposition, 2007-02, Vol.35 (2), p.275

2007

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Targeted Quantitative Proteomics for the Analysis of 14 UGT1As and -2Bs in Human Liver Using NanoUPLC–MS/MS with Selected Reaction Monitoring

Journal of proteome research, 2013-10, Vol.12 (10), p.4402-4413

2013

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Identification of the cytochrome P450 enzymes involved in the N-oxidation of voriconazole

Drug metabolism and disposition, 2003-05, Vol.31 (5), p.540

2003

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Reaction phenotyping in drug discovery: moving forward with confidence?

Current drug metabolism, 2003-12, Vol.4 (6), p.527

2003

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Investigation into UDP-glucuronosyltransferase (UGT) enzyme kinetics of imidazole- and triazole-containing antifungal drugs in human liver microsomes and recombinant UGT enzymes

Drug metabolism and disposition, 2010-06, Vol.38 (6), p.923

2010

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Interaction of terfenadine and its primary metabolites with cytochrome P450 2D6

Drug metabolism and disposition, 1998-09, Vol.26 (9), p.875

1998

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Medicinal chemistry approaches to avoid aldehyde oxidase metabolism

Bioorganic & medicinal chemistry letters, 2012-04, Vol.22 (8), p.2856-2860

2012

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Understanding CYP2D6 interactions

Drug discovery today, 2009-10, Vol.14 (19), p.964-972

2009

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Investigation of the mechanistic basis of N,N-dimethylformamide toxicity. Metabolism of N,N-dimethylformamide and its deuterated isotopomers by cytochrome P450 2E1

Chemical research in toxicology, 1993-03, Vol.6 (2), p.197-207

1993

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Excretion and metabolism of lersivirine (5-{[3,5-diethyl-1-(2-hydroxyethyl)(3,5-14C2)-1H-pyrazol-4-yl]oxy}benzene-1,3-dicarbonitrile), a next-generation non-nucleoside reverse transcriptase inhibitor, after administration of [14C]Lersivirine to healthy volunteers

Drug metabolism and disposition, 2010-05, Vol.38 (5), p.789

2010

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In vitro andin vivo glucuronidation of midazolam in humans

British journal of clinical pharmacology, 2009, Vol.67 (4), p.445-454

2009

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N-alkylformamides are metabolized to N-alkylcarbamoylating species by hepatic microsomes from rodents and humans

Chemical research in toxicology, , Vol.3 (4), p.357-362

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Utility of human/human-derived reagents in drug discovery and development: An industrial perspective

Environmental toxicology and pharmacology, 2006-02, Vol.21 (2), p.179-183

2006

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Human hepatocytes in primary culture predict lack of cytochrome P-450 3A4 induction by eletriptan in vivo

Drug metabolism and disposition, 2000-01, Vol.28 (1), p.51

2000

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Significance of metabolism in the disposition and action of the antidysrhythmic drug, dofetilide. In vitro studies and correlation with in vivo data

Drug metabolism and disposition, 1996-04, Vol.24 (4), p.447

1996

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Drug-drug interactions for UDP-glucuronosyltransferase substrates: a pharmacokinetic explanation for typically observed low exposure (AUCi/AUC) ratios

Optimized assays for human UDP-glucuronosyltransferase (UGT) activities: altered alamethicin concentration and utility to screen for UGT inhibitors

Comparison of different algorithms for predicting clinical drug-drug interactions, based on the use of CYP3A4 in vitro data: predictions of compounds as precipitants of interaction

Maraviroc: in vitro assessment of drug–drug interaction potential

Selective mechanism-based inactivation of CYP3A4 by CYP3cide (PF-04981517) and its utility as an in vitro tool for delineating the relative roles of CYP3A4 versus CYP3A5 in the metabolism of drugs

In vitro and in vivo glucuronidation of midazolam in humans

Application of CYP3A4 in vitro data to predict clinical drug–drug interactions; predictions of compounds as objects of interaction

Progress curve mechanistic modeling approach for assessing time-dependent inhibition of CYP3A4

Minimizing polymorphic metabolism in drug discovery: evaluation of the utility of in vitro methods for predicting pharmacokinetic consequences associated with CYP2D6 metabolism

Development of an in vitro drug–drug interaction assay to simultaneously monitor five cytochrome P450 isoforms and performance assessment using drug library compounds

Induction of cytochrome P450: assessment in an immortalized human hepatocyte cell line (Fa2N4) using a novel higher throughput cocktail assay

Targeted Quantitative Proteomics for the Analysis of 14 UGT1As and -2Bs in Human Liver Using NanoUPLC–MS/MS with Selected Reaction Monitoring

Identification of the cytochrome P450 enzymes involved in the N-oxidation of voriconazole

Reaction phenotyping in drug discovery: moving forward with confidence?

Investigation into UDP-glucuronosyltransferase (UGT) enzyme kinetics of imidazole- and triazole-containing antifungal drugs in human liver microsomes and recombinant UGT enzymes

Interaction of terfenadine and its primary metabolites with cytochrome P450 2D6

Medicinal chemistry approaches to avoid aldehyde oxidase metabolism

Understanding CYP2D6 interactions

Investigation of the mechanistic basis of N,N-dimethylformamide toxicity. Metabolism of N,N-dimethylformamide and its deuterated isotopomers by cytochrome P450 2E1

Excretion and metabolism of lersivirine (5-{[3,5-diethyl-1-(2-hydroxyethyl)(3,5-14C2)-1H-pyrazol-4-yl]oxy}benzene-1,3-dicarbonitrile), a next-generation non-nucleoside reverse transcriptase inhibitor, after administration of [14C]Lersivirine to healthy volunteers

In vitro andin vivo glucuronidation of midazolam in humans

N-alkylformamides are metabolized to N-alkylcarbamoylating species by hepatic microsomes from rodents and humans

Utility of human/human-derived reagents in drug discovery and development: An industrial perspective

Human hepatocytes in primary culture predict lack of cytochrome P-450 3A4 induction by eletriptan in vivo

Significance of metabolism in the disposition and action of the antidysrhythmic drug, dofetilide. In vitro studies and correlation with in vivo data

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