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Prodrugs--from serendipity to rational design

Pharmacological reviews, 2011-09, Vol.63 (3), p.750

2011

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L-Type amino acid transporter 1 as a target for drug delivery

Pharmaceutical research, 2020-05, Vol.37 (5), p.88-88, Article 88

2020

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Improving drug delivery to the brain: the prodrug approach

Expert opinion on drug delivery, 2024-05, Vol.21 (5), p.1-693

Huttunen, Kristiina M

2024

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Metformin – a Future Therapy for Neurodegenerative Diseases: Theme: Drug Discovery, Development and Delivery in Alzheimer's Disease Guest Editor: Davide Brambilla

Pharmaceutical research, 2017-12, Vol.34 (12), p.2614-2627

2017

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The Effect of Job Displacement on Couples’ Fertility Decisions

Journal of labor economics, 2016-04, Vol.34 (2), p.403-442

2016

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Amino acids as promoieties in prodrug design and development

Advanced drug delivery reviews, 2013-10, Vol.65 (10), p.1370-1385

2013

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L-type amino acid transporter 1 utilizing prodrugs: How to achieve effective brain delivery and low systemic exposure of drugs

Journal of controlled release, 2017-09, Vol.261, p.93-104

2017

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Metformin - a Future Therapy for Neurodegenerative Diseases

Pharmaceutical research, 2017-12, Vol.34 (12), p.2614-2627

2017

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Targeted efflux transporter inhibitors – A solution to improve poor cellular accumulation of anti-cancer agents

International journal of pharmaceutics, 2018-10, Vol.550 (1-2), p.278-289

2018

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L-type amino acid transporter 1 utilizing prodrugs of ferulic acid revealed structural features supporting the design of prodrugs for brain delivery

European journal of pharmaceutical sciences, 2019-03, Vol.129, p.99-109

2019

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L-Type amino acid transporter 1 (LAT1)-utilizing prodrugs are carrier-selective despite having low affinity for organic anion transporting polypeptides (OATPs)

International journal of pharmaceutics, 2019-11, Vol.571, p.118714, Article 118714

2019

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Prodrugs - an efficient way to breach delivery and targeting barriers

Current topics in medicinal chemistry, 2011-09, Vol.11 (18), p.2265

2011

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Pharmacoproteomics of Brain Barrier Transporters and Substrate Design for the Brain Targeted Drug Delivery

Pharmaceutical research, 2022-07, Vol.39 (7), p.1363-1392

2022

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Comparative Modelling of Organic Anion Transporting Polypeptides: Structural Insights and Comparison of Binding Modes

Molecules (Basel, Switzerland), 2022-12, Vol.27 (23), p.8531

2022

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Metformin derivatives – Researchers’ friends or foes?

Biochemical pharmacology, 2023-09, Vol.215, p.115743-115743, Article 115743

2023

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Orchestrated modulation of rheumatoid arthritis via crosstalking intracellular signaling pathways

Inflammopharmacology, 2021-08, Vol.29 (4), p.965-974

2021

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Hemocompatible LAT1-inhibitor can induce apoptosis in cancer cells without affecting brain amino acid homeostasis

Apoptosis (London), 2020-06, Vol.25 (5-6), p.426-440

2020

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Amino acid transporters in neurological disorders and neuroprotective effects of cysteine derivatives

Neurochemistry international, 2024-07, Vol.177, p.105771, Article 105771

2024

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A Selective and Slowly Reversible Inhibitor of l‑Type Amino Acid Transporter 1 (LAT1) Potentiates Antiproliferative Drug Efficacy in Cancer Cells

Journal of medicinal chemistry, 2016-06, Vol.59 (12), p.5740-5751

2016

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Sulfonamide metformin derivatives induce mitochondrial-associated apoptosis and cell cycle arrest in breast cancer cells

Chemico-biological interactions, 2022-01, Vol.352, p.109795-109795, Article 109795

2022

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Is Metformin a Perfect Drug? Updates in Pharmacokinetics and Pharmacodynamics

Current pharmaceutical design, 2017-01, Vol.23 (17), p.2532

2017

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Improved l-Type amino acid transporter 1 (LAT1)-mediated delivery of anti-inflammatory drugs into astrocytes and microglia with reduced prostaglandin production

International journal of pharmaceutics, 2021-05, Vol.601, p.120565-120565, Article 120565

2021

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Targeting of Perforin Inhibitor into the Brain Parenchyma Via a Prodrug Approach Can Decrease Oxidative Stress and Neuroinflammation and Improve Cell Survival

Molecular neurobiology, 2020-11, Vol.57 (11), p.4563-4577

2020

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Current approaches to facilitate improved drug delivery to the central nervous system

European journal of pharmaceutics and biopharmaceutics, 2022-12, Vol.181, p.249-262

2022

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L-type amino acid transporter 1 (LAT1)-utilizing efflux transporter inhibitors can improve the brain uptake and apoptosis-inducing effects of vinblastine in cancer cells

International journal of pharmaceutics, 2020-08, Vol.586, p.119585, Article 119585

2020

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Prodrugs--from serendipity to rational design

L-Type amino acid transporter 1 as a target for drug delivery

Improving drug delivery to the brain: the prodrug approach

Metformin – a Future Therapy for Neurodegenerative Diseases: Theme: Drug Discovery, Development and Delivery in Alzheimer's Disease Guest Editor: Davide Brambilla

The Effect of Job Displacement on Couples’ Fertility Decisions

Amino acids as promoieties in prodrug design and development

L-type amino acid transporter 1 utilizing prodrugs: How to achieve effective brain delivery and low systemic exposure of drugs

Metformin - a Future Therapy for Neurodegenerative Diseases

Targeted efflux transporter inhibitors – A solution to improve poor cellular accumulation of anti-cancer agents

L-type amino acid transporter 1 utilizing prodrugs of ferulic acid revealed structural features supporting the design of prodrugs for brain delivery

L-Type amino acid transporter 1 (LAT1)-utilizing prodrugs are carrier-selective despite having low affinity for organic anion transporting polypeptides (OATPs)

Prodrugs - an efficient way to breach delivery and targeting barriers

Pharmacoproteomics of Brain Barrier Transporters and Substrate Design for the Brain Targeted Drug Delivery

Comparative Modelling of Organic Anion Transporting Polypeptides: Structural Insights and Comparison of Binding Modes

Metformin derivatives – Researchers’ friends or foes?

Orchestrated modulation of rheumatoid arthritis via crosstalking intracellular signaling pathways

Hemocompatible LAT1-inhibitor can induce apoptosis in cancer cells without affecting brain amino acid homeostasis

Amino acid transporters in neurological disorders and neuroprotective effects of cysteine derivatives

A Selective and Slowly Reversible Inhibitor of l‑Type Amino Acid Transporter 1 (LAT1) Potentiates Antiproliferative Drug Efficacy in Cancer Cells

Sulfonamide metformin derivatives induce mitochondrial-associated apoptosis and cell cycle arrest in breast cancer cells

Is Metformin a Perfect Drug? Updates in Pharmacokinetics and Pharmacodynamics

Improved l-Type amino acid transporter 1 (LAT1)-mediated delivery of anti-inflammatory drugs into astrocytes and microglia with reduced prostaglandin production

Targeting of Perforin Inhibitor into the Brain Parenchyma Via a Prodrug Approach Can Decrease Oxidative Stress and Neuroinflammation and Improve Cell Survival

Current approaches to facilitate improved drug delivery to the central nervous system

L-type amino acid transporter 1 (LAT1)-utilizing efflux transporter inhibitors can improve the brain uptake and apoptosis-inducing effects of vinblastine in cancer cells

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