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phage abortive infection system, ToxIN, functions as a protein-RNA toxin-antitoxin pair

Proceedings of the National Academy of Sciences - PNAS, 2009-01, Vol.106 (3), p.894-899

2009

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Development of a high yielding E. coli periplasmic expression system for the production of humanized Fab' fragments

Biotechnology progress, 2017-01, Vol.33 (1), p.212-220

2017

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Interactions of the anti-FcRn monoclonal antibody, rozanolixizumab, with Fcγ receptors and functional impact on immune cells in vitro

mAbs, 2024, Vol.16 (1), p.2300155-2300155

2024

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TRYBE®: an Fc-free antibody format with three monovalent targeting arms engineered for long in vivo half-life

mAbs, 2023, Vol.15 (1), p.2160229-2160229

2023

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Relative Contribution of Framework and CDR Regions in Antibody Variable Domains to Multimerisation of Fv- and scFv-Containing Bispecific Antibodies

Antibodies (Basel), 2018-08, Vol.7 (3), p.35

2018

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Impact of Human FcγR Gene Polymorphisms on IgG-Triggered Cytokine Release: Critical Importance of Cell Assay Format

Frontiers in immunology, 2019-03, Vol.10, p.390-390

2019

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On-target IgG hexamerisation driven by a C-terminal IgM tail-piece fusion variant confers augmented complement activation

Communications biology, 2021-09, Vol.4 (1), p.1031-1031, Article 1031

2021

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Antibodies for treatment of Clostridium difficile infection

Clinical and vaccine immunology, 2014-07, Vol.21 (7), p.913-923

2014

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Escherichia coli “TatExpress” strains export several g/L human growth hormone to the periplasm by the Tat pathway

Biotechnology and bioengineering, 2019-12, Vol.116 (12), p.3282-3291

2019

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A comparative analysis of recombinant Fab and full‐length antibody production in Chinese hamster ovary cells

Biotechnology and bioengineering, 2021-12, Vol.118 (12), p.4815-4828

2021

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IgG light chain-independent secretion of heavy chain dimers: consequence for therapeutic antibody production and design

Biochemical journal, 2017-09, Vol.474 (18), p.3179-3188

2017

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Mitochondrial aconitase is a key regulator of energy production for growth and protein expression in Chinese hamster ovary cells

Metabolomics, 2018-10, Vol.14 (10), p.136-16, Article 136

2018

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A processed noncoding RNA regulates an altruistic bacterial antiviral system

Nature structural & molecular biology, 2011-02, Vol.18 (2), p.185-190

2011

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Alternative antibody Fab′ fragment PEGylation strategies: combination of strong reducing agents, disruption of the interchain disulphide bond and disulphide engineering

Protein engineering, design and selection, 2007-05, Vol.20 (5), p.227-234

2007

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Antibodies as drugs—a Keystone Symposia report

Annals of the New York Academy of Sciences, 2023-01, Vol.1519 (1), p.153-166

2023

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Extending the half-life of a fab fragment through generation of a humanized anti-human serum albumin Fv domain: An investigation into the correlation between affinity and serum half-life

mAbs, 2016-10, Vol.8 (7), p.1336-1346

2016

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High Prevalence of Subclass-Specific Binding and Neutralising Antibodies Against Clostridium Difficile Toxins in Adult Cystic Fibrosis Sera: Possible Mode of Protection Against Symptomatic Clostridium Difficile Infection

Gastroenterology (New York, N.Y. 1943), 2017-04, Vol.152 (5), p.S344-S344

2017

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Molecular Insights into the Thermal Stability of mAbs with Variable-Temperature Ion-Mobility Mass Spectrometry

Chembiochem : a European journal of chemical biology, 2016-01, Vol.17 (1), p.46-51

2016

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Fab-dsFv: A bispecific antibody format with extended serum half-life through albumin binding

mAbs, 2016-10, Vol.8 (7), p.1319-1335

2016

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Engineering an Improved IgG4 Molecule with Reduced Disulfide Bond Heterogeneity and Increased Fab Domain Thermal Stability

The Journal of biological chemistry, 2012-07, Vol.287 (29), p.24525-24533

2012

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Relative stabilities of IgG1 and IgG4 Fab domains: Influence of the light–heavy interchain disulfide bond architecture

Protein science, 2012-09, Vol.21 (9), p.1315-1322

2012

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A plasmid system for optimization of Fab ′ production in Escherichia coli: importance of balance of heavy chain and light chain synthesis

Protein expression and purification, 2002-11, Vol.26 (2), p.309-320

2002

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High prevalence of subclass-specific binding and neutralizing antibodies against Clostridium difficile toxins in adult cystic fibrosis sera: possible mode of immunoprotection against symptomatic C. difficile infection

Clinical and experimental gastroenterology, 2017-01, Vol.10, p.169-175

2017

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Engineered hexavalent Fc proteins with enhanced Fc-gamma receptor avidity provide insights into immune-complex interactions

Communications biology, 2018-01, Vol.1 (1), p.146-146, Article 146

2018

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phage abortive infection system, ToxIN, functions as a protein-RNA toxin-antitoxin pair

Development of a high yielding E. coli periplasmic expression system for the production of humanized Fab' fragments

Interactions of the anti-FcRn monoclonal antibody, rozanolixizumab, with Fcγ receptors and functional impact on immune cells in vitro

TRYBE®: an Fc-free antibody format with three monovalent targeting arms engineered for long in vivo half-life

Relative Contribution of Framework and CDR Regions in Antibody Variable Domains to Multimerisation of Fv- and scFv-Containing Bispecific Antibodies

Impact of Human FcγR Gene Polymorphisms on IgG-Triggered Cytokine Release: Critical Importance of Cell Assay Format

On-target IgG hexamerisation driven by a C-terminal IgM tail-piece fusion variant confers augmented complement activation

A Mixture of Functionally Oligoclonal Humanized Monoclonal Antibodies That Neutralize Clostridium difficile TcdA and TcdB with High Levels of In Vitro Potency Shows In Vivo Protection in a Hamster Infection Model

Antibodies for treatment of Clostridium difficile infection

Escherichia coli “TatExpress” strains export several g/L human growth hormone to the periplasm by the Tat pathway

A comparative analysis of recombinant Fab and full‐length antibody production in Chinese hamster ovary cells

IgG light chain-independent secretion of heavy chain dimers: consequence for therapeutic antibody production and design

Mitochondrial aconitase is a key regulator of energy production for growth and protein expression in Chinese hamster ovary cells

A processed noncoding RNA regulates an altruistic bacterial antiviral system

Alternative antibody Fab′ fragment PEGylation strategies: combination of strong reducing agents, disruption of the interchain disulphide bond and disulphide engineering

Antibodies as drugs—a Keystone Symposia report

Extending the half-life of a fab fragment through generation of a humanized anti-human serum albumin Fv domain: An investigation into the correlation between affinity and serum half-life

High Prevalence of Subclass-Specific Binding and Neutralising Antibodies Against Clostridium Difficile Toxins in Adult Cystic Fibrosis Sera: Possible Mode of Protection Against Symptomatic Clostridium Difficile Infection

Molecular Insights into the Thermal Stability of mAbs with Variable-Temperature Ion-Mobility Mass Spectrometry

Fab-dsFv: A bispecific antibody format with extended serum half-life through albumin binding

Engineering an Improved IgG4 Molecule with Reduced Disulfide Bond Heterogeneity and Increased Fab Domain Thermal Stability

Relative stabilities of IgG1 and IgG4 Fab domains: Influence of the light–heavy interchain disulfide bond architecture

A plasmid system for optimization of Fab ′ production in Escherichia coli: importance of balance of heavy chain and light chain synthesis

High prevalence of subclass-specific binding and neutralizing antibodies against Clostridium difficile toxins in adult cystic fibrosis sera: possible mode of immunoprotection against symptomatic C. difficile infection

Engineered hexavalent Fc proteins with enhanced Fc-gamma receptor avidity provide insights into immune-complex interactions

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