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Targeting P-glycoprotein: Investigation of piperine analogs for overcoming drug resistance in cancer

Scientific reports, 2017-08, Vol.7 (1), p.7972-18, Article 7972

2017

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Biomimetic Syntheses of (±)‐Isopalhinine A, (±)‐Palhinine A, and (±)‐Palhinine D

Angewandte Chemie International Edition, 2018-11, Vol.57 (47), p.15572-15576

International ed. in English, 2018

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A critical overview of current progress for COVID-19: development of vaccines, antiviral drugs, and therapeutic antibodies

Journal of biomedical science, 2022-09, Vol.29 (1), p.1-68, Article 68

2022

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Recent advances in total synthesis of natural products by masked ortho‐benzoquinones

Journal of the Chinese Chemical Society (Taipei), 2022-08, Vol.69 (8), p.1210-1222

2022

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Tumor‐agnostic inhibitors in oncology: A new phase for precision medicine

Journal of the Chinese Chemical Society (Taipei), 2020-12, Vol.67 (12), p.2216-2224

2020

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Design and synthesis of novel orally selective and type II pan-TRK inhibitors to overcome mutations by property-driven optimization

European journal of medicinal chemistry, 2021-11, Vol.224, p.113673-113673, Article 113673

2021

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Novel FLT3/AURK multikinase inhibitor is efficacious against sorafenib-refractory and sorafenib-resistant hepatocellular carcinoma

Journal of biomedical science, 2022-01, Vol.29 (1), p.5-5, Article 5

2022

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Identification of Entry Inhibitors against Delta and Omicron Variants of SARS-CoV-2

International journal of molecular sciences, 2022-04, Vol.23 (7), p.4050

2022

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Homology modeling of DFG-in FMS-like tyrosine kinase 3 (FLT3) and structure-based virtual screening for inhibitor identification

Scientific reports, 2015-06, Vol.5 (1), p.11702-11702, Article 11702

2015

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Natural product myricetin is a pan-KDM4 inhibitor which with poly lactic-co-glycolic acid formulation effectively targets castration-resistant prostate cancer

Journal of biomedical science, 2022-05, Vol.29 (1), p.29-29, Article 29

2022

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Overcoming vincristine resistance in cancer: Computational design and discovery of piperine‐inspired P‐glycoprotein inhibitors

Chemical biology & drug design, 2021-01, Vol.97 (1), p.51-66

2021

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Targeting cathepsin S promotes activation of OLF1-BDNF/TrkB axis to enhance cognitive function

Journal of biomedical science, 2024-05, Vol.31 (1), p.46-23, Article 46

2024

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Dual Kit/Aur Inhibitors as Chemosensitizing Agents for the Treatment of Melanoma: Design, Synthesis, Docking Studies and Functional Investigation

Scientific reports, 2019-07, Vol.9 (1), p.9943-10, Article 9943

2019

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Design and Synthesis of Tetrahydropyridothieno[2,3-d]pyrimidine Scaffold Based Epidermal Growth Factor Receptor (EGFR) Kinase Inhibitors: The Role of Side Chain Chirality and Michael Acceptor Group for Maximal Potency

Journal of medicinal chemistry, 2010-10, Vol.53 (20), p.7316-7326

2010

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Bortezomib Overcomes Tumor Necrosis Factor-related Apoptosis-inducing Ligand Resistance in Hepatocellular Carcinoma Cells in Part through the Inhibition of the Phosphatidylinositol 3-Kinase/Akt Pathway

The Journal of biological chemistry, 2009-04, Vol.284 (17), p.11121-11133

2009

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An antimitotic and antivascular agent BPR0L075 overcomes multidrug resistance and induces mitotic catastrophe in paclitaxel-resistant ovarian cancer cells

PloS one, 2013-06, Vol.8 (6), p.e65686

2013

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Scaffold-Hopping Strategy: Synthesis and Biological Evaluation of 5,6-Fused Bicyclic Heteroaromatics To Identify Orally Bioavailable Anticancer Agents

Journal of medicinal chemistry, 2011-04, Vol.54 (8), p.3076-3080

2011

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Strategies of development of antiviral agents directed against influenza virus replication

Current pharmaceutical design, 2007-12, Vol.13 (34), p.3531

2007

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Briarenols W-Z: Chlorine-Containing Polyoxygenated Briaranes from Octocoral Briareum stechei (Kükenthal, 1908)

Marine drugs, 2021-01, Vol.19 (2), p.77

2021

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Tubulin-destabilizing agent BPR0L075 induces vascular-disruption in human breast cancer mammary fat pad xenografts

PloS one, 2012-08, Vol.7 (8), p.e43314

2012

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Mimicking H3 Substrate Arginine in the Design of G9a Lysine Methyltransferase Inhibitors for Cancer Therapy: A Computational Study for Structure-Based Drug Design

ACS omega, 2021-03, Vol.6 (9), p.6100-6111

2021

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Identification of BPR3P0128 as an Inhibitor of Cap-Snatching Activities of Influenza Virus

Antimicrobial Agents and Chemotherapy, 2012-02, Vol.56 (2), p.647-657

2012

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Design of drug-like hepsin inhibitors against prostate cancer and kidney stones

Acta pharmaceutica Sinica. B, 2020-07, Vol.10 (7), p.1309-1320

2020

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Preliminary biomechanical study of different acetabular reinforcement devices for acetabular reconstruction

PloS one, 2015-03, Vol.10 (3), p.e0121588-e0121588

2015

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Synthesis and Biological Evaluation of 1-Methyl-2-(3′,4′,5′-trimethoxybenzoyl)-3-aminoindoles as a New Class of Antimitotic Agents and Tubulin Inhibitors

Journal of medicinal chemistry, 2008-03, Vol.51 (5), p.1464-1468

2008

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Targeting P-glycoprotein: Investigation of piperine analogs for overcoming drug resistance in cancer

Biomimetic Syntheses of (±)‐Isopalhinine A, (±)‐Palhinine A, and (±)‐Palhinine D

A critical overview of current progress for COVID-19: development of vaccines, antiviral drugs, and therapeutic antibodies

Recent advances in total synthesis of natural products by masked ortho‐benzoquinones

Tumor‐agnostic inhibitors in oncology: A new phase for precision medicine

Design and synthesis of novel orally selective and type II pan-TRK inhibitors to overcome mutations by property-driven optimization

Novel FLT3/AURK multikinase inhibitor is efficacious against sorafenib-refractory and sorafenib-resistant hepatocellular carcinoma

Identification of Entry Inhibitors against Delta and Omicron Variants of SARS-CoV-2

Homology modeling of DFG-in FMS-like tyrosine kinase 3 (FLT3) and structure-based virtual screening for inhibitor identification

Natural product myricetin is a pan-KDM4 inhibitor which with poly lactic-co-glycolic acid formulation effectively targets castration-resistant prostate cancer

Overcoming vincristine resistance in cancer: Computational design and discovery of piperine‐inspired P‐glycoprotein inhibitors

Targeting cathepsin S promotes activation of OLF1-BDNF/TrkB axis to enhance cognitive function

Dual Kit/Aur Inhibitors as Chemosensitizing Agents for the Treatment of Melanoma: Design, Synthesis, Docking Studies and Functional Investigation

Design and Synthesis of Tetrahydropyridothieno[2,3-d]pyrimidine Scaffold Based Epidermal Growth Factor Receptor (EGFR) Kinase Inhibitors: The Role of Side Chain Chirality and Michael Acceptor Group for Maximal Potency

Bortezomib Overcomes Tumor Necrosis Factor-related Apoptosis-inducing Ligand Resistance in Hepatocellular Carcinoma Cells in Part through the Inhibition of the Phosphatidylinositol 3-Kinase/Akt Pathway

An antimitotic and antivascular agent BPR0L075 overcomes multidrug resistance and induces mitotic catastrophe in paclitaxel-resistant ovarian cancer cells

Scaffold-Hopping Strategy: Synthesis and Biological Evaluation of 5,6-Fused Bicyclic Heteroaromatics To Identify Orally Bioavailable Anticancer Agents

Strategies of development of antiviral agents directed against influenza virus replication

Briarenols W-Z: Chlorine-Containing Polyoxygenated Briaranes from Octocoral Briareum stechei (Kükenthal, 1908)

Tubulin-destabilizing agent BPR0L075 induces vascular-disruption in human breast cancer mammary fat pad xenografts

Mimicking H3 Substrate Arginine in the Design of G9a Lysine Methyltransferase Inhibitors for Cancer Therapy: A Computational Study for Structure-Based Drug Design

Identification of BPR3P0128 as an Inhibitor of Cap-Snatching Activities of Influenza Virus

Design of drug-like hepsin inhibitors against prostate cancer and kidney stones

Preliminary biomechanical study of different acetabular reinforcement devices for acetabular reconstruction

Synthesis and Biological Evaluation of 1-Methyl-2-(3′,4′,5′-trimethoxybenzoyl)-3-aminoindoles as a New Class of Antimitotic Agents and Tubulin Inhibitors

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