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Evaluation of pyrrolidin-2-imines and 1,3-thiazolidin-2-imines as inhibitors of nitric oxide synthase

Bioorganic & medicinal chemistry letters, 2004-09, Vol.14 (17), p.4539-4544

2004

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Synthesis of analogs of (1,4)-3- and 5-imino oxazepane, thiazepane, and diazepane as inhibitors of nitric oxide synthases

Bioorganic & medicinal chemistry letters, 2004-12, Vol.14 (23), p.5907-5911

2004

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Bicyclic amidine inhibitors of nitric oxide synthase: discovery of perhydro-iminopyrindine and perhydro-iminoquinoline as potent, orally active inhibitors of inducible nitric oxide synthase

Bioorganic & medicinal chemistry letters, 2005-04, Vol.15 (8), p.1997-2001

2005

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The fibrinogen cleavage product A alpha-Val(360), a specific marker of neutrophil elastase activity in vivo

Thorax, 2011, Vol.66 (8), p.686

2011

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Inhibition of neutrophil elastase in CF sputum by L-658,758

The Journal of pharmacology and experimental therapeutics, 1997-12, Vol.283 (3), p.1201

1997

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28-kDa Mammalian Heat Shock Protein, a Novel Substrate of a Growth Regulatory Protease Involved in Differentiation of Human Leukemia Cells (∗)

The Journal of biological chemistry, 1995-01, Vol.270 (3), p.1003-1006

1995

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Inhibition of nitric oxide synthase by benzoxazolones

Bioorganic & medicinal chemistry letters, 1997-11, Vol.7 (22), p.2887-2892

1997

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The fibrinogen cleavage product Aα-Val360, a specific marker of neutrophil elastase activity in vivo

Thorax, 2011-08, Vol.66 (8), p.686-691

2011

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Physiological and Pharmacological Regulation of Prostaglandin and Leukotriene Production by Macrophages

Journal of leukocyte biology, 1984-01, Vol.35 (1), p.1-10

1984

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The fibrinogen cleavage product A -Val360, a specific marker of neutrophil elastase activity in vivo

Thorax, 2011-08, Vol.66 (8), p.686-691

2011

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Differential effects of prostaglandin synthetase stimulators on inhibition of cyclooxygenase

Biochemistry (Easton), 1978-05, Vol.17 (11), p.2230-2234

1978

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Substituted 2-aminopyridines as inhibitors of nitric oxide synthases

Bioorganic & medicinal chemistry letters, 2000-09, Vol.10 (17), p.1975-1978

2000

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Pharmacological modulation of eicosanoid levels and hyperalgesia in yeast-induced inflammation

Biochemical pharmacology, 1987-02, Vol.36 (4), p.547-551

1987

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Pharmacological effects of non-steroidal antiinflammatory agents on prostaglandin and leukotriene synthesis in mouse peritoneal macrophages

Biochemical pharmacology, 1983-08, Vol.32 (15), p.2319-2322

1983

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Studies on Polypeptides. XXV. The Adrenocorticotropic Potency of an Eicosapeptide Amide Corresponding to the N-Terminal Portion of the ACTH Molecule; Contribution to the Relation between Peptide Chain-Length and Biological Activity1-4

Journal of the American Chemical Society, 1962-12, Vol.84 (23), p.4481-4486

1962

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Prostaglandin and Leukotriene Synthesis in Mouse Ears Inflamed by Arachidonic Acid

Journal of investigative dermatology, 1985-04, Vol.84 (4), p.253-256

1985

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Testicular Adenyl Cyclase: Stimulation by the Pituitary Gonadotrophins

Biology of reproduction, 1970-02, Vol.2 (1), p.154-163

1970

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Intra-peritoneal free elastase in CAPD peritonitis

Kidney international, 1993-07, Vol.44 (1), p.87-90

1993

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Chemical, Biochemical, Pharmacokinetic, and Biological Properties of L-680, 833: A Potent, Orally Active Monocyclic β-Lactam Inhibitor of Human Polymorphonuclear Leukocyte Elastase

Proceedings of the National Academy of Sciences - PNAS, 1993-09, Vol.90 (18), p.8727-8731

1993

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Formation of polymorphonuclear leukocyte elastase: α1 proteinase inhibitor complex and Aα(1–21) fibrinopeptide in human blood stimulated with the calcium ionophore A23187 : A model to characterize inhibitors of polymorphonuclear leukocyte elastase

Biochemical pharmacology, 1995-05, Vol.49 (10), p.1513-1520

1995

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Regulation of Leukotriene Formation in Inflammatory Cells

Annals of the New York Academy of Sciences, 1988, Vol.524 (1), p.252-259

1988

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Studies on Polypeptides. XXII. High Adrenocorticotropic Activity in The Rat and in Man of A Synthetic Eicosapeptide Amide1-3

Journal of the American Chemical Society, 1962-03, Vol.84 (6), p.1054-1056

1962

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Antioxidant-based inhibitors of leukotriene biosynthesis. The discovery of 6-[1-[2-(hydroxymethyl)phenyl]-1-propen-3-yl]-2,3-dihydro-5-benzofuranol, a potent topical antiinflammatory agent

Journal of medicinal chemistry, 1990-03, Vol.33 (3), p.908-918

1990

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Effects of cyclooxygenase and lipoxygenase inhibitors on inflammation associated with oxazolone-induced delayed hypersensitivity

Biochemical pharmacology, 1988-09, Vol.37 (18), p.3511-3514

1988

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Formation of polymorphonuclear leukocyte elastase: α1 proteinase inhibitor complex and Aα(1–21) fibrinopeptide in human blood stimulated with the calcium ionophore A23187

Biochemical pharmacology, 1995-05, Vol.49 (10), p.1513-1520

1995

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Evaluation of pyrrolidin-2-imines and 1,3-thiazolidin-2-imines as inhibitors of nitric oxide synthase

Synthesis of analogs of (1,4)-3- and 5-imino oxazepane, thiazepane, and diazepane as inhibitors of nitric oxide synthases

Bicyclic amidine inhibitors of nitric oxide synthase: discovery of perhydro-iminopyrindine and perhydro-iminoquinoline as potent, orally active inhibitors of inducible nitric oxide synthase

The fibrinogen cleavage product A alpha-Val(360), a specific marker of neutrophil elastase activity in vivo

Inhibition of neutrophil elastase in CF sputum by L-658,758

28-kDa Mammalian Heat Shock Protein, a Novel Substrate of a Growth Regulatory Protease Involved in Differentiation of Human Leukemia Cells (∗)

Inhibition of nitric oxide synthase by benzoxazolones

The fibrinogen cleavage product Aα-Val360, a specific marker of neutrophil elastase activity in vivo

Physiological and Pharmacological Regulation of Prostaglandin and Leukotriene Production by Macrophages

The fibrinogen cleavage product A -Val360, a specific marker of neutrophil elastase activity in vivo

Differential effects of prostaglandin synthetase stimulators on inhibition of cyclooxygenase

Substituted 2-aminopyridines as inhibitors of nitric oxide synthases

Pharmacological modulation of eicosanoid levels and hyperalgesia in yeast-induced inflammation

Pharmacological effects of non-steroidal antiinflammatory agents on prostaglandin and leukotriene synthesis in mouse peritoneal macrophages

Studies on Polypeptides. XXV. The Adrenocorticotropic Potency of an Eicosapeptide Amide Corresponding to the N-Terminal Portion of the ACTH Molecule; Contribution to the Relation between Peptide Chain-Length and Biological Activity1-4

Prostaglandin and Leukotriene Synthesis in Mouse Ears Inflamed by Arachidonic Acid

Testicular Adenyl Cyclase: Stimulation by the Pituitary Gonadotrophins

Intra-peritoneal free elastase in CAPD peritonitis

Chemical, Biochemical, Pharmacokinetic, and Biological Properties of L-680, 833: A Potent, Orally Active Monocyclic β-Lactam Inhibitor of Human Polymorphonuclear Leukocyte Elastase

Formation of polymorphonuclear leukocyte elastase: α1 proteinase inhibitor complex and Aα(1–21) fibrinopeptide in human blood stimulated with the calcium ionophore A23187 : A model to characterize inhibitors of polymorphonuclear leukocyte elastase

Regulation of Leukotriene Formation in Inflammatory Cells

Studies on Polypeptides. XXII. High Adrenocorticotropic Activity in The Rat and in Man of A Synthetic Eicosapeptide Amide1-3

Antioxidant-based inhibitors of leukotriene biosynthesis. The discovery of 6-[1-[2-(hydroxymethyl)phenyl]-1-propen-3-yl]-2,3-dihydro-5-benzofuranol, a potent topical antiinflammatory agent

Effects of cyclooxygenase and lipoxygenase inhibitors on inflammation associated with oxazolone-induced delayed hypersensitivity

Formation of polymorphonuclear leukocyte elastase: α1 proteinase inhibitor complex and Aα(1–21) fibrinopeptide in human blood stimulated with the calcium ionophore A23187

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