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The Role of Human Carboxylesterases in Drug Metabolism: Have We Overlooked Their Importance?

Pharmacotherapy, 2013-02, Vol.33 (2), p.210-222

2013

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CYP3A4-mediated pharmacokinetic interactions in cancer therapy

Current drug metabolism, 2014-01, Vol.15 (8), p.808-817

2014

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A Phase I/Ib Trial of the VEGFR-Sparing Multikinase RET Inhibitor RXDX-105

Cancer discovery, 2019-03, Vol.9 (3), p.384-395

2019

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Combinatorial metabolism notably affects human systemic exposure to ginsenosides from orally administered extract of Panax notoginseng roots (Sanqi)

Drug metabolism and disposition, 2013-07, Vol.41 (7), p.1457-1469

2013

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Pediatric model‐based dose optimization using a pooled exposure–response safety analysis for nivolumab and nivolumab plus ipilimumab combination in melanoma

CPT: pharmacometrics and systems pharmacology, 2024-01, Vol.13 (1), p.168-179

2024

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Nivolumab and ipilimumab population pharmacokinetics in support of pediatric dose recommendations—Going beyond the body‐size effect

CPT: pharmacometrics and systems pharmacology, 2024-03, Vol.13 (3), p.476-493

2024

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HZ08 reverse P-glycoprotein mediated multidrug resistance in vitro and in vivo

PloS one, 2015-02, Vol.10 (2), p.e0116886-e0116886

2015

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Evaluation of Chlorpheniramine Maleate microparticles in orally disintegrating film and orally disintegrating tablet for pediatrics

Drug development and industrial pharmacy, 2014-07, Vol.40 (7), p.910-918

2014

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Association between Common CYP1A2 Polymorphisms and Theophylline Metabolism in Non‐smoking Healthy Volunteers

Basic & clinical pharmacology & toxicology, 2013-04, Vol.112 (4), p.257-263

2013

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Accurate determination of the anticancer prodrug simmitecan and its active metabolite chimmitecan in various plasma samples based on immediate deactivation of blood carboxylesterases

Journal of Chromatography A, 2011-09, Vol.1218 (38), p.6646-6653

2011

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Model-Informed Clinical Pharmacology Profile of a Novel Fixed-Dose Combination of Nivolumab and Relatlimab in Adult and Adolescent Patients with Solid Tumors

Clinical cancer research, 2024-07, Vol.30 (14), p.3050-3058

2024

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Characterization of angiotensin II antagonism displayed by Ib, a novel nonpeptide angiotensin AT1 receptor antagonist

European journal of pharmacology, 2008-07, Vol.589 (1-3), p.220-224

2008

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Exposure-Response Analysis to Support Nivolumab Once Every 4 Weeks Dosing in Combination with Cabozantinib in Renal Cell Carcinoma

Clinical cancer research, 2022-04, Vol.28 (8), p.1603-1613

2022

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Simultaneous determination of 6β-hydroxycortisol and cortisol in human urine and plasma by liquid chromatography with ultraviolet absorbance detection for phenotyping the CYP3A activity

Journal of chromatography. B, Analytical technologies in the biomedical and life sciences, 2005-11, Vol.826 (1), p.238-243

2005

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Oral bioavailability and brain penetration of (−)‐stepholidine, a tetrahydroprotoberberine agonist at dopamine D1 and antagonist at D2 receptors, in rats

British journal of pharmacology, 2009-11, Vol.158 (5), p.1302-1312

2009

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TRUST-II: a global phase II study of taletrectinib in ROS1 -positive non-small-cell lung cancer and other solid tumors

Future oncology (London, England), 2023-01, Vol.19 (2), p.123-135

2023

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Sequential hydrolysis of dabigatran etexilate to its active metabolite by human carboxylesterase 1 and 2 (1064.6)

The FASEB journal, 2014-04, Vol.28 (S1), p.n/a

2014

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Effect of alcohol on clopidogrel metabolism: Identification of a new alcohol‐dependent metabolic pathway (1141.14)

The FASEB journal, 2014-04, Vol.28 (S1), p.n/a

2014

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Oral bioavailability and brain penetration of (−)‐stepholidine, a tetrahydroprotoberberine agonist at dopamine D 1 and antagonist at D 2 receptors, in rats

British journal of pharmacology, 2009-11, Vol.158 (5), p.1302-1312

2009

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L-1416, a novel MDR reversing agent with possible reduced calcium antagonism

Pharmacological reports, 2014-12, Vol.66 (6), p.1140-1147

2014

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Association between Common CYP 1 A 2 Polymorphisms and Theophylline Metabolism in Non‐smoking Healthy Volunteers

Basic & clinical pharmacology & toxicology, 2013-04, Vol.112 (4), p.257-263

2013

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Association between Common CYPIA2 Polymorphisms and Theophylline Metabolism in Non-smoking Healthy Volunteers

Basic & clinical pharmacology & toxicology, 2013, Vol.112 (4), p.257-263

2013

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Characterization of angiotensin II antagonism displayed by Ib, a novel nonpeptide angiotensin AT(1) receptor antagonist

European journal of pharmacology, 2008-07, Vol.589 (1-3), p.220-224

2008

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Characterization of angiotensin II antagonism displayed by Ib, a novel nonpeptide angiotensin AT 1 receptor antagonist

European journal of pharmacology, 2008, Vol.589 (1), p.220-224

2008

Volltextzugriff (PDF)

Simultaneous determination of 6beta-hydroxycortisol and cortisol in human urine and plasma by liquid chromatography with ultraviolet absorbance detection for phenotyping the CYP3A activity

Journal of chromatography. B, Analytical technologies in the biomedical and life sciences, 2005-11, Vol.826 (1-2), p.238-243

2005

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The Role of Human Carboxylesterases in Drug Metabolism: Have We Overlooked Their Importance?

CYP3A4-mediated pharmacokinetic interactions in cancer therapy

A Phase I/Ib Trial of the VEGFR-Sparing Multikinase RET Inhibitor RXDX-105

Combinatorial metabolism notably affects human systemic exposure to ginsenosides from orally administered extract of Panax notoginseng roots (Sanqi)

Pediatric model‐based dose optimization using a pooled exposure–response safety analysis for nivolumab and nivolumab plus ipilimumab combination in melanoma

Nivolumab and ipilimumab population pharmacokinetics in support of pediatric dose recommendations—Going beyond the body‐size effect

HZ08 reverse P-glycoprotein mediated multidrug resistance in vitro and in vivo

Evaluation of Chlorpheniramine Maleate microparticles in orally disintegrating film and orally disintegrating tablet for pediatrics

Association between Common CYP1A2 Polymorphisms and Theophylline Metabolism in Non‐smoking Healthy Volunteers

Accurate determination of the anticancer prodrug simmitecan and its active metabolite chimmitecan in various plasma samples based on immediate deactivation of blood carboxylesterases

Model-Informed Clinical Pharmacology Profile of a Novel Fixed-Dose Combination of Nivolumab and Relatlimab in Adult and Adolescent Patients with Solid Tumors

Characterization of angiotensin II antagonism displayed by Ib, a novel nonpeptide angiotensin AT1 receptor antagonist

Exposure-Response Analysis to Support Nivolumab Once Every 4 Weeks Dosing in Combination with Cabozantinib in Renal Cell Carcinoma

Simultaneous determination of 6β-hydroxycortisol and cortisol in human urine and plasma by liquid chromatography with ultraviolet absorbance detection for phenotyping the CYP3A activity

Oral bioavailability and brain penetration of (−)‐stepholidine, a tetrahydroprotoberberine agonist at dopamine D1 and antagonist at D2 receptors, in rats

TRUST-II: a global phase II study of taletrectinib in ROS1 -positive non-small-cell lung cancer and other solid tumors

Sequential hydrolysis of dabigatran etexilate to its active metabolite by human carboxylesterase 1 and 2 (1064.6)

Effect of alcohol on clopidogrel metabolism: Identification of a new alcohol‐dependent metabolic pathway (1141.14)

Oral bioavailability and brain penetration of (−)‐stepholidine, a tetrahydroprotoberberine agonist at dopamine D 1 and antagonist at D 2 receptors, in rats

L-1416, a novel MDR reversing agent with possible reduced calcium antagonism

Association between Common CYP 1 A 2 Polymorphisms and Theophylline Metabolism in Non‐smoking Healthy Volunteers

Association between Common CYPIA2 Polymorphisms and Theophylline Metabolism in Non-smoking Healthy Volunteers

Characterization of angiotensin II antagonism displayed by Ib, a novel nonpeptide angiotensin AT(1) receptor antagonist

Characterization of angiotensin II antagonism displayed by Ib, a novel nonpeptide angiotensin AT 1 receptor antagonist

Simultaneous determination of 6beta-hydroxycortisol and cortisol in human urine and plasma by liquid chromatography with ultraviolet absorbance detection for phenotyping the CYP3A activity

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