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Recent advances in the discovery and development of factor XI/XIa inhibitors

Medicinal research reviews, 2018-11, Vol.38 (6), p.1974-2023

2018

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Potential Anti-SARS-CoV-2 Therapeutics That Target the Post-Entry Stages of the Viral Life Cycle: A Comprehensive Review

Viruses, 2020-09, Vol.12 (10), p.1092

2020

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Differential recycling of coral and algal dissolved organic matter via the sponge loop

Functional ecology, 2017-03, Vol.31 (3), p.778-789

2017

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Factor XI(a) inhibitors for thrombosis: an updated patent review (2016-present)

Expert opinion on therapeutic patents, 2020-01, Vol.30 (1), p.39-55

Al-Horani, Rami A.

2020

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Recent Advances on Plasmin Inhibitors for the Treatment of Fibrinolysis-Related Disorders

Medicinal research reviews, 2014-11, Vol.34 (6), p.1168-1216

2014

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Thrombin Inhibition by Argatroban: Potential Therapeutic Benefits in COVID-19

Cardiovascular drugs and therapy, 2021-04, Vol.35 (2), p.195-203

2021

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Potential Anti-COVID-19 Therapeutics that Block the Early Stage of the Viral Life Cycle: Structures, Mechanisms, and Clinical Trials

International journal of molecular sciences, 2020-07, Vol.21 (15), p.5224

2020

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Potential Therapeutic Benefits of Dipyridamole in COVID-19 Patients

Current pharmaceutical design, 2021-01, Vol.27 (6), p.866-875

2021

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Chemical sulfation of small molecules—advances and challenges

Tetrahedron, 2010-04, Vol.66 (16), p.2907-2918

2010

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Sulfonated non‐saccharide molecules and human factor XIa: Enzyme inhibition and computational studies

Chemical biology & drug design, 2022-07, Vol.100 (1), p.64-79

2022

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A synthetic heparin mimetic that allosterically inhibits factor XIa and reduces thrombosis in vivo without enhanced risk of bleeding

Journal of thrombosis and haemostasis, 2019-12, Vol.17 (12), p.2110-2122

2019

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The mechanism of calcification and its relation to photosynthesis and respiration in the scleractinian coral Galaxea fascicularis

Marine biology, 2003-03, Vol.142 (3), p.419-426

2003

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Chemically Synthesized 1,2,3,4,6-Pentakis-O-Galloyl-β-D-Glucopyranoside Blocks SARS-CoV-2 Spike Interaction with Host ACE-2 Receptor

Medicinal chemistry (Shp-sariqah, United Arab Emirates), 2024-01, Vol.20 (10), p.986-991

2024

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Tirzepatide: A New Generation Therapeutic for Diabetes Type 2

Endocrine, metabolic & immune disorders drug targets, 2023-01, Vol.23 (8), p.1046-1050

2023

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Coral mucus fuels the sponge loop in warm- and cold-water coral reef ecosystems

Scientific reports, 2016-01, Vol.6 (1), p.18715-18715, Article 18715

2016

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Sulfated Non-Saccharide Glycosaminoglycan Mimetics as Novel Drug Discovery Platform for Various Pathologies

Current medicinal chemistry, 2020-01, Vol.27 (21), p.3412-3447

2020

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Vericiguat: A New Hope for Heart Failure Patients

Cardiovascular therapeutics, 2022, Vol.2022, p.1554875-6

2022

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The In Vitro Effects of Pentamidine Isethionate on Coagulation and Fibrinolysis

Molecules (Basel, Switzerland), 2019-06, Vol.24 (11), p.2146

2019

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6-(Arylaminomethyl) Isoquinolines as Enzyme Inhibitors and Their Preparation: A Patent Highlight of Factor XIIa Inhibitors

Cardiovascular & hematological agents in medicinal chemistry, 2023-01, Vol.21 (3), p.243-249

Al-Horani, Rami A

2023

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3-( 1H -Imidazol-2-Yl)-2,3,8,8a-Tetrahydroindolizin-5( 1H )-One Derivatives are Useful as Factor Xia Inhibitors and Their Preparation

Cardiovascular & hematological agents in medicinal chemistry, 2023, Vol.21 (3), p.240-242

Al-Horani, Rami A

2023

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Prevalence of Vibrio coralliilyticus in stony coral Porites sp. in the Gulf of Aqaba, Jordan

Letters in applied microbiology, 2022-08, Vol.75 (2), p.460-469

2022

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First Therapeutic Approval for Eosinophilic Esophagitis

Gastroenterology insights, 2022-09, Vol.13 (3), p.238-244

2022

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Revisiting the effect of cholesteryl sulfate on clotting and fibrinolysis: Inhibition of human thrombin and other human blood proteases

Heliyon, 2024-03, Vol.10 (6), p.e28017, Article e28017

Al-Horani, Rami A.

2024

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Venous Thromboembolism Prophylaxis in Major Orthopedic Surgeries and Factor XIa Inhibitors

Medical sciences (Basel), 2023-08, Vol.11 (3), p.49

2023

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Discovery of Benzyl Tetraphosphonate Derivative as Inhibitor of Human Factor Xia

ChemistryOpen (Weinheim), 2020-11, Vol.9 (11), p.1161-1172

2020

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Recent advances in the discovery and development of factor XI/XIa inhibitors

Potential Anti-SARS-CoV-2 Therapeutics That Target the Post-Entry Stages of the Viral Life Cycle: A Comprehensive Review

Differential recycling of coral and algal dissolved organic matter via the sponge loop

Factor XI(a) inhibitors for thrombosis: an updated patent review (2016-present)

Recent Advances on Plasmin Inhibitors for the Treatment of Fibrinolysis-Related Disorders

Thrombin Inhibition by Argatroban: Potential Therapeutic Benefits in COVID-19

Potential Anti-COVID-19 Therapeutics that Block the Early Stage of the Viral Life Cycle: Structures, Mechanisms, and Clinical Trials

Potential Therapeutic Benefits of Dipyridamole in COVID-19 Patients

Chemical sulfation of small molecules—advances and challenges

Sulfonated non‐saccharide molecules and human factor XIa: Enzyme inhibition and computational studies

A synthetic heparin mimetic that allosterically inhibits factor XIa and reduces thrombosis in vivo without enhanced risk of bleeding

The mechanism of calcification and its relation to photosynthesis and respiration in the scleractinian coral Galaxea fascicularis

Chemically Synthesized 1,2,3,4,6-Pentakis-O-Galloyl-β-D-Glucopyranoside Blocks SARS-CoV-2 Spike Interaction with Host ACE-2 Receptor

Tirzepatide: A New Generation Therapeutic for Diabetes Type 2

Coral mucus fuels the sponge loop in warm- and cold-water coral reef ecosystems

Sulfated Non-Saccharide Glycosaminoglycan Mimetics as Novel Drug Discovery Platform for Various Pathologies

Vericiguat: A New Hope for Heart Failure Patients

The In Vitro Effects of Pentamidine Isethionate on Coagulation and Fibrinolysis

6-(Arylaminomethyl) Isoquinolines as Enzyme Inhibitors and Their Preparation: A Patent Highlight of Factor XIIa Inhibitors

3-( 1H -Imidazol-2-Yl)-2,3,8,8a-Tetrahydroindolizin-5( 1H )-One Derivatives are Useful as Factor Xia Inhibitors and Their Preparation

Prevalence of Vibrio coralliilyticus in stony coral Porites sp. in the Gulf of Aqaba, Jordan

First Therapeutic Approval for Eosinophilic Esophagitis

Revisiting the effect of cholesteryl sulfate on clotting and fibrinolysis: Inhibition of human thrombin and other human blood proteases

Venous Thromboembolism Prophylaxis in Major Orthopedic Surgeries and Factor XIa Inhibitors

Discovery of Benzyl Tetraphosphonate Derivative as Inhibitor of Human Factor Xia

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