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Use of precision cut lung slices as a translational model for the study of lung biology

Respiratory research, 2019-07, Vol.20 (1), p.162-14, Article 162

2019

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A high content screening assay to predict human drug-induced liver injury during drug discovery

Journal of pharmacological and toxicological methods, 2013-11, Vol.68 (3), p.302-313

2013

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Advances in Predictive Toxicology for Discovery Safety through High Content Screening

Chemical research in toxicology, 2016-12, Vol.29 (12), p.1998-2007

2016

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Exploratory toxicology as an integrated part of drug discovery. Part I: Why and how

Drug discovery today, 2014-08, Vol.19 (8), p.1131-1136

2014

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In vitro prediction of organ toxicity: the challenges of scaling and secondary mechanisms of toxicity

Archives of toxicology, 2020-02, Vol.94 (2), p.353-356

2020

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Mapping spatially resolved transcriptomes in human and mouse pulmonary fibrosis

Nature genetics, 2024-08, Vol.56 (8), p.1725-1736

2024

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Correction to: In vitro prediction of organ toxicity: the challenges of scaling and secondary mechanisms of toxicity

Archives of toxicology, 2021-09, Vol.95 (9), p.3141-3141

2021

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Compound selection and annotation to validate the predictivity of in vitro toxicity assays for use in drug discovery, in response to Commentary by Dr. Zink (Zink, D. Arch Toxicol (2018))

Archives of toxicology, 2019-01, Vol.93 (1), p.225-226

2019

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Exploratory toxicology as an integrated part of drug discovery. Part II: Screening strategies

Drug discovery today, 2014-08, Vol.19 (8), p.1137-1144

2014

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A novel multi-parametric high content screening assay in ciPTEC-OAT1 to predict drug-induced nephrotoxicity during drug discovery

Archives of toxicology, 2018-10, Vol.92 (10), p.3175-3190

2018

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A novel in vitro high-content imaging assay for the prediction of drug-induced lung toxicity

Archives of toxicology, 2024-09, Vol.98 (9), p.2985-2998

2024

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High‐Content Analysis/Screening for Predictive Toxicology: Application to Hepatotoxicity and Genotoxicity

Basic & clinical pharmacology & toxicology, 2014-07, Vol.115 (1), p.18-23

2014

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Cancer: A Systems Biology disease

BioSystems, 2006-02, Vol.83 (2), p.81-90

2006

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Validation of a high throughput flow cytometric in vitro micronucleus assay including assessment of metabolic activation in TK6 cells

Environmental and molecular mutagenesis, 2014-12, Vol.55 (9), p.704-718

2014

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How can we discover safer drugs?

Future medicinal chemistry, 2014-04, Vol.6 (5), p.481-483

2014

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Control of MAPK signalling: from complexity to what really matters

Oncogene, 2005-08, Vol.24 (36), p.5533-5542

2005

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Principles behind the multifarious control of signal transduction. ERK phosphorylation and kinase/phosphatase control

The FEBS journal, 2005-01, Vol.272 (1), p.244-258

2005

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Metabolic control analysis to identify optimal drug targets

Progress in drug research, 2007, Vol.64, p.171, 173

2007

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Designing multi-target drugs

1, 2012

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Characterization and optimization of a red-shifted fluorescence polarization ADP detection assay

Assay and drug development technologies, 2009-02, Vol.7 (1), p.56-67

2009

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Finding the way in the jungle of kinase drug targets

Drug discovery today. Technologies, 2007, Vol.4 (3), p.e91-e95

2007

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Oncogenes are to lose control on signaling following mutation: should we aim off target?

Molecular biotechnology, 2006-10, Vol.34 (2), p.109-116

2006

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Synthesis and Characterization of the Novel Rodent-Active and CNS-Penetrant P2X7 Receptor Antagonist Lu AF27139

Journal of medicinal chemistry, 2021-04, Vol.64 (8), p.4891-4902

2021

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Use of ex-vivo testis culture to explore mechanisms of seminiferous tubular atrophy upon PIM inhibition

Toxicology letters, 2017-10, Vol.280, p.S164-S164

2017

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The NosX and NirX Proteins of Paracoccus denitrificans Are Functional Homologues: Their Role in Maturation of Nitrous Oxide Reductase

Journal of Bacteriology, 2000-09, Vol.182 (18), p.5211-5217

2000

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Use of precision cut lung slices as a translational model for the study of lung biology

A high content screening assay to predict human drug-induced liver injury during drug discovery

Advances in Predictive Toxicology for Discovery Safety through High Content Screening

Exploratory toxicology as an integrated part of drug discovery. Part I: Why and how

In vitro prediction of organ toxicity: the challenges of scaling and secondary mechanisms of toxicity

Mapping spatially resolved transcriptomes in human and mouse pulmonary fibrosis

Correction to: In vitro prediction of organ toxicity: the challenges of scaling and secondary mechanisms of toxicity

Compound selection and annotation to validate the predictivity of in vitro toxicity assays for use in drug discovery, in response to Commentary by Dr. Zink (Zink, D. Arch Toxicol (2018))

Exploratory toxicology as an integrated part of drug discovery. Part II: Screening strategies

A novel multi-parametric high content screening assay in ciPTEC-OAT1 to predict drug-induced nephrotoxicity during drug discovery

A novel in vitro high-content imaging assay for the prediction of drug-induced lung toxicity

High‐Content Analysis/Screening for Predictive Toxicology: Application to Hepatotoxicity and Genotoxicity

Cancer: A Systems Biology disease

Validation of a high throughput flow cytometric in vitro micronucleus assay including assessment of metabolic activation in TK6 cells

How can we discover safer drugs?

Control of MAPK signalling: from complexity to what really matters

Principles behind the multifarious control of signal transduction. ERK phosphorylation and kinase/phosphatase control

Metabolic control analysis to identify optimal drug targets

Designing multi-target drugs

Characterization and optimization of a red-shifted fluorescence polarization ADP detection assay

Finding the way in the jungle of kinase drug targets

Oncogenes are to lose control on signaling following mutation: should we aim off target?

Synthesis and Characterization of the Novel Rodent-Active and CNS-Penetrant P2X7 Receptor Antagonist Lu AF27139

Use of ex-vivo testis culture to explore mechanisms of seminiferous tubular atrophy upon PIM inhibition

The NosX and NirX Proteins of Paracoccus denitrificans Are Functional Homologues: Their Role in Maturation of Nitrous Oxide Reductase

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