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L-743, 726 (DMP-266): a novel, highly potent nonnucleoside inhibitor of the human immunodeficiency virus type 1 reverse transcriptase

Antimicrobial Agents and Chemotherapy, 1995-12, Vol.39 (12), p.2602-2605

1995

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L-735,524: An Orally Bioavailable Human Immunodeficiency Virus Type 1 Protease Inhibitor

Proceedings of the National Academy of Sciences - PNAS, 1994-04, Vol.91 (9), p.4096-4100

1994

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HIV protease: a novel chemotherapeutic target for AIDS

Journal of medicinal chemistry, 1991-08, Vol.34 (8), p.2305-2314

Huff, Joel R

1991

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A peripherally acting alpha-2 adrenoceptor antagonist: L-659,066

The Journal of pharmacology and experimental therapeutics, 1988-04, Vol.245 (1), p.32

1988

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Abacavir sulfate

Bioorganic & medicinal chemistry, 1999-12, Vol.7 (12), p.2667-2669

HUFF, J. R

1999

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Metabolism of synthetic inositol trisphosphate analogs

The Journal of biological chemistry, 1988-08, Vol.263 (24), p.11922-11927

1988

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Identification of MK-944a: A Second Clinical Candidate from the Hydroxylaminepentanamide Isostere Series of HIV Protease Inhibitors

Journal of medicinal chemistry, 2000-09, Vol.43 (18), p.3386-3399

2000

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Nonpeptidal P2 Ligands for HIV Protease Inhibitors: Structure-Based Design, Synthesis, and Biological Evaluation

Journal of medicinal chemistry, 1996-08, Vol.39 (17), p.3278-3290

1996

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Structure-based design of HIV-1 protease inhibitors : replacement of two amides and a 10π-aromatic system by a fused bis-tetrahydrofuran

Journal of medicinal chemistry, 1994-08, Vol.37 (16), p.2506-2508

1994

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L-687,908, a potent hydroxyethylene containing HIV protease inhibitor

Journal of medicinal chemistry, 1991-03, Vol.34 (3), p.1225-1228

1991

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3'-Tetrahydrofuranylglycine as a novel, unnatural amino acid surrogate for asparagine in the design of inhibitors of the HIV protease

Journal of the American Chemical Society, 1993-01, Vol.115 (2), p.801-803

1993

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Conformational Restriction of Flexible Ligands Guided by the Transferred NOE Experiment: Potent Macrocyclic Inhibitors of Farnesyltransferase

Journal of the American Chemical Society, 2001-03, Vol.123 (9), p.2107-2108

2001

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L-735,524 : the design of a potent and orally bioavailable HIV protease inhibitor

Journal of medicinal chemistry, 1994-10, Vol.37 (21), p.3443-3451

1994

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Nonpeptide alpha(v)beta(3) antagonists. 1. Transformation of a potent, integrin-selective alpha(IIb)beta(3) antagonist into a potent alpha(v)beta(3) antagonist

Journal of medicinal chemistry, 2000-10, Vol.43 (20), p.3736-3745

2000

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Emergency Relief System Design Using DIERS Technology: The Design Institute for Emergency Relief Systems (DIERS) Project Manual

2010

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HIV-1 protease inhibitors: synthesis and biological evaluation of glycopeptidemimetics

Drug design and discovery, 1993, Vol.10 (1), p.77

1993

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Conformationally constrained HIV-1 protease inhibitors

Bioorganic & medicinal chemistry letters, 1994-02, Vol.4 (3), p.499-504

1994

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New drugs-reports of new drugs recently approved by the FDA. Abacavir sulfate

Bioorganic & medicinal chemistry, 1999-12, Vol.7 (12), p.2667-2669

Huff, J R

1999

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HIV Protease as an Inhibitor Target for the Treatment of AIDS

Advances in Pharmacology, 1994, Vol.25, p.399-454

1994

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[3H] L-657, 743 (MK-912): a new, high affinity, selective radioligand for brain α2-adrenoceptors

Life sciences (1973), 1989, Vol.44 (7), p.459-467

1989

Volltextzugriff (PDF)

Synthesis and antiviral activity of a series of HIV-1 protease inhibitors with functionality tethered to the P1 or P1' phenyl substituents : X-ray crystal structure assisted design

Journal of medicinal chemistry, 1992-05, Vol.35 (10), p.1685-1701

1992

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Structure-affinity relationships of arylquinolizines at .alpha.-adrenoceptors

Journal of medicinal chemistry, 1988-03, Vol.31 (3), p.641-645

1988

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Bioactive conformation of 1-arylpiperazines at central serotonin receptors

Journal of medicinal chemistry, 1985-07, Vol.28 (7), p.945-948

1985

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L-743, 726 (DMP-266): a novel, highly potent nonnucleoside inhibitor of the human immunodeficiency virus type 1 reverse transcriptase

L-735,524: An Orally Bioavailable Human Immunodeficiency Virus Type 1 Protease Inhibitor

HIV protease: a novel chemotherapeutic target for AIDS

A peripherally acting alpha-2 adrenoceptor antagonist: L-659,066

Design and Biological Activity of (S)-4-(5-{[1-(3-Chlorobenzyl)-2- oxopyrrolidin-3-ylamino]methyl}imidazol-1-ylmethyl)benzonitrile, a 3-Aminopyrrolidinone Farnesyltransferase Inhibitor with Excellent Cell Potency

Abacavir sulfate

Metabolism of synthetic inositol trisphosphate analogs

Identification of MK-944a: A Second Clinical Candidate from the Hydroxylaminepentanamide Isostere Series of HIV Protease Inhibitors

Nonpeptidal P2 Ligands for HIV Protease Inhibitors: Structure-Based Design, Synthesis, and Biological Evaluation

Structure-based design of HIV-1 protease inhibitors : replacement of two amides and a 10π-aromatic system by a fused bis-tetrahydrofuran

L-687,908, a potent hydroxyethylene containing HIV protease inhibitor

3'-Tetrahydrofuranylglycine as a novel, unnatural amino acid surrogate for asparagine in the design of inhibitors of the HIV protease

Conformational Restriction of Flexible Ligands Guided by the Transferred NOE Experiment: Potent Macrocyclic Inhibitors of Farnesyltransferase

L-735,524 : the design of a potent and orally bioavailable HIV protease inhibitor

Nonpeptide alpha(v)beta(3) antagonists. 1. Transformation of a potent, integrin-selective alpha(IIb)beta(3) antagonist into a potent alpha(v)beta(3) antagonist

Emergency Relief System Design Using DIERS Technology: The Design Institute for Emergency Relief Systems (DIERS) Project Manual

HIV-1 protease inhibitors: synthesis and biological evaluation of glycopeptidemimetics

Conformationally constrained HIV-1 protease inhibitors

New drugs-reports of new drugs recently approved by the FDA. Abacavir sulfate

N-Arylpiperazinone Inhibitors of Farnesyltransferase: Discovery and Biological Activity

HIV Protease as an Inhibitor Target for the Treatment of AIDS

[3H] L-657, 743 (MK-912): a new, high affinity, selective radioligand for brain α2-adrenoceptors

Synthesis and antiviral activity of a series of HIV-1 protease inhibitors with functionality tethered to the P1 or P1' phenyl substituents : X-ray crystal structure assisted design

Structure-affinity relationships of arylquinolizines at .alpha.-adrenoceptors

Bioactive conformation of 1-arylpiperazines at central serotonin receptors

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