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L-Type amino acid transporter 1 as a target for drug delivery

Pharmaceutical research, 2020-05, Vol.37 (5), p.88-88, Article 88

2020

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L-type amino acid transporter 1 utilizing prodrugs: How to achieve effective brain delivery and low systemic exposure of drugs

Journal of controlled release, 2017-09, Vol.261, p.93-104

2017

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L-Type amino acid transporter 1 (LAT1)-utilizing prodrugs are carrier-selective despite having low affinity for organic anion transporting polypeptides (OATPs)

International journal of pharmaceutics, 2019-11, Vol.571, p.118714, Article 118714

2019

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Pharmacoproteomics of Brain Barrier Transporters and Substrate Design for the Brain Targeted Drug Delivery

Pharmaceutical research, 2022-07, Vol.39 (7), p.1363-1392

2022

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Prodrugs - an efficient way to breach delivery and targeting barriers

Current topics in medicinal chemistry, 2011-09, Vol.11 (18), p.2265

2011

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Comparative Modelling of Organic Anion Transporting Polypeptides: Structural Insights and Comparison of Binding Modes

Molecules (Basel, Switzerland), 2022-12, Vol.27 (23), p.8531

2022

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A Selective and Slowly Reversible Inhibitor of l‑Type Amino Acid Transporter 1 (LAT1) Potentiates Antiproliferative Drug Efficacy in Cancer Cells

Journal of medicinal chemistry, 2016-06, Vol.59 (12), p.5740-5751

2016

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Hemocompatible LAT1-inhibitor can induce apoptosis in cancer cells without affecting brain amino acid homeostasis

Apoptosis (London), 2020-06, Vol.25 (5-6), p.426-440

2020

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Structural Comparison of Sulfonamide-Based Derivatives That Can Improve Anti-Coagulation Properties of Metformin

International journal of molecular sciences, 2022-04, Vol.23 (8), p.4132

2022

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Comparison of Experimental Strategies to Study l-Type Amino Acid Transporter 1 (LAT1) Utilization by Ligands

Molecules (Basel, Switzerland), 2021-12, Vol.27 (1), p.37

2021

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Incorporation of Sulfonamide Moiety into Biguanide Scaffold Results in Apoptosis Induction and Cell Cycle Arrest in MCF-7 Breast Cancer Cells

International journal of molecular sciences, 2021-05, Vol.22 (11), p.5642

2021

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Ganciclovir and Its Hemocompatible More Lipophilic Derivative Can Enhance the Apoptotic Effects of Methotrexate by Inhibiting Breast Cancer Resistance Protein (BCRP)

International journal of molecular sciences, 2021-07, Vol.22 (14), p.7727

2021

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Effective Cellular Transport of Ortho -Halogenated Sulfonamide Derivatives of Metformin Is Related to Improved Antiproliferative Activity and Apoptosis Induction in MCF-7 Cells

International journal of molecular sciences, 2020-03, Vol.21 (7), p.2389

2020

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Pleiotropic Activity of Metformin and Its Sulfonamide Derivatives on Vascular and Platelet Haemostasis

Molecules (Basel, Switzerland), 2019-12, Vol.25 (1), p.125

2019

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Neurosteroids: Structure-Uptake Relationships and Computational Modeling of Organic Anion Transporting Polypeptides (OATP)1A2

Molecules (Basel, Switzerland), 2021-09, Vol.26 (18), p.5662

2021

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Prodrugs--from serendipity to rational design

Pharmacological reviews, 2011-09, Vol.63 (3), p.750

2011

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Astrocyte-Targeted Transporter-Utilizing Derivatives of Ferulic Acid Can Have Multifunctional Effects Ameliorating Inflammation and Oxidative Stress in the Brain

Oxidative medicine and cellular longevity, 2019, Vol.2019, p.3528148-13

2019

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Species differences in the intra-brain distribution of an L-type amino acid transporter 1 (LAT1) -utilizing compound between mice and rats

International journal of pharmaceutics, 2021-03, Vol.596, p.120300, Article 120300

2021

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Increased/Targeted Brain (Pro)Drug Delivery via Utilization of Solute Carriers (SLCs)

Pharmaceutics, 2022-06, Vol.14 (6), p.1234

2022

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Mechanistic Study on the Use of the l‑Type Amino Acid Transporter 1 for Brain Intracellular Delivery of Ketoprofen via Prodrug: A Novel Approach Supporting the Development of Prodrugs for Intracellular Targets

Molecular pharmaceutics, 2019-07, Vol.16 (7), p.3261-3274

2019

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Structural properties for selective and efficient l-type amino acid transporter 1 (LAT1) mediated cellular uptake

International journal of pharmaceutics, 2018-06, Vol.544 (1), p.91-99

2018

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Improving drug delivery to the brain: the prodrug approach

Expert opinion on drug delivery, 2024-05, p.1-11

Huttunen, Kristiina M

2024

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Systemic and Brain Pharmacokinetics of Perforin Inhibitor Prodrugs

Molecular pharmaceutics, 2016-07, Vol.13 (7), p.2484-2491

2016

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Metformin and its sulphonamide derivative simultaneously potentiateanti-cholinesterase activity of donepezil and inhibit beta-amyloid aggregation

Journal of enzyme inhibition and medicinal chemistry, 2018-01, Vol.33 (1), p.1309-1322

2018

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Novel Sulfonamide-Based Analogs of Metformin Exert Promising Anti-Coagulant Effects without Compromising Glucose-Lowering Activity

Pharmaceuticals (Basel, Switzerland), 2020-10, Vol.13 (10), p.323

2020

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L-Type amino acid transporter 1 as a target for drug delivery

L-type amino acid transporter 1 utilizing prodrugs: How to achieve effective brain delivery and low systemic exposure of drugs

L-Type amino acid transporter 1 (LAT1)-utilizing prodrugs are carrier-selective despite having low affinity for organic anion transporting polypeptides (OATPs)

Pharmacoproteomics of Brain Barrier Transporters and Substrate Design for the Brain Targeted Drug Delivery

Prodrugs - an efficient way to breach delivery and targeting barriers

Comparative Modelling of Organic Anion Transporting Polypeptides: Structural Insights and Comparison of Binding Modes

A Selective and Slowly Reversible Inhibitor of l‑Type Amino Acid Transporter 1 (LAT1) Potentiates Antiproliferative Drug Efficacy in Cancer Cells

Hemocompatible LAT1-inhibitor can induce apoptosis in cancer cells without affecting brain amino acid homeostasis

Structural Comparison of Sulfonamide-Based Derivatives That Can Improve Anti-Coagulation Properties of Metformin

Comparison of Experimental Strategies to Study l-Type Amino Acid Transporter 1 (LAT1) Utilization by Ligands

Incorporation of Sulfonamide Moiety into Biguanide Scaffold Results in Apoptosis Induction and Cell Cycle Arrest in MCF-7 Breast Cancer Cells

Ganciclovir and Its Hemocompatible More Lipophilic Derivative Can Enhance the Apoptotic Effects of Methotrexate by Inhibiting Breast Cancer Resistance Protein (BCRP)

Effective Cellular Transport of Ortho -Halogenated Sulfonamide Derivatives of Metformin Is Related to Improved Antiproliferative Activity and Apoptosis Induction in MCF-7 Cells

Pleiotropic Activity of Metformin and Its Sulfonamide Derivatives on Vascular and Platelet Haemostasis

Neurosteroids: Structure-Uptake Relationships and Computational Modeling of Organic Anion Transporting Polypeptides (OATP)1A2

Prodrugs--from serendipity to rational design

Astrocyte-Targeted Transporter-Utilizing Derivatives of Ferulic Acid Can Have Multifunctional Effects Ameliorating Inflammation and Oxidative Stress in the Brain

Species differences in the intra-brain distribution of an L-type amino acid transporter 1 (LAT1) -utilizing compound between mice and rats

Increased/Targeted Brain (Pro)Drug Delivery via Utilization of Solute Carriers (SLCs)

Mechanistic Study on the Use of the l‑Type Amino Acid Transporter 1 for Brain Intracellular Delivery of Ketoprofen via Prodrug: A Novel Approach Supporting the Development of Prodrugs for Intracellular Targets

Structural properties for selective and efficient l-type amino acid transporter 1 (LAT1) mediated cellular uptake

Improving drug delivery to the brain: the prodrug approach

Systemic and Brain Pharmacokinetics of Perforin Inhibitor Prodrugs

Metformin and its sulphonamide derivative simultaneously potentiateanti-cholinesterase activity of donepezil and inhibit beta-amyloid aggregation

Novel Sulfonamide-Based Analogs of Metformin Exert Promising Anti-Coagulant Effects without Compromising Glucose-Lowering Activity

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