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Mutant INS-gene induced diabetes of youth: proinsulin cysteine residues impose dominant-negative inhibition on wild-type proinsulin transport

PloS one, 2010-10, Vol.5 (10), p.e13333-e13333

2010

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Design and Folding of [GluA4(OβThrB30)]Insulin ("Ester Insulin"): A Minimal Proinsulin Surrogate that Can Be Chemically Converted into Human Insulin

Angewandte Chemie (International ed.), 2010-07, Vol.49 (32), p.5489-5493

2010

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Mechanism of insulin fibrillation: the structure of insulin under amyloidogenic conditions resembles a protein-folding intermediate

The Journal of biological chemistry, 2004-05, Vol.279 (20), p.21449-21460

2004

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A Protein Caught in a Kinetic Trap: Structures and Stabilities of Insulin Disulfide Isomers

Biochemistry (Easton), 2002-12, Vol.41 (50), p.14700-14715

2002

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Solution Structure of Proinsulin: CONNECTING DOMAIN FLEXIBILITY AND PROHORMONE PROCESSING

The Journal of biological chemistry, 2010-03, Vol.285 (11), p.7847-7851

2010

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Achilles' Heel in an Amyloidogenic Protein and Its Repair: INSULIN FIBRILLATION AND THERAPEUTIC DESIGN

The Journal of biological chemistry, 2010-04, Vol.285 (14), p.10806-10821

2010

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Design of an Active Ultrastable Single-chain Insulin Analog: SYNTHESIS, STRUCTURE, AND THERAPEUTIC IMPLICATIONS

The Journal of biological chemistry, 2008-05, Vol.283 (21), p.14703-14716

2008

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Enhancing the Activity of a Protein by Stereospecific Unfolding: CONFORMATIONAL LIFE CYCLE OF INSULIN AND ITS EVOLUTIONARY ORIGINS

The Journal of biological chemistry, 2009-05, Vol.284 (21), p.14586-14596

2009

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Toward the active conformation of insulin: stereospecific modulation of a structural switch in the B chain

The Journal of biological chemistry, 2006-08, Vol.281 (34), p.24900

2006

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Folding Nucleus of the Insulin Superfamily: A FLEXIBLE PEPTIDE MODEL FORESHADOWS THE NATIVE STATE

The Journal of biological chemistry, 2006-09, Vol.281 (38), p.28131-28142

2006

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Supramolecular Protein Engineering: DESIGN OF ZINC-STAPLED INSULIN HEXAMERS AS A LONG ACTING DEPOT

The Journal of biological chemistry, 2010-04, Vol.285 (16), p.11755-11759

2010

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Crystal structure of a "nonfoldable" insulin: impaired folding efficiency despite native activity

The Journal of biological chemistry, 2009-12, Vol.284 (50), p.35259-35272

2009

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Deciphering the Hidden Informational Content of Protein Sequences: FOLDABILITY OF PROINSULIN HINGES ON A FLEXIBLE ARM THAT IS DISPENSABLE IN THE MATURE HORMONE

The Journal of biological chemistry, 2010-10, Vol.285 (40), p.30989-31001

2010

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Conformational dynamics of insulin

Frontiers in endocrinology (Lausanne), 2011, Vol.2, p.48-48

2011

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A-chain of Insulin Contacts the Insert Domain of the Insulin Receptor: PHOTO-CROSS-LINKING AND MUTAGENESIS OF A DIABETES-RELATED CREVICE

The Journal of biological chemistry, 2007-11, Vol.282 (48), p.35337-35349

2007

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Cover Picture: Design and Folding of [GluA4(OβThrB30)]Insulin ("Ester Insulin"): A Minimal Proinsulin Surrogate that Can Be Chemically Converted into Human Insulin (Angew. Chem. Int. Ed. 32/2010)

Angewandte Chemie (International ed.), 2010-07, Vol.49 (32), p.5389-5389

2010

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Activities of Monomeric Insulin Analogs at Position A8 Are Uncorrelated with Their Thermodynamic Stabilities

The Journal of biological chemistry, 2001-10, Vol.276 (43), p.40018-40024

2001

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Contribution of Residue B5 to the Folding and Function of Insulin and IGF-I: CONSTRAINTS AND FINE-TUNING IN THE EVOLUTION OF A PROTEIN FAMILY

The Journal of biological chemistry, 2010-02, Vol.285 (7), p.5040-5055

2010

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Chiral Mutagenesis of Insulin. Foldability and Function Are Inversely Regulated by a Stereospecific Switch in the B Chain

Biochemistry (Easton), 2005-04, Vol.44 (13), p.4984-4999

2005

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Chiral Mutagenesis of Insulin: CONTRIBUTION OF THE B20-B23 β-TURN TO ACTIVITY AND STABILITY

The Journal of biological chemistry, 2006-08, Vol.281 (31), p.22386-22396

2006

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In vitro refolding of human proinsulin. Kinetic intermediates, putative disulfide-forming pathway folding initiation site, and potential role of C-peptide in folding process

The Journal of biological chemistry, 2003-05, Vol.278 (20), p.17800-17809

2003

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How insulin binds: the B-chain alpha-helix contacts the L1 beta-helix of the insulin receptor

Journal of molecular biology, 2004-08, Vol.341 (2), p.529-550

2004

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Diabetes-Associated Mutations in a β -Cell Transcription Factor Destabilize an Antiparallel "Mini-Zipper" in a Dimerization Interface

Proceedings of the National Academy of Sciences - PNAS, 2000-02, Vol.97 (5), p.1999-2004

2000

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Mechanism of insulin chain combination. Asymmetric roles of A-chain alpha-helices in disulfide pairing

The Journal of biological chemistry, 2002-11, Vol.277 (45), p.43443

2002

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Solution Structure of Proinsulin

The Journal of biological chemistry, 2010-03, Vol.285 (11), p.7847-7851

2010

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Mutant INS-gene induced diabetes of youth: proinsulin cysteine residues impose dominant-negative inhibition on wild-type proinsulin transport

Design and Folding of [GluA4(OβThrB30)]Insulin ("Ester Insulin"): A Minimal Proinsulin Surrogate that Can Be Chemically Converted into Human Insulin

Mechanism of insulin fibrillation: the structure of insulin under amyloidogenic conditions resembles a protein-folding intermediate

A Protein Caught in a Kinetic Trap: Structures and Stabilities of Insulin Disulfide Isomers

Solution Structure of Proinsulin: CONNECTING DOMAIN FLEXIBILITY AND PROHORMONE PROCESSING

Achilles' Heel in an Amyloidogenic Protein and Its Repair: INSULIN FIBRILLATION AND THERAPEUTIC DESIGN

Design of an Active Ultrastable Single-chain Insulin Analog: SYNTHESIS, STRUCTURE, AND THERAPEUTIC IMPLICATIONS

Enhancing the Activity of a Protein by Stereospecific Unfolding: CONFORMATIONAL LIFE CYCLE OF INSULIN AND ITS EVOLUTIONARY ORIGINS

Toward the active conformation of insulin: stereospecific modulation of a structural switch in the B chain

Folding Nucleus of the Insulin Superfamily: A FLEXIBLE PEPTIDE MODEL FORESHADOWS THE NATIVE STATE

Supramolecular Protein Engineering: DESIGN OF ZINC-STAPLED INSULIN HEXAMERS AS A LONG ACTING DEPOT

Crystal structure of a "nonfoldable" insulin: impaired folding efficiency despite native activity

Deciphering the Hidden Informational Content of Protein Sequences: FOLDABILITY OF PROINSULIN HINGES ON A FLEXIBLE ARM THAT IS DISPENSABLE IN THE MATURE HORMONE

Conformational dynamics of insulin

A-chain of Insulin Contacts the Insert Domain of the Insulin Receptor: PHOTO-CROSS-LINKING AND MUTAGENESIS OF A DIABETES-RELATED CREVICE

Cover Picture: Design and Folding of [GluA4(OβThrB30)]Insulin ("Ester Insulin"): A Minimal Proinsulin Surrogate that Can Be Chemically Converted into Human Insulin (Angew. Chem. Int. Ed. 32/2010)

Activities of Monomeric Insulin Analogs at Position A8 Are Uncorrelated with Their Thermodynamic Stabilities

Contribution of Residue B5 to the Folding and Function of Insulin and IGF-I: CONSTRAINTS AND FINE-TUNING IN THE EVOLUTION OF A PROTEIN FAMILY

Chiral Mutagenesis of Insulin. Foldability and Function Are Inversely Regulated by a Stereospecific Switch in the B Chain

Chiral Mutagenesis of Insulin: CONTRIBUTION OF THE B20-B23 β-TURN TO ACTIVITY AND STABILITY

In vitro refolding of human proinsulin. Kinetic intermediates, putative disulfide-forming pathway folding initiation site, and potential role of C-peptide in folding process

How insulin binds: the B-chain alpha-helix contacts the L1 beta-helix of the insulin receptor

Diabetes-Associated Mutations in a β -Cell Transcription Factor Destabilize an Antiparallel "Mini-Zipper" in a Dimerization Interface

Mechanism of insulin chain combination. Asymmetric roles of A-chain alpha-helices in disulfide pairing

Solution Structure of Proinsulin

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