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Inhibition of Human Telomerase by a G-Quadruplex-Interactive Compound

Journal of medicinal chemistry, 1997-07, Vol.40 (14), p.2113-2116

1997

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Selective Interactions of Cationic Porphyrins with G-Quadruplex Structures

Journal of the American Chemical Society, 2001-09, Vol.123 (37), p.8902-8913

2001

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Quadruplex-Interactive Agents as Telomerase Inhibitors: Synthesis of Porphyrins and Structure−Activity Relationship for the Inhibition of Telomerase

Journal of medicinal chemistry, 2001-12, Vol.44 (26), p.4509-4523

2001

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DNA and its associated processes as targets for cancer therapy

Nature reviews. Cancer, 2002-03, Vol.2 (3), p.188-200

Hurley, Laurence H

2002

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Ecteinascidin 743: A Minor Groove Alkylator That Bends DNA toward the Major Groove

Journal of medicinal chemistry, 1999-07, Vol.42 (14), p.2493-2497

1999

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Cationic Porphyrins as Telomerase Inhibitors: the Interaction of Tetra-(N-methyl-4-pyridyl)porphine with Quadruplex DNA

Journal of the American Chemical Society, 1998-04, Vol.120 (13), p.3261-3262

1998

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A DNA polymerase stop assay for G-quadruplex-interactive compounds

Nucleic acids research, 1999-01, Vol.27 (2), p.537

1999

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Intramolecularly folded G-quadruplex and i-motif structures in the proximal promoter of the vascular endothelial growth factor gene

Nucleic acids research, 2008-08, Vol.36 (14), p.4598

2008

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Effects of cationic porphyrins as G-quadruplex interactive agents in human tumor cells

Cancer research (Chicago, Ill.), 1999-02, Vol.59 (3), p.639-644

1999

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Characterization of the G-quadruplexes in the duplex nuclease hypersensitive element of the PDGF-A promoter and modulation of PDGF-A promoter activity by TMPyP4

Nucleic acids research, 2007-12, Vol.35 (22), p.7698

2007

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Direct evidence for a G-quadruplex in a promoter region and its targeting with a small molecule to repress c-MYC transcription

Proceedings of the National Academy of Sciences - PNAS, 2002-09, Vol.99 (18), p.11593-11598

2002

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Secondary DNA structures as molecular targets for cancer therapeutics

Biochemical Society transactions, 2001-11, Vol.29 (Pt 6), p.692

Hurley, L H

2001

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Differential Rates of Reversibility of Ecteinascidin 743−DNA Covalent Adducts from Different Sequences Lead to Migration to Favored Bonding Sites

Journal of the American Chemical Society, 2001-07, Vol.123 (27), p.6485-6495

2001

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Cationic Porphyrins Promote the Formation of i-Motif DNA and Bind Peripherally by a Nonintercalative Mechanism

Biochemistry (Easton), 2000-12, Vol.39 (49), p.15083-15090

2000

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Inhibition of Unwinding of G-Quadruplex Structures by Sgs1 Helicase in the Presence of N,N‘-Bis[2-(1-piperidino)ethyl]-3,4,9,10-perylenetetracarboxylic Diimide, a G-Quadruplex-Interactive Ligand

Biochemistry (Easton), 2000-08, Vol.39 (31), p.9311-9316

2000

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G-quadruplex DNA: a potential target for anti-cancer drug design

Trends in Pharmacological Sciences, 2000-04, Vol.21 (4), p.136-142

2000

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Interactions of TMPyP4 and TMPyP2 with Quadruplex DNA. Structural Basis for the Differential Effects on Telomerase Inhibition

Journal of the American Chemical Society, 1999-04, Vol.121 (15), p.3561-3570

1999

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Design and Synthesis of a Novel DNA−DNA Interstrand Adenine−Guanine Cross-Linking Agent

Journal of the American Chemical Society, 2001-05, Vol.123 (20), p.4865-4866

2001

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Mechanism for the Catalytic Activation of Ecteinascidin 743 and Its Subsequent Alkylation of Guanine N2

Journal of the American Chemical Society, 1998-03, Vol.120 (10), p.2490-2491

1998

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Induction of Duplex to G-quadruplex Transition in the c-myc Promoter Region by a Small Molecule

The Journal of biological chemistry, 2001-02, Vol.276 (7), p.4640-4646

2001

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DNA and associated targets for drug design

Journal of medicinal chemistry, 1989-09, Vol.32 (9), p.2027-2033

Hurley, Laurence H

1989

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NMR-Based Model of a Telomerase-Inhibiting Compound Bound to G-Quadruplex DNA

Biochemistry (Easton), 1998-09, Vol.37 (36), p.12367-12374

1998

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Molecular struggle for transcriptional control

Nature medicine, 1995-06, Vol.1 (6), p.525-527

1995

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Targeting telomeres and telomerase

Methods in Enzymology, 2001, Vol.340, p.573,IN1,591-590,IN1,592

2001

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Accelerated Assembly of G-Quadruplex Structures by a Small Molecule

Biochemistry (Easton), 1999-06, Vol.38 (22), p.6981-6986

1999

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Inhibition of Human Telomerase by a G-Quadruplex-Interactive Compound

Selective Interactions of Cationic Porphyrins with G-Quadruplex Structures

Quadruplex-Interactive Agents as Telomerase Inhibitors: Synthesis of Porphyrins and Structure−Activity Relationship for the Inhibition of Telomerase

DNA and its associated processes as targets for cancer therapy

Ecteinascidin 743: A Minor Groove Alkylator That Bends DNA toward the Major Groove

Cationic Porphyrins as Telomerase Inhibitors: the Interaction of Tetra-(N-methyl-4-pyridyl)porphine with Quadruplex DNA

A DNA polymerase stop assay for G-quadruplex-interactive compounds

Intramolecularly folded G-quadruplex and i-motif structures in the proximal promoter of the vascular endothelial growth factor gene

Effects of cationic porphyrins as G-quadruplex interactive agents in human tumor cells

Characterization of the G-quadruplexes in the duplex nuclease hypersensitive element of the PDGF-A promoter and modulation of PDGF-A promoter activity by TMPyP4

Direct evidence for a G-quadruplex in a promoter region and its targeting with a small molecule to repress c-MYC transcription

Secondary DNA structures as molecular targets for cancer therapeutics

Differential Rates of Reversibility of Ecteinascidin 743−DNA Covalent Adducts from Different Sequences Lead to Migration to Favored Bonding Sites

Cationic Porphyrins Promote the Formation of i-Motif DNA and Bind Peripherally by a Nonintercalative Mechanism

Inhibition of Unwinding of G-Quadruplex Structures by Sgs1 Helicase in the Presence of N,N‘-Bis[2-(1-piperidino)ethyl]-3,4,9,10-perylenetetracarboxylic Diimide, a G-Quadruplex-Interactive Ligand

G-quadruplex DNA: a potential target for anti-cancer drug design

Interactions of TMPyP4 and TMPyP2 with Quadruplex DNA. Structural Basis for the Differential Effects on Telomerase Inhibition

Design and Synthesis of a Novel DNA−DNA Interstrand Adenine−Guanine Cross-Linking Agent

Mechanism for the Catalytic Activation of Ecteinascidin 743 and Its Subsequent Alkylation of Guanine N2

Induction of Duplex to G-quadruplex Transition in the c-myc Promoter Region by a Small Molecule

DNA and associated targets for drug design

NMR-Based Model of a Telomerase-Inhibiting Compound Bound to G-Quadruplex DNA

Molecular struggle for transcriptional control

Targeting telomeres and telomerase

Accelerated Assembly of G-Quadruplex Structures by a Small Molecule

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