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CNS Target Identification and Validation: Avoiding the Valley of Death or Naive Optimism?

Annual review of pharmacology and toxicology, 2017-01, Vol.57 (1), p.171-187

2017

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Genetic knockout and pharmacological blockade studies of the 5-HT7 receptor suggest therapeutic potential in depression

Neuropharmacology, 2005-03, Vol.48 (4), p.492-502

2005

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P.1.g.074 Acquired binge-eating behaviour produces alterations in dopaminergic neurochemistry in the brains of rats

European neuropsychopharmacology, 2014-10, Vol.24, p.S246-S247

2014

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Behavioral and biochemical characterization of a mutant mouse strain lacking d-amino acid oxidase activity and its implications for schizophrenia

Molecular and cellular neuroscience, 2006-08, Vol.32 (4), p.324-334

2006

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Expression of D-serine and glycine transporters in the prefrontal cortex and cerebellum in schizophrenia

Schizophrenia research, 2008-07, Vol.102 (1), p.283-294

2008

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The glycine/NMDA receptor antagonist, R‐(+)‐HA‐966, blocks activation of the mesolimbic dopaminergic system induced by phencyclidine and dizocilpine (MK‐801) in rodents

British journal of pharmacology, 1993-04, Vol.108 (4), p.1156-1163

1993

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Genetic knockout and pharmacological blockade studies of the 5-HT 7 receptor suggest therapeutic potential in depression

Neuropharmacology, 2005, Vol.48 (4), p.492-502

2005

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Glucocorticoid modulation of tryptophan hydroxylase-2 protein in raphe nuclei and 5-hydroxytryptophan concentrations in frontal cortex of C57/BI6 mice

Molecular psychiatry, 2008-05, Vol.13 (5), p.498-506

2008

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Pustative anxiolytics 8-OH-DPAT, buspirone and TVX Q 7821 are agonists at 5-HT1A autoreceptors in the raphé nuclei

Trends in pharmacological sciences (Regular ed.), 1986-01, Vol.7, p.212-214

1986

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The hypothermic effect of 5-CT in mice is mediated through the 5-HT7 receptor

Neuropharmacology, 2003-06, Vol.44 (8), p.1031-1037

2003

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Determination of guinea-pig cortical γ-secretase activity ex vivo following the systemic administration of a γ-secretase inhibitor

Neuropharmacology, 2005-06, Vol.48 (7), p.1002-1011

2005

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P.2.25 Characterisation of a caffeine-inducedmodel of insomnia in the rat

European neuropsychopharmacology, 2005, Vol.15, p.S49-S50

2005

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Evidence for accelerated desensitisation of 5-HT2C receptors following combined treatment with fluoxetine and the 5-HT1A receptor antagonist, WAY 100,635, in the rat

Neuropharmacology, 2000-06, Vol.39 (7), p.1222-1236

2000

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Gaboxadol, a selective extrasynaptic GABAA agonist, does not generalise to other sleep-enhancing drugs: A rat drug discrimination study

Neuropharmacology, 2007-03, Vol.52 (3), p.844-853

2007

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Activation of mesolimbic dopamine function by phencyclidine is enhanced by 5-HT2C/2B receptor antagonists: neurochemical and behavioural studies

Neuropharmacology, 2000-11, Vol.39 (12), p.2318-2328

2000

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Effect of the β3 adrenoceptor agonist CL 316243 on hypothalamic 5-HT synthesis and suppression of REM sleep in the rat

Journal of psychopharmacology (Oxford), 2007-08, Vol.21 (6), p.597-602

2007

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Gaboxadol, a selective extrasynaptic GABA A agonist, does not generalise to other sleep-enhancing drugs: A rat drug discrimination study

Neuropharmacology, 2007-03, Vol.52 (3), p.844-853

2007

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P.8.b.007 Gaboxadol does not generalise to other sleep-enhancing agents in drug discrimination in rats

European neuropsychopharmacology, 2006, Vol.16, p.S567-S567

2006

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Reduced social interaction following 3,4-methylenedioxymethamphetamine is not associated with enhanced 5-HT 2C receptor responsivity

Neuropharmacology, 2003-03, Vol.44 (4), p.439-448

2003

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Hippocampal 5-HT synthesis and release in vivo is decreased by infusion of 8-OHDPAT into the nucleus raphe dorsalis

Neuroscience letters, 1989-05, Vol.100 (1), p.276-280

1989

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Attenuation of stress induced cortical dopamine neurones by L-701,324, a selective glycine/NMDA antagonist is mediated via an interaction with GABAergic neurones

European neuropsychopharmacology, 1996-06, Vol.6, p.78-78

1996

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Evidence for accelerated desensitisation of 5-HT 2C receptors following combined treatment with fluoxetine and the 5-HT 1A receptor antagonist, WAY 100,635, in the rat

Neuropharmacology, 2000, Vol.39 (7), p.1222-1236

2000

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A simple apparatus for ultrafiltration of small volumes: Application to the measurement of free and albumin-bound tryptophan in plasma

Analytical biochemistry, 1977-11, Vol.83 (1), p.130-142

1977

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CNS Target Identification and Validation: Avoiding the Valley of Death or Naive Optimism?

Genetic knockout and pharmacological blockade studies of the 5-HT7 receptor suggest therapeutic potential in depression

P.1.g.074 Acquired binge-eating behaviour produces alterations in dopaminergic neurochemistry in the brains of rats

Behavioral and biochemical characterization of a mutant mouse strain lacking d-amino acid oxidase activity and its implications for schizophrenia

Expression of D-serine and glycine transporters in the prefrontal cortex and cerebellum in schizophrenia

The selective phosphodiesterase 9 (PDE9) inhibitor PF-04447943 (6-[(3S,4S)-4-methyl-1-(pyrimidin-2-ylmethyl)pyrrolidin-3-yl]-1-(tetrahydro-2H-pyran-4-yl)-1,5-dihydro-4H-pyrazolo[3,4-d]pyrimidin-4-one) enhances synaptic plasticity and cognitive function in rodents

The glycine/NMDA receptor antagonist, R‐(+)‐HA‐966, blocks activation of the mesolimbic dopaminergic system induced by phencyclidine and dizocilpine (MK‐801) in rodents

Genetic knockout and pharmacological blockade studies of the 5-HT 7 receptor suggest therapeutic potential in depression

Glucocorticoid modulation of tryptophan hydroxylase-2 protein in raphe nuclei and 5-hydroxytryptophan concentrations in frontal cortex of C57/BI6 mice

Pustative anxiolytics 8-OH-DPAT, buspirone and TVX Q 7821 are agonists at 5-HT1A autoreceptors in the raphé nuclei

The hypothermic effect of 5-CT in mice is mediated through the 5-HT7 receptor

Determination of guinea-pig cortical γ-secretase activity ex vivo following the systemic administration of a γ-secretase inhibitor

P.2.25 Characterisation of a caffeine-inducedmodel of insomnia in the rat

Evidence for accelerated desensitisation of 5-HT2C receptors following combined treatment with fluoxetine and the 5-HT1A receptor antagonist, WAY 100,635, in the rat

The selective phosphodiesterase 9 (PDE9) inhibitor PF-04447943 (6-[(3 S,4 S)-4-methyl-1-(pyrimidin-2-ylmethyl)pyrrolidin-3-yl]-1-(tetrahydro-2 H-pyran-4-yl)-1,5-dihydro-4 H-pyrazolo[3,4- d]pyrimidin-4-one) enhances synaptic plasticity and cognitive function in rodents

Gaboxadol, a selective extrasynaptic GABAA agonist, does not generalise to other sleep-enhancing drugs: A rat drug discrimination study

Activation of mesolimbic dopamine function by phencyclidine is enhanced by 5-HT2C/2B receptor antagonists: neurochemical and behavioural studies

Effect of the β3 adrenoceptor agonist CL 316243 on hypothalamic 5-HT synthesis and suppression of REM sleep in the rat

Gaboxadol, a selective extrasynaptic GABA A agonist, does not generalise to other sleep-enhancing drugs: A rat drug discrimination study

P.8.b.007 Gaboxadol does not generalise to other sleep-enhancing agents in drug discrimination in rats

Reduced social interaction following 3,4-methylenedioxymethamphetamine is not associated with enhanced 5-HT 2C receptor responsivity

Hippocampal 5-HT synthesis and release in vivo is decreased by infusion of 8-OHDPAT into the nucleus raphe dorsalis

Attenuation of stress induced cortical dopamine neurones by L-701,324, a selective glycine/NMDA antagonist is mediated via an interaction with GABAergic neurones

Evidence for accelerated desensitisation of 5-HT 2C receptors following combined treatment with fluoxetine and the 5-HT 1A receptor antagonist, WAY 100,635, in the rat

A simple apparatus for ultrafiltration of small volumes: Application to the measurement of free and albumin-bound tryptophan in plasma

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