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Structure and development of single domain antibodies as modules for therapeutics and diagnostics

Experimental Biology and Medicine, 2019-12, Vol.244 (17), p.1568-1576

2019

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Molecular recognition requires dimerization of a VHH antibody

mAbs, 2023, Vol.15 (1), p.2215363-2215363

2023

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A combinatorial histidine scanning library approach to engineer highly pH‐dependent protein switches

Protein science, 2011-09, Vol.20 (9), p.1619-1631

2011

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Inhibitors of Rickettsia prowazekii methionine aminopeptidase 1 identified from the Pandemic Response Box

Bioorganic & medicinal chemistry letters, 2024-11, Vol.112, p.129931, Article 129931

2024

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Structural basis of an engineered dual-specific antibody: conformational diversity leads to a hypervariable loop metal-binding site

Protein engineering, design and selection, 2014-10, Vol.27 (10), p.391-397

2014

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Hapten-Induced Dimerization of a Single-Domain VHH Camelid Antibody

Biochemistry (Easton), 2009-07, Vol.48 (29), p.6693-6695

2009

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Novel inhibitors of Rickettsia prowazekii methionine aminopeptidase from the Malaria Box

Bioorganic & medicinal chemistry letters, 2023-05, Vol.87, p.129281-129281, Article 129281

2023

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Engineering pH-Sensitive Single-Domain Antibodies

Methods in molecular biology (Clifton, N.J.), 2022, Vol.2446, p.269

2022

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Principal determinants leading to transition state formation of a protein-protein complex, orientation trumps side-chain interactions

Proceedings of the National Academy of Sciences - PNAS, 2009-02, Vol.106 (8), p.2559-2564

2009

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Production and characterization of a genetically engineered anti-caffeine camelid antibody and its use in immunoaffinity chromatography

Journal of chromatography. B, Analytical technologies in the biomedical and life sciences, 2010-01, Vol.878 (2), p.177-186

2010

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Reply to Kang and Brooks: Comment on the calculations in protein thermodynamics

The Journal of biological chemistry, 2018-04, Vol.293 (14), p.5063-5063

2018

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An anti‐hapten camelid antibody reveals a cryptic binding site with significant energetic contributions from a nonhypervariable loop

Protein science, 2011-07, Vol.20 (7), p.1196-1207

2011

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Engineered synthetic antibodies as probes to quantify the energetic contributions of ligand binding to conformational changes in proteins

The Journal of biological chemistry, 2018-02, Vol.293 (8), p.2815-2828

2018

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Structural and biophysical characterization of the Burkholderia pseudomallei IspF inhibitor L-tryptophan hydroxamate

Bioorganic & medicinal chemistry letters, 2021-09, Vol.48, p.128273-128273, Article 128273

2021

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Modular design of paper based switches for autonomous lab-on paper micro devices

Biomedical microdevices, 2021-03, Vol.23 (1), p.1, Article 1

2021

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Site-directed immobilization of a genetically engineered anti-methotrexate antibody via an enzymatically introduced biotin label significantly increases the binding capacity of immunoaffinity columns

Journal of chromatography. B, Analytical technologies in the biomedical and life sciences, 2016-05, Vol.1021, p.114-121

2016

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Shotgun Alanine Scanning Shows That Growth Hormone Can Bind Productively to Its Receptor through a Drastically Minimized Interface

The Journal of biological chemistry, 2005-07, Vol.280 (27), p.25524-25532

2005

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Antibacterial activity of 2-amino-4-hydroxypyrimidine-5-carboxylates and binding to Burkholderia pseudomallei 2-C-methyl-d-erythritol-2,4-cyclodiphosphate synthase

Bioorganic & medicinal chemistry letters, 2019-10, Vol.29 (20), p.126660-126660, Article 126660

2019

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Allosteric Inhibition Through Core Disruption

Journal of molecular biology, 2004-03, Vol.336 (5), p.1283-1291

2004

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Rickettsia prowazekii methionine aminopeptidase as a promising target for the development of antibacterial agents

Bioorganic & medicinal chemistry, 2017-02, Vol.25 (3), p.813-824

2017

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Crystal structure and biophysical characterization of IspD from Burkholderia thailandensis and Mycobacterium paratuberculosis

Acta crystallographica. Section F, Structural biology communications, 2024-02, Vol.80 (2), p.43-51

2024

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The identification of inhibitory compounds of Rickettsia prowazekii methionine aminopeptidase for antibacterial applications

Bioorganic & medicinal chemistry letters, 2018-05, Vol.28 (8), p.1376-1380

2018

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A Combinatorial Approach to Engineering a Dual-Specific Metal Switch Antibody

Biochemistry (Easton), 2011-06, Vol.50 (23), p.5093-5095

2011

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Mutations in the coat protein-binding cis-acting RNA motifs debilitate RNA recombination of Brome mosaic virus

Virus research, 2012-12, Vol.170 (1-2), p.138-149

2012

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van't Hoff and Calorimetric Enthalpies from Isothermal Titration Calorimetry: Are There Significant Discrepancies?

Biochemistry (Easton), 2001-02, Vol.40 (6), p.1774-1778

2001

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Structure and development of single domain antibodies as modules for therapeutics and diagnostics

Molecular recognition requires dimerization of a VHH antibody

A combinatorial histidine scanning library approach to engineer highly pH‐dependent protein switches

Inhibitors of Rickettsia prowazekii methionine aminopeptidase 1 identified from the Pandemic Response Box

Structural basis of an engineered dual-specific antibody: conformational diversity leads to a hypervariable loop metal-binding site

Hapten-Induced Dimerization of a Single-Domain VHH Camelid Antibody

Novel inhibitors of Rickettsia prowazekii methionine aminopeptidase from the Malaria Box

Engineering pH-Sensitive Single-Domain Antibodies

Principal determinants leading to transition state formation of a protein-protein complex, orientation trumps side-chain interactions

Production and characterization of a genetically engineered anti-caffeine camelid antibody and its use in immunoaffinity chromatography

Reply to Kang and Brooks: Comment on the calculations in protein thermodynamics

An anti‐hapten camelid antibody reveals a cryptic binding site with significant energetic contributions from a nonhypervariable loop

Engineered synthetic antibodies as probes to quantify the energetic contributions of ligand binding to conformational changes in proteins

Structural and biophysical characterization of the Burkholderia pseudomallei IspF inhibitor L-tryptophan hydroxamate

Modular design of paper based switches for autonomous lab-on paper micro devices

Site-directed immobilization of a genetically engineered anti-methotrexate antibody via an enzymatically introduced biotin label significantly increases the binding capacity of immunoaffinity columns

Shotgun Alanine Scanning Shows That Growth Hormone Can Bind Productively to Its Receptor through a Drastically Minimized Interface

Antibacterial activity of 2-amino-4-hydroxypyrimidine-5-carboxylates and binding to Burkholderia pseudomallei 2-C-methyl-d-erythritol-2,4-cyclodiphosphate synthase

Allosteric Inhibition Through Core Disruption

Rickettsia prowazekii methionine aminopeptidase as a promising target for the development of antibacterial agents

Crystal structure and biophysical characterization of IspD from Burkholderia thailandensis and Mycobacterium paratuberculosis

The identification of inhibitory compounds of Rickettsia prowazekii methionine aminopeptidase for antibacterial applications

A Combinatorial Approach to Engineering a Dual-Specific Metal Switch Antibody

Mutations in the coat protein-binding cis-acting RNA motifs debilitate RNA recombination of Brome mosaic virus

van't Hoff and Calorimetric Enthalpies from Isothermal Titration Calorimetry: Are There Significant Discrepancies?

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