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Targeting bacterial membrane function: an underexploited mechanism for treating persistent infections

Nature reviews. Microbiology, 2011-01, Vol.9 (1), p.62-75

2011

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Frizzled proteins are colonic epithelial receptors for C. difficile toxin B

Nature (London), 2016-10, Vol.538 (7625), p.350-355

2016

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Mechanisms and impact of antimicrobial resistance in Clostridioides difficile

Current opinion in microbiology, 2022-04, Vol.66, p.63-72

2022

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Decoding a cryptic mechanism of metronidazole resistance among globally disseminated fluoroquinolone-resistant Clostridioides difficile

Nature communications, 2023-07, Vol.14 (1), p.4130-4130, Article 4130

2023

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Design, synthesis and microbiological evaluation of ampicillin-tetramic acid hybrid antibiotics

Journal of antibiotics, 2017-01, Vol.70 (1), p.65-72

2017

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Genetic Mechanisms of Vancomycin Resistance in Clostridioides difficile : A Systematic Review

Antibiotics (Basel), 2022-02, Vol.11 (2), p.258

2022

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Progress in the discovery of treatments for C. difficile infection: A clinical and medicinal chemistry review

Current topics in medicinal chemistry, 2014-01, Vol.14 (1), p.152

2014

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Ebselen Not Only Inhibits Clostridioides difficile Toxins but Displays Redox-Associated Cellular Killing

Microbiology spectrum, 2021-10, Vol.9 (2), p.e0044821-e0044821

2021

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Pentacyclic nitrofurans with in vivo efficacy and activity against nonreplicating Mycobacterium tuberculosis

PloS one, 2014-02, Vol.9 (2), p.e87909

2014

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Evaluation of Flavonoid and Resveratrol Chemical Libraries Reveals Abyssinone II as a Promising Antibacterial Lead

ChemMedChem, 2012-09, Vol.7 (9), p.1541-1545

2012

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Chromosomal Resistance to Metronidazole in Clostridioides difficile Can Be Mediated by Epistasis between Iron Homeostasis and Oxidoreductases

Antimicrobial agents and chemotherapy, 2020-07, Vol.64 (8)

2020

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Bacterial persister cells tackled

Nature (London), 2018-04, Vol.556 (7699), p.40-41

2018

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Evaluation of Analogs of Reutericyclin as Prospective Candidates for Treatment of Staphylococcal Skin Infections

Antimicrobial Agents and Chemotherapy, 2009-09, Vol.53 (9), p.4028-4031

2009

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Reduced Vancomycin Susceptibility in Clostridioides difficile is Associated with Lower Rates of Initial Cure and Sustained Clinical Response

Clinical infectious diseases, 2024-02

2024

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Surveillance of Clostridioides difficile Antimicrobial Resistance in the United States

Clinical infectious diseases, 2023-06, Vol.76 (11), p.2038-2039

2023

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Pharmacophore Modeling, Synthesis, and Antibacterial Evaluation of Chalcones and Derivatives

ACS omega, 2018-12, Vol.3 (12), p.18343-18360

2018

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Mode of action and bactericidal properties of surotomycin against growing and nongrowing Clostridium difficile

Antimicrobial agents and chemotherapy, 2015-09, Vol.59 (9), p.5165-5170

2015

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Constitutive expression of the cryptic vanGCd operon promotes vancomycin resistance in Clostridioides difficile clinical isolates

Journal of antimicrobial chemotherapy, 2020-04, Vol.75 (4), p.859-867

2020

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Syntheses and evaluation of macrocyclic engelhardione analogs as antitubercular and antibacterial agents

Journal of antibiotics, 2013-06, Vol.66 (6), p.319-325

2013

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In vivo evaluation of Clostridioides difficile enoyl-ACP reductase II (FabK) inhibition by phenylimidazole unveils a promising narrow-spectrum antimicrobial strategy

Antimicrobial agents and chemotherapy, 2024-03, Vol.68 (3), p.e0122223

2024

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The Integrity of Heme Is Essential for Reproducible Detection of Metronidazole-Resistant Clostridioides difficile by Agar Dilution Susceptibility Tests

Journal of clinical microbiology, 2021-08, Vol.59 (9), p.e0058521-e0058521

2021

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Synthesis and evaluation of phenylimidazole FabK inhibitors as new Anti-C. Difficile agents

Bioorganic & medicinal chemistry, 2023-06, Vol.88-89, p.117330-117330, Article 117330

2023

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C. difficile intoxicates neurons and pericytes to drive neurogenic inflammation

Nature (London), 2023-10, Vol.622 (7983), p.611-618

2023

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Action of nitroheterocyclic drugs against Clostridium difficile

International journal of antimicrobial agents, 2014-10, Vol.44 (4), p.314-319

2014

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Secondary metabolites from Bacillus amyloliquefaciens isolated from soil can kill Burkholderia pseudomallei

AMB Express, 2017-12, Vol.7 (1), p.16-16, Article 16

2017

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Targeting bacterial membrane function: an underexploited mechanism for treating persistent infections

Frizzled proteins are colonic epithelial receptors for C. difficile toxin B

Mechanisms and impact of antimicrobial resistance in Clostridioides difficile

Decoding a cryptic mechanism of metronidazole resistance among globally disseminated fluoroquinolone-resistant Clostridioides difficile

Design, synthesis and microbiological evaluation of ampicillin-tetramic acid hybrid antibiotics

Genetic Mechanisms of Vancomycin Resistance in Clostridioides difficile : A Systematic Review

Progress in the discovery of treatments for C. difficile infection: A clinical and medicinal chemistry review

Ebselen Not Only Inhibits Clostridioides difficile Toxins but Displays Redox-Associated Cellular Killing

Pentacyclic nitrofurans with in vivo efficacy and activity against nonreplicating Mycobacterium tuberculosis

Evaluation of Flavonoid and Resveratrol Chemical Libraries Reveals Abyssinone II as a Promising Antibacterial Lead

Chromosomal Resistance to Metronidazole in Clostridioides difficile Can Be Mediated by Epistasis between Iron Homeostasis and Oxidoreductases

Bacterial persister cells tackled

Evaluation of Analogs of Reutericyclin as Prospective Candidates for Treatment of Staphylococcal Skin Infections

Reduced Vancomycin Susceptibility in Clostridioides difficile is Associated with Lower Rates of Initial Cure and Sustained Clinical Response

Surveillance of Clostridioides difficile Antimicrobial Resistance in the United States

Pharmacophore Modeling, Synthesis, and Antibacterial Evaluation of Chalcones and Derivatives

Mode of action and bactericidal properties of surotomycin against growing and nongrowing Clostridium difficile

Constitutive expression of the cryptic vanGCd operon promotes vancomycin resistance in Clostridioides difficile clinical isolates

Syntheses and evaluation of macrocyclic engelhardione analogs as antitubercular and antibacterial agents

In vivo evaluation of Clostridioides difficile enoyl-ACP reductase II (FabK) inhibition by phenylimidazole unveils a promising narrow-spectrum antimicrobial strategy

The Integrity of Heme Is Essential for Reproducible Detection of Metronidazole-Resistant Clostridioides difficile by Agar Dilution Susceptibility Tests

Synthesis and evaluation of phenylimidazole FabK inhibitors as new Anti-C. Difficile agents

C. difficile intoxicates neurons and pericytes to drive neurogenic inflammation

Action of nitroheterocyclic drugs against Clostridium difficile

Secondary metabolites from Bacillus amyloliquefaciens isolated from soil can kill Burkholderia pseudomallei

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