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Mechanistic study of dual‐function inhibitors targeting topoisomerase II and Rad51‐mediated DNA repair pathway against castration‐resistant prostate cancer

The Prostate, 2023-12, Vol.83 (16), p.1549-1563

2023

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A novel HDAC6 inhibitor interferes microtubule dynamics and spindle assembly checkpoint and sensitizes cisplatin‐induced apoptosis in castration‐resistant prostate cancer

The Prostate, 2024-05, Vol.84 (6), p.605-619

2024

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Dihydroartemisinin–Bile Acid Hybridization as an Effective Approach to Enhance Dihydroartemisinin Anticancer Activity

ChemMedChem, 2019-04, Vol.14 (7), p.779-787

2019

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Anticancer Activity and Molecular Mechanisms of an Ursodeoxycholic Acid Methyl Ester-Dihydroartemisinin Hybrid via a Triazole Linkage in Hepatocellular Carcinoma Cells

Molecules (Basel, Switzerland), 2023-03, Vol.28 (5), p.2358

2023

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Effects of lipopolysaccharide on the expression of plasma membrane monoamine transporter (PMAT) at the blood–brain barrier and its implications to the transport of neurotoxins

Journal of neurochemistry, 2015-12, Vol.135 (6), p.1178-1188

2015

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Evaluation of the Anticancer Activity of a Bile Acid-Dihydroartemisinin Hybrid Ursodeoxycholic-Dihydroartemisinin in Hepatocellular Carcinoma Cells

Frontiers in pharmacology, 2020-11, Vol.11, p.599067

2020

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The Combination of MK-2206 and WZB117 Exerts a Synergistic Cytotoxic Effect Against Breast Cancer Cells

Frontiers in pharmacology, 2019-11, Vol.10, p.1311-1311

2019

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Chalcones Display Anti-NLRP3 Inflammasome Activity in Macrophages through Inhibition of Both Priming and Activation Steps-Structure-Activity-Relationship and Mechanism Studies

Molecules (Basel, Switzerland), 2020-12, Vol.25 (24), p.5960

2020

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Phosphodiesterase Type 5 Inhibitors Synergize Vincristine in Killing Castration-Resistant Prostate Cancer Through Amplifying Mitotic Arrest Signaling

Frontiers in oncology, 2020-08, Vol.10, p.1274-1274

2020

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The (+)-Brevipolide H Displays Anticancer Activity against Human Castration-Resistant Prostate Cancer: The Role of Oxidative Stress and Akt/mTOR/p70S6K-Dependent Pathways in G1 Checkpoint Arrest and Apoptosis

Molecules (Basel, Switzerland), 2020-06, Vol.25 (12), p.2929

2020

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Para-Toluenesulfonamide Induces Anti-tumor Activity Through Akt-Dependent and -Independent mTOR/p70S6K Pathway: Roles of Lipid Raft and Cholesterol Contents

Frontiers in pharmacology, 2018-11, Vol.9, p.1223-1223

2018

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Discovery of Novel Agents on Spindle Assembly Checkpoint to Sensitize Vinorelbine-Induced Mitotic Cell Death Against Human Non-Small Cell Lung Cancers

International journal of molecular sciences, 2020-08, Vol.21 (16), p.5608

2020

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Reevesioside A, a cardenolide glycoside, induces anticancer activity against human hormone-refractory prostate cancers through suppression of c-myc expression and induction of G1 arrest of the cell cycle

PloS one, 2014-01, Vol.9 (1), p.e87323

2014

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Phosphodiesterase Type 5 (PDE5) Inhibitors Sensitize Topoisomerase II Inhibitors in Killing Prostate Cancer Through PDE5-Independent Impairment of HR and NHEJ DNA Repair Systems

Frontiers in oncology, 2019-01, Vol.8, p.681-681

2019

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Ardisianone, a natural benzoquinone, efficiently induces apoptosis in human hormone-refractory prostate cancers through mitochondrial damage stress and survivin downregulation

The Prostate, 2013-01, Vol.73 (2), p.133-145

2013

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Repurposing of phentolamine as a potential anticancer agent against human castration-resistant prostate cancer: A central role on microtubule stabilization and mitochondrial apoptosis pathway

The Prostate, 2015-09, Vol.75 (13), p.1454-1466

2015

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Terfenadine induces anti-proliferative and apoptotic activities in human hormone-refractory prostate cancer through histamine receptor-independent Mcl-1 cleavage and Bak up-regulation

Naunyn-Schmiedeberg's archives of pharmacology, 2014-01, Vol.387 (1), p.33-45

2014

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Sensitization of cancer cells to paclitaxel-induced apoptosis by canagliflozin

Biochemical pharmacology, 2024-05, Vol.223, p.116140, Article 116140

2024

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BRCA1 is Associated with the Centrosome during Mitosis

Proceedings of the National Academy of Sciences - PNAS, 1998-10, Vol.95 (22), p.12983-12988

1998

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Loss of distal 11q is associated with DNA repair deficiency and reduced sensitivity to ionizing radiation in head and neck squamous cell carcinoma

Genes chromosomes & cancer, 2007-08, Vol.46 (8), p.761-775

2007

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Targeting Colorectal Cancer with Conjugates of a Glucose Transporter Inhibitor and 5‑Fluorouracil

Journal of medicinal chemistry, 2021-04, Vol.64 (8), p.4450-4461

2021

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Design, Synthesis, and Evaluation of Glucose Transporter Inhibitor-SN38 Conjugates for Targeting Colorectal Cancer

Journal of medicinal chemistry, 2023-07, Vol.66 (14), p.9684-9696

2023

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Discovery of New Glucose Uptake Inhibitors as Potential Anticancer Agents by Non-Radioactive Cell-Based Assays

Molecules (Basel, Switzerland), 2022-11, Vol.27 (22), p.8106

2022

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Cardenolide glycosides sensitize gefitinib-induced apoptosis in non-small cell lung cancer: inhibition of Na+/K+-ATPase serving as a switch-on mechanism

Naunyn-Schmiedeberg's archives of pharmacology, 2024-09, Vol.397 (9), p.6533-6550

2024

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Doxazosin inhibits vasculogenic mimicry in human non‑small cell lung cancer through inhibition of the VEGF‑A/VE‑cadherin/mTOR/MMP pathway

Oncology letters, 2024-04, Vol.27 (4), Article 170

2024

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Mechanistic study of dual‐function inhibitors targeting topoisomerase II and Rad51‐mediated DNA repair pathway against castration‐resistant prostate cancer

A novel HDAC6 inhibitor interferes microtubule dynamics and spindle assembly checkpoint and sensitizes cisplatin‐induced apoptosis in castration‐resistant prostate cancer

Dihydroartemisinin–Bile Acid Hybridization as an Effective Approach to Enhance Dihydroartemisinin Anticancer Activity

Anticancer Activity and Molecular Mechanisms of an Ursodeoxycholic Acid Methyl Ester-Dihydroartemisinin Hybrid via a Triazole Linkage in Hepatocellular Carcinoma Cells

Effects of lipopolysaccharide on the expression of plasma membrane monoamine transporter (PMAT) at the blood–brain barrier and its implications to the transport of neurotoxins

Evaluation of the Anticancer Activity of a Bile Acid-Dihydroartemisinin Hybrid Ursodeoxycholic-Dihydroartemisinin in Hepatocellular Carcinoma Cells

The Combination of MK-2206 and WZB117 Exerts a Synergistic Cytotoxic Effect Against Breast Cancer Cells

Chalcones Display Anti-NLRP3 Inflammasome Activity in Macrophages through Inhibition of Both Priming and Activation Steps-Structure-Activity-Relationship and Mechanism Studies

Phosphodiesterase Type 5 Inhibitors Synergize Vincristine in Killing Castration-Resistant Prostate Cancer Through Amplifying Mitotic Arrest Signaling

The (+)-Brevipolide H Displays Anticancer Activity against Human Castration-Resistant Prostate Cancer: The Role of Oxidative Stress and Akt/mTOR/p70S6K-Dependent Pathways in G1 Checkpoint Arrest and Apoptosis

Para-Toluenesulfonamide Induces Anti-tumor Activity Through Akt-Dependent and -Independent mTOR/p70S6K Pathway: Roles of Lipid Raft and Cholesterol Contents

Discovery of Novel Agents on Spindle Assembly Checkpoint to Sensitize Vinorelbine-Induced Mitotic Cell Death Against Human Non-Small Cell Lung Cancers

Reevesioside A, a cardenolide glycoside, induces anticancer activity against human hormone-refractory prostate cancers through suppression of c-myc expression and induction of G1 arrest of the cell cycle

Phosphodiesterase Type 5 (PDE5) Inhibitors Sensitize Topoisomerase II Inhibitors in Killing Prostate Cancer Through PDE5-Independent Impairment of HR and NHEJ DNA Repair Systems

Ardisianone, a natural benzoquinone, efficiently induces apoptosis in human hormone-refractory prostate cancers through mitochondrial damage stress and survivin downregulation

Repurposing of phentolamine as a potential anticancer agent against human castration-resistant prostate cancer: A central role on microtubule stabilization and mitochondrial apoptosis pathway

Terfenadine induces anti-proliferative and apoptotic activities in human hormone-refractory prostate cancer through histamine receptor-independent Mcl-1 cleavage and Bak up-regulation

Sensitization of cancer cells to paclitaxel-induced apoptosis by canagliflozin

BRCA1 is Associated with the Centrosome during Mitosis

Loss of distal 11q is associated with DNA repair deficiency and reduced sensitivity to ionizing radiation in head and neck squamous cell carcinoma

Targeting Colorectal Cancer with Conjugates of a Glucose Transporter Inhibitor and 5‑Fluorouracil

Design, Synthesis, and Evaluation of Glucose Transporter Inhibitor-SN38 Conjugates for Targeting Colorectal Cancer

Discovery of New Glucose Uptake Inhibitors as Potential Anticancer Agents by Non-Radioactive Cell-Based Assays

Cardenolide glycosides sensitize gefitinib-induced apoptosis in non-small cell lung cancer: inhibition of Na+/K+-ATPase serving as a switch-on mechanism

Doxazosin inhibits vasculogenic mimicry in human non‑small cell lung cancer through inhibition of the VEGF‑A/VE‑cadherin/mTOR/MMP pathway

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