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The output of Hedgehog signaling is controlled by the dynamic association between Suppressor of Fused and the Gli proteins

Genes & development, 2010-04, Vol.24 (7), p.670-682

2010

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Gli protein activity is controlled by multisite phosphorylation in vertebrate Hedgehog signaling

Cell reports (Cambridge), 2014-01, Vol.6 (1), p.168-181

2014

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NOD2-NALP1 complex mediates caspase-1-dependent IL-1β secretion in response to Bacillus anthracis infection and muramyl dipeptide

Proceedings of the National Academy of Sciences - PNAS, 2008-06, Vol.105 (22), p.7803-7808

2008

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Kif3a is necessary for initiation and maintenance of medulloblastoma

Carcinogenesis (New York), 2013-06, Vol.34 (6), p.1382-1392

2013

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Learning from Jekyll to control Hyde: Hedgehog signaling in development and cancer

Trends in molecular medicine, 2010-08, Vol.16 (8), p.337-348

2010

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Multimeric Anti-DR5 IgM Agonist Antibody IGM-8444 Is a Potent Inducer of Cancer Cell Apoptosis and Synergizes with Chemotherapy and BCL-2 Inhibitor ABT-199

Molecular cancer therapeutics, 2021-12, Vol.20 (12), p.2483-2494

2021

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Isolation and mutational analysis of circulating tumor cells from lung cancer patients with magnetic sifters and biochips

Lab on a chip, 2014-01, Vol.14 (1), p.78-88

2014

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An Open-label Phase I Study of GDC-0927 in Postmenopausal Women with Locally Advanced or Metastatic Estrogen Receptor-Positive Breast Cancer

Clinical cancer research, 2023-08, Vol.29 (15), p.2781

2023

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Phase 1b study of anti-NaPi2b antibody-drug conjugate lifastuzumab vedotin (DNIB0600A) in patients with platinum-sensitive recurrent ovarian cancer

Gynecologic oncology, 2020-09, Vol.158 (3), p.631-639

2020

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Phase I study of the anti-FcRH5 antibody-drug conjugate DFRF4539A in relapsed or refractory multiple myeloma

Blood cancer journal (New York), 2019-02, Vol.9 (2), p.17-17, Article 17

2019

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ICEBERG: A Novel Inhibitor of Interleukin-1β Generation

Cell, 2000-09, Vol.103 (1), p.99-111

2000

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Caspase-9 Can Be Activated without Proteolytic Processing

The Journal of biological chemistry, 1999-03, Vol.274 (13), p.8359-8362

1999

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The PYRIN domain: A member of the death domain‐fold superfamily

Protein science, 2001-09, Vol.10 (9), p.1911-1918

2001

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Activation of caspases triggered by cytochrome c in vitro

FEBS letters, 1998-04, Vol.426 (1), p.151-154

1998

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ERICE, a Novel FLICE-activatable Caspase

The Journal of biological chemistry, 1998-06, Vol.273 (25), p.15702-15707

1998

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Abstract P5-11-07: Real-world predictors of first-line treatment and descriptive outcomes in HR+/HER2− metastatic breast cancer patients in the US

Cancer research (Chicago, Ill.), 2020-02, Vol.80 (4_Supplement), p.P5-P5-11-07

2020

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The Anti-Tumor Activity of Igm-8444, an Agonistic Death Receptor 5 (DR5) IgM Antibody, Is Sensitized in Combination with Chemotherapy and Bcl-2 Inhibitors in NHL and AML

Blood, 2020-11, Vol.136 (Supplement 1), p.43-44

2020

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Abstract 52: Mechanistic evaluation of anti-DR5 IgM antibody IGM-8444 with potent tumor cytotoxicity, without in vitro hepatotoxicity

Cancer research (Chicago, Ill.), 2021-07, Vol.81 (13_Supplement), p.52-52

2021

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Abstract P2-11-05: ER pathway activity signature as a biomarker for endocrine agent GDC-9545

Cancer research (Chicago, Ill.), 2020-02, Vol.80 (4_Supplement), p.P2-P2-11-05

2020

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Abstract CT036: Targeting MUC16 with the THIOMABTM-drug conjugate DMUC4064A in patients with platinum-resistant ovarian cancer: A phase I expansion study

Cancer research (Chicago, Ill.), 2018-07, Vol.78 (13_Supplement), p.CT036-CT036

2018

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Abstract 6123: Characterization of the synergistic tumor cytotoxicity of agonistic DR5 IgM antibody IGM-8444 with chemotherapeutic agents

Cancer research (Chicago, Ill.), 2023-04, Vol.83 (7_Supplement), p.6123-6123

2023

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Abstract 1068: Anti-DR5 agonist IgM antibody IGM-8444 combined with SMAC mimetic birinapant induces strong synergistic tumor cytotoxicity

Cancer research (Chicago, Ill.), 2022-06, Vol.82 (12_Supplement), p.1068-1068

2022

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Abstract CT009: Targeting MUC16 with the THIOMABTM-drug conjugate DMUC4064A in patients with platinum-resistant ovarian cancer: a Phase I escalation study

Cancer research (Chicago, Ill.), 2017-07, Vol.77 (13_Supplement), p.CT009-CT009

2017

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The output of Hedgehog signaling is controlled by the dynamic association between Suppressor of Fused and the Gli proteins

Gli protein activity is controlled by multisite phosphorylation in vertebrate Hedgehog signaling

NOD2-NALP1 complex mediates caspase-1-dependent IL-1β secretion in response to Bacillus anthracis infection and muramyl dipeptide

Kif3a is necessary for initiation and maintenance of medulloblastoma

Learning from Jekyll to control Hyde: Hedgehog signaling in development and cancer

Multimeric Anti-DR5 IgM Agonist Antibody IGM-8444 Is a Potent Inducer of Cancer Cell Apoptosis and Synergizes with Chemotherapy and BCL-2 Inhibitor ABT-199

Isolation and mutational analysis of circulating tumor cells from lung cancer patients with magnetic sifters and biochips

An Open-label Phase I Study of GDC-0927 in Postmenopausal Women with Locally Advanced or Metastatic Estrogen Receptor-Positive Breast Cancer

Phase 1b study of anti-NaPi2b antibody-drug conjugate lifastuzumab vedotin (DNIB0600A) in patients with platinum-sensitive recurrent ovarian cancer

Phase Ia Study of Anti-NaPi2b Antibody-Drug Conjugate Lifastuzumab Vedotin DNIB0600A in Patients with Non-Small Cell Lung Cancer and Platinum-Resistant Ovarian Cancer

Phase I study of the anti-FcRH5 antibody-drug conjugate DFRF4539A in relapsed or refractory multiple myeloma

ICEBERG: A Novel Inhibitor of Interleukin-1β Generation

Caspase-9 Can Be Activated without Proteolytic Processing

The PYRIN domain: A member of the death domain‐fold superfamily

Activation of caspases triggered by cytochrome c in vitro

ERICE, a Novel FLICE-activatable Caspase

Abstract P5-11-07: Real-world predictors of first-line treatment and descriptive outcomes in HR+/HER2− metastatic breast cancer patients in the US

The Anti-Tumor Activity of Igm-8444, an Agonistic Death Receptor 5 (DR5) IgM Antibody, Is Sensitized in Combination with Chemotherapy and Bcl-2 Inhibitors in NHL and AML

Abstract 52: Mechanistic evaluation of anti-DR5 IgM antibody IGM-8444 with potent tumor cytotoxicity, without in vitro hepatotoxicity

Abstract P2-11-05: ER pathway activity signature as a biomarker for endocrine agent GDC-9545

Abstract CT036: Targeting MUC16 with the THIOMABTM-drug conjugate DMUC4064A in patients with platinum-resistant ovarian cancer: A phase I expansion study

Abstract 6123: Characterization of the synergistic tumor cytotoxicity of agonistic DR5 IgM antibody IGM-8444 with chemotherapeutic agents

Abstract 1068: Anti-DR5 agonist IgM antibody IGM-8444 combined with SMAC mimetic birinapant induces strong synergistic tumor cytotoxicity

Abstract CT009: Targeting MUC16 with the THIOMABTM-drug conjugate DMUC4064A in patients with platinum-resistant ovarian cancer: a Phase I escalation study

Isolation and mutational analysis of circulating tumor cells from lung cancer patients with magnetic sifters and biochipsElectronic supplementary information (ESI) available: Fig. S1-S12, Movies S1-S3. See DOI: 10.1039/c3lc50580d

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