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A high-throughput phenotypic screen identifies clofazimine as a potential treatment for cryptosporidiosis

PLoS neglected tropical diseases, 2017-02, Vol.11 (2), p.e0005373-e0005373

2017

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Direct RT-qPCR detection of SARS-CoV-2 RNA from patient nasopharyngeal swabs without an RNA extraction step

PLoS biology, 2020-10, Vol.18 (10), p.e3000896-e3000896

2020

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Drug Repurposing Screen Reveals FDA-Approved Inhibitors of Human HMG-CoA Reductase and Isoprenoid Synthesis That Block Cryptosporidium parvum Growth

Antimicrobial Agents and Chemotherapy, 2013-04, Vol.57 (4), p.1804-1814

2013

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Targeting Prolyl-tRNA Synthetase to Accelerate Drug Discovery against Malaria, Leishmaniasis, Toxoplasmosis, Cryptosporidiosis, and Coccidiosis

Structure (London), 2017-10, Vol.25 (10), p.1495-1505.e6

2017

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Cryptosporidiosis should be designated as a tropical disease by the US Food and Drug Administration

PLoS neglected tropical diseases, 2020-07, Vol.14 (7), p.e0008252-e0008252

2020

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Characterization of flux distribution in the pool of the RMC SLOWPOKE-2

Applied radiation and isotopes, 2024-05, Vol.207, p.111262-111262, Article 111262

2024

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Identification of a potent benzoxaborole drug candidate for treating cryptosporidiosis

Nature communications, 2019-06, Vol.10 (1), p.2816-11, Article 2816

2019

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Orogenesis in Paleo‐Mesoproterozoic Eastern Australia: A response to Arc‐Continent and Continent‐Continent Collision During Assembly of the Nuna Supercontinent

Tectonics (Washington, D.C.), 2020-02, Vol.39 (2), p.n/a

2020

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Identification of Cryptosporidium parvum Active Chemical Series by Repurposing the Open Access Malaria Box

Antimicrobial agents and chemotherapy, 2014-05, Vol.58 (5), p.2731-2739

2014

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A suite of phenotypic assays to ensure pipeline diversity when prioritizing drug-like Cryptosporidium growth inhibitors

Nature communications, 2019-04, Vol.10 (1), p.1862-1862, Article 1862

2019

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Cryptosporidium life cycle small molecule probing implicates translational repression and an Apetala 2 transcription factor in macrogamont differentiation

PLoS pathogens, 2024-04, Vol.20 (4), p.e1011906-e1011906

2024

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Knockdown of Five Genes Encoding Uncharacterized Proteins Inhibits Entamoeba histolytica Phagocytosis of Dead Host Cells

Infection and immunity, 2016-04, Vol.84 (4), p.1045-1053

2016

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The Clofazimine for Treatment of Cryptosporidiosis in HIV-Infected Adults (CRYPTOFAZ) and Lessons Learned for Anticryptosporidial Drug Development

Clinical infectious diseases, 2021-07, Vol.73 (2), p.192-194

Huston, Christopher D

2021

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A Novel Piperazine-Based Drug Lead for Cryptosporidiosis from the Medicines for Malaria Venture Open-Access Malaria Box

Antimicrobial agents and chemotherapy, 2018-04, Vol.62 (4)

2018

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A Proposed Target Product Profile and Developmental Cascade for New Cryptosporidiosis Treatments

PLoS neglected tropical diseases, 2015-10, Vol.9 (10), p.e0003987-e0003987

2015

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Identification of anisomycin, prodigiosin and obatoclax as compounds with broad-spectrum anti-parasitic activity

PLoS neglected tropical diseases, 2020-03, Vol.14 (3), p.e0008150

2020

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Coactosin Phosphorylation Controls Entamoeba histolytica Cell Membrane Protrusions and Cell Motility

mBio, 2020-08, Vol.11 (4)

2020

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Amebiasis

The New England journal of medicine, 2003-04, Vol.348 (16), p.1565-1573

2003

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Drug repurposing: mining protozoan proteomes for targets of known bioactive compounds

Journal of the American Medical Informatics Association : JAMIA, 2014-03, Vol.21 (2), p.238-244

2014

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Isorchis cannoni n. sp. (Digenea: Atractotrematidae) from Great Barrier Reef rabbitfishes and the molecular elucidation of its life cycle

Journal of helminthology, 2018-09, Vol.92 (5), p.604-611

2018

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Crustal architecture and geodynamics of North Queensland, Australia: Insights from deep seismic reflection profiling

Tectonophysics, 2012-10, Vol.572-573, p.76-99

2012

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SNAP-tag technology optimized for use in Entamoeba histolytica

PloS one, 2013-12, Vol.8 (12), p.e83997-e83997

2013

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Control of Entamoeba histolytica Adherence Involves Metallosurface Protease 1, an M8 Family Surface Metalloprotease with Homology to Leishmanolysin

Infection and Immunity, 2012-06, Vol.80 (6), p.2165-2176

2012

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Entamoeba histolytica Cell Surface Calreticulin Binds Human C1q and Functions in Amebic Phagocytosis of Host Cells

Infection and Immunity, 2012-06, Vol.80 (6), p.2008-2018

2012

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A high-throughput phenotypic screen identifies clofazimine as a potential treatment for cryptosporidiosis

Direct RT-qPCR detection of SARS-CoV-2 RNA from patient nasopharyngeal swabs without an RNA extraction step

A review of the global burden, novel diagnostics, therapeutics, and vaccine targets for cryptosporidium

Drug Repurposing Screen Reveals FDA-Approved Inhibitors of Human HMG-CoA Reductase and Isoprenoid Synthesis That Block Cryptosporidium parvum Growth

Targeting Prolyl-tRNA Synthetase to Accelerate Drug Discovery against Malaria, Leishmaniasis, Toxoplasmosis, Cryptosporidiosis, and Coccidiosis

Cryptosporidiosis should be designated as a tropical disease by the US Food and Drug Administration

Characterization of flux distribution in the pool of the RMC SLOWPOKE-2

Identification of a potent benzoxaborole drug candidate for treating cryptosporidiosis

Orogenesis in Paleo‐Mesoproterozoic Eastern Australia: A response to Arc‐Continent and Continent‐Continent Collision During Assembly of the Nuna Supercontinent

Identification of Cryptosporidium parvum Active Chemical Series by Repurposing the Open Access Malaria Box

A suite of phenotypic assays to ensure pipeline diversity when prioritizing drug-like Cryptosporidium growth inhibitors

Cryptosporidium life cycle small molecule probing implicates translational repression and an Apetala 2 transcription factor in macrogamont differentiation

Knockdown of Five Genes Encoding Uncharacterized Proteins Inhibits Entamoeba histolytica Phagocytosis of Dead Host Cells

The Clofazimine for Treatment of Cryptosporidiosis in HIV-Infected Adults (CRYPTOFAZ) and Lessons Learned for Anticryptosporidial Drug Development

A Novel Piperazine-Based Drug Lead for Cryptosporidiosis from the Medicines for Malaria Venture Open-Access Malaria Box

A Proposed Target Product Profile and Developmental Cascade for New Cryptosporidiosis Treatments

Identification of anisomycin, prodigiosin and obatoclax as compounds with broad-spectrum anti-parasitic activity

Coactosin Phosphorylation Controls Entamoeba histolytica Cell Membrane Protrusions and Cell Motility

Amebiasis

Drug repurposing: mining protozoan proteomes for targets of known bioactive compounds

Isorchis cannoni n. sp. (Digenea: Atractotrematidae) from Great Barrier Reef rabbitfishes and the molecular elucidation of its life cycle

Crustal architecture and geodynamics of North Queensland, Australia: Insights from deep seismic reflection profiling

SNAP-tag technology optimized for use in Entamoeba histolytica

Control of Entamoeba histolytica Adherence Involves Metallosurface Protease 1, an M8 Family Surface Metalloprotease with Homology to Leishmanolysin

Entamoeba histolytica Cell Surface Calreticulin Binds Human C1q and Functions in Amebic Phagocytosis of Host Cells

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