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POE Immunoassay: Plate-based oligonucleotide electro-chemiluminescent immunoassay for the quantification of nucleic acids in biological matrices

Scientific reports, 2020-06, Vol.10 (1), p.10425-9, Article 10425

2020

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The two faces of aldehyde oxidase: Oxidative and reductive transformations of 5-nitroquinoline

Biochemical pharmacology, 2017-12, Vol.145, p.210-217

2017

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Utility of physiologically based pharmacokinetic modeling to predict inter-antibody variability in monoclonal antibody pharmacokinetics in mice

mAbs, 2023-12, Vol.15 (1), p.2263926-2263926

2023

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Development of in silico models to predict viscosity and mouse clearance using a comprehensive analytical data set collected on 83 scaffold-consistent monoclonal antibodies

mAbs, 2023-12, Vol.15 (1), p.2256745-2256745

2023

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Introducing an In Vitro Liver Stability Assay Capable of Predicting the In Vivo Pharmacodynamic Efficacy of siRNAs for IVIVC

Molecular therapy. Nucleic acids, 2020-09, Vol.21, p.725-736

2020

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Prolonged cultured human hepatocytes as an in vitro experimental system for the evaluation of potency and duration of activity of RNA therapeutics: Demonstration of prolonged duration of gene silencing effects of a GalNAc-conjugated human hypoxanthine phosphoribosyl transferase (HPRT1) siRNA

Biochemical pharmacology, 2021-07, Vol.189, p.114374-114374, Article 114374

2021

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Modeling the CRL4A ligase complex to predict target protein ubiquitination induced by cereblon-recruiting PROTACs

The Journal of biological chemistry, 2022-04, Vol.298 (4), p.101653-101653, Article 101653

2022

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Emerging siRNA Design Principles and Consequences for Biotransformation and Disposition in Drug Development

Journal of medicinal chemistry, 2020-06, Vol.63 (12), p.6407-6422

2020

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ecoAO: A Simple System for the Study of Human Aldehyde Oxidases Role in Drug Metabolism

ACS omega, 2017-08, Vol.2 (8), p.4820-4827

2017

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Plasma and Liver Protein Binding of N -Acetylgalactosamine-Conjugated Small Interfering RNA

Drug metabolism and disposition, 2019-10, Vol.47 (10), p.1174-1182

2019

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Half-life extension of peptidic APJ agonists by N-terminal lipid conjugation

Bioorganic & medicinal chemistry letters, 2020-11, Vol.30 (21), p.127499-127499, Article 127499

2020

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Microphysiological endothelial models to characterize subcutaneous drug absorption

ALTEX, 2023-01, Vol.40 (2), p.299–313

2023

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Substrate Dependent Native Luminescence from Cytochromes P450 3A4, 2C9, and P450cam

The journal of physical chemistry. B, 2016-03, Vol.120 (12), p.3038-3047

2016

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The Role of Protein-Protein and Protein-Membrane Interactions on P450 Function

Drug metabolism and disposition, 2016-04, Vol.44 (4), p.576-590

2016

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Tracking individual membrane proteins and their biochemistry: The power of direct observation

Neuropharmacology, 2015-11, Vol.98, p.22-30

2015

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Super-Resolution Imaging and Reaction Mapping of P450 3A4 and P450 Reductase in Heterogeneous Biomimetics: Starry Night

Biophysical journal, 2015-01, Vol.108 (2), p.250a-250a

2015

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ADME considerations for siRNA-based therapeutics

Overcoming Obstacles in Drug Discovery and Development, 2023

2023

Volltextzugriff (PDF)

Utility of physiologically based pharmacokinetic modeling to predict inter-antibody variability in monoclonal antibody pharmacokinetics in mice

mAbs, 2023, Vol.15 (1)

2023

Volltextzugriff (PDF)

Development of in silico models to predict viscosity and mouse clearance using a comprehensive analytical data set collected on 83 scaffold-consistent monoclonal antibodies

mAbs, 2023, Vol.15 (1)

2023

Volltextzugriff (PDF)

Depressive symptoms in parents are associated with reduced empathy toward their young children

PloS one, 2020-03, Vol.15 (3), p.e0230636-e0230636

2020

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The Effect of COVID-19 on Corneal Donor Volumes and Eye Bank Processes: An Analysis From the Eye Bank of Canada (Ontario Division)

Cornea, 2022-06, Vol.41 (6), p.757

2022

Volltextzugriff (PDF)

Modeling the evolution of the US opioid crisis for national policy development

Proceedings of the National Academy of Sciences - PNAS, 2022-06, Vol.119 (23), p.e2115714119-e2115714119

2022

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Behavioral coping phenotypes and associated psychosocial outcomes of pregnant and postpartum women during the COVID-19 pandemic

Scientific reports, 2022-01, Vol.12 (1), p.1209-1209, Article 1209

2022

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Metabolite changes in blood predict the onset of tuberculosis

Nature communications, 2018-12, Vol.9 (1), p.5208-12, Article 5208

2018

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POE Immunoassay: Plate-based oligonucleotide electro-chemiluminescent immunoassay for the quantification of nucleic acids in biological matrices

The two faces of aldehyde oxidase: Oxidative and reductive transformations of 5-nitroquinoline

Utility of physiologically based pharmacokinetic modeling to predict inter-antibody variability in monoclonal antibody pharmacokinetics in mice

Development of in silico models to predict viscosity and mouse clearance using a comprehensive analytical data set collected on 83 scaffold-consistent monoclonal antibodies

Introducing an In Vitro Liver Stability Assay Capable of Predicting the In Vivo Pharmacodynamic Efficacy of siRNAs for IVIVC

Prolonged cultured human hepatocytes as an in vitro experimental system for the evaluation of potency and duration of activity of RNA therapeutics: Demonstration of prolonged duration of gene silencing effects of a GalNAc-conjugated human hypoxanthine phosphoribosyl transferase (HPRT1) siRNA

Modeling the CRL4A ligase complex to predict target protein ubiquitination induced by cereblon-recruiting PROTACs

Emerging siRNA Design Principles and Consequences for Biotransformation and Disposition in Drug Development

ecoAO: A Simple System for the Study of Human Aldehyde Oxidases Role in Drug Metabolism

Plasma and Liver Protein Binding of N -Acetylgalactosamine-Conjugated Small Interfering RNA

Half-life extension of peptidic APJ agonists by N-terminal lipid conjugation

Microphysiological endothelial models to characterize subcutaneous drug absorption

Substrate Dependent Native Luminescence from Cytochromes P450 3A4, 2C9, and P450cam

The Role of Protein-Protein and Protein-Membrane Interactions on P450 Function

Tracking individual membrane proteins and their biochemistry: The power of direct observation

Super-Resolution Imaging and Reaction Mapping of P450 3A4 and P450 Reductase in Heterogeneous Biomimetics: Starry Night

ADME considerations for siRNA-based therapeutics

Utility of physiologically based pharmacokinetic modeling to predict inter-antibody variability in monoclonal antibody pharmacokinetics in mice

Development of in silico models to predict viscosity and mouse clearance using a comprehensive analytical data set collected on 83 scaffold-consistent monoclonal antibodies

Depressive symptoms in parents are associated with reduced empathy toward their young children

The Effect of COVID-19 on Corneal Donor Volumes and Eye Bank Processes: An Analysis From the Eye Bank of Canada (Ontario Division)

Modeling the evolution of the US opioid crisis for national policy development

A genetically inducible endothelial niche enables vascularization of human kidney organoids with multilineage maturation and emergence of renin expressing cells

Behavioral coping phenotypes and associated psychosocial outcomes of pregnant and postpartum women during the COVID-19 pandemic

Metabolite changes in blood predict the onset of tuberculosis

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