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Selective inhibition of the p38α MAPK-MK2 axis inhibits inflammatory cues including inflammasome priming signals

The Journal of experimental medicine, 2018-05, Vol.215 (5), p.1315-1325

2018

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Selective Inhibition of the MK2 Pathway: Data From a Phase IIa Randomized Clinical Trial in Rheumatoid Arthritis

ACR open rheumatology, 2023-02, Vol.5 (2), p.63-70

2023

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Anti-inflammatory properties of a novel N-phenyl pyridinone inhibitor of p38 mitogen-activated protein kinase: preclinical-to-clinical translation

The Journal of pharmacology and experimental therapeutics, 2009-12, Vol.331 (3), p.882-895

2009

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Structural Bioinformatics-Based Prediction of Exceptional Selectivity of p38 MAP Kinase Inhibitor PH-797804

Biochemistry (Easton), 2009-07, Vol.48 (27), p.6402-6411

2009

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Healing by Creating: Patient Evaluations of Art‐Making Program

The Journal of creative behavior, 2017-03, Vol.51 (1), p.35-44

2017

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Safety, Tolerability, Pharmacokinetics, and Pharmacodynamics of the MK2 Inhibitor ATI-450 in Healthy Subjects: A Placebo-Controlled, Randomized Phase 1 Study

Clinical pharmacology: advances and applications, 2021, Vol.13, p.123-134

2021

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Interleukin-1β-induced interleukin-6 production in A549 cells is mediated by both phosphatidylinositol 3-kinase and interleukin-1 receptor-associated kinase-4

Cell biology international, 2011-04, Vol.35 (4), p.355-358

2011

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Discovery of Clinical Candidate 1‑{[(2S,3S,4S)‑3-Ethyl-4-fluoro-5-oxopyrrolidin-2-yl]methoxy}-7-methoxyisoquinoline-6-carboxamide (PF-06650833), a Potent, Selective Inhibitor of Interleukin‑1 Receptor Associated Kinase 4 (IRAK4), by Fragment-Based Drug Design

Journal of medicinal chemistry, 2017-07, Vol.60 (13), p.5521-5542

2017

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ATI-1777, a Topical Jak1/3 Inhibitor, May Benefit Atopic Dermatitis without Systemic Drug Exposure: Results from Preclinical Development and Phase 2a Randomized Control Study ATI-1777-AD-201

JID innovations, 2024-03, Vol.4 (2), p.100251-100251, Article 100251

2024

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Inhibition of cholesteryl ester transfer protein by substituted dithiobisnicotinic acid dimethyl ester: involvement Of a critical cysteine

Journal of lipid research, 2000-10, Vol.41 (10), p.1604-1614

2000

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Phosphoinositides and phosphoinositide-utilizing enzymes in detergent-insoluble lipid domains

Molecular biology of the cell, 1996-06, Vol.7 (6), p.843-851

1996

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Healing Icons: Art Support Program for Patients with Cancer

Cancer practice, 1999-07, Vol.7 (4), p.183-189

1999

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SD0006: A Potent, Selective and Orally Available Inhibitor of p38 Kinase

Pharmacology, 2009-01, Vol.84 (1), p.42-60

2009

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Development and Comparison of Two 3T3-L1 Adipocyte Models of Insulin Resistance: Increased Glucose Flux vs Glucosamine Treatment

Biochemical and biophysical research communications, 2000-07, Vol.273 (3), p.1033-1041

2000

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Large-Scale Purification of Myeloperoxidase from HL60 Promyelocytic Cells: Characterization and Comparison to Human Neutrophil Myeloperoxidase

Protein expression and purification, 2000-04, Vol.18 (3), p.269-276

2000

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Detection in their power: Women sleuths, women writers, and the Victorian novel

Johnson, Heidi Hope

2001

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Purification and characterization of a polyphosphoinositide phosphatase from rat brain

The Journal of biological chemistry, 1994-09, Vol.269 (38), p.23648-23654

1994

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Phase II Randomized Study of Neoadjuvant Everolimus Plus Letrozole Compared With Placebo Plus Letrozole in Patients With Estrogen Receptor–Positive Breast Cancer

Journal of clinical oncology, 2009-06, Vol.27 (16), p.2630-2637

2009

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Functional modulation of cardiac form through regionally confined cell shape changes

PLoS biology, 2007-03, Vol.5 (3), p.e53-e53

2007

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Risk-Based Screening for Cancer in Patients With Dermatomyositis: Toward a More Individualized Approach

JAMA dermatology (Chicago, Ill.), 2022-03, Vol.158 (3), p.244

2022

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Wavefront sensorless adaptive optics ophthalmoscopy in the human eye

Optics express, 2011-07, Vol.19 (15), p.14160-14171

2011

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Phase I Trial of the Oral Antiangiogenesis Agent AG-013736 in Patients With Advanced Solid Tumors: Pharmacokinetic and Clinical Results

Journal of clinical oncology, 2005-08, Vol.23 (24), p.5474-5483

2005

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Defining the Time-limited Trial for Patients with Critical Illness: An Official American Thoracic Society Workshop Report

Annals of the American Thoracic Society, 2024-02, Vol.21 (2), p.187

2024

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Maternal Iodine Intake and Offspring Attention-Deficit/Hyperactivity Disorder: Results from a Large Prospective Cohort Study

Nutrients, 2017-11, Vol.9 (11), p.1239

2017

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Bidirectional genetic overlap between autism spectrum disorder and cognitive traits

Translational psychiatry, 2023-09, Vol.13 (1), p.295-9, Article 295

2023

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Selective inhibition of the p38α MAPK-MK2 axis inhibits inflammatory cues including inflammasome priming signals

Selective Inhibition of the MK2 Pathway: Data From a Phase IIa Randomized Clinical Trial in Rheumatoid Arthritis

Anti-inflammatory properties of a novel N-phenyl pyridinone inhibitor of p38 mitogen-activated protein kinase: preclinical-to-clinical translation

Structural Bioinformatics-Based Prediction of Exceptional Selectivity of p38 MAP Kinase Inhibitor PH-797804

Healing by Creating: Patient Evaluations of Art‐Making Program

Safety, Tolerability, Pharmacokinetics, and Pharmacodynamics of the MK2 Inhibitor ATI-450 in Healthy Subjects: A Placebo-Controlled, Randomized Phase 1 Study

Interleukin-1β-induced interleukin-6 production in A549 cells is mediated by both phosphatidylinositol 3-kinase and interleukin-1 receptor-associated kinase-4

Discovery of Clinical Candidate 1‑{[(2S,3S,4S)‑3-Ethyl-4-fluoro-5-oxopyrrolidin-2-yl]methoxy}-7-methoxyisoquinoline-6-carboxamide (PF-06650833), a Potent, Selective Inhibitor of Interleukin‑1 Receptor Associated Kinase 4 (IRAK4), by Fragment-Based Drug Design

ATI-1777, a Topical Jak1/3 Inhibitor, May Benefit Atopic Dermatitis without Systemic Drug Exposure: Results from Preclinical Development and Phase 2a Randomized Control Study ATI-1777-AD-201

Inhibition of cholesteryl ester transfer protein by substituted dithiobisnicotinic acid dimethyl ester: involvement Of a critical cysteine

Phosphoinositides and phosphoinositide-utilizing enzymes in detergent-insoluble lipid domains

Healing Icons: Art Support Program for Patients with Cancer

SD0006: A Potent, Selective and Orally Available Inhibitor of p38 Kinase

Development and Comparison of Two 3T3-L1 Adipocyte Models of Insulin Resistance: Increased Glucose Flux vs Glucosamine Treatment

Large-Scale Purification of Myeloperoxidase from HL60 Promyelocytic Cells: Characterization and Comparison to Human Neutrophil Myeloperoxidase

Detection in their power: Women sleuths, women writers, and the Victorian novel

Purification and characterization of a polyphosphoinositide phosphatase from rat brain

Phase II Randomized Study of Neoadjuvant Everolimus Plus Letrozole Compared With Placebo Plus Letrozole in Patients With Estrogen Receptor–Positive Breast Cancer

Functional modulation of cardiac form through regionally confined cell shape changes

Risk-Based Screening for Cancer in Patients With Dermatomyositis: Toward a More Individualized Approach

Wavefront sensorless adaptive optics ophthalmoscopy in the human eye

Phase I Trial of the Oral Antiangiogenesis Agent AG-013736 in Patients With Advanced Solid Tumors: Pharmacokinetic and Clinical Results

Defining the Time-limited Trial for Patients with Critical Illness: An Official American Thoracic Society Workshop Report

Maternal Iodine Intake and Offspring Attention-Deficit/Hyperactivity Disorder: Results from a Large Prospective Cohort Study

Bidirectional genetic overlap between autism spectrum disorder and cognitive traits

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