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Evaluation of recent Protein A stationary phase innovations for capture of biotherapeutics

Journal of Chromatography A, 2018-06, Vol.1554, p.45-60

2018

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Host cell proteins in biologics development: Identification, quantitation and risk assessment

Biotechnology and bioengineering, 2009-06, Vol.103 (3), p.446-458

2009

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Engineering of novel Staphylococcal Protein A ligands to enable milder elution pH and high dynamic binding capacity

Journal of Chromatography A, 2014-10, Vol.1362, p.180-185

2014

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Adsorption equilibrium and kinetics of monomer–dimer monoclonal antibody mixtures on a cation exchange resin

Journal of Chromatography A, 2015-07, Vol.1402, p.46-59

2015

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Leveraging light chain binding avidity for control of mispaired byproducts during production of asymmetric bispecific antibodies

Journal of Chromatography A, 2022-11, Vol.1683, p.463533, Article 463533

2022

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Comparison of agarose and dextran-grafted agarose strong ion exchangers for the separation of protein aggregates

Journal of Chromatography A, 2009-07, Vol.1216 (27), p.5256-5264

2009

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Chromatographic behavior of bivalent bispecific antibodies on cation exchange columns. I. Experimental observations and phenomenological model

Journal of Chromatography A, 2019-09, Vol.1601, p.121-132

2019

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Formation of transient highly-charged mAb clusters strengthens interactions with host cell proteins and results in poor clearance of host cell proteins by protein A chromatography

Journal of Chromatography A, 2022-08, Vol.1679, p.463385, Article 463385

2022

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Comparison of strong anion-exchangers for the purification of a PEGylated protein

Journal of Chromatography A, 2007-04, Vol.1147 (2), p.172-182

2007

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Role of configurational flexibility on the adsorption kinetics of bivalent bispecific antibodies on porous cation exchange resins

Journal of Chromatography A, 2021-10, Vol.1655, p.462479, Article 462479

2021

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Chromatographic behavior of bivalent bispecific antibodies on hydrophobic interaction chromatography columns

Journal of Chromatography A, 2020-04, Vol.1617, p.460836, Article 460836

2020

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Chromatographic behavior of bivalent bispecific antibodies on cation exchange columns. II. Biomolecular perspectives

Journal of Chromatography A, 2019-09, Vol.1601, p.133-144

2019

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Process-scale purification and analytical characterization of highly gamma-carboxylated recombinant human prothrombin

Journal of Chromatography A, 2014-01, Vol.1325, p.171-178

2014

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Separation of antibody monomer-dimer mixtures by frontal analysis

Journal of Chromatography A, 2017-06, Vol.1500, p.96-104

2017

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Chromatographic and adsorptive behavior of a bivalent bispecific antibody and associated fragments

Journal of Chromatography A, 2021-07, Vol.1648, p.462181, Article 462181

2021

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Cathepsin L Causes Proteolytic Cleavage of Chinese‐Hamster‐Ovary Cell Expressed Proteins During Processing and Storage: Identification, Characterization, and Mitigation

Biotechnology progress, 2019-01, Vol.35 (1), p.e2732-n/a

2019

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Identification of compendial nonionic detergents for the replacement of Triton X‐100 in bioprocessing

Biotechnology progress, 2022-03, Vol.38 (2), p.e3235-n/a

2022

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Challenges for design of aggregation-resistant variants of granulocyte colony-stimulating factor

Biophysical chemistry, 2021-10, Vol.277, p.106630, Article 106630

2021

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Liquid-liquid phase separation causes high turbidity and pressure during low pH elution process in Protein A chromatography

Journal of Chromatography A, 2017-03, Vol.1488, p.57-67

2017

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Process optimization and protein engineering mitigated manufacturing challenges of a monoclonal antibody with liquid-liquid phase separation issue by disrupting inter-molecule electrostatic interactions

mAbs, 2019-05, Vol.11 (4), p.789-802

2019

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Camelid VHH affinity ligands enable separation of closely related biopharmaceuticals

Biotechnology journal, 2017-02, Vol.12 (2), p.n/a

2017

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Development and scale-up of a commercial fed batch refolding process for an anti-CD22 two chain immunotoxin

Biotechnology progress, 2014-11, Vol.30 (6), p.1380-1389

2014

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Protein separations with induced pH gradients using cation-exchange chromatographic columns containing weak acid groups

Journal of Chromatography A, 2008-02, Vol.1181 (1), p.83-94

2008

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Camelid V H H affinity ligands enable separation of closely related biopharmaceuticals

Biotechnology journal, 2017-02, Vol.12 (2)

2017

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Process scale separation of an anti-CD22 immunotoxin charge variant

Journal of Chromatography A, 2012-10, Vol.1260, p.120-125

2012

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Evaluation of recent Protein A stationary phase innovations for capture of biotherapeutics

Host cell proteins in biologics development: Identification, quantitation and risk assessment

Engineering of novel Staphylococcal Protein A ligands to enable milder elution pH and high dynamic binding capacity

Adsorption equilibrium and kinetics of monomer–dimer monoclonal antibody mixtures on a cation exchange resin

Leveraging light chain binding avidity for control of mispaired byproducts during production of asymmetric bispecific antibodies

Comparison of agarose and dextran-grafted agarose strong ion exchangers for the separation of protein aggregates

Chromatographic behavior of bivalent bispecific antibodies on cation exchange columns. I. Experimental observations and phenomenological model

Formation of transient highly-charged mAb clusters strengthens interactions with host cell proteins and results in poor clearance of host cell proteins by protein A chromatography

Comparison of strong anion-exchangers for the purification of a PEGylated protein

Role of configurational flexibility on the adsorption kinetics of bivalent bispecific antibodies on porous cation exchange resins

Chromatographic behavior of bivalent bispecific antibodies on hydrophobic interaction chromatography columns

Chromatographic behavior of bivalent bispecific antibodies on cation exchange columns. II. Biomolecular perspectives

Process-scale purification and analytical characterization of highly gamma-carboxylated recombinant human prothrombin

Separation of antibody monomer-dimer mixtures by frontal analysis

Chromatographic and adsorptive behavior of a bivalent bispecific antibody and associated fragments

Cathepsin L Causes Proteolytic Cleavage of Chinese‐Hamster‐Ovary Cell Expressed Proteins During Processing and Storage: Identification, Characterization, and Mitigation

Identification of compendial nonionic detergents for the replacement of Triton X‐100 in bioprocessing

Challenges for design of aggregation-resistant variants of granulocyte colony-stimulating factor

Liquid-liquid phase separation causes high turbidity and pressure during low pH elution process in Protein A chromatography

Process optimization and protein engineering mitigated manufacturing challenges of a monoclonal antibody with liquid-liquid phase separation issue by disrupting inter-molecule electrostatic interactions

Camelid VHH affinity ligands enable separation of closely related biopharmaceuticals

Development and scale-up of a commercial fed batch refolding process for an anti-CD22 two chain immunotoxin

Protein separations with induced pH gradients using cation-exchange chromatographic columns containing weak acid groups

Camelid V H H affinity ligands enable separation of closely related biopharmaceuticals

Process scale separation of an anti-CD22 immunotoxin charge variant

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