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Druggability Indices for Protein Targets Derived from NMR-Based Screening Data

Journal of medicinal chemistry, 2005-04, Vol.48 (7), p.2518-2525

2005

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ALARM NMR: A Rapid and Robust Experimental Method To Detect Reactive False Positives in Biochemical Screens

Journal of the American Chemical Society, 2005-01, Vol.127 (1), p.217-224

2005

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Novel p-Arylthio Cinnamides as Antagonists of Leukocyte Function-Associated Antigen-1/Intracellular Adhesion Molecule-1 Interaction. 2. Mechanism of Inhibition and Structure-Based Improvement of Pharmaceutical Properties

Journal of medicinal chemistry, 2001-04, Vol.44 (8), p.1202-1210

2001

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Molecular Determinants of Species-Specific Activation or Blockade of TRPA1 Channels

The Journal of neuroscience, 2008-05, Vol.28 (19), p.5063-5071

2008

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Discovery of a potent and selective Bcl-2 inhibitor using SAR by NMR

Bioorganic & medicinal chemistry letters, 2010-11, Vol.20 (22), p.6587-6591

2010

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Workers' compensation costs for healthcare caregivers: Home healthcare, long‐term care, and hospital nurses and nursing aides

American journal of industrial medicine, 2021-05, Vol.64 (5), p.369-380

2021

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Predicting protein druggability

Drug discovery today, 2005-12, Vol.10 (23-24), p.1675-1682

2005

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Molecular basis of human 46X,Y sex reversal revealed from the three-dimensional solution structure of the human SRY-DNA complex

Cell, 1995-06, Vol.81 (5), p.705-714

1995

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NMR and Mutagenesis Evidence for an I Domain Allosteric Site That Regulates Lymphocyte Function-Associated Antigen 1 Ligand Binding

Proceedings of the National Academy of Sciences - PNAS, 2000-05, Vol.97 (10), p.5231-5236

2000

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Discovery of novel inhibitors of Bcl-xL using multiple high-throughput screening platforms

Analytical biochemistry, 2004-05, Vol.328 (2), p.131-138

2004

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Enhancement of chemical rules for predicting compound reactivity towards protein thiol groups

Journal of computer-aided molecular design, 2007-01, Vol.21 (1-3), p.139-144

2007

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Discovery of Novel p-Arylthio Cinnamides as Antagonists of Leukocyte Function-Associated Antigen-1/Intercellular Adhesion Molecule-1 Interaction. 4. Structure−Activity Relationship of Substituents on the Benzene Ring of the Cinnamide

Journal of medicinal chemistry, 2001-12, Vol.44 (25), p.4393-4403

2001

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Ligand binding to domain-3 of human serum albumin: a chemometric analysis

Journal of computer-aided molecular design, 2003-02, Vol.17 (2-4), p.93-102

2003

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Toxicological Evaluation of Thiol-Reactive Compounds Identified Using a La Assay To Detect Reactive Molecules by Nuclear Magnetic Resonance

Chemical research in toxicology, 2007-12, Vol.20 (12), p.1752-1759

2007

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The solution structure of an HMG-I(Y)-DNA complex defines a new architectural minor groove binding motif

Nature structural biology, 1997-08, Vol.4 (8), p.657-665

1997

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N-Aryl-benzimidazolones as novel small molecule HSP90 inhibitors

Bioorganic & medicinal chemistry letters, 2010-12, Vol.20 (24), p.7503-7506

2010

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Discovery and Design of Novel HSP90 Inhibitors Using Multiple Fragment-based Design Strategies

Chemical biology & drug design, 2007-07, Vol.70 (1), p.1-12

2007

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Non-peptide entry inhibitors of HIV-1 that target the gp41 coiled coil pocket

Bioorganic & medicinal chemistry letters, 2010-01, Vol.20 (2), p.612-617

2010

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Utilization of NMR-Derived Fragment Leads in Drug Design

Methods in Enzymology, 2005, Vol.394, p.549-571

2005

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Scaffold oriented synthesis. Part 2: Design, synthesis and biological evaluation of pyrimido-diazepines as receptor tyrosine kinase inhibitors

Bioorganic & medicinal chemistry, 2008-04, Vol.18 (8), p.2691-2695

2008

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Design of an expression system for detecting folded protein domains and mapping macromolecular interactions by NMR

Protein science, 1997-11, Vol.6 (11), p.2359-2364

1997

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Solution structure of human thioredoxin in a mixed disulfide intermediate complex with its target peptide from the transcription factor NFκB

Structure (London), 1995-03, Vol.3 (3), p.289-297

1995

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Scaffold oriented synthesis. Part 1: Design, preparation, and biological evaluation of thienopyrazoles as kinase inhibitors

Bioorganic & medicinal chemistry letters, 2006, Vol.16 (1), p.96-99

2006

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NMR-Driven Discovery of Benzoylanthranilic Acid Inhibitors of Far Upstream Element Binding Protein Binding to the Human Oncogene c-myc Promoter

Journal of medicinal chemistry, 2004-09, Vol.47 (20), p.4851-4857

2004

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NMR in Pharmacokinetic and Pharmacodynamic Profiling

Chembiochem : a European journal of chemical biology, 2005-09, Vol.6 (9), p.1592-1600

2005

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Druggability Indices for Protein Targets Derived from NMR-Based Screening Data

ALARM NMR: A Rapid and Robust Experimental Method To Detect Reactive False Positives in Biochemical Screens

Novel p-Arylthio Cinnamides as Antagonists of Leukocyte Function-Associated Antigen-1/Intracellular Adhesion Molecule-1 Interaction. 2. Mechanism of Inhibition and Structure-Based Improvement of Pharmaceutical Properties

Molecular Determinants of Species-Specific Activation or Blockade of TRPA1 Channels

Discovery of a potent and selective Bcl-2 inhibitor using SAR by NMR

Workers' compensation costs for healthcare caregivers: Home healthcare, long‐term care, and hospital nurses and nursing aides

Predicting protein druggability

Molecular basis of human 46X,Y sex reversal revealed from the three-dimensional solution structure of the human SRY-DNA complex

NMR and Mutagenesis Evidence for an I Domain Allosteric Site That Regulates Lymphocyte Function-Associated Antigen 1 Ligand Binding

Discovery of novel inhibitors of Bcl-xL using multiple high-throughput screening platforms

Enhancement of chemical rules for predicting compound reactivity towards protein thiol groups

Discovery of Novel p-Arylthio Cinnamides as Antagonists of Leukocyte Function-Associated Antigen-1/Intercellular Adhesion Molecule-1 Interaction. 4. Structure−Activity Relationship of Substituents on the Benzene Ring of the Cinnamide

Ligand binding to domain-3 of human serum albumin: a chemometric analysis

Toxicological Evaluation of Thiol-Reactive Compounds Identified Using a La Assay To Detect Reactive Molecules by Nuclear Magnetic Resonance

The solution structure of an HMG-I(Y)-DNA complex defines a new architectural minor groove binding motif

N-Aryl-benzimidazolones as novel small molecule HSP90 inhibitors

Discovery and Design of Novel HSP90 Inhibitors Using Multiple Fragment-based Design Strategies

Non-peptide entry inhibitors of HIV-1 that target the gp41 coiled coil pocket

Utilization of NMR-Derived Fragment Leads in Drug Design

Scaffold oriented synthesis. Part 2: Design, synthesis and biological evaluation of pyrimido-diazepines as receptor tyrosine kinase inhibitors

Design of an expression system for detecting folded protein domains and mapping macromolecular interactions by NMR

Solution structure of human thioredoxin in a mixed disulfide intermediate complex with its target peptide from the transcription factor NFκB

Scaffold oriented synthesis. Part 1: Design, preparation, and biological evaluation of thienopyrazoles as kinase inhibitors

NMR-Driven Discovery of Benzoylanthranilic Acid Inhibitors of Far Upstream Element Binding Protein Binding to the Human Oncogene c-myc Promoter

NMR in Pharmacokinetic and Pharmacodynamic Profiling

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