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Propensity for somatic expansion increases over the course of life in Huntington disease

eLife, 2021-05, Vol.10

2021

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Huntington's disease alters human neurodevelopment

Science (American Association for the Advancement of Science), 2020-08, Vol.369 (6505), p.787-793

2020

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Vasohibins/SVBP are tubulin carboxypeptidases (TCPs) that regulate neuron differentiation

Science (American Association for the Advancement of Science), 2017-12, Vol.358 (6369), p.1448-1453

2017

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Potential function for the Huntingtin protein as a scaffold for selective autophagy

Proceedings of the National Academy of Sciences - PNAS, 2014-11, Vol.111 (47), p.16889-16894

2014

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Huntingtin Is Required for Epithelial Polarity through RAB11A-Mediated Apical Trafficking of PAR3-aPKC

PLoS biology, 2015-05, Vol.13 (5), p.e1002142-e1002142

2015

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Characterization of Behavioral, Neuropathological, Brain Metabolic and Key Molecular Changes in zQ175 Knock-In Mouse Model of Huntington's Disease

PloS one, 2016-02, Vol.11 (2), p.e0148839-e0148839

2016

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Histone Deacetylase 6 Inhibition Compensates for the Transport Deficit in Huntington's Disease by Increasing Tubulin Acetylation

The Journal of neuroscience, 2007-03, Vol.27 (13), p.3571-3583

2007

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Presynaptic APP levels and synaptic homeostasis are regulated by Akt phosphorylation of huntingtin

eLife, 2020-05, Vol.9

2020

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Huntingtin phosphorylation acts as a molecular switch for anterograde/retrograde transport in neurons

The EMBO journal, 2008-08, Vol.27 (15), p.2124-2134

2008

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Scalable production in human cells and biochemical characterization of full-length normal and mutant huntingtin

PloS one, 2015-03, Vol.10 (3), p.e0121055-e0121055

2015

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Early Alterations of Brain Cellular Energy Homeostasis in Huntington Disease Models

The Journal of biological chemistry, 2012-01, Vol.287 (2), p.1361-1370

2012

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The Biology of Huntingtin

Neuron (Cambridge, Mass.), 2016-03, Vol.89 (5), p.910-926

2016

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Huntingtin Controls Neurotrophic Support and Survival of Neurons by Enhancing BDNF Vesicular Transport along Microtubules

Cell, 2004-07, Vol.118 (1), p.127-138

2004

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Phosphorylation of mutant huntingtin at S421 restores anterograde and retrograde transport in neurons

Human molecular genetics, 2008-12, Vol.17 (24), p.3837-3846

2008

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Shh Signaling Protects Atoh1 from Degradation Mediated by the E3 Ubiquitin Ligase Huwe1 in Neural Precursors

Developmental cell, 2014-06, Vol.29 (6), p.649-661

2014

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Serine 421 regulates mutant huntingtin toxicity and clearance in mice

The Journal of clinical investigation, 2016-09, Vol.126 (9), p.3585-3597

2016

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Discovery of novel isoforms of huntingtin reveals a new hominid-specific exon

PloS one, 2015-05, Vol.10 (5), p.e0127687-e0127687

2015

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Comparison of mHTT Antibodies in Huntington's Disease Mouse Models Reveal Specific Binding Profiles and Steady-State Ubiquitin Levels with Disease Development

PloS one, 2016-05, Vol.11 (5), p.e0155834-e0155834

2016

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The striatal kinase DCLK3 produces neuroprotection against mutant huntingtin

Brain (London, England : 1878), 2018-05, Vol.141 (5), p.1434-1454

2018

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Mitogen- and stress-activated protein kinase-1 deficiency is involved in expanded-huntingtin-induced transcriptional dysregulation and striatal death

The FASEB journal, 2008-04, Vol.22 (4), p.1083-1093

2008

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Recreating mouse cortico-hippocampal neuronal circuit in microfluidic devices to study BDNF axonal transport upon glucocorticoid treatment

STAR protocols, 2021-03, Vol.2 (1), p.100382-100382, Article 100382

2021

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Dominant-Negative Effects of Adult-Onset Huntingtin Mutations Alter the Division of Human Embryonic Stem Cells-Derived Neural Cells

PloS one, 2016-02, Vol.11 (2), p.e0148680-e0148680

2016

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Huntington's disease and brain development

Comptes rendus. Biologies, 2022-12, Vol.345 (2), p.77-90

2022

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Huntingtin Subcellular Localisation Is Regulated by Kinase Signalling Activity in the StHdhQ111 Model of HD

PloS one, 2015-12, Vol.10 (12), p.e0144864-e0144864

2015

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The IGF-1/Akt Pathway Is Neuroprotective in Huntington's Disease and Involves Huntingtin Phosphorylation by Akt

Developmental cell, 2002-06, Vol.2 (6), p.831-837

2002

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Propensity for somatic expansion increases over the course of life in Huntington disease

Huntington's disease alters human neurodevelopment

Vasohibins/SVBP are tubulin carboxypeptidases (TCPs) that regulate neuron differentiation

Potential function for the Huntingtin protein as a scaffold for selective autophagy

Huntingtin Is Required for Epithelial Polarity through RAB11A-Mediated Apical Trafficking of PAR3-aPKC

Characterization of Behavioral, Neuropathological, Brain Metabolic and Key Molecular Changes in zQ175 Knock-In Mouse Model of Huntington's Disease

Histone Deacetylase 6 Inhibition Compensates for the Transport Deficit in Huntington's Disease by Increasing Tubulin Acetylation

Presynaptic APP levels and synaptic homeostasis are regulated by Akt phosphorylation of huntingtin

Huntingtin phosphorylation acts as a molecular switch for anterograde/retrograde transport in neurons

Scalable production in human cells and biochemical characterization of full-length normal and mutant huntingtin

Early Alterations of Brain Cellular Energy Homeostasis in Huntington Disease Models

The Biology of Huntingtin

Huntingtin Controls Neurotrophic Support and Survival of Neurons by Enhancing BDNF Vesicular Transport along Microtubules

Phosphorylation of mutant huntingtin at S421 restores anterograde and retrograde transport in neurons

Shh Signaling Protects Atoh1 from Degradation Mediated by the E3 Ubiquitin Ligase Huwe1 in Neural Precursors

Serine 421 regulates mutant huntingtin toxicity and clearance in mice

Discovery of novel isoforms of huntingtin reveals a new hominid-specific exon

Comparison of mHTT Antibodies in Huntington's Disease Mouse Models Reveal Specific Binding Profiles and Steady-State Ubiquitin Levels with Disease Development

The striatal kinase DCLK3 produces neuroprotection against mutant huntingtin

Mitogen- and stress-activated protein kinase-1 deficiency is involved in expanded-huntingtin-induced transcriptional dysregulation and striatal death

Recreating mouse cortico-hippocampal neuronal circuit in microfluidic devices to study BDNF axonal transport upon glucocorticoid treatment

Dominant-Negative Effects of Adult-Onset Huntingtin Mutations Alter the Division of Human Embryonic Stem Cells-Derived Neural Cells

Huntington's disease and brain development

Huntingtin Subcellular Localisation Is Regulated by Kinase Signalling Activity in the StHdhQ111 Model of HD

The IGF-1/Akt Pathway Is Neuroprotective in Huntington's Disease and Involves Huntingtin Phosphorylation by Akt

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