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Part 3: Synthesis and biological evaluation of some analogs of the antitumor agents, 2-{4-[(7-chloro-2-quinoxalinyl)oxy]phenoxy}propionic acid, and 2-{4-[(7-bromo-2-quinolinyl)oxy]phenoxy}propionic acid

Bioorganic & medicinal chemistry, 2005-02, Vol.13 (4), p.1069-1081

2005

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The role of autophagy in the death of L1210 leukemia cells initiated by the new antitumor agents, XK469 and SH80

Molecular cancer therapeutics, 2007-01, Vol.6 (1), p.370-379

2007

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Synthetic modification of the 2-oxypropionic acid moiety in 2-{4-[(7-chloro-2-quinoxalinyl)oxy]phenoxy}propionic acid (XK469), and consequent antitumor effects. Part 4

Bioorganic & medicinal chemistry, 2005-06, Vol.13 (12), p.3910-3920

2005

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Design, Synthesis, and Biological Evaluation of Analogues of the Antitumor Agent, 2-{4-[(7-Chloro-2-quinoxalinyl)oxy]phenoxy}propionic Acid (XK469)

Journal of medicinal chemistry, 2001-05, Vol.44 (11), p.1758-1776

2001

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II. Synthesis and Biological Evaluation of Some Bioisosteres and Congeners of the Antitumor Agent, 2-{4-[(7-Chloro-2-quinoxalinyl)oxy]phenoxy}propionic Acid (XK469)

Journal of medicinal chemistry, 2002-07, Vol.45 (14), p.3130-3137

2002

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Synthesis and biological evaluation of conformationally constrained analogs of the antitumor agents XK469 and SH80. Part 5

Bioorganic & medicinal chemistry, 2006-04, Vol.14 (7), p.2462-2467

2006

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A dihydropyridine carrier system for sustained delivery of 2',3'-dideoxynucleosides to the brain

Journal of medicinal chemistry, 1989-03, Vol.32 (3), p.622-625

1989

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Pro-apoptotic interactions between XK469 and the peripheral benzodiazepine receptor

Cancer letters, 2001-07, Vol.168 (2), p.141-144

2001

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Pharmacokinetics and tissue distribution of cryptophycin 52 (C-52) epoxide and cryptophycin 55 (C-55) chlorohydrin in mice with subcutaneous tumors

Cancer chemotherapy and pharmacology, 2003-07, Vol.52 (1), p.25-33

2003

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Preclinical efficacy evaluations of XK-469: Dose schedule, route and cross-resistance behavior in tumor bearing mice

Investigational new drugs, 2002-02, Vol.20 (1), p.13-22

2002

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Preclinical efficacy of thioxanthone SR271425 against transplanted solid tumors of mouse and human origin

Investigational new drugs, 1999-02, Vol.17 (1), p.17-27

1999

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Lack of in vitro-in vivo correlation of a novel investigational anticancer agent, SH 30

Investigational new drugs, 2002-02, Vol.20 (1), p.23-33

2002

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Synthesis and in vitro evaluation of some modified 4-thiopyrimidine nucleosides for prevention or reversal of AIDS - associated neurological disorders

Journal of medicinal chemistry, 1990-01, Vol.33 (1), p.258-263

1990

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Comparative molecular field analysis of in vitro growth inhibition of L1210 and HCT-8 cells by some pyrazoloacridines

Journal of medicinal chemistry, 1993-11, Vol.36 (23), p.3511-3516

1993

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Nucleosides. XVII. Benzylation-debenzylation studies on nucleosides

Journal of organic chemistry, 1975-06, Vol.40 (12), p.1856-1858

1975

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Comparative Molecular Field Analysis of the Antitumor Activity of 9H-Thiioxanthen-9-one Derivatives against Pancreatic Ductal Carcinoma 03

Journal of medicinal chemistry, 1994-03, Vol.37 (6), p.781-786

1994

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Addition of diazomethane to 1,2-O-isopropylidene-5-O-trityl-.alpha.-D-erythro-pentos-3-ulose

Journal of organic chemistry, 1970-07, Vol.35 (7), p.2335-2339

1970

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Nucleosides. II. 5'-O-Mesylthymidine and 3'-O-Mesylthymidine1

Journal of organic chemistry, 1962-09, Vol.27 (9), p.3300-3302

1962

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The Synthesis of 1-Substituted 5(4H)Tetrazolinones1a,b

Journal of the American Chemical Society, 1959-06, Vol.81 (12), p.3076-3079

1959

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Alkoxyl migration in displacement of a 5-trifluoromethanesulfonyloxy group from ribofuranosides

Journal of organic chemistry, 1982-02, Vol.47 (4), p.644-649

1982

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The Effect of Structure on the Course of the Schmidt Reaction on Unsymmetrical Ketones1

Journal of the American Chemical Society, 1950-08, Vol.72 (8), p.3718-3722

1950

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In vitro inhibition of estrogen sulfoconjugation by some 2- and 4-substituted estra-1,3,5(10)-trien-17.beta.-ols

Journal of medicinal chemistry, 1986-05, Vol.29 (5), p.692-698

1986

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Factors influencing the H6 chemical shift in pyrimidine nucleosides

Journal of the American Chemical Society, 1975-07, Vol.97 (14), p.4089-4095

1975

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II. Synthesis and biological evaluation of some bioisosteres and congeners of the antitumor agent, 2-(4-[(7-chloro-2-quinoxalinyl)oxy]phenoxy)propionic acid (XK469)

Journal of medicinal chemistry, 2002-07, Vol.45 (14), p.3130-3137

2002

Volltextzugriff (PDF)

Preclinical antitumor efficacy of analogs of XK469: sodium-(2-[4-(7-chloro-2-quinoxalinyloxy)phenoxy]propionate

Investigational new drugs, 1998-01, Vol.16 (2), p.129-139

1998

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Part 3: Synthesis and biological evaluation of some analogs of the antitumor agents, 2-{4-[(7-chloro-2-quinoxalinyl)oxy]phenoxy}propionic acid, and 2-{4-[(7-bromo-2-quinolinyl)oxy]phenoxy}propionic acid

The role of autophagy in the death of L1210 leukemia cells initiated by the new antitumor agents, XK469 and SH80

Synthetic modification of the 2-oxypropionic acid moiety in 2-{4-[(7-chloro-2-quinoxalinyl)oxy]phenoxy}propionic acid (XK469), and consequent antitumor effects. Part 4

Design, Synthesis, and Biological Evaluation of Analogues of the Antitumor Agent, 2-{4-[(7-Chloro-2-quinoxalinyl)oxy]phenoxy}propionic Acid (XK469)

II. Synthesis and Biological Evaluation of Some Bioisosteres and Congeners of the Antitumor Agent, 2-{4-[(7-Chloro-2-quinoxalinyl)oxy]phenoxy}propionic Acid (XK469)

Synthesis and biological evaluation of conformationally constrained analogs of the antitumor agents XK469 and SH80. Part 5

A dihydropyridine carrier system for sustained delivery of 2',3'-dideoxynucleosides to the brain

Pro-apoptotic interactions between XK469 and the peripheral benzodiazepine receptor

Pharmacokinetics and tissue distribution of cryptophycin 52 (C-52) epoxide and cryptophycin 55 (C-55) chlorohydrin in mice with subcutaneous tumors

Preclinical efficacy evaluations of XK-469: Dose schedule, route and cross-resistance behavior in tumor bearing mice

Preclinical efficacy of thioxanthone SR271425 against transplanted solid tumors of mouse and human origin

Lack of in vitro-in vivo correlation of a novel investigational anticancer agent, SH 30

Synthesis and in vitro evaluation of some modified 4-thiopyrimidine nucleosides for prevention or reversal of AIDS - associated neurological disorders

Comparative molecular field analysis of in vitro growth inhibition of L1210 and HCT-8 cells by some pyrazoloacridines

Nucleosides. XVII. Benzylation-debenzylation studies on nucleosides

Comparative Molecular Field Analysis of the Antitumor Activity of 9H-Thiioxanthen-9-one Derivatives against Pancreatic Ductal Carcinoma 03

Addition of diazomethane to 1,2-O-isopropylidene-5-O-trityl-.alpha.-D-erythro-pentos-3-ulose

Nucleosides. II. 5'-O-Mesylthymidine and 3'-O-Mesylthymidine1

The Synthesis of 1-Substituted 5(4H)Tetrazolinones1a,b

Alkoxyl migration in displacement of a 5-trifluoromethanesulfonyloxy group from ribofuranosides

The Effect of Structure on the Course of the Schmidt Reaction on Unsymmetrical Ketones1

In vitro inhibition of estrogen sulfoconjugation by some 2- and 4-substituted estra-1,3,5(10)-trien-17.beta.-ols

Factors influencing the H6 chemical shift in pyrimidine nucleosides

II. Synthesis and biological evaluation of some bioisosteres and congeners of the antitumor agent, 2-(4-[(7-chloro-2-quinoxalinyl)oxy]phenoxy)propionic acid (XK469)

Preclinical antitumor efficacy of analogs of XK469: sodium-(2-[4-(7-chloro-2-quinoxalinyloxy)phenoxy]propionate

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