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Targeting bacterial membrane function: an underexploited mechanism for treating persistent infections

Nature reviews. Microbiology, 2011-01, Vol.9 (1), p.62-75

2011

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Frizzled proteins are colonic epithelial receptors for C. difficile toxin B

Nature (London), 2016-10, Vol.538 (7625), p.350-355

2016

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Mechanisms and impact of antimicrobial resistance in Clostridioides difficile

Current opinion in microbiology, 2022-04, Vol.66, p.63-72

2022

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Decoding a cryptic mechanism of metronidazole resistance among globally disseminated fluoroquinolone-resistant Clostridioides difficile

Nature communications, 2023-07, Vol.14 (1), p.4130-4130, Article 4130

2023

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Genetic Mechanisms of Vancomycin Resistance in Clostridioides difficile : A Systematic Review

Antibiotics (Basel), 2022-02, Vol.11 (2), p.258

2022

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Design, synthesis and microbiological evaluation of ampicillin–tetramic acid hybrid antibiotics

Journal of antibiotics, 2017-01, Vol.70 (1), p.65-72

2017

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Progress in the discovery of treatments for C. difficile infection: A clinical and medicinal chemistry review

Current topics in medicinal chemistry, 2014-01, Vol.14 (1), p.152-175

2014

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Ebselen Not Only Inhibits Clostridioides difficile Toxins but Displays Redox-Associated Cellular Killing

Microbiology spectrum, 2021-10, Vol.9 (2), p.e0044821-e0044821

2021

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Chromosomal Resistance to Metronidazole in Clostridioides difficile Can Be Mediated by Epistasis between Iron Homeostasis and Oxidoreductases

Antimicrobial agents and chemotherapy, 2020-07, Vol.64 (8)

2020

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Reduced Vancomycin Susceptibility in Clostridioides difficile Is Associated With Lower Rates of Initial Cure and Sustained Clinical Response

Clinical infectious diseases, 2024-07, Vol.79 (1), p.15-21

2024

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Pentacyclic nitrofurans with in vivo efficacy and activity against nonreplicating Mycobacterium tuberculosis

PloS one, 2014-02, Vol.9 (2), p.e87909

2014

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Bacterial persister cells tackled

Nature (London), 2018-04, Vol.556 (7699), p.40-41

2018

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Evaluation of Flavonoid and Resveratrol Chemical Libraries Reveals Abyssinone II as a Promising Antibacterial Lead

ChemMedChem, 2012-09, Vol.7 (9), p.1541-1545

2012

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Surveillance of Clostridioides difficile Antimicrobial Resistance in the United States

Clinical infectious diseases, 2023-06, Vol.76 (11), p.2038-2039

2023

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Mode of action and bactericidal properties of surotomycin against growing and nongrowing Clostridium difficile

Antimicrobial agents and chemotherapy, 2015-09, Vol.59 (9), p.5165-5170

2015

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Constitutive expression of the cryptic vanGCd operon promotes vancomycin resistance in Clostridioides difficile clinical isolates

Journal of antimicrobial chemotherapy, 2020-04, Vol.75 (4), p.859-867

2020

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In vivo evaluation of Clostridioides difficile enoyl-ACP reductase II (FabK) inhibition by phenylimidazole unveils a promising narrow-spectrum antimicrobial strategy

Antimicrobial agents and chemotherapy, 2024-03, Vol.68 (3), p.e0122223

2024

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Evaluation of Analogs of Reutericyclin as Prospective Candidates for Treatment of Staphylococcal Skin Infections

Antimicrobial Agents and Chemotherapy, 2009-09, Vol.53 (9), p.4028-4031

2009

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The Integrity of Heme Is Essential for Reproducible Detection of Metronidazole-Resistant Clostridioides difficile by Agar Dilution Susceptibility Tests

Journal of clinical microbiology, 2021-08, Vol.59 (9), p.e0058521-e0058521

2021

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Pharmacophore Modeling, Synthesis, and Antibacterial Evaluation of Chalcones and Derivatives

ACS omega, 2018-12, Vol.3 (12), p.18343-18360

2018

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Secondary metabolites from Bacillus amyloliquefaciens isolated from soil can kill Burkholderia pseudomallei

AMB Express, 2017-12, Vol.7 (1), p.16-16, Article 16

2017

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C. difficile intoxicates neurons and pericytes to drive neurogenic inflammation

Nature (London), 2023-10, Vol.622 (7983), p.611-618

2023

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Synthesis and evaluation of phenylimidazole FabK inhibitors as new Anti-C. Difficile agents

Bioorganic & medicinal chemistry, 2023-06, Vol.88-89, p.117330-117330, Article 117330

2023

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Syntheses and evaluation of macrocyclic engelhardione analogs as antitubercular and antibacterial agents

Journal of antibiotics, 2013-06, Vol.66 (6), p.319-325

2013

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Chemical genetic analysis of enoxolone inhibition of C. difficile toxin production reveals adenine deaminase and ATP synthase as anti-virulence targets

The Journal of biological chemistry, 2024-09, p.107839, Article 107839

2024

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Targeting bacterial membrane function: an underexploited mechanism for treating persistent infections

Frizzled proteins are colonic epithelial receptors for C. difficile toxin B

Mechanisms and impact of antimicrobial resistance in Clostridioides difficile

Decoding a cryptic mechanism of metronidazole resistance among globally disseminated fluoroquinolone-resistant Clostridioides difficile

Genetic Mechanisms of Vancomycin Resistance in Clostridioides difficile : A Systematic Review

Design, synthesis and microbiological evaluation of ampicillin–tetramic acid hybrid antibiotics

Progress in the discovery of treatments for C. difficile infection: A clinical and medicinal chemistry review

Ebselen Not Only Inhibits Clostridioides difficile Toxins but Displays Redox-Associated Cellular Killing

Chromosomal Resistance to Metronidazole in Clostridioides difficile Can Be Mediated by Epistasis between Iron Homeostasis and Oxidoreductases

Reduced Vancomycin Susceptibility in Clostridioides difficile Is Associated With Lower Rates of Initial Cure and Sustained Clinical Response

Pentacyclic nitrofurans with in vivo efficacy and activity against nonreplicating Mycobacterium tuberculosis

Bacterial persister cells tackled

Evaluation of Flavonoid and Resveratrol Chemical Libraries Reveals Abyssinone II as a Promising Antibacterial Lead

Surveillance of Clostridioides difficile Antimicrobial Resistance in the United States

Mode of action and bactericidal properties of surotomycin against growing and nongrowing Clostridium difficile

Constitutive expression of the cryptic vanGCd operon promotes vancomycin resistance in Clostridioides difficile clinical isolates

In vivo evaluation of Clostridioides difficile enoyl-ACP reductase II (FabK) inhibition by phenylimidazole unveils a promising narrow-spectrum antimicrobial strategy

Evaluation of Analogs of Reutericyclin as Prospective Candidates for Treatment of Staphylococcal Skin Infections

The Integrity of Heme Is Essential for Reproducible Detection of Metronidazole-Resistant Clostridioides difficile by Agar Dilution Susceptibility Tests

Pharmacophore Modeling, Synthesis, and Antibacterial Evaluation of Chalcones and Derivatives

Secondary metabolites from Bacillus amyloliquefaciens isolated from soil can kill Burkholderia pseudomallei

C. difficile intoxicates neurons and pericytes to drive neurogenic inflammation

Synthesis and evaluation of phenylimidazole FabK inhibitors as new Anti-C. Difficile agents

Syntheses and evaluation of macrocyclic engelhardione analogs as antitubercular and antibacterial agents

Chemical genetic analysis of enoxolone inhibition of C. difficile toxin production reveals adenine deaminase and ATP synthase as anti-virulence targets

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