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Cellular and physiological functions of C9ORF72 and implications for ALS/FTD

Journal of neurochemistry, 2021-05, Vol.157 (3), p.334-350

2021

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The lysosomal function of progranulin, a guardian against neurodegeneration

Acta neuropathologica, 2018-07, Vol.136 (1), p.1-17

2018

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Spatiotemporal control of phosphatidylinositol 4-phosphate by Sac2 regulates endocytic recycling

The Journal of cell biology, 2015-04, Vol.209 (1), p.97-110

2015

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The frontotemporal lobar degeneration risk factor, TMEM106B, regulates lysosomal morphology and function

Human molecular genetics, 2013-02, Vol.22 (4), p.685-695

2013

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Prosaposin facilitates sortilin-independent lysosomal trafficking of progranulin

The Journal of cell biology, 2015-09, Vol.210 (6), p.991-1002

2015

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Sortilin-Mediated Endocytosis Determines Levels of the Frontotemporal Dementia Protein, Progranulin

Neuron (Cambridge, Mass.), 2010-11, Vol.68 (4), p.654-667

2010

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Regulation of TDP‐43 aggregation by phosphorylation andp62/SQSTM1

Journal of neurochemistry, 2011-01, Vol.116 (2), p.248-259

2011

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C9ORF72 suppresses JAK-STAT mediated inflammation

iScience, 2023-05, Vol.26 (5), p.106579-106579, Article 106579

2023

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Impaired prosaposin lysosomal trafficking in frontotemporal lobar degeneration due to progranulin mutations

Nature communications, 2017-05, Vol.8 (1), p.15277-15277, Article 15277

2017

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Progranulin deficiency leads to reduced glucocerebrosidase activity

PloS one, 2019-07, Vol.14 (7), p.e0212382-e0212382

2019

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The interaction between progranulin and prosaposin is mediated by granulins and the linker region between saposin B and C

Journal of neurochemistry, 2017-10, Vol.143 (2), p.236-243

2017

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The N-Terminal Domain of Nogo-A Inhibits Cell Adhesion and Axonal Outgrowth by an Integrin-Specific Mechanism

The Journal of neuroscience, 2008-01, Vol.28 (5), p.1262-1269

2008

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Regulated Intramembrane Proteolysis of the Frontotemporal Lobar Degeneration Risk Factor, TMEM106B, by Signal Peptide Peptidase-like 2a (SPPL2a)

The Journal of biological chemistry, 2014-07, Vol.289 (28), p.19670-19680

2014

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Effect of serum autoantibodies on the COVID-19 patient's prognosis

Frontiers in microbiology, 2023, Vol.14, p.1259960-1259960

2023

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C-terminus of progranulin interacts with the beta-propeller region of sortilin to regulate progranulin trafficking

PloS one, 2011-06, Vol.6 (6), p.e21023-e21023

2011

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Differential regulation of progranulin derived granulin peptides

Molecular neurodegeneration, 2022-02, Vol.17 (1), p.15-15, Article 15

2022

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Crystal structure of the yeast Sac1: implications for its phosphoinositide phosphatase function

The EMBO journal, 2010-05, Vol.29 (9), p.1489-1498

2010

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Unveiling TMEM106B: SARS-CoV-2’s secret entrance to the cell

Cell, 2023-08, Vol.186 (16), p.3329-3331

2023

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Regulation of lysosomal trafficking of progranulin by sortilin and prosaposin

Brain communications, 2022-01, Vol.4 (1), p.fcab310-fcab310

2022

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A longitudinal study of humoral immune responses induced by a 3-dose inactivated COVID-19 vaccine in an observational, prospective cohort

BMC immunology, 2022-11, Vol.23 (1), p.57-57, Article 57

2022

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TMEM106B deficiency impairs cerebellar myelination and synaptic integrity with Purkinje cell loss

Acta neuropathologica communications, 2022-03, Vol.10 (1), p.33-33, Article 33

2022

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A PH domain within OCRL bridges clathrin-mediated membrane trafficking to phosphoinositide metabolism

The EMBO journal, 2009-07, Vol.28 (13), p.1831-1842

2009

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The neogenin/DCC homolog UNC-40 promotes BMP signaling via the RGM protein DRAG-1 in C. elegans

Development (Cambridge), 2013-10, Vol.140 (19), p.4070-4080

2013

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Role and mechanism of REG2 depletion in insulin secretion augmented by glutathione peroxidase-1 overproduction

Redox biology, 2022-10, Vol.56, p.102457, Article 102457

2022

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AAV-GRN partially corrects motor deficits and ALS/FTLD-related pathology in Tmem106b−/−Grn−/− mice

iScience, 2023-07, Vol.26 (7), p.107247-107247, Article 107247

2023

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Cellular and physiological functions of C9ORF72 and implications for ALS/FTD

The lysosomal function of progranulin, a guardian against neurodegeneration

Spatiotemporal control of phosphatidylinositol 4-phosphate by Sac2 regulates endocytic recycling

The frontotemporal lobar degeneration risk factor, TMEM106B, regulates lysosomal morphology and function

Prosaposin facilitates sortilin-independent lysosomal trafficking of progranulin

Sortilin-Mediated Endocytosis Determines Levels of the Frontotemporal Dementia Protein, Progranulin

Regulation of TDP‐43 aggregation by phosphorylation andp62/SQSTM1

C9ORF72 suppresses JAK-STAT mediated inflammation

Impaired prosaposin lysosomal trafficking in frontotemporal lobar degeneration due to progranulin mutations

Progranulin deficiency leads to reduced glucocerebrosidase activity

The interaction between progranulin and prosaposin is mediated by granulins and the linker region between saposin B and C

The N-Terminal Domain of Nogo-A Inhibits Cell Adhesion and Axonal Outgrowth by an Integrin-Specific Mechanism

Regulated Intramembrane Proteolysis of the Frontotemporal Lobar Degeneration Risk Factor, TMEM106B, by Signal Peptide Peptidase-like 2a (SPPL2a)

Effect of serum autoantibodies on the COVID-19 patient's prognosis

C-terminus of progranulin interacts with the beta-propeller region of sortilin to regulate progranulin trafficking

Differential regulation of progranulin derived granulin peptides

Crystal structure of the yeast Sac1: implications for its phosphoinositide phosphatase function

Unveiling TMEM106B: SARS-CoV-2’s secret entrance to the cell

Regulation of lysosomal trafficking of progranulin by sortilin and prosaposin

A longitudinal study of humoral immune responses induced by a 3-dose inactivated COVID-19 vaccine in an observational, prospective cohort

TMEM106B deficiency impairs cerebellar myelination and synaptic integrity with Purkinje cell loss

A PH domain within OCRL bridges clathrin-mediated membrane trafficking to phosphoinositide metabolism

The neogenin/DCC homolog UNC-40 promotes BMP signaling via the RGM protein DRAG-1 in C. elegans

Role and mechanism of REG2 depletion in insulin secretion augmented by glutathione peroxidase-1 overproduction

AAV-GRN partially corrects motor deficits and ALS/FTLD-related pathology in Tmem106b−/−Grn−/− mice

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