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Discovery of antitumor effects of leczymes

Glycoconjugate journal, 2022-04, Vol.39 (2), p.157-165

2022

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Catfish egg lectin affects influx and efflux rates of sunitinib in human cervical carcinoma HeLa cells

Glycobiology (Oxford), 2020-09, Vol.30 (10), p.802-816

2020

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Sialic acid-binding lectin from bullfrog eggs inhibits human malignant mesothelioma cell growth in vitro and in vivo

PloS one, 2018-01, Vol.13 (1), p.e0190653-e0190653

2018

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Increased sialidase activity in serum of cancer patients: Identification of sialidase and inhibitor activities in human serum

Cancer science, 2015-04, Vol.106 (4), p.383-389

2015

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A Sweet Delivery for a Really Bitter Pill: Globo H and RNase 1

ACS central science, 2015-07, Vol.1 (4), p.166-167

Hosono, Masahiro

2015

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Catfish Egg Lectin Enhances the Cytotoxicity of Sunitinib on Gb3-Expressing Renal Cancer Cells

Biomedicines, 2023-08, Vol.11 (8), p.2317

2023

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Sialic Acid-Binding Lectin from Bullfrog Eggs Exhibits an Anti-Tumor Effect Against Breast Cancer Cells Including Triple-Negative Phenotype Cells

Molecules (Basel, Switzerland), 2018-10, Vol.23 (10), p.2714

2018

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Synergistic anti-tumor effect of bullfrog sialic acid-binding lectin and pemetrexed in malignant mesothelioma

Oncotarget, 2017-06, Vol.8 (26), p.42466-42477

2017

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Sialidase NEU3 defines invasive potential of human glioblastoma cells by regulating calpain-mediated proteolysis of focal adhesion proteins

Biochimica et biophysica acta. General subjects, 2017-11, Vol.1861 (11), p.2778-2788

2017

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A Lectin from the Mussel Mytilus galloprovincialis Has a Highly Novel Primary Structure and Induces Glycan-mediated Cytotoxicity of Globotriaosylceramide-expressing Lymphoma Cells

The Journal of biological chemistry, 2012-12, Vol.287 (53), p.44772-44783

2012

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Upregulation of sialidase NEU3 in head and neck squamous cell carcinoma associated with lymph node metastasis

Cancer science, 2015-11, Vol.106 (11), p.1544-1553

2015

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Sialidase NEU3 Contributes to the Invasiveness of Bladder Cancer

Biomedicines, 2024-01, Vol.12 (1), p.192

2024

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Sialidase NEU3 contributes neoplastic potential on colon cancer cells as a key modulator of gangliosides by regulating Wnt signaling

International journal of cancer, 2015-10, Vol.137 (7), p.1560-1573

2015

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Lissoclibadin 1, a Polysulfur Aromatic Alkaloid from the Indonesian Ascidian Lissoclinum cf. badium, Induces Caspase-Dependent Apoptosis in Human Colon Cancer Cells and Suppresses Tumor Growth in Nude Mice

Journal of natural products (Washington, D.C.), 2017-02, Vol.80 (2), p.499-502

2017

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RNase activity of sialic acid-binding lectin from bullfrog eggs drives antitumor effect via the activation of p38 MAPK to caspase-3/7 signaling pathway in human breast cancer cells

International journal of oncology, 2016-10, Vol.49 (4), p.1334-1342

2016

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A GM1b/asialo‐GM1 oligosaccharide‐binding R‐type lectin from purplish bifurcate mussels Mytilisepta virgata and its effect on MAP kinases

The FEBS journal, 2020-06, Vol.287 (12), p.2612-2630

2020

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Sialic acid-binding lectin (leczyme) induces caspase-dependent apoptosis-mediated mitochondrial perturbation in Jurkat cells

International journal of oncology, 2013-11, Vol.43 (5), p.1402-1412

2013

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Human cytosolic sialidase NEU2-low general tissue expression but involvement in PC-3 prostate cancer cell survival

Biochemical and biophysical research communications, 2012-11, Vol.428 (1), p.142-149

2012

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Potentiation of epidermal growth factor-mediated oncogenic transformation by sialidase NEU3 leading to Src activation

PloS one, 2015-03, Vol.10 (3), p.e0120578

2015

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Involvement of ER stress in apoptosis induced by sialic acid-binding lectin (leczyme) from bullfrog eggs

International journal of oncology, 2013-12, Vol.43 (6), p.1799-1808

2013

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Catfish rhamnose-binding lectin induces G0/1 cell cycle arrest in Burkitt’s lymphoma cells via membrane surface Gb3

Glycoconjugate journal, 2017-02, Vol.34 (1), p.127-138

2017

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Phosphatidic acid‐mediated activation and translocation to the cell surface of sialidase NEU3, promoting signaling for cell migration

The FASEB journal, 2015-05, Vol.29 (5), p.2099-2111

2015

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MytiLec, a Mussel R-Type Lectin, Interacts with Surface Glycan Gb3 on Burkitt's Lymphoma Cells to Trigger Apoptosis through Multiple Pathways

Marine drugs, 2015-12, Vol.13 (12), p.7377-7389

2015

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Sialidase NEU4 Hydrolyzes Polysialic Acids of Neural Cell Adhesion Molecules and Negatively Regulates Neurite Formation by Hippocampal Neurons

The Journal of biological chemistry, 2012-04, Vol.287 (18), p.14816-14826

2012

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Plasma Membrane-Associated Sialidase Confers Cancer Initiation, Promotion and Progression

Advances in experimental medicine and biology, 2015-01, Vol.842, p.139-145

2015

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Discovery of antitumor effects of leczymes

Catfish egg lectin affects influx and efflux rates of sunitinib in human cervical carcinoma HeLa cells

Sialic acid-binding lectin from bullfrog eggs inhibits human malignant mesothelioma cell growth in vitro and in vivo

Increased sialidase activity in serum of cancer patients: Identification of sialidase and inhibitor activities in human serum

A Sweet Delivery for a Really Bitter Pill: Globo H and RNase 1

Catfish Egg Lectin Enhances the Cytotoxicity of Sunitinib on Gb3-Expressing Renal Cancer Cells

Sialic Acid-Binding Lectin from Bullfrog Eggs Exhibits an Anti-Tumor Effect Against Breast Cancer Cells Including Triple-Negative Phenotype Cells

Synergistic anti-tumor effect of bullfrog sialic acid-binding lectin and pemetrexed in malignant mesothelioma

Sialidase NEU3 defines invasive potential of human glioblastoma cells by regulating calpain-mediated proteolysis of focal adhesion proteins

A Lectin from the Mussel Mytilus galloprovincialis Has a Highly Novel Primary Structure and Induces Glycan-mediated Cytotoxicity of Globotriaosylceramide-expressing Lymphoma Cells

Upregulation of sialidase NEU3 in head and neck squamous cell carcinoma associated with lymph node metastasis

Sialidase NEU3 Contributes to the Invasiveness of Bladder Cancer

Sialidase NEU3 contributes neoplastic potential on colon cancer cells as a key modulator of gangliosides by regulating Wnt signaling

Lissoclibadin 1, a Polysulfur Aromatic Alkaloid from the Indonesian Ascidian Lissoclinum cf. badium, Induces Caspase-Dependent Apoptosis in Human Colon Cancer Cells and Suppresses Tumor Growth in Nude Mice

RNase activity of sialic acid-binding lectin from bullfrog eggs drives antitumor effect via the activation of p38 MAPK to caspase-3/7 signaling pathway in human breast cancer cells

A GM1b/asialo‐GM1 oligosaccharide‐binding R‐type lectin from purplish bifurcate mussels Mytilisepta virgata and its effect on MAP kinases

Sialic acid-binding lectin (leczyme) induces caspase-dependent apoptosis-mediated mitochondrial perturbation in Jurkat cells

Human cytosolic sialidase NEU2-low general tissue expression but involvement in PC-3 prostate cancer cell survival

Potentiation of epidermal growth factor-mediated oncogenic transformation by sialidase NEU3 leading to Src activation

Involvement of ER stress in apoptosis induced by sialic acid-binding lectin (leczyme) from bullfrog eggs

Catfish rhamnose-binding lectin induces G0/1 cell cycle arrest in Burkitt’s lymphoma cells via membrane surface Gb3

Phosphatidic acid‐mediated activation and translocation to the cell surface of sialidase NEU3, promoting signaling for cell migration

MytiLec, a Mussel R-Type Lectin, Interacts with Surface Glycan Gb3 on Burkitt's Lymphoma Cells to Trigger Apoptosis through Multiple Pathways

Sialidase NEU4 Hydrolyzes Polysialic Acids of Neural Cell Adhesion Molecules and Negatively Regulates Neurite Formation by Hippocampal Neurons

Plasma Membrane-Associated Sialidase Confers Cancer Initiation, Promotion and Progression

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