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Inhibitors of Cathepsin B Improve Memory and Reduce β-Amyloid in Transgenic Alzheimer Disease Mice Expressing the Wild-type, but Not the Swedish Mutant, β-Secretase Site of the Amyloid Precursor Protein

The Journal of biological chemistry, 2008-03, Vol.283 (12), p.7745-7753

2008

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Human Tau Isoforms and Proteolysis for Production of Toxic Tau Fragments in Neurodegeneration

Frontiers in neuroscience, 2021-10, Vol.15, p.702788-702788

2021

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Cathepsin B Gene Knockout Improves Behavioral Deficits and Reduces Pathology in Models of Neurologic Disorders

Pharmacological reviews, 2022-07, Vol.74 (3), p.600-629

2022

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Cathepsin B in neurodegeneration of Alzheimer's disease, traumatic brain injury, and related brain disorders

Biochimica et biophysica acta. Proteins and proteomics, 2020-08, Vol.1868 (8), p.140428-140428, Article 140428

2020

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A Commensal Dipeptidyl Aminopeptidase with Specificity for N‑Terminal Glycine Degrades Human-Produced Antimicrobial Peptides in Vitro

ACS chemical biology, 2018-09, Vol.13 (9), p.2513-2521

2018

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Cellular Senescence: From Mechanisms to Current Biomarkers and Senotherapies

Pharmacological reviews, 2023-07, Vol.75 (4), p.675-713

2023

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Lysosomal Cathepsin Protease Gene Expression Profiles in the Human Brain During Normal Development

Journal of molecular neuroscience, 2018-08, Vol.65 (4), p.420-431

2018

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Genetic cathepsin B deficiency reduces β-amyloid in transgenic mice expressing human wild-type amyloid precursor protein

Biochemical and biophysical research communications, 2009-08, Vol.386 (2), p.284-288

2009

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Cathepsin B inhibition blocks neurite outgrowth in cultured neurons by regulating lysosomal trafficking and remodeling

Journal of neurochemistry, 2020-11, Vol.155 (3), p.300-312

2020

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Cognitive Impairment in Older Adults and Therapeutic Strategies

Pharmacological reviews, 2021-01, Vol.73 (1), p.152-162

2021

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Multi-omics of human plasma reveals molecular features of dysregulated inflammation and accelerated aging in schizophrenia

Molecular psychiatry, 2022-02, Vol.27 (2), p.1217-1225

2022

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Mass Spectrometry Approaches Empowering Neuropeptide Discovery and Therapeutics

Pharmacological reviews, 2022-07, Vol.74 (3), p.662-679

2022

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NeuroPedia: neuropeptide database and spectral library

Bioinformatics, 2011-10, Vol.27 (19), p.2772-2773

2011

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Design of Gallinamide A Analogs as Potent Inhibitors of the Cysteine Proteases Human Cathepsin L and Trypanosoma cruzi Cruzain

Journal of medicinal chemistry, 2019-10, Vol.62 (20), p.9026-9044

2019

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Diversity of Neuropeptide Cell-Cell Signaling Molecules Generated by Proteolytic Processing Revealed by Neuropeptidomics Mass Spectrometry

Journal of the American Society for Mass Spectrometry, 2018-05, Vol.29 (5), p.807-816

2018

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Cathepsin B is a New Drug Target for Traumatic Brain Injury Therapeutics: Evidence for E64d as a Promising Lead Drug Candidate

Frontiers in neurology, 2015-09, Vol.6, p.178-178

2015

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Selective Neutral pH Inhibitor of Cathepsin B Designed Based on Cleavage Preferences at Cytosolic and Lysosomal pH Conditions

ACS chemical biology, 2021-09, Vol.16 (9), p.1628-1643

2021

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The cysteine protease cathepsin B is a key drug target and cysteine protease inhibitors are potential therapeutics for traumatic brain injury

Journal of neurotrauma, 2014-03, Vol.31 (5), p.515-529

2014

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Cysteine Cathepsins in the secretory vesicle produce active peptides: Cathepsin L generates peptide neurotransmitters and cathepsin B produces beta-amyloid of Alzheimer's disease

Biochimica et biophysica acta, 2012-01, Vol.1824 (1), p.89-104

2012

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Penetrating Traumatic Brain Injury Triggers Dysregulation of Cathepsin B Protein Levels Independent of Cysteine Protease Activity in Brain and Cerebral Spinal Fluid

Journal of neurotrauma, 2020-07, Vol.37 (13), p.1574-1586

2020

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The NASA Twins Study: A multidimensional analysis of a year-long human spaceflight

Science (American Association for the Advancement of Science), 2019-04, Vol.364 (6436)

2019

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Human iPSC Neurons Display Activity-Dependent Neurotransmitter Secretion: Aberrant Catecholamine Levels in Schizophrenia Neurons

Stem cell reports, 2014-10, Vol.3 (4), p.531-538

2014

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High-Resolution Mass Spectrometry-Based Approaches for the Detection and Quantification of Peptidase Activity in Plasma

Molecules (Basel, Switzerland), 2020-09, Vol.25 (18), p.4071

2020

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Demonstration of GTG as an endogenous initiation codon for a human mRNA transcript revealed by molecular cloning of the serpin endopin 2B

The Journal of biological chemistry, 2015-07, Vol.290 (31), p.19010-19010

2015

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The Marine Cyanobacterial Metabolite Gallinamide A Is a Potent and Selective Inhibitor of Human Cathepsin L

Journal of natural products (Washington, D.C.), 2014-01, Vol.77 (1), p.92-99

2014

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Inhibitors of Cathepsin B Improve Memory and Reduce β-Amyloid in Transgenic Alzheimer Disease Mice Expressing the Wild-type, but Not the Swedish Mutant, β-Secretase Site of the Amyloid Precursor Protein

Human Tau Isoforms and Proteolysis for Production of Toxic Tau Fragments in Neurodegeneration

Cathepsin B Gene Knockout Improves Behavioral Deficits and Reduces Pathology in Models of Neurologic Disorders

Cathepsin B in neurodegeneration of Alzheimer's disease, traumatic brain injury, and related brain disorders

A Commensal Dipeptidyl Aminopeptidase with Specificity for N‑Terminal Glycine Degrades Human-Produced Antimicrobial Peptides in Vitro

Cellular Senescence: From Mechanisms to Current Biomarkers and Senotherapies

Lysosomal Cathepsin Protease Gene Expression Profiles in the Human Brain During Normal Development

Genetic cathepsin B deficiency reduces β-amyloid in transgenic mice expressing human wild-type amyloid precursor protein

Cathepsin B inhibition blocks neurite outgrowth in cultured neurons by regulating lysosomal trafficking and remodeling

Cognitive Impairment in Older Adults and Therapeutic Strategies

Multi-omics of human plasma reveals molecular features of dysregulated inflammation and accelerated aging in schizophrenia

Mass Spectrometry Approaches Empowering Neuropeptide Discovery and Therapeutics

NeuroPedia: neuropeptide database and spectral library

Design of Gallinamide A Analogs as Potent Inhibitors of the Cysteine Proteases Human Cathepsin L and Trypanosoma cruzi Cruzain

Diversity of Neuropeptide Cell-Cell Signaling Molecules Generated by Proteolytic Processing Revealed by Neuropeptidomics Mass Spectrometry

Cathepsin B is a New Drug Target for Traumatic Brain Injury Therapeutics: Evidence for E64d as a Promising Lead Drug Candidate

Selective Neutral pH Inhibitor of Cathepsin B Designed Based on Cleavage Preferences at Cytosolic and Lysosomal pH Conditions

The cysteine protease cathepsin B is a key drug target and cysteine protease inhibitors are potential therapeutics for traumatic brain injury

Cysteine Cathepsins in the secretory vesicle produce active peptides: Cathepsin L generates peptide neurotransmitters and cathepsin B produces beta-amyloid of Alzheimer's disease

Penetrating Traumatic Brain Injury Triggers Dysregulation of Cathepsin B Protein Levels Independent of Cysteine Protease Activity in Brain and Cerebral Spinal Fluid

The NASA Twins Study: A multidimensional analysis of a year-long human spaceflight

Human iPSC Neurons Display Activity-Dependent Neurotransmitter Secretion: Aberrant Catecholamine Levels in Schizophrenia Neurons

High-Resolution Mass Spectrometry-Based Approaches for the Detection and Quantification of Peptidase Activity in Plasma

Demonstration of GTG as an endogenous initiation codon for a human mRNA transcript revealed by molecular cloning of the serpin endopin 2B

The Marine Cyanobacterial Metabolite Gallinamide A Is a Potent and Selective Inhibitor of Human Cathepsin L

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