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Pt(IV) prodrugs containing microtubule inhibitors displayed potent antitumor activity and ability to overcome cisplatin resistance

European journal of medicinal chemistry, 2018-08, Vol.156, p.666-679

2018

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Genome-wide CRISPR screenings identified SMCHD1 as a host-restricting factor for AAV transduction

PLoS pathogens, 2024-07, Vol.20 (7), p.e1012344

2024

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Dual-targeting antitumor conjugates derived from platinum(IV) prodrugs and microtubule inhibitor CA-4 significantly exhibited potent ability to overcome cisplatin resistance

Bioorganic chemistry, 2019-11, Vol.92, p.103236-103236, Article 103236

2019

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Anticancer Platinum(IV) Prodrugs Containing Monoaminophosphonate Ester as a Targeting Group Inhibit Matrix Metalloproteinases and Reverse Multidrug Resistance

Bioconjugate chemistry, 2017-04, Vol.28 (4), p.1305-1323

2017

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A CK2-targeted Pt(IV) prodrug to disrupt DNA damage response

Cancer letters, 2017-01, Vol.385, p.168-178

2017

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Novel NF-κB Inhibitor-Conjugated Pt(IV) Prodrug to Enable Cancer Therapy through ROS/ER Stress and Mitochondrial Dysfunction and Overcome Multidrug Resistance

Journal of medicinal chemistry, 2024-04, Vol.67 (8), p.6218-6237

2024

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Synthesis of Derivatives of Artesunate α-Aminophosphonate and Their Antimicrobial Activities

Letters in drug design & discovery, 2015-01, Vol.12 (5), p.408-416

2015

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Synthesis and biological evaluation of novel chalcone derivatives as a new class of microtubule destabilizing agents

European journal of medicinal chemistry, 2017-05, Vol.132, p.11-25

2017

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Novel Indole–Chalcone Derivative-Ligated Platinum(IV) Prodrugs Attenuate Cisplatin Resistance in Lung Cancer through ROS/ER Stress and Mitochondrial Dysfunction

Journal of medicinal chemistry, 2023-04, Vol.66 (7), p.4868-4887

2023

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Combretastatin A‑4 Analogue: A Dual-Targeting and Tubulin Inhibitor Containing Antitumor Pt(IV) Moiety with a Unique Mode of Action

Bioconjugate chemistry, 2016-09, Vol.27 (9), p.2132-2148

2016

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A novel method for real-time ATR system of AUV based on Attention-MobileNetV3 network and pixel correction algorithm

Ocean engineering, 2023-02, Vol.270, p.113403, Article 113403

2023

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Ligustrazine-Derived Chalcones-Modified Platinum(IV) Complexes Intervene in Cisplatin Resistance in Pancreatic Cancer through Ferroptosis and Apoptosis

Journal of medicinal chemistry, 2023-10, Vol.66 (19), p.13587-13606

2023

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An autonomous cooperative system of multi-AUV for underwater targets detection and localization

Engineering applications of artificial intelligence, 2023-05, Vol.121, p.105907, Article 105907

2023

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Bifunctional Naphthoquinone Aromatic Amide-Oxime Derivatives Exert Combined Immunotherapeutic and Antitumor Effects through Simultaneous Targeting of Indoleamine-2,3-dioxygenase and Signal Transducer and Activator of Transcription 3

Journal of medicinal chemistry, 2020-02, Vol.63 (4), p.1544-1563

2020

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Novel combretastatin A-4 derivative containing aminophosphonates as dual inhibitors of tubulin and matrix metalloproteinases for lung cancer treatment

European journal of medicinal chemistry, 2022-12, Vol.244, p.114817-114817, Article 114817

2022

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Dual-targeting tumor cells hybrids derived from Pt(IV) species and NF-κB inhibitors enables cancer therapy through mitochondrial dysfunction and ER stress and overcomes cisplatin resistance

European journal of medicinal chemistry, 2024-02, Vol.266, p.116095-116095, Article 116095

2024

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Pt(IV) complexes conjugating with chalcone analogue as inhibitors of microtubule polymerization exhibited selective inhibition in human cancer cells

European journal of medicinal chemistry, 2018-02, Vol.146, p.435-450

2018

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Discovery of 18β-glycyrrhetinic acid conjugated aminobenzothiazole derivatives as Hsp90-Cdc37 interaction disruptors that inhibit cell migration and reverse drug resistance

Bioorganic & medicinal chemistry, 2018-05, Vol.26 (8), p.1759-1775

2018

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Dual-targeting antitumor hybrids derived from Pt(IV) species and millepachine analogues

European journal of medicinal chemistry, 2018-03, Vol.148, p.1-25

2018

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Glycyrrhetinic acid derivatives containing aminophosphonate ester species as multidrug resistance reversers that block the NF-κB pathway and cell proliferation

Bioorganic & medicinal chemistry letters, 2018-12, Vol.28 (23-24), p.3700-3707

2018

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Glycyrrhetinic Acid as a Hepatocyte Targeting Ligand-Functionalized Platinum(IV) Complexes for Hepatocellular Carcinoma Therapy and Overcoming Multidrug Resistance

Journal of medicinal chemistry, 2024-05, Vol.67 (10), p.8020-8042

2024

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Synthesis and pharmacological evaluation of dehydroabietic acid thiourea derivatives containing bisphosphonate moiety as an inducer of apoptosis

European journal of medicinal chemistry, 2016-01, Vol.108, p.381-391

2016

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Novel Platinum(IV) complexes intervene oxaliplatin resistance in colon cancer via inducing ferroptosis and apoptosis

European journal of medicinal chemistry, 2024-01, Vol.263, p.115968-115968, Article 115968

2024

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Synthesis, mechanisms of action, and toxicity of novel aminophosphonates derivatives conjugated irinotecan in vitro and in vivo as potent antitumor agents

European journal of medicinal chemistry, 2020-03, Vol.189, p.112067-112067, Article 112067

2020

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Promoting antitumor efficacy by suppressing hypoxia via nano self-assembly of two irinotecan-based dual drug conjugates having a HIF-1α inhibitor

Journal of materials chemistry. B, Materials for biology and medicine, 2019-09, Vol.7 (35), p.5352-5362

2019

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Pt(IV) prodrugs containing microtubule inhibitors displayed potent antitumor activity and ability to overcome cisplatin resistance

Genome-wide CRISPR screenings identified SMCHD1 as a host-restricting factor for AAV transduction

Dual-targeting antitumor conjugates derived from platinum(IV) prodrugs and microtubule inhibitor CA-4 significantly exhibited potent ability to overcome cisplatin resistance

Anticancer Platinum(IV) Prodrugs Containing Monoaminophosphonate Ester as a Targeting Group Inhibit Matrix Metalloproteinases and Reverse Multidrug Resistance

A CK2-targeted Pt(IV) prodrug to disrupt DNA damage response

Novel NF-κB Inhibitor-Conjugated Pt(IV) Prodrug to Enable Cancer Therapy through ROS/ER Stress and Mitochondrial Dysfunction and Overcome Multidrug Resistance

Synthesis of Derivatives of Artesunate α-Aminophosphonate and Their Antimicrobial Activities

Synthesis and biological evaluation of novel chalcone derivatives as a new class of microtubule destabilizing agents

Novel Indole–Chalcone Derivative-Ligated Platinum(IV) Prodrugs Attenuate Cisplatin Resistance in Lung Cancer through ROS/ER Stress and Mitochondrial Dysfunction

Combretastatin A‑4 Analogue: A Dual-Targeting and Tubulin Inhibitor Containing Antitumor Pt(IV) Moiety with a Unique Mode of Action

A novel method for real-time ATR system of AUV based on Attention-MobileNetV3 network and pixel correction algorithm

Ligustrazine-Derived Chalcones-Modified Platinum(IV) Complexes Intervene in Cisplatin Resistance in Pancreatic Cancer through Ferroptosis and Apoptosis

An autonomous cooperative system of multi-AUV for underwater targets detection and localization

Bifunctional Naphthoquinone Aromatic Amide-Oxime Derivatives Exert Combined Immunotherapeutic and Antitumor Effects through Simultaneous Targeting of Indoleamine-2,3-dioxygenase and Signal Transducer and Activator of Transcription 3

Novel combretastatin A-4 derivative containing aminophosphonates as dual inhibitors of tubulin and matrix metalloproteinases for lung cancer treatment

Dual-targeting tumor cells hybrids derived from Pt(IV) species and NF-κB inhibitors enables cancer therapy through mitochondrial dysfunction and ER stress and overcomes cisplatin resistance

Pt(IV) complexes conjugating with chalcone analogue as inhibitors of microtubule polymerization exhibited selective inhibition in human cancer cells

Discovery of 18β-glycyrrhetinic acid conjugated aminobenzothiazole derivatives as Hsp90-Cdc37 interaction disruptors that inhibit cell migration and reverse drug resistance

Dual-targeting antitumor hybrids derived from Pt(IV) species and millepachine analogues

Glycyrrhetinic acid derivatives containing aminophosphonate ester species as multidrug resistance reversers that block the NF-κB pathway and cell proliferation

Glycyrrhetinic Acid as a Hepatocyte Targeting Ligand-Functionalized Platinum(IV) Complexes for Hepatocellular Carcinoma Therapy and Overcoming Multidrug Resistance

Synthesis and pharmacological evaluation of dehydroabietic acid thiourea derivatives containing bisphosphonate moiety as an inducer of apoptosis

Novel Platinum(IV) complexes intervene oxaliplatin resistance in colon cancer via inducing ferroptosis and apoptosis

Synthesis, mechanisms of action, and toxicity of novel aminophosphonates derivatives conjugated irinotecan in vitro and in vivo as potent antitumor agents

Promoting antitumor efficacy by suppressing hypoxia via nano self-assembly of two irinotecan-based dual drug conjugates having a HIF-1α inhibitor

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