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Cyclic Opioid Peptides

Current medicinal chemistry, 2016-01, Vol.23 (13), p.1288-1303

2016

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The Melanocortin Receptor System: A Target for Multiple Degenerative Diseases

Current protein & peptide science, 2016-01, Vol.17 (5), p.488-496

2016

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Peptidomimetics, a synthetic tool of drug discovery

Current opinion in chemical biology, 2008-06, Vol.12 (3), p.292-296

2008

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Fentanyl-related compounds and derivatives: current status and future prospects for pharmaceutical applications

Future medicinal chemistry, 2014-03, Vol.6 (4), p.385-412

2014

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Synthesis of Best-Seller Drugs

1, 2016

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Synthesis of Essential Drugs

1, 2006

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Development of N -Acetylated Dipalmitoyl- S -Glyceryl Cysteine Analogs as Efficient TLR2/TLR6 Agonists

Molecules (Basel, Switzerland), 2019-09, Vol.24 (19), p.3512

2019

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Aged Brains Express Less Melanocortin Receptors, Which Correlates with Age-Related Decline of Cognitive Functions

Molecules (Basel, Switzerland), 2021-10, Vol.26 (20), p.6266

2021

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Recent Advances in the Realm of Allosteric Modulators for Opioid Receptors for Future Therapeutics

ACS chemical neuroscience, 2017-06, Vol.8 (6), p.1147-1158

2017

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Enkephalin-Fentanyl Multifunctional Opioids as Potential Neuroprotectants for Ischemic Stroke Treatment

Current pharmaceutical design, 2016-01, Vol.22 (42), p.6459-6468

2016

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Multiple N-Methylation of MT-II Backbone Amide Bonds Leads to Melanocortin Receptor Subtype hMC1R Selectivity: Pharmacological and Conformational Studies

Journal of the American Chemical Society, 2010-06, Vol.132 (23), p.8115-8128

2010

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Toward a Universal μ‑Agonist Template for Template-Based Alignment Modeling of Opioid Ligands

ACS omega, 2019-10, Vol.4 (17), p.17457-17476

2019

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Heterobivalent ligands target cell-surface receptor combinations in vivo

Proceedings of the National Academy of Sciences - PNAS, 2012-12, Vol.109 (52), p.21295-21300

2012

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Multivalent peptide and peptidomimetic ligands for the treatment of pain without toxicities and addiction

Peptides (New York, N.Y. : 1980), 2019-06, Vol.116, p.63-67

Hruby, Victor J.

2019

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MC4R biased signalling and the conformational basis of biological function selections

Journal of cellular and molecular medicine, 2022-08, Vol.26 (15), p.4125-4136

2022

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Role of melanocortinergic neurons in feeding and the agouti obesity syndrome

Nature (London), 1997-01, Vol.385 (6612), p.165-168

1997

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Neuropathic pain is maintained by brainstem neurons co-expressing opioid and cholecystokinin receptors

Brain (London, England : 1878), 2009-03, Vol.132 (3), p.778-787

2009

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Design of cyclic peptides with biological activities from biologically active peptides: the case of peptide modulators of melanocortin receptors

Biopolymers, 2016-11, Vol.106 (6), p.884-888

Hruby, Victor J.

2016

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Sex-specific Mediation of Opioid-induced Hyperalgesia by the Melanocortin-1 Receptor

Anesthesiology (Philadelphia), 2010, Vol.112 (1), p.181-188

2010

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Development and in Vivo Quantitative Magnetic Resonance Imaging of Polymer Micelles Targeted to the Melanocortin 1 Receptor

Journal of medicinal chemistry, 2013-08, Vol.56 (16), p.6330-6338

2013

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Designing peptide receptor agonists and antagonists

Nature reviews. Drug discovery, 2002-11, Vol.1 (11), p.847-858

Hruby, Victor J

2002

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Multifunctional Enkephalin Analogs with a New Biological Profile: MOR/DOR Agonism and KOR Antagonism

Biomedicines, 2021-05, Vol.9 (6), p.625

2021

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Ψ and χ Angle Constrains at the C-Terminus Trp Position of the Melanotropin Tetrapeptide Ac-His-d-Phe-Arg-Trp-NH 2 Lead to Potent and Selective Agonists at hMC1R and hMC4R

Journal of medicinal chemistry, 2023-05, Vol.66 (10), p.6715-6724

2023

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Heterobivalent Ligands Crosslink Multiple Cell-Surface Receptors: The Human Melanocortin-4 and δ-Opioid Receptors

Angewandte Chemie (International ed.), 2008-01, Vol.47 (9), p.1685-1688

2008

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Enhanced targeting with heterobivalent ligands

Molecular cancer therapeutics, 2009-08, Vol.8 (8), p.2356-2365

2009

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Cyclic Opioid Peptides

The Melanocortin Receptor System: A Target for Multiple Degenerative Diseases

Peptidomimetics, a synthetic tool of drug discovery

Fentanyl-related compounds and derivatives: current status and future prospects for pharmaceutical applications

Synthesis of Best-Seller Drugs

Synthesis of Essential Drugs

Development of N -Acetylated Dipalmitoyl- S -Glyceryl Cysteine Analogs as Efficient TLR2/TLR6 Agonists

Aged Brains Express Less Melanocortin Receptors, Which Correlates with Age-Related Decline of Cognitive Functions

Recent Advances in the Realm of Allosteric Modulators for Opioid Receptors for Future Therapeutics

Enkephalin-Fentanyl Multifunctional Opioids as Potential Neuroprotectants for Ischemic Stroke Treatment

Multiple N-Methylation of MT-II Backbone Amide Bonds Leads to Melanocortin Receptor Subtype hMC1R Selectivity: Pharmacological and Conformational Studies

Toward a Universal μ‑Agonist Template for Template-Based Alignment Modeling of Opioid Ligands

Heterobivalent ligands target cell-surface receptor combinations in vivo

Multivalent peptide and peptidomimetic ligands for the treatment of pain without toxicities and addiction

MC4R biased signalling and the conformational basis of biological function selections

Role of melanocortinergic neurons in feeding and the agouti obesity syndrome

Neuropathic pain is maintained by brainstem neurons co-expressing opioid and cholecystokinin receptors

Design of cyclic peptides with biological activities from biologically active peptides: the case of peptide modulators of melanocortin receptors

Sex-specific Mediation of Opioid-induced Hyperalgesia by the Melanocortin-1 Receptor

Development and in Vivo Quantitative Magnetic Resonance Imaging of Polymer Micelles Targeted to the Melanocortin 1 Receptor

Designing peptide receptor agonists and antagonists

Multifunctional Enkephalin Analogs with a New Biological Profile: MOR/DOR Agonism and KOR Antagonism

Ψ and χ Angle Constrains at the C-Terminus Trp Position of the Melanotropin Tetrapeptide Ac-His-d-Phe-Arg-Trp-NH 2 Lead to Potent and Selective Agonists at hMC1R and hMC4R

Heterobivalent Ligands Crosslink Multiple Cell-Surface Receptors: The Human Melanocortin-4 and δ-Opioid Receptors

Enhanced targeting with heterobivalent ligands

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