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Adverse outcome pathways: A conceptual framework to support ecotoxicology research and risk assessment

Environmental toxicology and chemistry, 2010-03, Vol.29 (3), p.730-741

2010

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Screening the ToxCast Phase 1, Phase 2, and e1k Chemical Libraries for Inhibitors of Iodothyronine Deiodinases

Toxicological sciences, 2019-04, Vol.168 (2), p.430-442

2019

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Screening the ToxCast Phase 1 Chemical Library for Inhibition of Deiodinase Type 1 Activity

Toxicological sciences, 2018-04, Vol.162 (2), p.570-581

2018

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Evaluating Chemicals for Thyroid Disruption: Opportunities and Challenges with in Vitro Testing and Adverse Outcome Pathway Approaches

Environmental health perspectives, 2019-09, Vol.127 (9), p.95001

2019

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Early temporal effects of three thyroid hormone synthesis inhibitors in Xenopus laevis

Aquatic toxicology, 2010-06, Vol.98 (1), p.44-50

2010

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Tiered High-Throughput Screening Approach to Identify Thyroperoxidase Inhibitors Within the ToxCast Phase I and II Chemical Libraries

Toxicological sciences, 2016-05, Vol.151 (1), p.160-180

2016

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Assessing utility of thyroid in vitro screening assays through comparisons to observed impacts in vivo

Regulatory toxicology and pharmacology, 2023-10, Vol.144 (C), p.105491-105491, Article 105491

2023

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In Vitro, Ex Vivo, and In Vivo Determination of Thyroid Hormone Modulating Activity of Benzothiazoles

Toxicological sciences, 2015-08, Vol.146 (2), p.254-264

2015

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Cross-species comparison of chemical inhibition of human and Xenopus iodotyrosine deiodinase

Aquatic toxicology, 2022-08, Vol.249, p.106227-106227, Article 106227

2022

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Thyroid-stimulating hormone (TSH): Measurement of intracellular, secreted, and circulating hormone in Xenopus laevis and Xenopus tropicalis

General and comparative endocrinology, 2011-05, Vol.171 (3), p.319-325

2011

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Tissue Distribution and Metabolism of Benzo[a]pyrene in Embryonic and Larval Medaka (Oryzias latipes)

Toxicological sciences, 2007-12, Vol.100 (2), p.393-405

2007

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Development of a Thyroperoxidase Inhibition Assay for High-Throughput Screening

Chemical research in toxicology, 2014-03, Vol.27 (3), p.387-399

2014

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A biologically based computational model for the hypothalamic-pituitary-thyroid (HPT) axis in Xenopus laevis larvae

Mathematical biosciences, 2023-08, Vol.362, p.109021-109021, Article 109021

2023

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In vitro screening of per- and polyfluorinated substances (PFAS) for interference with seven thyroid hormone system targets across nine assays

Toxicology in vitro, 2024-03, Vol.95 (C), p.105762-105762, Article 105762

2024

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Characterization of the Mechanistic Linkages Between Iodothyronine Deiodinase Inhibition and Impaired Thyroid-Mediated Growth and Development in Xenopus laevis Using Iopanoic Acid

Toxicological sciences, 2022-04, Vol.187 (1), p.139-149

2022

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In vitro screening for chemical inhibition of the iodide recycling enzyme, iodotyrosine deiodinase

Toxicology in vitro, 2021-03, Vol.71, p.105073-105073, Article 105073

2021

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Evaluation of the scientific underpinnings for identifying estrogenic chemicals in nonmammalian taxa using mammalian test systems

Environmental toxicology and chemistry, 2016-11, Vol.35 (11), p.2806-2816

2016

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Targeted Pathway-based In Vivo Testing Using Thyroperoxidase Inhibition to Evaluate Plasma Thyroxine as a Surrogate Metric of Metamorphic Success in Model Amphibian Xenopus laevis

Toxicological sciences, 2020-06, Vol.175 (2), p.236-250

2020

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Evaluating potential developmental toxicity of perfluoroalkyl and polyfluoroalkyl substances in Xenopus laevis embryos and larvae

Journal of applied toxicology, 2024-07, Vol.44 (7), p.1040-1049

2024

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Xenopus laevis and human type 3 iodothyronine deiodinase enzyme cross-species sensitivity to inhibition by ToxCast chemicals

Toxicology in vitro, 2021-06, Vol.73, p.105141-105141, Article 105141

2021

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Evaluating Iodide Recycling Inhibition as a Novel Molecular Initiating Event for Thyroid Axis Disruption in Amphibians

Toxicological sciences, 2018-12, Vol.166 (2), p.318-331

2018

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Cross-species analysis of thyroperoxidase inhibition by xenobiotics demonstrates conservation of response between pig and rat

Toxicology (Amsterdam), 2013-10, Vol.312, p.97-107

2013

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Metabolism of cyclic phenones in rainbow trout in vitro assays

Xenobiotica, 2020-02, Vol.50 (2), p.115-131

2020

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Evaluation of the Aromatase Inhibitor Fadrozole in a Short-Term Reproduction Assay with the Fathead Minnow (Pimephales promelas)

Toxicological sciences, 2002-05, Vol.67 (1), p.121-130

2002

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Effects of the androgenic growth promoter 17-β-trenbolone on fecundity and reproductive endocrinology of the fathead minnow

Environmental toxicology and chemistry, 2003-06, Vol.22 (6), p.1350-1360

2003

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Adverse outcome pathways: A conceptual framework to support ecotoxicology research and risk assessment

Screening the ToxCast Phase 1, Phase 2, and e1k Chemical Libraries for Inhibitors of Iodothyronine Deiodinases

Screening the ToxCast Phase 1 Chemical Library for Inhibition of Deiodinase Type 1 Activity

Evaluating Chemicals for Thyroid Disruption: Opportunities and Challenges with in Vitro Testing and Adverse Outcome Pathway Approaches

Early temporal effects of three thyroid hormone synthesis inhibitors in Xenopus laevis

Tiered High-Throughput Screening Approach to Identify Thyroperoxidase Inhibitors Within the ToxCast Phase I and II Chemical Libraries

Assessing utility of thyroid in vitro screening assays through comparisons to observed impacts in vivo

In Vitro, Ex Vivo, and In Vivo Determination of Thyroid Hormone Modulating Activity of Benzothiazoles

Cross-species comparison of chemical inhibition of human and Xenopus iodotyrosine deiodinase

Thyroid-stimulating hormone (TSH): Measurement of intracellular, secreted, and circulating hormone in Xenopus laevis and Xenopus tropicalis

Tissue Distribution and Metabolism of Benzo[a]pyrene in Embryonic and Larval Medaka (Oryzias latipes)

Development of a Thyroperoxidase Inhibition Assay for High-Throughput Screening

A biologically based computational model for the hypothalamic-pituitary-thyroid (HPT) axis in Xenopus laevis larvae

In vitro screening of per- and polyfluorinated substances (PFAS) for interference with seven thyroid hormone system targets across nine assays

Characterization of the Mechanistic Linkages Between Iodothyronine Deiodinase Inhibition and Impaired Thyroid-Mediated Growth and Development in Xenopus laevis Using Iopanoic Acid

In vitro screening for chemical inhibition of the iodide recycling enzyme, iodotyrosine deiodinase

Evaluation of the scientific underpinnings for identifying estrogenic chemicals in nonmammalian taxa using mammalian test systems

Targeted Pathway-based In Vivo Testing Using Thyroperoxidase Inhibition to Evaluate Plasma Thyroxine as a Surrogate Metric of Metamorphic Success in Model Amphibian Xenopus laevis

Evaluating potential developmental toxicity of perfluoroalkyl and polyfluoroalkyl substances in Xenopus laevis embryos and larvae

Xenopus laevis and human type 3 iodothyronine deiodinase enzyme cross-species sensitivity to inhibition by ToxCast chemicals

Evaluating Iodide Recycling Inhibition as a Novel Molecular Initiating Event for Thyroid Axis Disruption in Amphibians

Cross-species analysis of thyroperoxidase inhibition by xenobiotics demonstrates conservation of response between pig and rat

Metabolism of cyclic phenones in rainbow trout in vitro assays

Evaluation of the Aromatase Inhibitor Fadrozole in a Short-Term Reproduction Assay with the Fathead Minnow (Pimephales promelas)

Effects of the androgenic growth promoter 17-β-trenbolone on fecundity and reproductive endocrinology of the fathead minnow

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