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Pharmacological properties and underlying mechanisms of curcumin and prospects in medicinal potential

Biomedicine & pharmacotherapy, 2021-09, Vol.141, p.111888-111888, Article 111888

2021

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Discovery of QCA570 as an Exceptionally Potent and Efficacious Proteolysis Targeting Chimera (PROTAC) Degrader of the Bromodomain and Extra-Terminal (BET) Proteins Capable of Inducing Complete and Durable Tumor Regression

Journal of medicinal chemistry, 2018-08, Vol.61 (15), p.6685-6704

2018

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Research on coupled thermo-hydro-mechanical dynamic response characteristics of saturated porous deep-sea sediments under vibration of mining vehicle

Applied mathematics and mechanics, 2021-09, Vol.42 (9), p.1349-1362

English ed., 2021

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A narrative review: The pharmaceutical evolution of phenolic syringaldehyde

Biomedicine & pharmacotherapy, 2022-09, Vol.153, p.113339-113339, Article 113339

2022

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Discovery of a Highly Potent, Cell-Permeable Macrocyclic Peptidomimetic (MM-589) Targeting the WD Repeat Domain 5 Protein (WDR5)–Mixed Lineage Leukemia (MLL) Protein–Protein Interaction

Journal of medicinal chemistry, 2017-06, Vol.60 (12), p.4818-4839

2017

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Barium Chloride-Induced Cardiac Arrhythmia Mouse Model Exerts an Experimental Arrhythmia for Pharmacological Investigations

Life (Basel, Switzerland), 2024-08, Vol.14 (8), p.1047

2024

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Syringaldehyde promoting intestinal motility with suppressing α-amylase hinders starch digestion in diabetic mice

Biomedicine & pharmacotherapy, 2021-09, Vol.141, p.111865-111865, Article 111865

2021

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ATP-dependent transport of rosuvastatin in membrane vesicles expressing breast cancer resistance protein

Drug metabolism and disposition, 2006-05, Vol.34 (5), p.738-742

2006

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Combination of plant metabolites hinders starch digestion and glucose absorption while facilitating insulin sensitivity to diabetes

Frontiers in pharmacology, 2024-06, Vol.15, p.1362150

2024

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Pharmaceutical Prospects of Curcuminoids for the Remedy of COVID-19: Truth or Myth

Frontiers in pharmacology, 2022-04, Vol.13, p.863082-863082

2022

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Discovery of Novel, Induced-Pocket Binding Oxazolidinones as Potent, Selective, and Orally Bioavailable Tankyrase Inhibitors

Journal of medicinal chemistry, 2013-06, Vol.56 (11), p.4320-4342

2013

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Rational use of in vitro P-glycoprotein assays in drug discovery

The Journal of pharmacology and experimental therapeutics, 2001-11, Vol.299 (2), p.620

2001

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Discovery of a Potent, Selective, and Orally Bioavailable c-Met Inhibitor: 1-(2-Hydroxy-2-methylpropyl)-N-(5-(7-methoxyquinolin-4-yloxy)pyridin-2-yl)-5-methyl-3-oxo-2-phenyl-2,3-dihydro-1H-pyrazole-4-carboxamide (AMG 458)

Journal of medicinal chemistry, 2008-07, Vol.51 (13), p.3688-3691

2008

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A Practical Perspective on the Evaluation of Small Molecule CNS Penetration in Drug Discovery

Drug metabolism letters, 2019, Vol.13 (2), p.78-94

2019

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Inhibition of Inactive States of Tetrodotoxin-Sensitive Sodium Channels Reduces Spontaneous Firing of C-Fiber Nociceptors and Produces Analgesia in Formalin and Complete Freund's Adjuvant Models of Pain

PloS one, 2015-09, Vol.10 (9), p.e0138140

2015

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Structure-Based Design of 2‑Aminopyridine Oxazolidinones as Potent and Selective Tankyrase Inhibitors

ACS medicinal chemistry letters, 2013-12, Vol.4 (12), p.1218-1223

2013

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Sulfonamides as Selective NaV1.7 Inhibitors: Optimizing Potency and Pharmacokinetics to Enable in Vivo Target Engagement

ACS medicinal chemistry letters, 2016-12, Vol.7 (12), p.1062-1067

2016

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Discovery and Optimization of a Novel Series of N-Arylamide Oxadiazoles as Potent, Highly Selective and Orally Bioavailable Cannabinoid Receptor 2 (CB2) Agonists

Journal of medicinal chemistry, 2008-08, Vol.51 (16), p.5019-5034

2008

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Activated hepatic stellate cells regulate MDSC migration through the SDF-1/CXCR4 axis in an orthotopic mouse model of hepatocellular carcinoma

Cancer Immunology, Immunotherapy, 2019-12, Vol.68 (12), p.1959-1969

2019

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Discovery and optimization of aminopyrimidinones as potent and state-dependent Nav1.7 antagonists

Bioorganic & medicinal chemistry letters, 2012-01, Vol.22 (2), p.1055-1060

2012

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Induction of P-glycoprotein and cytochrome P450 3A by HIV protease inhibitors

Drug metabolism and disposition, 2001-05, Vol.29 (5), p.754

2001

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Mrp2 Is Essential for Estradiol-17β(β-d -glucuronide)–Induced Cholestasis in Rats

Hepatology (Baltimore, Md.), 2000-07, Vol.32 (1), p.66-72

2000

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Discovery of SMD-3040 as a Potent and Selective SMARCA2 PROTAC Degrader with Strong in vivo Antitumor Activity

Journal of medicinal chemistry, 2023-08, Vol.66 (15), p.10761-10781

2023

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Discovery and optimization of substituted piperidines as potent, selective, CNS-penetrant α4β2 nicotinic acetylcholine receptor potentiators

Bioorganic & medicinal chemistry letters, 2008-10, Vol.18 (19), p.5209-5212

2008

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Abstract 1231: Identification of selective Brd4 degrader for cancer treatment

Cancer research (Chicago, Ill.), 2021-07, Vol.81 (13_Supplement), p.1231-1231

2021

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Pharmacological properties and underlying mechanisms of curcumin and prospects in medicinal potential

Discovery of QCA570 as an Exceptionally Potent and Efficacious Proteolysis Targeting Chimera (PROTAC) Degrader of the Bromodomain and Extra-Terminal (BET) Proteins Capable of Inducing Complete and Durable Tumor Regression

Research on coupled thermo-hydro-mechanical dynamic response characteristics of saturated porous deep-sea sediments under vibration of mining vehicle

A narrative review: The pharmaceutical evolution of phenolic syringaldehyde

Discovery of a Highly Potent, Cell-Permeable Macrocyclic Peptidomimetic (MM-589) Targeting the WD Repeat Domain 5 Protein (WDR5)–Mixed Lineage Leukemia (MLL) Protein–Protein Interaction

Barium Chloride-Induced Cardiac Arrhythmia Mouse Model Exerts an Experimental Arrhythmia for Pharmacological Investigations

Syringaldehyde promoting intestinal motility with suppressing α-amylase hinders starch digestion in diabetic mice

ATP-dependent transport of rosuvastatin in membrane vesicles expressing breast cancer resistance protein

Combination of plant metabolites hinders starch digestion and glucose absorption while facilitating insulin sensitivity to diabetes

Pharmaceutical Prospects of Curcuminoids for the Remedy of COVID-19: Truth or Myth

Discovery of Novel, Induced-Pocket Binding Oxazolidinones as Potent, Selective, and Orally Bioavailable Tankyrase Inhibitors

Rational use of in vitro P-glycoprotein assays in drug discovery

Discovery of a Potent, Selective, and Orally Bioavailable c-Met Inhibitor: 1-(2-Hydroxy-2-methylpropyl)-N-(5-(7-methoxyquinolin-4-yloxy)pyridin-2-yl)-5-methyl-3-oxo-2-phenyl-2,3-dihydro-1H-pyrazole-4-carboxamide (AMG 458)

A Practical Perspective on the Evaluation of Small Molecule CNS Penetration in Drug Discovery

Inhibition of Inactive States of Tetrodotoxin-Sensitive Sodium Channels Reduces Spontaneous Firing of C-Fiber Nociceptors and Produces Analgesia in Formalin and Complete Freund's Adjuvant Models of Pain

Structure-Based Design of 2‑Aminopyridine Oxazolidinones as Potent and Selective Tankyrase Inhibitors

Sulfonamides as Selective NaV1.7 Inhibitors: Optimizing Potency and Pharmacokinetics to Enable in Vivo Target Engagement

Discovery and Optimization of a Novel Series of N-Arylamide Oxadiazoles as Potent, Highly Selective and Orally Bioavailable Cannabinoid Receptor 2 (CB2) Agonists

Activated hepatic stellate cells regulate MDSC migration through the SDF-1/CXCR4 axis in an orthotopic mouse model of hepatocellular carcinoma

Discovery and optimization of aminopyrimidinones as potent and state-dependent Nav1.7 antagonists

Induction of P-glycoprotein and cytochrome P450 3A by HIV protease inhibitors

Mrp2 Is Essential for Estradiol-17β(β-d -glucuronide)–Induced Cholestasis in Rats

Discovery of SMD-3040 as a Potent and Selective SMARCA2 PROTAC Degrader with Strong in vivo Antitumor Activity

Discovery and optimization of substituted piperidines as potent, selective, CNS-penetrant α4β2 nicotinic acetylcholine receptor potentiators

Abstract 1231: Identification of selective Brd4 degrader for cancer treatment

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