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Epac: A New cAMP-Binding Protein in Support of Glucagon-Like Peptide-1 Receptor-Mediated Signal Transduction in the Pancreatic β-Cell

Diabetes (New York, N.Y.), 2004-01, Vol.53 (1), p.5-13

HOLZ, George G

2004

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Cytotoxic Activity of Novel GnRH Analogs Conjugated with Mitoxantrone in Ovarian Cancer Cells

Molecules (Basel, Switzerland), 2024-08, Vol.29 (17), p.4127

2024

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GTS-21, a selective alpha7 nicotinic acetylcholine receptor agonist, ameliorates diabetic nephropathy in Leprdb/db mice

Scientific reports, 2022-12, Vol.12 (1), p.22360-9, Article 22360

2022

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Therapeutic potential of α7 nicotinic acetylcholine receptor agonists to combat obesity, diabetes, and inflammation

Reviews in endocrine & metabolic disorders, 2020-12, Vol.21 (4), p.431-447

2020

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Isoform-specific antagonists of exchange proteins directly activated by cAMP

Proceedings of the National Academy of Sciences - PNAS, 2012-11, Vol.109 (45), p.18613-18618

2012

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Cell physiology of cAMP sensor Epac

The Journal of physiology, 2006-11, Vol.577 (1), p.5-15

2006

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A peptide triple agonist of GLP-1, neuropeptide Y1, and neuropeptide Y2 receptors promotes glycemic control and weight loss

Scientific reports, 2023-06, Vol.13 (1), p.9554-9554, Article 9554

2023

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In vivo derivation of glucose-competent pancreatic endocrine cells from bone marrow without evidence of cell fusion

The Journal of clinical investigation, 2003-03, Vol.111 (6), p.843-850

2003

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Identification and Characterization of Small Molecules as Potent and Specific EPAC2 Antagonists

Journal of medicinal chemistry, 2013-02, Vol.56 (3), p.952-962

2013

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Corrination of a GLP-1 Receptor Agonist for Glycemic Control without Emesis

Cell reports (Cambridge), 2020-06, Vol.31 (11), p.107768-107768, Article 107768

2020

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Nonpeptidic Z360-Analogs Tagged with Trivalent Radiometals as Anti-CCK2R Cancer Theranostic Agents: A Preclinical Study

Pharmaceutics, 2022-03, Vol.14 (3), p.666

2022

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Rp-cAMPS Prodrugs Reveal the cAMP Dependence of First-Phase Glucose-Stimulated Insulin Secretion

Molecular endocrinology (Baltimore, Md.), 2015-07, Vol.29 (7), p.988-1005

2015

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Epac2-Dependent Rap1 Activation and the Control of Islet Insulin Secretion by Glucagon-Like Peptide-1

Incretins and Insulin Secretion, 2010, Vol.84, p.279-302

2010

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Stimulation of Proglucagon Gene Expression by Human GPR119 in Enteroendocrine L-cell Line GLUTag

Molecular endocrinology (Baltimore, Md.), 2013-08, Vol.27 (8), p.1267-1282

2013

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Role of phospholipase Cε in physiological phosphoinositide signaling networks

Cellular signalling, 2012-06, Vol.24 (6), p.1333-1343

2012

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Intra-islet glucagon confers β-cell glucose competence for first-phase insulin secretion and favors GLP-1R stimulation by exogenous glucagon

The Journal of biological chemistry, 2022-02, Vol.298 (2), p.101484-101484, Article 101484

2022

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Glucagon-like peptide-1 induced signaling and insulin secretion do not drive fuel and energy metabolism in primary rodent pancreatic beta-cells

PloS one, 2009-07, Vol.4 (7), p.e6221

2009

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Regulation of Glucose Homeostasis by GLP-1

Progress in Molecular Biology and Translational Science, 2014, Vol.121, p.23-65

2014

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Glucagon-like peptide-1 mobilizes intracellular Ca2+ and stimulates mitochondrial ATP synthesis in pancreatic MIN6 beta-cells

Biochemical journal, 2003-01, Vol.369 (Pt 2), p.287-299

2003

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A novel cyclic adenosine monophosphate responsive luciferase reporter incorporating a nonpalindromic cyclic adenosine monophosphate response element provides optimal performance for use in G protein coupled receptor drug discovery efforts

Journal of biomolecular screening, 2007-08, Vol.12 (5), p.740-746

2007

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Phospholipase C-ε links Epac2 activation to the potentiation of glucose-stimulated insulin secretion from mouse islets of Langerhans

Islets, 2011-05, Vol.3 (3), p.121-128

2011

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PI3 kinases p110 α and PI3K-C2 β negatively regulate cAMP via PDE3/8 to control insulin secretion in mouse and human islets

Molecular metabolism (Germany), 2016-07, Vol.5 (7), p.459-471

2016

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Nonconventional glucagon and GLP-1 receptor agonist and antagonist interplay at the GLP-1 receptor revealed in high-throughput FRET assays for cAMP

The Journal of biological chemistry, 2019-03, Vol.294 (10), p.3514-3531

2019

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Restoration of Glucose-Stimulated Cdc42-Pak1 Activation and Insulin Secretion by a Selective Epac Activator in Type 2 Diabetic Human Islets

Diabetes (New York, N.Y.), 2018-10, Vol.67 (10), p.1999-2011

2018

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Epac-selective cAMP analogs: New tools with which to evaluate the signal transduction properties of cAMP-regulated guanine nucleotide exchange factors

Cellular signalling, 2008-01, Vol.20 (1), p.10-20

2008

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Epac: A New cAMP-Binding Protein in Support of Glucagon-Like Peptide-1 Receptor-Mediated Signal Transduction in the Pancreatic β-Cell

Cytotoxic Activity of Novel GnRH Analogs Conjugated with Mitoxantrone in Ovarian Cancer Cells

GTS-21, a selective alpha7 nicotinic acetylcholine receptor agonist, ameliorates diabetic nephropathy in Leprdb/db mice

Therapeutic potential of α7 nicotinic acetylcholine receptor agonists to combat obesity, diabetes, and inflammation

Isoform-specific antagonists of exchange proteins directly activated by cAMP

Cell physiology of cAMP sensor Epac

A peptide triple agonist of GLP-1, neuropeptide Y1, and neuropeptide Y2 receptors promotes glycemic control and weight loss

In vivo derivation of glucose-competent pancreatic endocrine cells from bone marrow without evidence of cell fusion

Identification and Characterization of Small Molecules as Potent and Specific EPAC2 Antagonists

Corrination of a GLP-1 Receptor Agonist for Glycemic Control without Emesis

Nonpeptidic Z360-Analogs Tagged with Trivalent Radiometals as Anti-CCK2R Cancer Theranostic Agents: A Preclinical Study

Rp-cAMPS Prodrugs Reveal the cAMP Dependence of First-Phase Glucose-Stimulated Insulin Secretion

Epac2-Dependent Rap1 Activation and the Control of Islet Insulin Secretion by Glucagon-Like Peptide-1

Stimulation of Proglucagon Gene Expression by Human GPR119 in Enteroendocrine L-cell Line GLUTag

Role of phospholipase Cε in physiological phosphoinositide signaling networks

Intra-islet glucagon confers β-cell glucose competence for first-phase insulin secretion and favors GLP-1R stimulation by exogenous glucagon

Glucagon-like peptide-1 induced signaling and insulin secretion do not drive fuel and energy metabolism in primary rodent pancreatic beta-cells

Regulation of Glucose Homeostasis by GLP-1

Glucagon-like peptide-1 mobilizes intracellular Ca2+ and stimulates mitochondrial ATP synthesis in pancreatic MIN6 beta-cells

A novel cyclic adenosine monophosphate responsive luciferase reporter incorporating a nonpalindromic cyclic adenosine monophosphate response element provides optimal performance for use in G protein coupled receptor drug discovery efforts

Phospholipase C-ε links Epac2 activation to the potentiation of glucose-stimulated insulin secretion from mouse islets of Langerhans

PI3 kinases p110 α and PI3K-C2 β negatively regulate cAMP via PDE3/8 to control insulin secretion in mouse and human islets

Nonconventional glucagon and GLP-1 receptor agonist and antagonist interplay at the GLP-1 receptor revealed in high-throughput FRET assays for cAMP

Restoration of Glucose-Stimulated Cdc42-Pak1 Activation and Insulin Secretion by a Selective Epac Activator in Type 2 Diabetic Human Islets

Epac-selective cAMP analogs: New tools with which to evaluate the signal transduction properties of cAMP-regulated guanine nucleotide exchange factors

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