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Benefit Profile of Thrombomodulin Alfa Combined with Antithrombin Concentrate in Patients with Sepsis-Induced Disseminated Intravascular Coagulation

Clinical and applied thrombosis/hemostasis, 2022-02, Vol.28, p.10760296221077096-10760296221077096

2022

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Specific detection of high mobility group box 1 degradation product with a novel ELISA

Molecular medicine (Cambridge, Mass.), 2021-06, Vol.27 (1), p.59-59, Article 59

2021

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Thrombomodulin protects endothelial cells from a calcineurin inhibitor-induced cytotoxicity by upregulation of extracellular signal-regulated kinase/myeloid leukemia cell-1 signaling

Arteriosclerosis, thrombosis, and vascular biology, 2012-09, Vol.32 (9), p.2259

2012

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A Japanese Family Meeting the Clinical Diagnostic Criteria for MEN1 with a MEN1 Variant of Uncertain Significance

Internal Medicine, 2024/04/15, Vol.63(8), pp.1119-1123

2024

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Clinical Features of Disseminated Intravascular Coagulation According to the French-American-British Classification in Patients With Acute Leukemia and Thrombomodulin Alfa Treatment—A Cohort Study Using a Postmarketing Surveillance Database

Clinical and applied thrombosis/hemostasis, 2021-12, Vol.27, p.10760296211054094-10760296211054094

2021

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G-protein coupled receptor 15 mediates angiogenesis and cytoprotective function of thrombomodulin

Scientific reports, 2017-04, Vol.7 (1), p.692-10, Article 692

2017

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LFA-1 and Mac-1 integrins bind to the serine/threonine-rich domain of thrombomodulin

Biochemical and biophysical research communications, 2016-05, Vol.473 (4), p.1005-1012

2016

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Human soluble thrombomodulin-induced blockade of peripheral HMGB1-dependent allodynia in mice requires both the lectin-like and EGF-like domains

Biochemical and biophysical research communications, 2018-01, Vol.495 (1), p.634-638

2018

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Two Japanese families with familial pancreatic cancer with suspected pathogenic variants of CDKN2A: a case report

Hereditary cancer in clinical practice, 2024-07, Vol.22 (1), p.1-6, Article 11

2024

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Severe Antithrombin Deficiency May be Associated With a High Risk of Pathological Progression of DIC With Suppressed Fibrinolysis

Clinical and applied thrombosis/hemostasis, 2020, Vol.26, p.107602962094111-1076029620941112

2020

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Large-scale identification and characterization of human genes that activate NF-κB and MAPK signaling pathways

Oncogene, 2003-05, Vol.22 (21), p.3307-3318

2003

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Hypofibrinogenemia is associated with a high degree of risk in infectious diseases: a post-hoc analysis of post-marketing surveillance of patients with disseminated intravascular coagulation treated with thrombomodulin alfa

Thrombosis journal, 2021-02, Vol.19 (1), p.12-12, Article 12

2021

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Sepsis-Associated DIC with Decreased Levels of Antithrombin and Fibrinogen is the Target for Combination Therapy with Thrombomodulin Alfa and Antithrombin

TH open : companion journal to thrombosis and haemostasis, 2023-01, Vol.7 (1), p.e65-e75

2023

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Recombinant soluble human thrombomodulin (thrombomodulin alfa) in the treatment of neonatal disseminated intravascular coagulation

European journal of pediatrics, 2014-03, Vol.173 (3), p.303-311

2014

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Effects of thrombomodulin alfa on hemostatic parameters in disseminated intravascular coagulation: Post hoc analysis of a phase 3 randomized controlled trial

Research and practice in thrombosis and haemostasis, 2020-10, Vol.4 (7), p.1141-1149

2020

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A Thrombomodulin Promoter Gene Polymorphism, rs2239562, Influences Both Susceptibility to and Outcome of Sepsis

Frontiers in medicine, 2022-01, Vol.8, p.762198-762198

2022

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Thrombomodulin enhances the antifibrinolytic and antileukemic effects of all– trans retinoic acid in acute promyelocytic leukemia cells

Experimental hematology, 2012-06, Vol.40 (6), p.457-465

2012

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Thrombomodulin-induced differentiation of acute myelomonocytic leukemia cells via JNK signaling

Leukemia research, 2012-05, Vol.36 (5), p.625-633

2012

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Postmarketing Surveillance of Recombinant Human Soluble Thrombomodulin (Thrombomodulin α) in Pediatric Patients With Disseminated Intravascular Coagulation

Clinical and applied thrombosis/hemostasis, 2014-07, Vol.20 (5), p.465-472

2014

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The Fifth Epidermal Growth Factor–like Region of Thrombomodulin Alleviates Murine Graft-versus-Host Disease in a G-Protein Coupled Receptor 15 Dependent Manner

Biology of blood and marrow transplantation, 2017-05, Vol.23 (5), p.746-756

2017

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The fifth epidermal growth factor like region of thrombomodulin alleviates LPS-induced sepsis through interacting with GPR15

Thrombosis and haemostasis, 2017, Vol.117 (3), p.570

2017

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Surveillance of the safety and efficacy of recombinant human soluble thrombomodulin in patients with obstetrical disseminated intravascular coagulation

Thrombosis research, 2017-11, Vol.159, p.109-115

2017

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The C Loop of Fifth Epidermal Growth Factor-like Domain of Thrombomodulin Exerts Cytoprotective and Angiogenic Effects in Vitro and In Vivo

Blood, 2017-12, Vol.130, p.2298-2298

2017

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A Japanese Family Meeting the Clinical Diagnostic Criteria for MEN1 with a MEN1 Variant of Uncertain Significance

Internal Medicine, 2023, pp.2300-23

2023

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Abstract 5348: The extracellular domain of thrombomodulin induces erythroid differentiation and hampers proliferation of human leukemia cells in vitro and in vivo

Cancer research (Chicago, Ill.), 2015-08, Vol.75 (15_Supplement), p.5348-5348

2015

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Benefit Profile of Thrombomodulin Alfa Combined with Antithrombin Concentrate in Patients with Sepsis-Induced Disseminated Intravascular Coagulation

Specific detection of high mobility group box 1 degradation product with a novel ELISA

Thrombomodulin protects endothelial cells from a calcineurin inhibitor-induced cytotoxicity by upregulation of extracellular signal-regulated kinase/myeloid leukemia cell-1 signaling

A Japanese Family Meeting the Clinical Diagnostic Criteria for MEN1 with a MEN1 Variant of Uncertain Significance

Clinical Features of Disseminated Intravascular Coagulation According to the French-American-British Classification in Patients With Acute Leukemia and Thrombomodulin Alfa Treatment—A Cohort Study Using a Postmarketing Surveillance Database

G-protein coupled receptor 15 mediates angiogenesis and cytoprotective function of thrombomodulin

LFA-1 and Mac-1 integrins bind to the serine/threonine-rich domain of thrombomodulin

Human soluble thrombomodulin-induced blockade of peripheral HMGB1-dependent allodynia in mice requires both the lectin-like and EGF-like domains

Two Japanese families with familial pancreatic cancer with suspected pathogenic variants of CDKN2A: a case report

Severe Antithrombin Deficiency May be Associated With a High Risk of Pathological Progression of DIC With Suppressed Fibrinolysis

Large-scale identification and characterization of human genes that activate NF-κB and MAPK signaling pathways

Hypofibrinogenemia is associated with a high degree of risk in infectious diseases: a post-hoc analysis of post-marketing surveillance of patients with disseminated intravascular coagulation treated with thrombomodulin alfa

Sepsis-Associated DIC with Decreased Levels of Antithrombin and Fibrinogen is the Target for Combination Therapy with Thrombomodulin Alfa and Antithrombin

Recombinant soluble human thrombomodulin (thrombomodulin alfa) in the treatment of neonatal disseminated intravascular coagulation

Effects of thrombomodulin alfa on hemostatic parameters in disseminated intravascular coagulation: Post hoc analysis of a phase 3 randomized controlled trial

A Thrombomodulin Promoter Gene Polymorphism, rs2239562, Influences Both Susceptibility to and Outcome of Sepsis

Thrombomodulin enhances the antifibrinolytic and antileukemic effects of all– trans retinoic acid in acute promyelocytic leukemia cells

Thrombomodulin-induced differentiation of acute myelomonocytic leukemia cells via JNK signaling

Postmarketing Surveillance of Recombinant Human Soluble Thrombomodulin (Thrombomodulin α) in Pediatric Patients With Disseminated Intravascular Coagulation

The Fifth Epidermal Growth Factor–like Region of Thrombomodulin Alleviates Murine Graft-versus-Host Disease in a G-Protein Coupled Receptor 15 Dependent Manner

The fifth epidermal growth factor like region of thrombomodulin alleviates LPS-induced sepsis through interacting with GPR15

Surveillance of the safety and efficacy of recombinant human soluble thrombomodulin in patients with obstetrical disseminated intravascular coagulation

The C Loop of Fifth Epidermal Growth Factor-like Domain of Thrombomodulin Exerts Cytoprotective and Angiogenic Effects in Vitro and In Vivo

A Japanese Family Meeting the Clinical Diagnostic Criteria for MEN1 with a MEN1 Variant of Uncertain Significance

Abstract 5348: The extracellular domain of thrombomodulin induces erythroid differentiation and hampers proliferation of human leukemia cells in vitro and in vivo

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