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Effects of CYP46A1 Inhibition on Long-Term-Depression in Hippocampal Slices ex vivo and 24S-Hydroxycholesterol Levels in Mice in vivo

Frontiers in molecular neuroscience, 2020-10, Vol.13, p.568641-568641

2020

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Discovery of Selective Toxoplasma gondii Dihydrofolate Reductase Inhibitors for the Treatment of Toxoplasmosis

Journal of medicinal chemistry, 2019-02, Vol.62 (3), p.1562-1576

2019

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Optimizing Pyrazolopyrimidine Inhibitors of Calcium Dependent Protein Kinase 1 for Treatment of Acute and Chronic Toxoplasmosis

Journal of medicinal chemistry, 2020-06, Vol.63 (11), p.6144-6163

2020

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Effects of the novel PDE4 inhibitors MEM1018 and MEM1091 on memory in the radial-arm maze and inhibitory avoidance tests in rats

Psychopharmacologia, 2005-05, Vol.179 (3), p.613-619

2005

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Allosteric Modalities for Membrane-Bound Receptors: Insights from Drug Hunting for Brain Diseases

Journal of medicinal chemistry, 2019-07, Vol.62 (13), p.5979-6002

2019

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Antidepressant-like effects of PDE4 inhibitors mediated by the high-affinity rolipram binding state (HARBS) of the phosphodiesterase-4 enzyme (PDE4) in rats

Psychopharmacologia, 2006-06, Vol.186 (2), p.209-217

2006

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Synthesis and Characterization of the Novel Rodent-Active and CNS-Penetrant P2X7 Receptor Antagonist Lu AF27139

Journal of medicinal chemistry, 2021-04, Vol.64 (8), p.4891-4902

2021

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P2X7 receptor‐mediated release of microglial prostanoids and miRNAs correlates with reversal of neuropathic hypersensitivity in rats

European journal of pain, 2022-07, Vol.26 (6), p.1304-1321

2022

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Fused thiazolyl alkynes as potent mGlu5 receptor positive allosteric modulators

Bioorganic & medicinal chemistry letters, 2013-07, Vol.23 (14), p.4037-4043

2013

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Design, Synthesis, and Biological Evaluation of Conformationally Constrained a ci-Reductone Mimics of Arachidonic Acid

Journal of medicinal chemistry, 1998-02, Vol.41 (4), p.420-427

1998

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Synthesis of Enantiomerically Pure Stereogenically Labile 4-Aryl-2-hydroxytetronic Acids from Enantiomerically Pure Silyl-Protected Mandelaldehydes: aci-Reductone Analogs of Propionic Acid Nonsteroidal Anti-inflammatory Agents

Journal of organic chemistry, 1995-06, Vol.60 (11), p.3334-3341

1995

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Recent Developments in Targeting Neuroinflammation in Disease

Annual Reports in Medicinal Chemistry, 2012, Vol.47, p.37-53

2012

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Neuroinflammation in Mood Disorders: Mechanisms and Drug Targets

Annual Reports in Medicinal Chemistry, 2013, Vol.48, p.317-331

2013

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Design, Synthesis, and Biological Evaluation of Conformationally Constrained aci-Reductone Mimics of Arachidonic Acid

Journal of medicinal chemistry, 1998-02, Vol.41 (4), p.420-427

1998

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Elastic-plastic analysis of edge-notched panels subjected to fixed grip loading

Engineering fracture mechanics, 1991, Vol.38 (4), p.283-294

1991

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Pharmaceuticals, Chiral

Van Nostrand's Encyclopedia of Chemistry, 2005, p.1265-1269

2005

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Neuroinflammation in Mood Disorders

Annual Reports in Medicinal Chemistry, 2013, Vol.48, p.317-331

2013

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aci-Reductones: Drug design, enantioselective syntheses and biological activities within lipid membranes

Pharmacochemistry Library, 1997, Vol.28, p.149-162

1997

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Biological Significance of Serum Albumin Binding Parameters Determined In Vitro for Clofibrate-Related Hypolipemic Drugs: Use of 2-(4'-Hydroxybenzeneazo)benzoic Acid to Mirror L-Thyroxine Binding to and Displacement from Serum Albumins

Journal of pharmaceutical sciences, 1974-02, Vol.63 (2), p.203-211

1974

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Use of 2-(4′-Hydroxybenzeneazo)benzoic Acid to Study the Binding of L-Thyroxine to Serum Albumins

Journal of pharmaceutical sciences, 1974-02, Vol.63 (2), p.199-202

1974

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The Left Ventricle in Congenital Diaphragmatic Hernia: Implications for the Management of Pulmonary Hypertension

The Journal of pediatrics, 2018-06, Vol.197, p.17-22

2018

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House dust mite sensitization in toddlers predicts current wheeze at age 12 years

Journal of allergy and clinical immunology, 2011-10, Vol.128 (4), p.782-788.e9

2011

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Bivariate mixture models for the joint distribution of repeated serum ferritin and transferrin saturation measured 12 years apart in a cohort of healthy middle-aged Australians

PloS one, 2019-03, Vol.14 (3), p.e0214196

2019

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Recommendations for the Use of Inhaled Nitric Oxide Therapy in Premature Newborns with Severe Pulmonary Hypertension

The Journal of pediatrics, 2016-03, Vol.170, p.312-314

2016

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Rapid synthesis of 1,7-bis(t-butoxycarbonylmethyl)-1,4,7,10-tetraazacyclododecane (DO2A-t-Bu ester)

Tetrahedron letters, 2014-10, Vol.55 (40), p.5560-5561

2014

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Effects of CYP46A1 Inhibition on Long-Term-Depression in Hippocampal Slices ex vivo and 24S-Hydroxycholesterol Levels in Mice in vivo

Discovery of Selective Toxoplasma gondii Dihydrofolate Reductase Inhibitors for the Treatment of Toxoplasmosis

Optimizing Pyrazolopyrimidine Inhibitors of Calcium Dependent Protein Kinase 1 for Treatment of Acute and Chronic Toxoplasmosis

Effects of the novel PDE4 inhibitors MEM1018 and MEM1091 on memory in the radial-arm maze and inhibitory avoidance tests in rats

Allosteric Modalities for Membrane-Bound Receptors: Insights from Drug Hunting for Brain Diseases

Antidepressant-like effects of PDE4 inhibitors mediated by the high-affinity rolipram binding state (HARBS) of the phosphodiesterase-4 enzyme (PDE4) in rats

Synthesis and Characterization of the Novel Rodent-Active and CNS-Penetrant P2X7 Receptor Antagonist Lu AF27139

P2X7 receptor‐mediated release of microglial prostanoids and miRNAs correlates with reversal of neuropathic hypersensitivity in rats

Fused thiazolyl alkynes as potent mGlu5 receptor positive allosteric modulators

Design, Synthesis, and Biological Evaluation of Conformationally Constrained a ci-Reductone Mimics of Arachidonic Acid

Synthesis of Enantiomerically Pure Stereogenically Labile 4-Aryl-2-hydroxytetronic Acids from Enantiomerically Pure Silyl-Protected Mandelaldehydes: aci-Reductone Analogs of Propionic Acid Nonsteroidal Anti-inflammatory Agents

Recent Developments in Targeting Neuroinflammation in Disease

Neuroinflammation in Mood Disorders: Mechanisms and Drug Targets

Design, Synthesis, and Biological Evaluation of Conformationally Constrained aci-Reductone Mimics of Arachidonic Acid

Elastic-plastic analysis of edge-notched panels subjected to fixed grip loading

Pharmaceuticals, Chiral

Neuroinflammation in Mood Disorders

aci-Reductones: Drug design, enantioselective syntheses and biological activities within lipid membranes

Biological Significance of Serum Albumin Binding Parameters Determined In Vitro for Clofibrate-Related Hypolipemic Drugs: Use of 2-(4'-Hydroxybenzeneazo)benzoic Acid to Mirror L-Thyroxine Binding to and Displacement from Serum Albumins

Use of 2-(4′-Hydroxybenzeneazo)benzoic Acid to Study the Binding of L-Thyroxine to Serum Albumins

The Left Ventricle in Congenital Diaphragmatic Hernia: Implications for the Management of Pulmonary Hypertension

House dust mite sensitization in toddlers predicts current wheeze at age 12 years

Bivariate mixture models for the joint distribution of repeated serum ferritin and transferrin saturation measured 12 years apart in a cohort of healthy middle-aged Australians

Recommendations for the Use of Inhaled Nitric Oxide Therapy in Premature Newborns with Severe Pulmonary Hypertension

Rapid synthesis of 1,7-bis(t-butoxycarbonylmethyl)-1,4,7,10-tetraazacyclododecane (DO2A-t-Bu ester)

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