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ALDH5A1-deficient iPSC-derived excitatory and inhibitory neurons display cell type specific alterations

Neurobiology of disease, 2024-01, Vol.190, p.106386-106386, Article 106386

2024

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High-content screening identifies a small molecule that restores AP-4-dependent protein trafficking in neuronal models of AP-4-associated hereditary spastic paraplegia

Nature communications, 2024-01, Vol.15 (1), p.584-584, Article 584

2024

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Ni(II) Bis(oxazoline)-Catalyzed Enantioselective Syn Aldol Reactions of N-Propionylthiazolidinethiones in the Presence of Silyl Triflates

Journal of the American Chemical Society, 2003-07, Vol.125 (29), p.8706-8707

2003

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Optimization of a Natural Product-Based Class of γ‑Secretase Modulators

Journal of medicinal chemistry, 2012-11, Vol.55 (21), p.9270-9282

2012

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Itch suppression in mice and dogs by modulation of spinal α2 and α3GABAA receptors

Nature communications, 2018-08, Vol.9 (1), p.1-15, Article 3230

2018

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A Second-Generation Synthesis of the C1−C28 Portion of the Altohyrtins (Spongistatins)

Journal of the American Chemical Society, 2003-10, Vol.125 (42), p.12836-12843

2003

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Efficacy of SPI-1865, a novel gamma-secretase modulator, in multiple rodent models

Alzheimer's research & therapy, 2013-04, Vol.5 (2), p.19-19

2013

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Minimization of drug–drug interaction risk and candidate selection in a natural product-based class of gamma-secretase modulators

Bioorganic & medicinal chemistry letters, 2015-04, Vol.25 (7), p.1621-1626

2015

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Optimization of a Kilogram-Scale Synthesis of a Potent Cycloartenol Triterpenoid-Derived γ‑Secretase Modulator

Organic process research & development, 2014-06, Vol.18 (6), p.683-692

2014

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Multikilogram-Scale Production of Cycloartenol Triterpenoid Glycosides as Synthetic Intermediates for a γ‑Secretase Modulator

Organic process research & development, 2014-06, Vol.18 (6), p.676-682

2014

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Multigram Synthesis of the C29−C51 Subunit and Completion of the Total Synthesis of Altohyrtin C (Spongistatin 2)

Journal of the American Chemical Society, 2003-10, Vol.125 (42), p.12844-12849

2003

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Modulation of Gamma-Secretase for the Treatment of Alzheimer's Disease

International journal of alzheimer's disease, 2012, Vol.2012, p.210756-10

2012

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Initial Optimization of a New Series of γ‑Secretase Modulators Derived from a Triterpene Glycoside

ACS medicinal chemistry letters, 2012-11, Vol.3 (11), p.908-913

2012

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Purine derivatives as potent γ-secretase modulators

Bioorganic & medicinal chemistry letters, 2010-04, Vol.20 (7), p.2279-2282

2010

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SAR investigations on a novel class of gamma-secretase modulators based on a unique scaffold

MedChemComm, 2013-03, Vol.4 (3), p.569-574

2013

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Amino acid derivatives as histone deacetylase inhibitors

Bioorganic & medicinal chemistry, 2008, Vol.18 (1), p.34-38

2008

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Total Synthesis of (±)-Isoschizogamine

Organic letters, 1999-10, Vol.1 (8), p.1315-1317

1999

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The development of a Selectfluor®-mediated oxidative Mannich reaction

Tetrahedron letters, 2011-07, Vol.52 (28), p.3543-3546

2011

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Itch suppression in mice and dogs by modulation of spinal α2 and α3GABA A receptors

Nature communications, 2018-08, Vol.9 (1), p.3230

2018

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Delayed and Prolonged Histone Hyperacetylation with a Selective HDAC1/HDAC2 Inhibitor

ACS medicinal chemistry letters, 2014-04, Vol.5 (4), p.340-345

2014

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Fluorinated piperidine acetic acids as γ-secretase modulators

Bioorganic & medicinal chemistry letters, 2010-01, Vol.20 (2), p.755-758

2010

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Gamma—secretase modulators do not show a potency shift in high expressing model systems

Alzheimer's & dementia, 2011-07, Vol.7 (4), p.S119-S120

2011

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P1‐028: Gamma—secretase modulators do not show a potency shift in high expressing model systems

Alzheimer's & dementia, 2011-07, Vol.7 (4S_Part_3), p.S119-S120

2011

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Satori gamma-secretase modulators are efficacious in wild-type rodents following either acute or steady-state dosing

Alzheimer's & dementia, 2012-07, Vol.8 (4), p.P104-P104

2012

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P4‐199: Pharmacokinetic properties of a Satori gamma‐secretase modulator, SPI‐1865, in multiple animal model systems

Alzheimer's & dementia, 2012-07, Vol.8 (4S_Part_19), p.P705-P705

2012

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ALDH5A1-deficient iPSC-derived excitatory and inhibitory neurons display cell type specific alterations

High-content screening identifies a small molecule that restores AP-4-dependent protein trafficking in neuronal models of AP-4-associated hereditary spastic paraplegia

Ni(II) Bis(oxazoline)-Catalyzed Enantioselective Syn Aldol Reactions of N-Propionylthiazolidinethiones in the Presence of Silyl Triflates

Optimization of a Natural Product-Based Class of γ‑Secretase Modulators

Itch suppression in mice and dogs by modulation of spinal α2 and α3GABAA receptors

A Second-Generation Synthesis of the C1−C28 Portion of the Altohyrtins (Spongistatins)

Efficacy of SPI-1865, a novel gamma-secretase modulator, in multiple rodent models

Minimization of drug–drug interaction risk and candidate selection in a natural product-based class of gamma-secretase modulators

Optimization of a Kilogram-Scale Synthesis of a Potent Cycloartenol Triterpenoid-Derived γ‑Secretase Modulator

Multikilogram-Scale Production of Cycloartenol Triterpenoid Glycosides as Synthetic Intermediates for a γ‑Secretase Modulator

Multigram Synthesis of the C29−C51 Subunit and Completion of the Total Synthesis of Altohyrtin C (Spongistatin 2)

Modulation of Gamma-Secretase for the Treatment of Alzheimer's Disease

Initial Optimization of a New Series of γ‑Secretase Modulators Derived from a Triterpene Glycoside

Purine derivatives as potent γ-secretase modulators

SAR investigations on a novel class of gamma-secretase modulators based on a unique scaffold

Amino acid derivatives as histone deacetylase inhibitors

Total Synthesis of (±)-Isoschizogamine

The development of a Selectfluor®-mediated oxidative Mannich reaction

Itch suppression in mice and dogs by modulation of spinal α2 and α3GABA A receptors

Delayed and Prolonged Histone Hyperacetylation with a Selective HDAC1/HDAC2 Inhibitor

Fluorinated piperidine acetic acids as γ-secretase modulators

Gamma—secretase modulators do not show a potency shift in high expressing model systems

P1‐028: Gamma—secretase modulators do not show a potency shift in high expressing model systems

Satori gamma-secretase modulators are efficacious in wild-type rodents following either acute or steady-state dosing

P4‐199: Pharmacokinetic properties of a Satori gamma‐secretase modulator, SPI‐1865, in multiple animal model systems

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