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Targeting Epigenetic Readers in Cancer

The New England journal of medicine, 2012-08, Vol.367 (7), p.647-657

2012

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Unified classification and risk-stratification in Acute Myeloid Leukemia

Nature communications, 2022-08, Vol.13 (1), p.4622-4622, Article 4622

2022

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Inhibition of BET recruitment to chromatin as an effective treatment for MLL-fusion leukaemia

Nature (London), 2011-10, Vol.478 (7370), p.529-533

2011

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KAT7 is a genetic vulnerability of acute myeloid leukemias driven by MLL rearrangements

Leukemia, 2021-04, Vol.35 (4), p.1012-1022

2021

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Molecular landscape of acute myeloid leukemia in younger adults and its clinical relevance

Blood, 2016-01, Vol.127 (1), p.29-41

2016

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Leukaemia stem cells and the evolution of cancer-stem-cell research

Nature reviews. Cancer, 2005-04, Vol.5 (4), p.311-321

2005

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Dissecting the early steps of MLL induced leukaemogenic transformation using a mouse model of AML

Nature communications, 2020-03, Vol.11 (1), p.1407-15, Article 1407

2020

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Distinct and targetable role of calcium-sensing receptor in leukaemia

Nature communications, 2023-10, Vol.14 (1), p.6242-6242, Article 6242

2023

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Population dynamics of normal human blood inferred from somatic mutations

Nature (London), 2018-09, Vol.561 (7724), p.473-478

2018

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Mannose metabolism inhibition sensitizes acute myeloid leukaemia cells to therapy by driving ferroptotic cell death

Nature communications, 2023-04, Vol.14 (1), p.2132-2132, Article 2132

2023

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The Antiproliferative Activity of Kinase Inhibitors in Chronic Myeloid Leukemia Cells Is Mediated by FOXO Transcription Factors

Stem cells (Dayton, Ohio), 2014-09, Vol.32 (9), p.2324-2337

2014

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Effects of the JAK2 mutation on the hematopoietic stem and progenitor compartment in human myeloproliferative neoplasms

Blood, 2011-07, Vol.118 (1), p.177-181

2011

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Histone modifiers are oxygen sensors

Science (American Association for the Advancement of Science), 2019-03, Vol.363 (6432), p.1148-1149

2019

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Molecular Landscape of Acute Myeloid Leukemia: Prognostic and Therapeutic Implications

Current oncology reports, 2020-06, Vol.22 (6), p.61-61, Article 61

2020

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Core outcome set measurement for future clinical trials in acute myeloid leukemia: the HARMONY study protocol using a multi-stakeholder consensus-based Delphi process and a final consensus meeting

Trials, 2020-05, Vol.21 (1), p.437-437, Article 437

2020

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Dynamic regulation of hypoxia-inducible factor-1α activity is essential for normal B cell development

Nature immunology, 2020-11, Vol.21 (11), p.1408-1420

2020

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A guide to epigenetics in leukaemia stem cells

Molecular oncology, 2023-12, Vol.17 (12), p.2493-2506

2023

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Early loss of Crebbp confers malignant stem cell properties on lymphoid progenitors

Nature cell biology, 2017-09, Vol.19 (9), p.1093-1104

2017

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Molecular basis of histone H3K36me3 recognition by the PWWP domain of Brpf1

Nature structural & molecular biology, 2010-05, Vol.17 (5), p.617-619

2010

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Common and Overlapping Oncogenic Pathways Contribute to the Evolution of Acute Myeloid Leukemias

Cancer research (Chicago, Ill.), 2011-06, Vol.71 (12), p.4117-4129

2011

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Clonal diversity in the myeloproliferative neoplasms: independent origins of genetically distinct clones

British journal of haematology, 2009-03, Vol.144 (6), p.904-908

2009

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JAK2 V617F impairs hematopoietic stem cell function in a conditional knock-in mouse model of JAK2 V617F–positive essential thrombocythemia

Blood, 2010-09, Vol.116 (9), p.1528-1538

2010

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Genetic modification of primary human B cells to model high-grade lymphoma

Nature communications, 2019-10, Vol.10 (1), p.4543-16, Article 4543

2019

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Hematopoietic stem cells made BETter by inhibition

Haematologica (Roma), 2018-06, Vol.103 (6), p.919-921

2018

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Targeting Epigenetic Readers in Cancer

Unified classification and risk-stratification in Acute Myeloid Leukemia

Inhibition of BET recruitment to chromatin as an effective treatment for MLL-fusion leukaemia

KAT7 is a genetic vulnerability of acute myeloid leukemias driven by MLL rearrangements

Molecular landscape of acute myeloid leukemia in younger adults and its clinical relevance

Leukaemia stem cells and the evolution of cancer-stem-cell research

Dissecting the early steps of MLL induced leukaemogenic transformation using a mouse model of AML

Distinct and targetable role of calcium-sensing receptor in leukaemia

Population dynamics of normal human blood inferred from somatic mutations

Mannose metabolism inhibition sensitizes acute myeloid leukaemia cells to therapy by driving ferroptotic cell death

The Antiproliferative Activity of Kinase Inhibitors in Chronic Myeloid Leukemia Cells Is Mediated by FOXO Transcription Factors

Effects of the JAK2 mutation on the hematopoietic stem and progenitor compartment in human myeloproliferative neoplasms

Histone modifiers are oxygen sensors

Molecular Landscape of Acute Myeloid Leukemia: Prognostic and Therapeutic Implications

Core outcome set measurement for future clinical trials in acute myeloid leukemia: the HARMONY study protocol using a multi-stakeholder consensus-based Delphi process and a final consensus meeting

Dynamic regulation of hypoxia-inducible factor-1α activity is essential for normal B cell development

A guide to epigenetics in leukaemia stem cells

Early loss of Crebbp confers malignant stem cell properties on lymphoid progenitors

Molecular basis of histone H3K36me3 recognition by the PWWP domain of Brpf1

Common and Overlapping Oncogenic Pathways Contribute to the Evolution of Acute Myeloid Leukemias

Clonal diversity in the myeloproliferative neoplasms: independent origins of genetically distinct clones

JAK2 V617F impairs hematopoietic stem cell function in a conditional knock-in mouse model of JAK2 V617F–positive essential thrombocythemia

Genetic modification of primary human B cells to model high-grade lymphoma

Unbiased cell surface proteomics identifies SEMA4A as an effective immunotherapy target for myeloma

Hematopoietic stem cells made BETter by inhibition

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