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Pharmacodynamic effects of semorinemab on plasma and CSF biomarkers of Alzheimer's disease pathophysiology

Alzheimer's & dementia, 2024-11

2024

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Fully defined NGN2 neuron protocol reveals diverse signatures of neuronal maturation

Cell reports methods, 2024-09, Vol.4 (9), p.100858, Article 100858

2024

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Axonal endoplasmic reticulum tubules control local translation via P180/RRBP1-mediated ribosome interactions

Developmental cell, 2024-08, Vol.59 (16), p.2053-2068.e9

2024

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Context-Specific Stress Causes Compartmentalized SARM1 Activation and Local Degeneration in Cortical Neurons

The Journal of neuroscience, 2024-06, Vol.44 (24), p.e2424232024

2024

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A fluorescent splice-switching mouse model enables high-throughput, sensitive quantification of antisense oligonucleotide delivery and activity

Cell reports methods, 2024-01, Vol.4 (1), p.100673-100673, Article 100673

2024

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TMEM106B reduction does not rescue GRN deficiency in iPSC-derived human microglia and mouse models

iScience, 2023-11, Vol.26 (11), p.108362-108362, Article 108362

2023

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Polarized microtubule remodeling transforms the morphology of reactive microglia and drives cytokine release

Nature communications, 2023-10, Vol.14 (1), p.6322-6322, Article 6322

2023

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Sodium channel endocytosis drives axon initial segment plasticity

Science advances, 2023-09, Vol.9 (37), p.eadf3885-eadf3885

2023

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Correlating the Structure and Gene Silencing Activity of Oligonucleotide-Loaded Lipid Nanoparticles Using Small-Angle X‑ray Scattering

ACS nano, 2023-06, Vol.17 (12), p.11454-11465

2023

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Lipid nanoparticle delivery limits antisense oligonucleotide activity and cellular distribution in the brain after intracerebroventricular injection

Molecular therapy. Nucleic acids, 2023-06, Vol.32, p.773-793

2023

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PTRN-1

PLoS biology, 2022-11, Vol.20 (11)

2022

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PTRN-1 (CAMSAP) and NOCA-2 (NINEIN) are required for microtubule polarity in Caenorhabditis elegans dendrites

PLoS biology, 2022-11, Vol.20 (11), p.e3001855

2022

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Stress‐induced vesicular assemblies of dual leucine zipper kinase are signaling hubs involved in kinase activation and neurodegeneration

The EMBO journal, 2022-07, Vol.41 (14), p.e110155-n/a

2022

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Predictive high-throughput screening of PEGylated lipids in oligonucleotide-loaded lipid nanoparticles for neuronal gene silencing

Nanoscale advances, 2022-05, Vol.4 (9), p.217-2123

2022

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Organization and dynamics of the cortical complexes controlling insulin secretion in β-cells

Journal of cell science, 2022-02, Vol.135 (3)

2022

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Specific KIF1A–adaptor interactions control selective cargo recognition

The Journal of cell biology, 2021-10, Vol.220 (10)

2021

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Inducible manipulation of motor–cargo interaction using engineered kinesin motors

Journal of cell science, 2021-08, Vol.134 (15)

2021

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Multiple layers of spatial regulation coordinate axonal cargo transport

Current opinion in neurobiology, 2021-08, Vol.69, p.241-246

2021

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ER – lysosome contacts at a pre-axonal region regulate axonal lysosome availability

Nature communications, 2021-07, Vol.12 (1), p.4493-4493, Article 4493

2021

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WDR47 protects neuronal microtubule minus ends from katanin-mediated severing

Cell reports (Cambridge), 2021-07, Vol.36 (2), p.109371-109371, Article 109371

2021

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Combined kinesin-1 and kinesin-3 activity drives axonal trafficking of TrkB receptors in Rab6 carriers

Developmental cell, 2021-05, Vol.56 (10), p.1552-1554

2021

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Centrosome‐mediated microtubule remodeling during axon formation in human iPSC‐derived neurons

The EMBO journal, 2021-05, Vol.40 (10), p.e106798-n/a

2021

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Combined kinesin-1 and kinesin-3 activity drives axonal trafficking of TrkB receptors in Rab6 carriers

Developmental cell, 2021-02, Vol.56 (4), p.494-508.e7

2021

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The Mechanism of Selective Kinesin Inhibition by Kinesin Binding Protein

Biophysical journal, 2021-02, Vol.120 (3), p.6a-6a

2021

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Temporal Quantitative Proteomics of mGluR-induced Protein Translation and Phosphorylation in Neurons

Molecular & cellular proteomics, 2020-12, Vol.19 (12), p.1952

2020

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Pharmacodynamic effects of semorinemab on plasma and CSF biomarkers of Alzheimer's disease pathophysiology

Fully defined NGN2 neuron protocol reveals diverse signatures of neuronal maturation

Axonal endoplasmic reticulum tubules control local translation via P180/RRBP1-mediated ribosome interactions

Context-Specific Stress Causes Compartmentalized SARM1 Activation and Local Degeneration in Cortical Neurons

A fluorescent splice-switching mouse model enables high-throughput, sensitive quantification of antisense oligonucleotide delivery and activity

TMEM106B reduction does not rescue GRN deficiency in iPSC-derived human microglia and mouse models

Polarized microtubule remodeling transforms the morphology of reactive microglia and drives cytokine release

Sodium channel endocytosis drives axon initial segment plasticity

Correlating the Structure and Gene Silencing Activity of Oligonucleotide-Loaded Lipid Nanoparticles Using Small-Angle X‑ray Scattering

Lipid nanoparticle delivery limits antisense oligonucleotide activity and cellular distribution in the brain after intracerebroventricular injection

PTRN-1

PTRN-1 (CAMSAP) and NOCA-2 (NINEIN) are required for microtubule polarity in Caenorhabditis elegans dendrites

Stress‐induced vesicular assemblies of dual leucine zipper kinase are signaling hubs involved in kinase activation and neurodegeneration

Predictive high-throughput screening of PEGylated lipids in oligonucleotide-loaded lipid nanoparticles for neuronal gene silencing

Organization and dynamics of the cortical complexes controlling insulin secretion in β-cells

Specific KIF1A–adaptor interactions control selective cargo recognition

Inducible manipulation of motor–cargo interaction using engineered kinesin motors

Multiple layers of spatial regulation coordinate axonal cargo transport

ER – lysosome contacts at a pre-axonal region regulate axonal lysosome availability

WDR47 protects neuronal microtubule minus ends from katanin-mediated severing

Combined kinesin-1 and kinesin-3 activity drives axonal trafficking of TrkB receptors in Rab6 carriers

Centrosome‐mediated microtubule remodeling during axon formation in human iPSC‐derived neurons

Combined kinesin-1 and kinesin-3 activity drives axonal trafficking of TrkB receptors in Rab6 carriers

The Mechanism of Selective Kinesin Inhibition by Kinesin Binding Protein

Temporal Quantitative Proteomics of mGluR-induced Protein Translation and Phosphorylation in Neurons

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