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Orexins contribute to restraint stress-induced cocaine relapse by endocannabinoid-mediated disinhibition of dopaminergic neurons

Nature communications, 2016-07, Vol.7 (1), p.12199-12199, Article 12199

2016

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Caveolin‐1 Secreted from Adipose Tissues and Adipocytes Functions as an Adipogenesis Enhancer

Obesity (Silver Spring, Md.), 2017-11, Vol.25 (11), p.1932-1940

2017

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A structure-function approach identifies L-PGDS as a mediator responsible for glucocorticoid-induced leptin expression in adipocytes

Biochemical pharmacology, 2019-08, Vol.166, p.203-211

2019

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Mesenchymal stem cells tune the development of monocyte-derived dendritic cells toward a myeloid-derived suppressive phenotype through growth-regulated oncogene chemokines

The Journal of immunology (1950), 2013-05, Vol.190 (10), p.5065-5077

2013

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Decrypting orphan GPCR drug discovery via multitask learning

Journal of cheminformatics, 2024-01, Vol.16 (1), p.10-10, Article 10

2024

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Identification of Substituted Naphthotriazolediones as Novel Tryptophan 2,3-Dioxygenase (TDO) Inhibitors through Structure-Based Virtual Screening

Journal of medicinal chemistry, 2015-10, Vol.58 (19), p.7807-7819

2015

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Identification of the transcription factor ARNTL2 as a candidate gene for the type 1 diabetes locus Idd6

Human molecular genetics, 2006-09, Vol.15 (18), p.2732-2742

2006

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Important Hydrogen Bond Networks in Indoleamine 2,3-Dioxygenase 1 (IDO1) Inhibitor Design Revealed by Crystal Structures of Imidazoleisoindole Derivatives with IDO1

Journal of medicinal chemistry, 2016-01, Vol.59 (1), p.282-293

2016

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A new perspective of cannabinoid 1 receptor antagonists: approaches toward peripheral CB1R blockers without crossing the blood-brain barrier

Current topics in medicinal chemistry, 2011-06, Vol.11 (12), p.1421-1429

2011

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Median nerve stimulation induces analgesia via orexin-initiated endocannabinoid disinhibition in the periaqueductal gray

Proceedings of the National Academy of Sciences - PNAS, 2018-11, Vol.115 (45), p.E10720-E10729

2018

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DUSP6 mediates T cell receptor-engaged glycolysis and restrains TFH cell differentiation

Proceedings of the National Academy of Sciences - PNAS, 2018-08, Vol.115 (34), p.E8027-E8036

2018

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Unique Sulfur–Aromatic Interactions Contribute to the Binding of Potent Imidazothiazole Indoleamine 2,3-Dioxygenase Inhibitors

Journal of medicinal chemistry, 2020-02, Vol.63 (4), p.1642-1659

2020

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Natural fucoidans inhibit coronaviruses by targeting viral spike protein and host cell furin

Biochemical pharmacology, 2023-09, Vol.215, p.115688-115688, Article 115688

2023

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Phenyl Benzenesulfonylhydrazides Exhibit Selective Indoleamine 2,3-Dioxygenase Inhibition with Potent in Vivo Pharmacodynamic Activity and Antitumor Efficacy

Journal of medicinal chemistry, 2016-01, Vol.59 (1), p.419-430

2016

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Discovery and structure-activity relationships of phenyl benzenesulfonylhydrazides as novel indoleamine 2,3-dioxygenase inhibitors

Bioorganic & medicinal chemistry letters, 2014-08, Vol.24 (15), p.3403-3406

2014

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Discovery of 1-(2,4-Dichlorophenyl)-4-ethyl-5-(5-(2-(4-(trifluoromethyl)phenyl)ethynyl)thiophen-2-yl)-N-(piperidin-1-yl)-1H-pyrazole-3-carboxamide as a Potential Peripheral Cannabinoid-1 Receptor Inverse Agonist

ChemMedChem, 2010-09, Vol.5 (9), p.1439-1443

2010

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Discovery and development of a novel N-(3-bromophenyl)-{[(phenylcarbamoyl)amino]methyl}-N-hydroxythiophene-2-carboximidamide indoleamine 2,3-dioxygenase inhibitor using knowledge-based drug design

European journal of medicinal chemistry, 2022-02, Vol.229, p.114043-114043, Article 114043

2022

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Fluorine-18 isotope labeling for positron emission tomography imaging. Direct evidence for DBPR211 as a peripherally restricted CB1 inverse agonist

Bioorganic & medicinal chemistry, 2019-01, Vol.27 (1), p.216-223

2019

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The Eukaryotic DNMT2 Genes Encode a New Class of Cytosine-5 DNA Methyltransferases

The Journal of biological chemistry, 2003-09, Vol.278 (36), p.33613-33616

2003

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Modulating the affinity and signaling bias of cannabinoid receptor 1 antagonists

Bioorganic chemistry, 2023-01, Vol.130, p.106236-106236, Article 106236

2023

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1,2,3-Triazole derivatives as new cannabinoid CB1 receptor antagonists

Bioorganic & medicinal chemistry letters, 2009-02, Vol.19 (3), p.1022-1025

2009

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Discovery of Novel N-β-d-Xylosylindole Derivatives as Sodium-Dependent Glucose Cotransporter 2 (SGLT2) Inhibitors for the Management of Hyperglycemia in Diabetes

Journal of medicinal chemistry, 2011-01, Vol.54 (1), p.166-178

2011

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Discovery of 2-[5-(4-Chloro-phenyl)-1-(2,4-dichloro-phenyl)-4-ethyl-1H-pyrazol-3-yl]-1,5,5-trimethyl-1,5-dihydro-imidazol-4-thione (BPR-890) via an Active Metabolite. A Novel, Potent and Selective Cannabinoid-1 Receptor Inverse Agonist with High Antiobesity Efficacy in DIO Mice

Journal of medicinal chemistry, 2009-07, Vol.52 (14), p.4496-4510

2009

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4-Bromophenylhydrazinyl benzenesulfonylphenylureas as indoleamine 2,3-dioxygenase inhibitors with in vivo target inhibition and anti-tumor efficacy

Bioorganic chemistry, 2018-04, Vol.77, p.600-607

2018

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Orexins contribute to restraint stress-induced cocaine relapse by endocannabinoid-mediated disinhibition of dopaminergic neurons

Caveolin‐1 Secreted from Adipose Tissues and Adipocytes Functions as an Adipogenesis Enhancer

A structure-function approach identifies L-PGDS as a mediator responsible for glucocorticoid-induced leptin expression in adipocytes

Mesenchymal stem cells tune the development of monocyte-derived dendritic cells toward a myeloid-derived suppressive phenotype through growth-regulated oncogene chemokines

Decrypting orphan GPCR drug discovery via multitask learning

Identification of Substituted Naphthotriazolediones as Novel Tryptophan 2,3-Dioxygenase (TDO) Inhibitors through Structure-Based Virtual Screening

Identification of the transcription factor ARNTL2 as a candidate gene for the type 1 diabetes locus Idd6

Important Hydrogen Bond Networks in Indoleamine 2,3-Dioxygenase 1 (IDO1) Inhibitor Design Revealed by Crystal Structures of Imidazoleisoindole Derivatives with IDO1

A new perspective of cannabinoid 1 receptor antagonists: approaches toward peripheral CB1R blockers without crossing the blood-brain barrier

Median nerve stimulation induces analgesia via orexin-initiated endocannabinoid disinhibition in the periaqueductal gray

DUSP6 mediates T cell receptor-engaged glycolysis and restrains TFH cell differentiation

Unique Sulfur–Aromatic Interactions Contribute to the Binding of Potent Imidazothiazole Indoleamine 2,3-Dioxygenase Inhibitors

Natural fucoidans inhibit coronaviruses by targeting viral spike protein and host cell furin

Phenyl Benzenesulfonylhydrazides Exhibit Selective Indoleamine 2,3-Dioxygenase Inhibition with Potent in Vivo Pharmacodynamic Activity and Antitumor Efficacy

Discovery and structure-activity relationships of phenyl benzenesulfonylhydrazides as novel indoleamine 2,3-dioxygenase inhibitors

Discovery of 1-(2,4-Dichlorophenyl)-4-ethyl-5-(5-(2-(4-(trifluoromethyl)phenyl)ethynyl)thiophen-2-yl)-N-(piperidin-1-yl)-1H-pyrazole-3-carboxamide as a Potential Peripheral Cannabinoid-1 Receptor Inverse Agonist

Discovery and development of a novel N-(3-bromophenyl)-{[(phenylcarbamoyl)amino]methyl}-N-hydroxythiophene-2-carboximidamide indoleamine 2,3-dioxygenase inhibitor using knowledge-based drug design

Fluorine-18 isotope labeling for positron emission tomography imaging. Direct evidence for DBPR211 as a peripherally restricted CB1 inverse agonist

The Eukaryotic DNMT2 Genes Encode a New Class of Cytosine-5 DNA Methyltransferases

Modulating the affinity and signaling bias of cannabinoid receptor 1 antagonists

1,2,3-Triazole derivatives as new cannabinoid CB1 receptor antagonists

Discovery of Novel N-β-d-Xylosylindole Derivatives as Sodium-Dependent Glucose Cotransporter 2 (SGLT2) Inhibitors for the Management of Hyperglycemia in Diabetes

Discovery of 2-[5-(4-Chloro-phenyl)-1-(2,4-dichloro-phenyl)-4-ethyl-1H-pyrazol-3-yl]-1,5,5-trimethyl-1,5-dihydro-imidazol-4-thione (BPR-890) via an Active Metabolite. A Novel, Potent and Selective Cannabinoid-1 Receptor Inverse Agonist with High Antiobesity Efficacy in DIO Mice

4-Bromophenylhydrazinyl benzenesulfonylphenylureas as indoleamine 2,3-dioxygenase inhibitors with in vivo target inhibition and anti-tumor efficacy

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