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Inhibitors of Cathepsin B Improve Memory and Reduce β-Amyloid in Transgenic Alzheimer Disease Mice Expressing the Wild-type, but Not the Swedish Mutant, β-Secretase Site of the Amyloid Precursor Protein

The Journal of biological chemistry, 2008-03, Vol.283 (12), p.7745-7753

2008

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The NASA Twins Study: A multidimensional analysis of a year-long human spaceflight

Science (American Association for the Advancement of Science), 2019-04, Vol.364 (6436)

2019

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The Novel Bovine Serpin Endopin 2C Demonstrates Selective Inhibition of the Cysteine Protease Cathepsin L Compared to the Serine Protease Elastase, in Cross-Class Inhibition

Biochemistry (Easton), 2005-05, Vol.44 (21), p.7757-7767

2005

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Genetic cathepsin B deficiency reduces β-amyloid in transgenic mice expressing human wild-type amyloid precursor protein

Biochemical and biophysical research communications, 2009-08, Vol.386 (2), p.284-288

2009

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Obliteration of α‐melanocyte‐stimulating hormone derived from POMC in pituitary and brains of PC2‐deficient mice

Journal of neurochemistry, 2003-08, Vol.86 (3), p.556-563

2003

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β‐Amyloid peptide in regulated secretory vesicles of chromaffin cells: evidence for multiple cysteine proteolytic activities in distinct pathways for β‐secretase activity in chromaffin vesicles

Journal of neurochemistry, 2002-04, Vol.81 (2), p.237-256

2002

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Catecholamine storage vesicles and the metabolic syndrome: the role of the chromogranin A fragment pancreastatin

Diabetes, obesity & metabolism, 2006-11, Vol.8 (6), p.621-633

2006

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Identification of novel loci affecting circulating chromogranins and related peptides

Human molecular genetics, 2017-01, Vol.26 (1), p.233-242

2017

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Cysteine protease inhibitors reduce brain β-amyloid and β-secretase activity in vivo and are potential Alzheimer's disease therapeutics

Biological chemistry, 2007-09, Vol.388 (9), p.979-983

2007

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Sorting of the Neuroendocrine Secretory Protein Secretogranin II into the Regulated Secretory Pathway: ROLE OF N- AND C-TERMINAL α-HELICAL DOMAINS

The Journal of biological chemistry, 2008-04, Vol.283 (17), p.11807-11822

2008

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The Novel Serpin Endopin 2 Demonstrates Cross-Class Inhibition of Papain and Elastase: Localization of Endopin 2 to Regulated Secretory Vesicles of Neuroendocrine Chromaffin Cells

Biochemistry (Easton), 2002-08, Vol.41 (33), p.10397-10405

2002

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Chromogranin B: intra‐ and extra‐cellular mechanisms to regulate catecholamine storage and release, in catecholaminergic cells and organisms

Journal of neurochemistry, 2014-04, Vol.129 (1), p.48-59

2014

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Neuroproteases in peptide neurotransmission and neurodegenerative diseases: applications to drug discovery research

BioDrugs : clinical immunotherapeutics, biopharmaceuticals, and gene therapy, 2006-01, Vol.20 (2), p.105-119

Hook, Vivian Y H

2006

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Tissue-Specific Proteolysis of Huntingtin (htt) in Human Brain: Evidence of Enhanced Levels of N- and C-Terminal htt Fragments in Huntington's Disease Striatum

The Journal of neuroscience, 2001-03, Vol.21 (6), p.1830-1837

2001

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Genes and environment: novel, functional polymorphism in the human cathepsin L (CTSL1) promoter disrupts a xenobiotic response element (XRE) to alter transcription and blood pressure

Journal of hypertension, 2012-10, Vol.30 (10), p.1961-1969

2012

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Primary culture of bovine chromaffin cells

Nature protocols, 2007-05, Vol.2 (5), p.1248-1253

2007

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Unique neuronal functions of cathepsin L and cathepsin B in secretory vesicles: biosynthesis of peptides in neurotransmission and neurodegenerative disease

Biological chemistry, 2006-10, Vol.387 (10/11), p.1429-1439

Hook, Vivian Y H

2006

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Protease pathways in peptide neurotransmission and neurodegenerative diseases

Cellular and molecular neurobiology, 2006-07, Vol.26 (4-6), p.449-467

Hook, Vivian Y H

2006

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Multiple domains of endopin 2A for serpin cross-class inhibition of papain

Archives of biochemistry and biophysics, 2007-05, Vol.461 (2), p.219-224

2007

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Sorting of the Neuroendocrine Secretory Protein Secretogranin II into the Regulated Secretory Pathway

The Journal of biological chemistry, 2008-04, Vol.283 (17), p.11807-11822

2008

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Naturally Occurring Genetic Variants in Human Chromogranin A (CHGA) Associated with Hypertension as well as Hypertensive Renal Disease

Cellular and molecular neurobiology, 2010-11, Vol.30 (8), p.1395-1400

2010

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Evidence for the Proenkephalin Processing Enzyme Prohormone Thiol Protease (PTP) as a Multicatalytic Cysteine Protease Complex: Activation by Glutathione Localized to Secretory Vesicles

Biochemistry (Easton), 1999-06, Vol.38 (23), p.7421-7430

1999

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Selective roles for the PC2 processing enzyme in the regulation of peptide neurotransmitter levels in brain and peripheral neuroendocrine tissues of PC2 deficient mice

Neuropeptides (Edinburgh), 2003-06, Vol.37 (3), p.140-148

2003

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Demonstration of GTG as an endogenous initiation codon for a human mRNA transcript revealed by molecular cloning of the serpin endopin 2B

The Journal of biological chemistry, 2015-07, Vol.290 (31), p.19010-19010

2015

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Regulation of ACTH levels in anterior pituitary cells during stimulated secretion: evidence for aspartyl and cysteine proteases in the cellular metabolism of ACTH

Peptides (New York, N.Y. : 1980), 2003-05, Vol.24 (5), p.717-725

2003

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Inhibitors of Cathepsin B Improve Memory and Reduce β-Amyloid in Transgenic Alzheimer Disease Mice Expressing the Wild-type, but Not the Swedish Mutant, β-Secretase Site of the Amyloid Precursor Protein

The NASA Twins Study: A multidimensional analysis of a year-long human spaceflight

The Novel Bovine Serpin Endopin 2C Demonstrates Selective Inhibition of the Cysteine Protease Cathepsin L Compared to the Serine Protease Elastase, in Cross-Class Inhibition

Genetic cathepsin B deficiency reduces β-amyloid in transgenic mice expressing human wild-type amyloid precursor protein

Obliteration of α‐melanocyte‐stimulating hormone derived from POMC in pituitary and brains of PC2‐deficient mice

β‐Amyloid peptide in regulated secretory vesicles of chromaffin cells: evidence for multiple cysteine proteolytic activities in distinct pathways for β‐secretase activity in chromaffin vesicles

Catecholamine storage vesicles and the metabolic syndrome: the role of the chromogranin A fragment pancreastatin

Identification of novel loci affecting circulating chromogranins and related peptides

Cysteine protease inhibitors reduce brain β-amyloid and β-secretase activity in vivo and are potential Alzheimer's disease therapeutics

Sorting of the Neuroendocrine Secretory Protein Secretogranin II into the Regulated Secretory Pathway: ROLE OF N- AND C-TERMINAL α-HELICAL DOMAINS

The Novel Serpin Endopin 2 Demonstrates Cross-Class Inhibition of Papain and Elastase: Localization of Endopin 2 to Regulated Secretory Vesicles of Neuroendocrine Chromaffin Cells

Chromogranin B: intra‐ and extra‐cellular mechanisms to regulate catecholamine storage and release, in catecholaminergic cells and organisms

Neuroproteases in peptide neurotransmission and neurodegenerative diseases: applications to drug discovery research

Tissue-Specific Proteolysis of Huntingtin (htt) in Human Brain: Evidence of Enhanced Levels of N- and C-Terminal htt Fragments in Huntington's Disease Striatum

Genes and environment: novel, functional polymorphism in the human cathepsin L (CTSL1) promoter disrupts a xenobiotic response element (XRE) to alter transcription and blood pressure

Primary culture of bovine chromaffin cells

Unique neuronal functions of cathepsin L and cathepsin B in secretory vesicles: biosynthesis of peptides in neurotransmission and neurodegenerative disease

Protease pathways in peptide neurotransmission and neurodegenerative diseases

Multiple domains of endopin 2A for serpin cross-class inhibition of papain

Sorting of the Neuroendocrine Secretory Protein Secretogranin II into the Regulated Secretory Pathway

Naturally Occurring Genetic Variants in Human Chromogranin A (CHGA) Associated with Hypertension as well as Hypertensive Renal Disease

Evidence for the Proenkephalin Processing Enzyme Prohormone Thiol Protease (PTP) as a Multicatalytic Cysteine Protease Complex: Activation by Glutathione Localized to Secretory Vesicles

Selective roles for the PC2 processing enzyme in the regulation of peptide neurotransmitter levels in brain and peripheral neuroendocrine tissues of PC2 deficient mice

Demonstration of GTG as an endogenous initiation codon for a human mRNA transcript revealed by molecular cloning of the serpin endopin 2B

Regulation of ACTH levels in anterior pituitary cells during stimulated secretion: evidence for aspartyl and cysteine proteases in the cellular metabolism of ACTH

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