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Discovery of clinical candidate Sivopixant (S-600918): Lead optimization of dioxotriazine derivatives as selective P2X3 receptor antagonists

Bioorganic & medicinal chemistry letters, 2021-11, Vol.52, p.128384-128384, Article 128384

2021

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Relationship between the Structures of Taxane Derivatives and Their Microtubule Polymerization Activity

Bioscience, biotechnology, and biochemistry, 2012, Vol.76 (2), p.349-352

2012

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Studies on Taxol biosynthesis: preparation of taxadiene-diol and triol derivatives by deoxygenation of taxusin

Tetrahedron, 2008-01, Vol.64 (27), p.6561-6567

2008

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Dioxotriazine derivatives as a new class of P2X3 receptor antagonists: Identification of a lead and initial SAR studies

Bioorganic & medicinal chemistry letters, 2021-04, Vol.37, p.127833-127833, Article 127833

2021

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Pyrrolinone derivatives as a new class of P2X3 receptor antagonists. Part 3: Structure-activity relationships of pyrropyrazolone derivatives

Bioorganic & medicinal chemistry letters, 2020-12, Vol.30 (24), p.127636-127636, Article 127636

2020

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Pyrrolinone derivatives as a new class of P2X3 receptor antagonists Part 2: Discovery of orally bioavailable compounds

Bioorganic & medicinal chemistry letters, 2019-03, Vol.29 (5), p.688-693

2019

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Dioxotriazine derivatives as a new class of P2X 3 receptor antagonists: Identification of a lead and initial SAR studies

Bioorganic & medicinal chemistry letters, 2021-04, Vol.37, p.127833

2021

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Two novel taxane diterpenoids from the needles of Japanese yew, Taxus cuspidata

Bioscience, biotechnology, and biochemistry, 2000-04, Vol.64 (4), p.894-898

2000

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Four novel taxane diterpenoids from the needles of Japanese yew, Taxus cuspidata

Bioscience, biotechnology, and biochemistry, 1999, Vol.63 (5), p.924-929

1999

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A novel rearranged taxoid from needles of the Japanese yew, Taxus cuspidata Sieb. et Zucc

Bioscience, biotechnology, and biochemistry, 1999-01, Vol.63 (9), p.1660-1663

1999

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Three New Rearranged Taxane Diterpenoids from the Bark of Taxus chinensis var. mairei and the Needles of Taxus cuspidata

Heterocycles, 1999-04, Vol.51 (4), p.841

1999

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Et2AlCl-Mediated Reaction of α-4(20)-Epoxy-5α -hydroxy Taxinine B

中国化学快报, 2000-03, Vol.11 (3), p.199-202

2000

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Imaging of Digital Versatile Rewritable Disc using the Reflection-Mode Scattering-Type Scanning Near-Field Optical Microscope

Japanese Journal of Applied Physics, 2001-03, Vol.40 (3S), p.1578

2001

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Administering cultured Taxus cells with early precursors reveals bifurcations in the taxoid biosynthetic pathway

Phytochemistry (Oxford), 2007-02, Vol.68 (3), p.335-341

2007

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Synthesis and biological evaluation of 4-Deacetoxy-1,7-dideoxy azetidine paclitaxel analogues

Bioorganic & medicinal chemistry letters, 2003-03, Vol.13 (6), p.1075-1077

2003

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Feeding Cultured Taxus Cells with Early Precursors Reveals Bifurcations in the Taxoid Biosynthetic Pathway

Phytochemistry (Oxford), 2006-12, Vol.68 (3), p.335-341

2006

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Studies on Taxol® biosynthesis. Preparation and tritium labeling of biosynthetic intermediates by deoxygenation of a taxadiene tetra-acetate obtained from Japanese yew

Journal of labelled compounds & radiopharmaceuticals, 2008-08, Vol.51 (9), p.325-328

2008

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Synthesis and antitumor activity of 2-( m-substituted-benzoyl)baccatin III analogs from taxinine

Tetrahedron, 2003-02, Vol.59 (9), p.1529-1538

2003

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( iPrO) 3TiCl-induced reactions of α- and β-4(20)-epoxy-5-hydroxytriacetyltaxicin I

Tetrahedron, 1999-10, Vol.55 (41), p.12099-12108

1999

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Studies on taxol biosynthesis. Preparation of 5α-acetoxytaxa-4(20),11-dien-2α,10β-diol derivatives by deoxygenation of a taxadiene tetra-acetate obtained from Japanese yew

Tetrahedron, 2003, Vol.59 (2), p.267-273

2003

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Studies on Taxol Biosynthesis. Preparation of Taxa-4(20),11(12)-dien-5α-acetoxy-10β-ol by Deoxygenation of a Taxadiene Tetraacetate Obtained from Japanese Yew

Journal of organic chemistry, 2002-07, Vol.67 (14), p.4901-4903

2002

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A study on the mechanism of enhanced diuresis following direct hemoperfusion with polymyxin B-immobilized fiber

The Japanese Journal of Nephrology, 2000/07/25, Vol.42(5), pp.359-364

2000

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Highly regio- and stereospecific hydroxylation of C-1 position of 2-deacetoxytaxinine J derivative with DMDO

Tetrahedron letters, 2000-05, Vol.41 (20), p.3907-3910

2000

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The Synthesis and Biological Activity of 9- and 2′-cAMP 7-Deoxypaclitaxel Analogues from 5-Cinnamoyltriacetyltaxicin-I

Tetrahedron, 2000-03, Vol.56 (12), p.1667-1679

2000

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Synthesis and biological evaluation of novel 9-functional heterocyclic coupled 7-deoxy-9-Dihydropaclitaxel analogue

Bioorganic & medicinal chemistry letters, 2000-03, Vol.10 (5), p.517-521

2000

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Discovery of clinical candidate Sivopixant (S-600918): Lead optimization of dioxotriazine derivatives as selective P2X3 receptor antagonists

Relationship between the Structures of Taxane Derivatives and Their Microtubule Polymerization Activity

Studies on Taxol biosynthesis: preparation of taxadiene-diol and triol derivatives by deoxygenation of taxusin

Dioxotriazine derivatives as a new class of P2X3 receptor antagonists: Identification of a lead and initial SAR studies

Pyrrolinone derivatives as a new class of P2X3 receptor antagonists. Part 3: Structure-activity relationships of pyrropyrazolone derivatives

Pyrrolinone derivatives as a new class of P2X3 receptor antagonists Part 2: Discovery of orally bioavailable compounds

Dioxotriazine derivatives as a new class of P2X 3 receptor antagonists: Identification of a lead and initial SAR studies

Two novel taxane diterpenoids from the needles of Japanese yew, Taxus cuspidata

Four novel taxane diterpenoids from the needles of Japanese yew, Taxus cuspidata

A novel rearranged taxoid from needles of the Japanese yew, Taxus cuspidata Sieb. et Zucc

Three New Rearranged Taxane Diterpenoids from the Bark of Taxus chinensis var. mairei and the Needles of Taxus cuspidata

Et2AlCl-Mediated Reaction of α-4(20)-Epoxy-5α -hydroxy Taxinine B

Imaging of Digital Versatile Rewritable Disc using the Reflection-Mode Scattering-Type Scanning Near-Field Optical Microscope

Administering cultured Taxus cells with early precursors reveals bifurcations in the taxoid biosynthetic pathway

Synthesis and biological evaluation of 4-Deacetoxy-1,7-dideoxy azetidine paclitaxel analogues

Feeding Cultured Taxus Cells with Early Precursors Reveals Bifurcations in the Taxoid Biosynthetic Pathway

Studies on Taxol® biosynthesis. Preparation and tritium labeling of biosynthetic intermediates by deoxygenation of a taxadiene tetra-acetate obtained from Japanese yew

Synthesis and antitumor activity of 2-( m-substituted-benzoyl)baccatin III analogs from taxinine

( iPrO) 3TiCl-induced reactions of α- and β-4(20)-epoxy-5-hydroxytriacetyltaxicin I

Studies on taxol biosynthesis. Preparation of 5α-acetoxytaxa-4(20),11-dien-2α,10β-diol derivatives by deoxygenation of a taxadiene tetra-acetate obtained from Japanese yew

Studies on Taxol Biosynthesis. Preparation of Taxa-4(20),11(12)-dien-5α-acetoxy-10β-ol by Deoxygenation of a Taxadiene Tetraacetate Obtained from Japanese Yew

A study on the mechanism of enhanced diuresis following direct hemoperfusion with polymyxin B-immobilized fiber

Highly regio- and stereospecific hydroxylation of C-1 position of 2-deacetoxytaxinine J derivative with DMDO

The Synthesis and Biological Activity of 9- and 2′-cAMP 7-Deoxypaclitaxel Analogues from 5-Cinnamoyltriacetyltaxicin-I

Synthesis and biological evaluation of novel 9-functional heterocyclic coupled 7-deoxy-9-Dihydropaclitaxel analogue

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