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Mechanistic Insights into Regulation of JAK2 Tyrosine Kinase

Frontiers in endocrinology (Lausanne), 2018-01, Vol.8, p.361-361

Hubbard, Stevan R

2018

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Mechanism of homodimeric cytokine receptor activation and dysregulation by oncogenic mutations

Science (American Association for the Advancement of Science), 2020-02, Vol.367 (6478), p.643-652

2020

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Insulin receptor Thr1160 phosphorylation mediates lipid-induced hepatic insulin resistance

The Journal of clinical investigation, 2016-11, Vol.126 (11), p.4361-4371

2016

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Crystal structures of the JAK2 pseudokinase domain and the pathogenic mutant V617F

Nature structural & molecular biology, 2012-08, Vol.19 (8), p.754-759

2012

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Structure and activation of MuSK, a receptor tyrosine kinase central to neuromuscular junction formation

Biochimica et biophysica acta, 2013-10, Vol.1834 (10), p.2166-2169

2013

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Proteasomal Control of Cytokinin Synthesis Protects Mycobacterium tuberculosis against Nitric Oxide

Molecular cell, 2015-03, Vol.57 (6), p.984-994

2015

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Structural basis of Janus kinase trans-activation

Cell reports (Cambridge), 2023-03, Vol.42 (3), p.112201-112201, Article 112201

2023

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Molecular basis for pseudokinase-dependent autoinhibition of JAK2 tyrosine kinase

Nature structural & molecular biology, 2014-07, Vol.21 (7), p.579-584

2014

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ATP binding to the pseudokinase domain of JAK2 is critical for pathogenic activation

Proceedings of the National Academy of Sciences - PNAS, 2015-04, Vol.112 (15), p.4642-4647

2015

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Agrin Binds to the N-terminal Region of Lrp4 Protein and Stimulates Association between Lrp4 and the First Immunoglobulin-like Domain in Muscle-specific Kinase (MuSK)

The Journal of biological chemistry, 2011-11, Vol.286 (47), p.40624-40630

2011

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IRAK4 Activation: A Cautious Embrace

Molecular cell, 2014-09, Vol.55 (6), p.805-806

Hubbard, Stevan R.

2014

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The Cytoplasmic Adaptor Protein Dok7 Activates the Receptor Tyrosine Kinase MuSK via Dimerization

Molecular cell, 2010-07, Vol.39 (1), p.100-109

2010

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Structural basis for the interaction of the adaptor protein grb14 with activated ras

PloS one, 2013-08, Vol.8 (8), p.e72473-e72473

2013

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Crystal structure of the C-terminal four-helix bundle of the potassium channel KCa3.1

PloS one, 2018-06, Vol.13 (6), p.e0199942-e0199942

2018

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Correction: Crystal structure of the C-terminal four-helix bundle of the potassium channel KCa3.1

PloS one, 2018-10, Vol.13 (10), p.e0205540-e0205540

2018

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New insights into the structure and function of the pseudokinase domain in JAK2

Biochemical Society transactions, 2013-08, Vol.41 (4), p.1002-1007

2013

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Targeting the Inactive Conformation of JAK2 in Hematological Malignancies

Cancer cell, 2015-07, Vol.28 (1), p.1-2

2015

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Histidine phosphorylation relieves copper inhibition in the mammalian potassium channel KCa3.1

eLife, 2016-08, Vol.5

2016

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A DNA sequence recognition loop on APOBEC3A controls substrate specificity

PloS one, 2014-05, Vol.9 (5), p.e97062-e97062

2014

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PROTEIN TYROSINE KINASE STRUCTURE AND FUNCTION

Annual review of biochemistry, 2000-01, Vol.69 (1), p.373-398

2000

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Identification of Novel Small Molecule Ligands for JAK2 Pseudokinase Domain

Pharmaceuticals (Basel, Switzerland), 2023-01, Vol.16 (1), p.75

2023

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Molecular analysis of the prokaryotic ubiquitin-like protein (Pup) conjugation pathway in Mycobacterium tuberculosis

Molecular microbiology, 2010-09, Vol.77 (5), p.1123-1135

2010

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The insulin receptor: both a prototypical and atypical receptor tyrosine kinase

Cold Spring Harbor perspectives in biology, 2013-03, Vol.5 (3), p.a008946-a008946

Hubbard, Stevan R

2013

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Molecular insights into regulation of JAK2 in myeloproliferative neoplasms

Blood, 2015-05, Vol.125 (22), p.3388-3392

2015

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Structural basis for FGF receptor dimerization and activation

Cell, 1999-09, Vol.98 (5), p.641-650

1999

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Mechanistic Insights into Regulation of JAK2 Tyrosine Kinase

Mechanism of homodimeric cytokine receptor activation and dysregulation by oncogenic mutations

Insulin receptor Thr1160 phosphorylation mediates lipid-induced hepatic insulin resistance

Crystal structures of the JAK2 pseudokinase domain and the pathogenic mutant V617F

Structure and activation of MuSK, a receptor tyrosine kinase central to neuromuscular junction formation

Proteasomal Control of Cytokinin Synthesis Protects Mycobacterium tuberculosis against Nitric Oxide

Structural basis of Janus kinase trans-activation

Molecular basis for pseudokinase-dependent autoinhibition of JAK2 tyrosine kinase

ATP binding to the pseudokinase domain of JAK2 is critical for pathogenic activation

Agrin Binds to the N-terminal Region of Lrp4 Protein and Stimulates Association between Lrp4 and the First Immunoglobulin-like Domain in Muscle-specific Kinase (MuSK)

IRAK4 Activation: A Cautious Embrace

The Cytoplasmic Adaptor Protein Dok7 Activates the Receptor Tyrosine Kinase MuSK via Dimerization

Structural basis for the interaction of the adaptor protein grb14 with activated ras

Crystal structure of the C-terminal four-helix bundle of the potassium channel KCa3.1

Correction: Crystal structure of the C-terminal four-helix bundle of the potassium channel KCa3.1

New insights into the structure and function of the pseudokinase domain in JAK2

Targeting the Inactive Conformation of JAK2 in Hematological Malignancies

Histidine phosphorylation relieves copper inhibition in the mammalian potassium channel KCa3.1

A DNA sequence recognition loop on APOBEC3A controls substrate specificity

PROTEIN TYROSINE KINASE STRUCTURE AND FUNCTION

Identification of Novel Small Molecule Ligands for JAK2 Pseudokinase Domain

Molecular analysis of the prokaryotic ubiquitin-like protein (Pup) conjugation pathway in Mycobacterium tuberculosis

The insulin receptor: both a prototypical and atypical receptor tyrosine kinase

Molecular insights into regulation of JAK2 in myeloproliferative neoplasms

Structural basis for FGF receptor dimerization and activation

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