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Mechanisms of secretion and spreading of pathological tau protein

Cellular and molecular life sciences : CMLS, 2020-05, Vol.77 (9), p.1721-1744

2020

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CDNF Protein Therapy in Parkinson’s Disease

Cell Transplantation, 2019-04, Vol.28 (4), p.349-366

2019

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Secretion of Tau via an Unconventional Non-vesicular Mechanism

Cell reports (Cambridge), 2018-11, Vol.25 (8), p.2027-2035.e4

2018

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Mitochondria and NMDA receptor-dependent toxicity of berberine sensitizes neurons to glutamate and rotenone injury

PloS one, 2014-09, Vol.9 (9), p.e107129

2014

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Internalized Tau sensitizes cells to stress by promoting formation and stability of stress granules

Scientific reports, 2016-07, Vol.6 (1), p.30498-30498, Article 30498

2016

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The Cell Biology of Tau Secretion

Frontiers in molecular neuroscience, 2020-09, Vol.13, p.569818-569818

2020

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Structural basis of CDNF interaction with the UPR regulator GRP78

Nature communications, 2024-09, Vol.15 (1), p.8175-13, Article 8175

2024

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Brain-penetrating neurotrophic factor mimetics: HER-096 as a disease-modifying therapy for Parkinson’s disease

Neural regeneration research, 2025-04, Vol.20 (4), p.1094-1095

2025

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Live-cell monitoring of protein localization to membrane rafts using protein-fragment complementation

Bioscience reports, 2020-01, Vol.40 (1)

2020

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Membrane interaction and disulphide-bridge formation in the unconventional secretion of Tau

Bioscience reports, 2021-08, Vol.41 (8)

2021

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FRMD4A-cytohesin signaling modulates the cellular release of tau

Journal of cell science, 2016-05, Vol.129 (10), p.2003-2015

2016

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Augmenting hematoma-scavenging capacity of innate immune cells by CDNF reduces brain injury and promotes functional recovery after intracerebral hemorrhage

Cell death & disease, 2023-02, Vol.14 (2), p.128-128, Article 128

2023

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Genetically Targeted Clinical Trials in Parkinson's Disease: Learning from the Successes Made in Oncology

Genes, 2021-09, Vol.12 (10), p.1529

2021

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Reduced evoked activity and cortical oscillations are correlated with anisometric amblyopia and impairment of visual acuity

Scientific reports, 2021-04, Vol.11 (1), p.8310-8310, Article 8310

2021

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Multiplex assay for live-cell monitoring of cellular fates of amyloid-β precursor protein (APP)

PloS one, 2014-06, Vol.9 (6), p.e98619

2014

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Receptor for Advanced Glycation End Products (RAGE) Signaling Induces CREB-dependent Chromogranin Expression during Neuronal Differentiation

The Journal of biological chemistry, 2002-10, Vol.277 (41), p.38635-38646

2002

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The ACAT Inhibitor CP-113,818 Markedly Reduces Amyloid Pathology in a Mouse Model of Alzheimer's Disease

Neuron (Cambridge, Mass.), 2004-10, Vol.44 (2), p.227-238

2004

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The interaction of α-synuclein and Tau: A molecular conspiracy in neurodegeneration?

Seminars in cell & developmental biology, 2020-03, Vol.99, p.55-64

2020

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The Acyl-Coenzyme A: Cholesterol Acyltransferase Inhibitor CI-1011 Reverses Diffuse Brain Amyloid Pathology in Aged Amyloid Precursor Protein Transgenic Mice

Journal of neuropathology and experimental neurology, 2010-08, Vol.69 (8), p.777-788

2010

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Inhibition of acyl-coenzyme A: cholesterol acyl transferase modulates amyloid precursor protein trafficking in the early secretory pathway

The FASEB journal, 2009-11, Vol.23 (11), p.3819-3828

2009

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Stress-induced upregulation of VLDL receptor alters Wnt-signaling in neurons

Experimental cell research, 2016-01, Vol.340 (2), p.238-247

2016

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Knockdown of ACAT-1 reduces amyloidogenic processing of APP

FEBS letters, 2007-04, Vol.581 (8), p.1688-1692

2007

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HER-096 is a CDNF-derived brain-penetrating peptidomimetic that protects dopaminergic neurons in a mouse synucleinopathy model of Parkinson’s disease

Cell chemical biology, 2024-03, Vol.31 (3), p.593-606.e9

2024

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PCSK9 regulates neuronal apoptosis by adjusting ApoER2 levels and signaling

Cellular and molecular life sciences : CMLS, 2012-06, Vol.69 (11), p.1903-1916

2012

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Mechanisms of secretion and spreading of pathological tau protein

CDNF Protein Therapy in Parkinson’s Disease

Secretion of Tau via an Unconventional Non-vesicular Mechanism

Mitochondria and NMDA receptor-dependent toxicity of berberine sensitizes neurons to glutamate and rotenone injury

Internalized Tau sensitizes cells to stress by promoting formation and stability of stress granules

The Cell Biology of Tau Secretion

Structural basis of CDNF interaction with the UPR regulator GRP78

Brain-penetrating neurotrophic factor mimetics: HER-096 as a disease-modifying therapy for Parkinson’s disease

Live-cell monitoring of protein localization to membrane rafts using protein-fragment complementation

Membrane interaction and disulphide-bridge formation in the unconventional secretion of Tau

Intraputamenal Cerebral Dopamine Neurotrophic Factor in Parkinson's Disease: A Randomized, Double‐Blind, Multicenter Phase 1 Trial

FRMD4A-cytohesin signaling modulates the cellular release of tau

Augmenting hematoma-scavenging capacity of innate immune cells by CDNF reduces brain injury and promotes functional recovery after intracerebral hemorrhage

Genetically Targeted Clinical Trials in Parkinson's Disease: Learning from the Successes Made in Oncology

Reduced evoked activity and cortical oscillations are correlated with anisometric amblyopia and impairment of visual acuity

Multiplex assay for live-cell monitoring of cellular fates of amyloid-β precursor protein (APP)

Receptor for Advanced Glycation End Products (RAGE) Signaling Induces CREB-dependent Chromogranin Expression during Neuronal Differentiation

The ACAT Inhibitor CP-113,818 Markedly Reduces Amyloid Pathology in a Mouse Model of Alzheimer's Disease

The interaction of α-synuclein and Tau: A molecular conspiracy in neurodegeneration?

The Acyl-Coenzyme A: Cholesterol Acyltransferase Inhibitor CI-1011 Reverses Diffuse Brain Amyloid Pathology in Aged Amyloid Precursor Protein Transgenic Mice

Inhibition of acyl-coenzyme A: cholesterol acyl transferase modulates amyloid precursor protein trafficking in the early secretory pathway

Stress-induced upregulation of VLDL receptor alters Wnt-signaling in neurons

Knockdown of ACAT-1 reduces amyloidogenic processing of APP

HER-096 is a CDNF-derived brain-penetrating peptidomimetic that protects dopaminergic neurons in a mouse synucleinopathy model of Parkinson’s disease

PCSK9 regulates neuronal apoptosis by adjusting ApoER2 levels and signaling

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