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The role of DYRK1A in neurodegenerative diseases

The FEBS journal, 2011-01, Vol.278 (2), p.236-245

2011

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Development of Novel Fluorinated Polyphenols as Selective Inhibitors of DYRK1A/B Kinase for Treatment of Neuroinflammatory Diseases including Parkinson's Disease

Pharmaceuticals (Basel, Switzerland), 2023-03, Vol.16 (3), p.443

2023

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Harmine is an ATP-competitive inhibitor for dual-specificity tyrosine phosphorylation-regulated kinase 1A (Dyrk1A)

Archives of biochemistry and biophysics, 2011-03, Vol.507 (2), p.212-218

2011

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Overexpression of Dyrk1A contributes to neurofibrillary degeneration in Down syndrome

The FASEB journal, 2008-09, Vol.22 (9), p.3224-3233

2008

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Abnormalities of DYRK1A-Cytoskeleton Complexes in the Blood Cells as Potential Biomarkers of Alzheimer's Disease

Journal of Alzheimer's disease, 2019-01, Vol.72 (4), p.1059

2019

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Increased Dosage of Dyrk1A Alters Alternative Splicing Factor (ASF)-regulated Alternative Splicing of Tau in Down Syndrome

The Journal of biological chemistry, 2008-10, Vol.283 (42), p.28660-28669

2008

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Phosphorylation by Dyrk1A of clathrin coated vesicle-associated proteins: identification of the substrate proteins and the effects of phosphorylation

PloS one, 2012-04, Vol.7 (4), p.e34845-e34845

2012

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Effect of DYRK1A activity inhibition on development of neuronal progenitors isolated from Ts65Dn mice

Journal of neuroscience research, 2012-05, Vol.90 (5), p.999-1010

2012

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Design, synthesis, and biological evaluation of polyphenol derivatives as DYRK1A inhibitors. The discovery of a potentially promising treatment for Multiple Sclerosis

Bioorganic & medicinal chemistry letters, 2022-05, Vol.64, p.128675-128675, Article 128675

2022

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Dyrk1A Binds to Multiple Endocytic Proteins Required for Formation of Clathrin-Coated Vesicles

Biochemistry (Easton), 2009-10, Vol.48 (39), p.9297-9305

2009

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The role of overexpressed DYRK1A protein in the early onset of neurofibrillary degeneration in Down syndrome

Acta neuropathologica, 2008-10, Vol.116 (4), p.391-407

2008

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Promotion of Neuronal Plasticity by (−)-Epigallocatechin-3-Gallate

Neurochemical research, 2008-05, Vol.33 (5), p.776-783

2008

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An ELISA DYRK1A non-radioactive assay suitable for the characterization of inhibitors

F1000 research, 2017, Vol.6, p.42

2017

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Kinetic Properties of a MNB/DYRK1A Mutant Suitable for the Elucidation of Biochemical Pathways

Biochemistry (Easton), 2006-10, Vol.45 (39), p.12011-12019

2006

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Phosphorylation of Amphiphysin I by Minibrain Kinase/Dual-specificity Tyrosine Phosphorylation-regulated Kinase, a Kinase Implicated in Down Syndrome

The Journal of biological chemistry, 2006-08, Vol.281 (33), p.23712-23724

2006

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Dynamin Is a Minibrain Kinase/Dual Specificity Yak1-related Kinase 1A Substrate

The Journal of biological chemistry, 2002-05, Vol.277 (20), p.17597-17604

2002

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Cell type- and brain structure-specific patterns of distribution of minibrain kinase in human brain

Brain research, 2004-06, Vol.1010 (1), p.69-80

2004

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Gene Dosage–Dependent Association of DYRK1A With the Cytoskeleton in the Brain and Lymphocytes of Down Syndrome Patients

Journal of neuropathology and experimental neurology, 2012-12, Vol.71 (12), p.1100-1112

2012

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Activity-Dependent Phosphorylation of Dynamin 1 at Serine 857

Biochemistry (Easton), 2012-08, Vol.51 (34), p.6786-6796

2012

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Link Between DYRK1A Overexpression and Several-Fold Enhancement of Neurofibrillary Degeneration With 3-Repeat Tau Protein in Down Syndrome

Journal of neuropathology and experimental neurology, 2011-01, Vol.70 (1), p.36-50

2011

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An ELISA DYRK1A non-radioactive kinase assay suitable for the characterization of inhibitors [version 2; peer review: 2 approved]

F1000 research, 2017, Vol.6, p.42-42

2017

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MNB/DYRK1A phosphorylation regulates the interactions of synaptojanin 1 with endocytic accessory proteins

Biochemical and biophysical research communications, 2006-12, Vol.351 (4), p.1060-1065

2006

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Dual-Specificity Tyrosine Phosphorylation-Regulated Kinase 1A Does Not Require Tyrosine Phosphorylation for Activity in Vitro

Biochemistry (Easton), 2007-06, Vol.46 (25), p.7614-7624

2007

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Trisomy-driven overexpression of DYRK1A kinase in the brain of subjects with Down syndrome

Neuroscience letters, 2007-02, Vol.413 (1), p.77-81

2007

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Mnb/Dyrk1A Phosphorylation Regulates the Interaction of Dynamin 1 with SH3 Domain-Containing Proteins

Biochemistry (Easton), 2004-08, Vol.43 (31), p.10173-10185

2004

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The role of DYRK1A in neurodegenerative diseases

Development of Novel Fluorinated Polyphenols as Selective Inhibitors of DYRK1A/B Kinase for Treatment of Neuroinflammatory Diseases including Parkinson's Disease

Harmine is an ATP-competitive inhibitor for dual-specificity tyrosine phosphorylation-regulated kinase 1A (Dyrk1A)

Overexpression of Dyrk1A contributes to neurofibrillary degeneration in Down syndrome

Abnormalities of DYRK1A-Cytoskeleton Complexes in the Blood Cells as Potential Biomarkers of Alzheimer's Disease

Increased Dosage of Dyrk1A Alters Alternative Splicing Factor (ASF)-regulated Alternative Splicing of Tau in Down Syndrome

Phosphorylation by Dyrk1A of clathrin coated vesicle-associated proteins: identification of the substrate proteins and the effects of phosphorylation

Effect of DYRK1A activity inhibition on development of neuronal progenitors isolated from Ts65Dn mice

Design, synthesis, and biological evaluation of polyphenol derivatives as DYRK1A inhibitors. The discovery of a potentially promising treatment for Multiple Sclerosis

Dyrk1A Binds to Multiple Endocytic Proteins Required for Formation of Clathrin-Coated Vesicles

The role of overexpressed DYRK1A protein in the early onset of neurofibrillary degeneration in Down syndrome

Promotion of Neuronal Plasticity by (−)-Epigallocatechin-3-Gallate

An ELISA DYRK1A non-radioactive assay suitable for the characterization of inhibitors

Kinetic Properties of a MNB/DYRK1A Mutant Suitable for the Elucidation of Biochemical Pathways

Phosphorylation of Amphiphysin I by Minibrain Kinase/Dual-specificity Tyrosine Phosphorylation-regulated Kinase, a Kinase Implicated in Down Syndrome

Dynamin Is a Minibrain Kinase/Dual Specificity Yak1-related Kinase 1A Substrate

Cell type- and brain structure-specific patterns of distribution of minibrain kinase in human brain

Gene Dosage–Dependent Association of DYRK1A With the Cytoskeleton in the Brain and Lymphocytes of Down Syndrome Patients

Activity-Dependent Phosphorylation of Dynamin 1 at Serine 857

Link Between DYRK1A Overexpression and Several-Fold Enhancement of Neurofibrillary Degeneration With 3-Repeat Tau Protein in Down Syndrome

An ELISA DYRK1A non-radioactive kinase assay suitable for the characterization of inhibitors [version 2; peer review: 2 approved]

MNB/DYRK1A phosphorylation regulates the interactions of synaptojanin 1 with endocytic accessory proteins

Dual-Specificity Tyrosine Phosphorylation-Regulated Kinase 1A Does Not Require Tyrosine Phosphorylation for Activity in Vitro

Trisomy-driven overexpression of DYRK1A kinase in the brain of subjects with Down syndrome

Mnb/Dyrk1A Phosphorylation Regulates the Interaction of Dynamin 1 with SH3 Domain-Containing Proteins

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