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Fentanyl-related compounds and derivatives: current status and future prospects for pharmaceutical applications

Future medicinal chemistry, 2014-03, Vol.6 (4), p.385-412

2014

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Designing peptide receptor agonists and antagonists

Nature reviews. Drug discovery, 2002-11, Vol.1 (11), p.847-858

Hruby, Victor J

2002

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Synthesis and Evaluation of a Novel Bivalent Selective Antagonist for the Mu-Delta Opioid Receptor Heterodimer that Reduces Morphine Withdrawal in Mice

Journal of medicinal chemistry, 2018-07, Vol.61 (14), p.6075-6086

2018

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Synthesis of Essential Drugs

1, 2006

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SNC 80, a selective, nonpeptidic and systemically active opioid delta agonist

The Journal of pharmacology and experimental therapeutics, 1995-04, Vol.273 (1), p.359

1995

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Multiple Applications of a Novel Biarsenical Imaging Probe in Fluorescence and PET Imaging of Melanoma

Bioconjugate chemistry, 2021-03, Vol.32 (3), p.497-501

2021

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Design in Topographical Space of Peptide and Peptidomimetic Ligands That Affect Behavior. A Chemist's Glimpse at the Mind−Body Problem

Accounts of chemical research, 2001-05, Vol.34 (5), p.389-397

Hruby, Victor J

2001

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Blood-brain barrier permeability and bioavailability of a highly potent and mu-selective opioid receptor antagonist, CTAP: comparison with morphine

The Journal of pharmacology and experimental therapeutics, 1997-01, Vol.280 (1), p.402

1997

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Role of melanocortinergic neurons in feeding and the agouti obesity syndrome

Nature (London), 1997-01, Vol.385 (6612), p.165-168

1997

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Conformational and topographical considerations in designing agonist peptidomimetics from peptide leads

Current medicinal chemistry, 2000-09, Vol.7 (9), p.945-970

2000

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Spinal or systemic TY005, a peptidic opioid agonist/neurokinin 1 antagonist, attenuates pain with reduced tolerance

British journal of pharmacology, 2010-11, Vol.161 (5), p.986-1001

2010

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Opioid antinociception in a rat model of visceral pain: systemic versus local drug administration

The Journal of pharmacology and experimental therapeutics, 1995-12, Vol.275 (3), p.1535

1995

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Exploring Ramachandran and chi space: conformationally constrained amino acids and peptides in the design of bioactive polypeptide ligands

Current medicinal chemistry, 2004-11, Vol.11 (21), p.2785-2798

2004

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Michael Addition Reactions between Chiral Equivalents of a Nucleophilic Glycine and (S)- or (R)-3-[(E)-Enoyl]-4-phenyl-1,3-oxazolidin-2-ones as a General Method for Efficient Preparation of β-Substituted Pyroglutamic Acids. Case of Topographically Controlled Stereoselectivity

Journal of the American Chemical Society, 2005-11, Vol.127 (43), p.15296-15303

2005

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Development and characterisation of novel fentanyl-delta opioid receptor antagonist based bivalent ligands

British journal of anaesthesia : BJA, 2015-04, Vol.114 (4), p.646-656

2015

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Role of NK-1 neurotransmission in opioid-induced hyperalgesia

Pain (Amsterdam), 2005-08, Vol.116 (3), p.276-288

2005

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Local inhibitory effects of dynorphin A-(1–17) on capsaicin-induced thermal allodynia in rhesus monkeys

European journal of pharmacology, 2000-08, Vol.402 (1), p.69-76

2000

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Pronociceptive Actions of Dynorphin Maintain Chronic Neuropathic Pain

The Journal of neuroscience, 2001-03, Vol.21 (5), p.1779-1786

2001

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Phosphatidylethanolamine Enhances Rhodopsin Photoactivation and Transducin Binding in a Solid Supported Lipid Bilayer as Determined Using Plasmon-Waveguide Resonance Spectroscopy

Biophysical journal, 2005-01, Vol.88 (1), p.198-210

2005

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Large-scale asymmetric synthesis of novel sterically constrained 2′,6′-dimethyl- and α,2′,6′-trimethyltyrosine and -phenylalanine derivatives via alkylation of chiral equivalents of nucleophilic glycine and alanine

Tetrahedron, 2001-07, Vol.57 (30), p.6375-6382

2001

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Virtually Complete Control of Simple and Face Diastereoselectivity in the Michael Addition Reactions between Achiral Equivalents of a Nucleophilic Glycine and (S)- or (R)-3-(E-Enoyl)-4-phenyl-1,3-oxazolidin-2-ones: Practical Method for Preparation of β-Substituted Pyroglutamic Acids and Prolines

Journal of organic chemistry, 2004-07, Vol.69 (15), p.4984-4990

2004

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Ligand Modulation of Lateral Segregation of a G-Protein-Coupled Receptor into Lipid Microdomains in Sphingomyelin/Phosphatidylcholine Solid-Supported Bilayers

Biochemistry (Easton), 2005-06, Vol.44 (25), p.9168-9178

2005

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Design of cyclic and other templates for potent and selective peptide α-MSH analogues

Current opinion in chemical biology, 2005-08, Vol.9 (4), p.352-358

2005

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Solid-Phase Synthesis of O-Linked Glycopeptide Analogues of Enkephalin

Journal of organic chemistry, 2001-04, Vol.66 (7), p.2327-2342

2001

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Structure-activity relationships of a series of [D-Ala2]deltorphin I and II analogues; in vitro blood-brain barrier permeability and stability

The Journal of pharmacology and experimental therapeutics, 1997-05, Vol.281 (2), p.817

1997

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Fentanyl-related compounds and derivatives: current status and future prospects for pharmaceutical applications

Designing peptide receptor agonists and antagonists

Synthesis and Evaluation of a Novel Bivalent Selective Antagonist for the Mu-Delta Opioid Receptor Heterodimer that Reduces Morphine Withdrawal in Mice

Synthesis of Essential Drugs

SNC 80, a selective, nonpeptidic and systemically active opioid delta agonist

Multiple Applications of a Novel Biarsenical Imaging Probe in Fluorescence and PET Imaging of Melanoma

Design in Topographical Space of Peptide and Peptidomimetic Ligands That Affect Behavior. A Chemist's Glimpse at the Mind−Body Problem

Blood-brain barrier permeability and bioavailability of a highly potent and mu-selective opioid receptor antagonist, CTAP: comparison with morphine

Role of melanocortinergic neurons in feeding and the agouti obesity syndrome

Conformational and topographical considerations in designing agonist peptidomimetics from peptide leads

Spinal or systemic TY005, a peptidic opioid agonist/neurokinin 1 antagonist, attenuates pain with reduced tolerance

Opioid antinociception in a rat model of visceral pain: systemic versus local drug administration

Exploring Ramachandran and chi space: conformationally constrained amino acids and peptides in the design of bioactive polypeptide ligands

Michael Addition Reactions between Chiral Equivalents of a Nucleophilic Glycine and (S)- or (R)-3-[(E)-Enoyl]-4-phenyl-1,3-oxazolidin-2-ones as a General Method for Efficient Preparation of β-Substituted Pyroglutamic Acids. Case of Topographically Controlled Stereoselectivity

Development and characterisation of novel fentanyl-delta opioid receptor antagonist based bivalent ligands

Role of NK-1 neurotransmission in opioid-induced hyperalgesia

Local inhibitory effects of dynorphin A-(1–17) on capsaicin-induced thermal allodynia in rhesus monkeys

Pronociceptive Actions of Dynorphin Maintain Chronic Neuropathic Pain

Phosphatidylethanolamine Enhances Rhodopsin Photoactivation and Transducin Binding in a Solid Supported Lipid Bilayer as Determined Using Plasmon-Waveguide Resonance Spectroscopy

Large-scale asymmetric synthesis of novel sterically constrained 2′,6′-dimethyl- and α,2′,6′-trimethyltyrosine and -phenylalanine derivatives via alkylation of chiral equivalents of nucleophilic glycine and alanine

Virtually Complete Control of Simple and Face Diastereoselectivity in the Michael Addition Reactions between Achiral Equivalents of a Nucleophilic Glycine and (S)- or (R)-3-(E-Enoyl)-4-phenyl-1,3-oxazolidin-2-ones: Practical Method for Preparation of β-Substituted Pyroglutamic Acids and Prolines

Ligand Modulation of Lateral Segregation of a G-Protein-Coupled Receptor into Lipid Microdomains in Sphingomyelin/Phosphatidylcholine Solid-Supported Bilayers

Design of cyclic and other templates for potent and selective peptide α-MSH analogues

Solid-Phase Synthesis of O-Linked Glycopeptide Analogues of Enkephalin

Structure-activity relationships of a series of [D-Ala2]deltorphin I and II analogues; in vitro blood-brain barrier permeability and stability

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